Saudi Journal of Pathology and Microbiology最新文献

{"title":"Multiple Complex Odontomas in Maxilla and Mandible: A Rare Case Report","authors":"L. Cherian, Swathi Sanil, K. S, Manjusha Mohanan, S. S, Binuja Elsa Varghese","doi":"10.36348/sjpm.2022.v07i11.001","DOIUrl":"https://doi.org/10.36348/sjpm.2022.v07i11.001","url":null,"abstract":"of the jaws. Rather than true neoplasm, odontomas are considered to be hamartomas. Usually odontomas are found to be asymptomatic, although a few incidences of swelling, delayed eruption of permanent tooth and in severe cases, infection or lymphadenopathy has been reported. Multiple complex odontomas pose a therapeutic challenge in some cases especially in the mandible due to proximity of vital anatomic structures. They have also been associated with complications like cystic transformation. Here we are presenting a case of multiple complex odontomas in the maxilla and mandible in a 32-year-old male patient.","PeriodicalId":407259,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131043573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Anti-Diabetic Potential of Probiotic Lactobacillus fermentum (PRI 29) Isolated from Cameroonian Fermented Cow Milk in Alloxan Induced Diabetes Type-1 Mice Model","authors":"Pride Tanyi Bobga, Bertrand Tatsinkou Fossi, G. S. Taiwé, Kelly Teyowo Nkanpira, Nokwe Ebote Yolande, Fabrice Ambe Ngwa, Liliane Laure Toukam Tatsinkou, Wanyu Bertrand Yuwong, L. Ndip","doi":"10.36348/sjpm.2022.v07i10.001","DOIUrl":"https://doi.org/10.36348/sjpm.2022.v07i10.001","url":null,"abstract":"Background: Diabetes remains a global public health concern in the world. Much is known about the burden of type 2 diabetes as opposed to type 1 diabetes mellitus (T1DM) hence underdiagnosis is evident. Diabetes type 1 is often associated with multiple symptoms and patients with type 1 diabetes are left with regular insulin injection as remedy despite odds of the fact that it is sprout by multiple challenges ranging from hypoglycemia, expensive nature and inconveniences. The use of probiotic bacteria appears today as one of safer alternative to alleviate diabetes and symptoms. Aim of the study: This study aims at characterizing potential hypoglycemic probiotic lactic acid bacterium from fermented cow milk and to evaluate its effects on anthropometric parameters of type-1 diabetes mellitus (T1DM) in an alloxan-induced mice model. Methods: The lactic acid bacteria were isolated from samples of Fulani cow milk using pour plating technique on de Man Rogosa and Sharpe (MRS) agar. The isolates were then further characterized phenotypically and molecularly using the 16s rRNA gene sequencing. Type-1 diabetes mellitus was induced in Balb-c mice by administration of 150mg/Kg B.w of alloxan intraperitoneally, twice consecutively. Animals were randomly divided into 6 groups after induction with 150mg/kg of alloxan per body weight except Group I (normal control). Animals were treated with different probiotic doses of concentration: 9x108 CFU/mL, 1.8x109 CFU/mL and 2.7x109CFU/mL respectively and insulin as positive control. MDA, NO levels as well as anti-oxidant levels (SOD, CAT, GSH) were measured from pancreatic homogenate. Results: One isolate (PRI 29) was selected based on its functional properties like resistance to simulated gastro-intestinal stress environment (acid and bile salt tolerance) and absence of hemolytic activity. This probiotic isolate was identified as a strain of Lactobacillus fermentum. The isolate was sensitive to 10 tested antibiotics including vancomycin, Imipenem and Ciprofloxacin. The isolate resisted acid and bile salts since there was no significant difference (p >0.05) between viable count before and after incubation pH 2.5 and bile salts concentration of 0.3 and 0.6%. Administration of probiotic LAB significantly (p<0.001) ameliorated polydipsia and polyphagia. The glucose and oral glucose tolerance levels were ameliorated in probiotics treated groups p<0.05 as compared to the untreated group. Administration of Lactobacillus fermentum strain was capable of significantly ameliorating oxidative stress in LAB treated mice compared to untreated group (p<0.001) demonstrated by decrease in pro-oxidant NO and MDA. The administration of probiotics led to increase in anti-oxidants (SOD, GSH & CAT) to scavenge oxidative stress biomarkers within the mice treated group (p<0.05). Conclusion: The selected Probiotic lactic acid bacterium isolated from cow milk possess antidiabetic and anti -oxidant properties.","PeriodicalId":407259,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130909992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameloblastomatous Transformation of Dentigerous Cyst-Report of Two Rare Cases","authors":"Dr. Sabu Paul, Dr. Manjusha Mohanan, Dr. Latha Mary Cherian, Dr. Swathi Sanil, Dr. Krishnapriya S, Dr. Rasla P C","doi":"10.36348/sjpm.2022.v07i09.003","DOIUrl":"https://doi.org/10.36348/sjpm.2022.v07i09.003","url":null,"abstract":"Dentigerous cyst is a developmental odontogenic cyst that encloses the crown of an unerupted tooth. Dentigerous cyst linings were found to have the potential to transform into ameloblastoma. Two distinct examples of ameloblastoma developing in the wall of a dentigerous cyst are described here.","PeriodicalId":407259,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115862173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Vaccines Before and During Fourth Wave of COVID-19 in Pakistan - A Comparative Study","authors":"Hafsa Waseem, A. Niazi, Syed Sufyan Khaliq, N. Khaliq, Shafaq Khadija, M. Mufti","doi":"10.36348/sjpm.2022.v07i09.001","DOIUrl":"https://doi.org/10.36348/sjpm.2022.v07i09.001","url":null,"abstract":"Background: Covid-19 is caused by SARS-CoV-2 that effect human respiratory system. This has led to create pandemic situation throughout the world and became the reason for millions of deaths worldwide. For securing the lives of people pharmaceutical companies has rushed to develop vaccines. Some of the notable vaccines being developed include Sinopharm, Sinovac Pfizer, Moderna, Astrazeneca and Cansino. The efficacy of these vaccines varies however the companies claim 70-80% efficacy rate of these vaccines. The current study aims to determine and compare the efficacy of Covid-19 vaccines before and during the fourth wave of Covid-19 in Pakistan. The questionnaire-based survey throughout Pakistan was conducted via google survey form and data was recorded. 1050 responses were recorded in total. The data reveals that most commonly used vaccines in Pakistan were Sinopharm and Sinovac, Cansino. The overall efficacy of all vaccines was 96% before the fourth wave of Covid-19. Whereas, the efficacy of these vaccines got a major drop to 72.4% as soon as the fourth wave emerged in Pakistan.","PeriodicalId":407259,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125616659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Hepatic Hemangioma: A Surgical Surprise","authors":"Abdesslam Bouassria, Tarik Anis, A. Ousadden","doi":"10.36348/sjpm.2022.v07i09.002","DOIUrl":"https://doi.org/10.36348/sjpm.2022.v07i09.002","url":null,"abstract":"Hepatic hemangioma is the most common benign hepatic tumor. Ultrasound is sufficient for diagnosis. Otherwise, magnetic resonance imaging is necessary. Surgical resection is indicated only in the rare case of complications or disabling functional impairment. We report the case of a hepatic hemangioma initially diagnosed as a gastrointestinal stromal tumor of the stomach, in which surgical resection allowed the disappearance of the painful epigastric symptomatology.","PeriodicalId":407259,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131865532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperglycaemia in COVID-19 Patients at Admission, a Study during the Beginning of the Pandemic in Sidi-Bel-Abbes, Algeria","authors":"Y. Merad, M. Belkacemi, Z. Belmokhtar, Khalil Mebarki, Zakaria Merad, Adila Bassaid, Derouicha Matmour, H. Derrar, Mehdi Zidour, Ouziane Megherbi, Bennadji Bouhafs, Z. Nadji, N. Belhadj, Sid Taj Hebri","doi":"10.36348/sjpm.2022.v07i08.006","DOIUrl":"https://doi.org/10.36348/sjpm.2022.v07i08.006","url":null,"abstract":"Reportedly, SARS-CoV-2 infection impairs glucose homeostasis and metabolism. Moreover, hyperglycaemia has emerged as an important risk factor for COVID-19 mortality. A cross-sectional study involving hospitalized patients in Sidi-Bel-Abbes with COVID-19 critical infection regardless of diabetes status was conducted. Data was collected from COVID-19 Registry, including age, sex, and blood sugar level at admission. Out of 800 patients admitted for SARS-CoV-2 with, 332 patients (206 males, 126 females) exhibited hyperglycaemia, which equates to a prevalence of 41,5%. Patients had a median age of 64 years and a median blood sugar of 1,59. Admission hyperglycaemia was not statically associated with age and sex. Blood glucose status is paramount for ensuring safe and effective treatment of inpatients COVID-19. Additional studies are forthcoming to address the study's limitations and to better understand the impact of hyperglycaemia on COVID-19 patients.","PeriodicalId":407259,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121722791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Lying Giant Chorangioma with Myometrial Attachment: A Rare Histopathological Finding","authors":"Uchechi Azuoma Ewurum, C. Obiorah, Echichechi Wamadi Nnah","doi":"10.36348/sjpm.2022.v07i08.005","DOIUrl":"https://doi.org/10.36348/sjpm.2022.v07i08.005","url":null,"abstract":"Chorangioma is a placental lesion consisting of capillary proliferation in chorionic villi and typically presents as a nodule or as multiple nodules on the placenta. It is a rare abnormality of placental vascular development and its clinical characteristics depend on size of the lesion. Giant chorangioma is chorangioma with an average diameter greater than 5cm. It is associated with both maternal and foetal complications. This report documents our findings in a hysterectomy specimen removed from a 40-year old female, following emergency hysterectomy for intractable postpartum haemorrhage after an elective caesarean section for three previous sections. A giant chorangioma was discovered in association with both placenta praevia and placenta increta. The outcomes for both mother and child were good.","PeriodicalId":407259,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"290 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117316104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of Biochemical Markers in the Early Diagnosis of Acute Myocardial Infarction (AMI)","authors":"M. Sohaib, Hannana Maryam, Dr. Abid Ali, M. Fatima, Waqar Ahmad","doi":"10.36348/sjpm.2022.v07i08.004","DOIUrl":"https://doi.org/10.36348/sjpm.2022.v07i08.004","url":null,"abstract":"Background: One of the most effective instances of readily detected biomarkers diagnosing a very big health concern is the measuring of proteins in blood to represent heart damage. The idea of utilizing a blood test to reflect organ or cell harm necessitates a chemical that is plentiful in the target cell, can reach blood, has a suitable half-life in blood, and is preferably in a particular form that only reflects the target cell in tissue. Because contraction is the primary function of the myocyte, proteins involved in contraction or the energy required to sustain it should be suitable potential indicators. The work on diagnostic tests for myofibrillar proteins begins in 1978. Different key pieces of evidence fueled in the research. In Ist-year outcomes were identical in chest pain patients whose acute myocardial infarction (AMI) was ruled out by electrocardiography and cardiac enzymes, demonstrating that the existing diagnostic tools were not beneficial for risk prediction and treatment recommendations. Second, CK and lactate dehydrogenase isoenzymes were brought into clinical practice and demonstrated to have higher specificity and sensitivity than traditional tests. All of the biomarkers used to diagnose cardiac injury are involved in contraction or energy metabolism, but the markers evolved via trial and error, beginning with transaminases in the 1950s and ending with troponins in the 1990s. This background is discussed, along with observations on my experiences establishing CK-MB and Troponin I assays. Methods: 140 individuals with AMI are included who are diagnosed using WHO criteria. A cross-sectional study with purposive sampling technique is conducted in wazirabad institute of Cardiology. This research is last around 6 months. Before the examinations, blood samples are obtained from patients by vein puncture using syringes and preserved in clot tubes. The research includes patients experiencing chest pressure, tightness, or discomfort, shortness of breath, and irregular cardiac rhythms on ECG. Patients having a normal ECG are not included in the study. Different equipments are utilized to assess appropriate heart function and to obtain serum for the identification of various cardiac biomarkers. Result: The sensitivities of all biochemical markers change depending on the time of infarction, as previously demonstrated and expected from a patho-physiologic standpoint, the blood sample of all the patients was collected and used for further investigation in the Lab. In the current study, 140 patients are enrolled, and all of the patients who had a single episode of AMI had their ECGs taken. All of the patients' ECGs are abnormal. In compared to other Bio-Cardiac Markers, the Troponin –I has a higher ratio of patients, according to the present findings. When a person undergoes AMI, the first protein that is released is troponin-I. When these tests are conducted over a period of time, they provide us with a quick assessment of the severity of ","PeriodicalId":407259,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124701348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Uric Acid and Lipid Profile in Untreated Dyslipidemic Patients","authors":"Talha Tariq, M. Fatima, Dr. Abid Ali, Hanana Maryam, Waqar Ahmad","doi":"10.36348/sjpm.2022.v07i08.003","DOIUrl":"https://doi.org/10.36348/sjpm.2022.v07i08.003","url":null,"abstract":"Background: The effects of cholesterol and statin therapy on serum uric acid (SUA) concentration are poorly known, and the latter's effects are even less clear. A mean atorvastatin dosage of 24 mg/dl satisfies the American Cardiovascular Assessment Campaign management objectives and dramatically lowers prevalence of chronic in individuals with cardiovascular events, according to the Greek Drug and Cardiovascular Evaluation research. We compare the temporal evolution of SUA levels in patients receiving standard treatment who received insufficient statin therapy (12 percent received statins) to patients receiving formalised care who received atorvastatin therapy almost exclusively (98 percent). Methods: In this study 160 individuals with abnormal lipid profiles in their blood were enrolled to investigate the connection between lipid profile and uric acid in dyslipidemic patients (dyslipidemia). It was a 5-month cross-sectional study conducted at Dr Abdul Sattar Lab Sialkot using a convenient sampling method. The uric acid, total cholesterol, triglycerides, LDL, and HDL cholesterol levels of enrolled participants were measured. In short, we performed uric acid and lipid profile tests on under-observation samples to investigate the association between uric acid and lipid profile parameters in the enrolled (dyslipidemic) individuals. Result: This research looks at people between the ages of 20 and 60. The Graph shows that (15) patients are between the ages of 20 and 30, (46) patients are between the ages of 31 and 40, (74) patients are between the ages of 41 and 50, and (25) patients are between the ages of 51 and 60.Patients of both sexes are covered. It was found that there exist significant positive relationship between uric acid and lipid profile in dyslipidemic patients. This study shows a positive correlation between LDL, triglycerides, total cholesterol and uric acid whereas a negative correlation was observed between HDL and uric acid. According to the current results, when uric acid rises, Total Cholesterol, Triglycerides, and Low Density Lipoproteins (LDL) rise as well. But High Density Lipoproteins (HDL) falls with the increase in uric acid levels. As a result, this study may be useful in reducing the incidence of related cardiovascular morbidities, and we will be able to predict dyslipidemia more accurately, which may further leads to CVDs. As the rate of CVDs rises in Pakistan, it is becoming increasingly necessary to investigate the factors that are directly linked to the disease. Conclusion: This article's objective was to investigate any connections between Uric Acid and Lipid Profile. Because dyslipidemia predicts the risk of coronary artery disease, so uric acid levels should be considered in these individuals for more complete risk factor prediction and treatment. Increased levels of lipid profile parameters can lead to serious heart diseases, and the only way to avoid this is to get a quick diagnosis of the disease.","PeriodicalId":407259,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130800515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive Squamous-Cell Carcinoma of the Scalp","authors":"B. Eljebbouri, M. Allaoui, A. Belhachmi, Brahim El Mostarchid","doi":"10.36348/sjpm.2022.v07i08.002","DOIUrl":"https://doi.org/10.36348/sjpm.2022.v07i08.002","url":null,"abstract":"Squamous Cell Carcinoma (SCC) is an epithelial neoplasm arising from the malignant proliferation of keratinocytes and it is the second most common type of skin cancer behind basal cell carcinoma (BCC). SCC presents with a wide variety of clinical manifestations including erythematous patches and nodules although its most usual presentation includes indurated well demarcated ulcerative lesions. We present historical case of SCC of the scalp who made the extension and invasion the brain after eroding the vault.","PeriodicalId":407259,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116693997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}