Journal of Medical and Life Science最新文献

Assessment of Cartilage Oligomeric Matrix Protein Biomarker for Laboratory Diagnosis of Hepatocellular Carcinoma 评估用于肝细胞癌实验室诊断的软骨寡聚基质蛋白生物标记物

Journal of Medical and Life Science Pub Date : 2024-06-08 DOI: 10.21608/jmals.2024.288820.1024

O. Othman

引用次数: 0

Isolation and Identification of some fresh Protozoa from surface water sources and taps in Dakahlyia Governorate, Egypt 埃及达卡利亚省地表水源和水龙头中一些新鲜原生动物的分离与鉴定

Journal of Medical and Life Science Pub Date : 2024-06-01 DOI: 10.21608/jmals.2024.350552

Samir El-Abbassy, Enayat Reda, Asmaa Marzouk

引用次数: 0

IMMUNOHISTOCHEMICAL EXPRESSION OF ESTROGEN RECEPTORS AS PROGNOSTIC MARKER AND CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN HUMAN ENDOMETRIAL ADENOCARCINOMA 人子宫内膜腺癌中作为预后标志的雌激素受体的免疫组化表达及其与临床病理参数的相关性

Journal of Medical and Life Science Pub Date : 2024-06-01 DOI: 10.21608/jmals.2024.350487

Saeed Mohamed, A. Amin, Aisha Salih, S. Al-Qadasi, R. Sultan

引用次数: 0

The relationship between Celiac Disease (CD) and obesity: A Review 乳糜泻（CD）与肥胖之间的关系：综述

Journal of Medical and Life Science Pub Date : 2024-06-01 DOI: 10.21608/jmals.2024.358399

Allaa Jamel Shhaet, Muhanad Mahdi Mohammed

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Annona muricata leaves extract mitigates the testicular oxidative stress induced by doxorubicin in male rats 牡丹叶提取物可减轻多柔比星对雄性大鼠睾丸的氧化应激作用

Journal of Medical and Life Science Pub Date : 2024-06-01 DOI: 10.21608/jmals.2024.349721

Rania Abou-El-magd, Olfat Elghareeb, Hanem El-sherbiny, Najamul Nisa

{"title":"Annona muricata leaves extract mitigates the testicular oxidative stress induced by doxorubicin in male rats","authors":"Rania Abou-El-magd, Olfat Elghareeb, Hanem El-sherbiny, Najamul Nisa","doi":"10.21608/jmals.2024.349721","DOIUrl":"https://doi.org/10.21608/jmals.2024.349721","url":null,"abstract":"Background: Doxorubicin (DOX) is a strong antineoplastic drug that is used for the treatment of several types of cancer and has toxic effects, Annona muricata fruits and leaves possess phytotherapeutic bioactive constituents have potency in the treatment of several diseases. Aim: This study aims to evaluate the therapeutic role of Annona muricata extract (AME) against the testicular damage induced by doxorubicin in male rats. Material &methods: Thirty-two male adult albino rats were used in this study. The rats were divided into four groups (n = 8): the control group, the AME-supplemented group (100 mg/kg b.wt. daily for consecutive 28 days), the DOX-treated group (2 mg/kg twice a week for 4 weeks), and the DOX-treated group that was supplemented with AME. Results : Treatment of male rats with DOX showed a remarkable increase in the levels of serum pro-inflammatory markers, decreased sexual hormones, and decreased testicular antioxidant activities. The treatment of DOX-injected rats with ASE revealed a pronounced return to normalcy of the oxidative stress markers, as evidenced by a remarkable decrease in the testicular MDA and an improvement of SOD, CAT, and GSH activities. On the other hand, the rats administered DOX and AME had considerably decreased serum levels of TNF-α and IL-6 and improved serum FSH, LH, and testosterone levels. AME successfully restored the testicular histopathological signs induced by DOX through amelioration of the architecture of disrupted seminiferous tubules with AME. Conclusion: Annon muricata extract has a potential alleviation role against DOX-induced oxidative stress and inflammation in the testicular tissues.","PeriodicalId":406966,"journal":{"name":"Journal of Medical and Life Science","volume":"6 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141235465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The possibility of using Culex pipiens (Diptera: Culicidae) larvae as a bioindicator of water pollution in Burullus Lake, Egypt 利用库蚊（双翅目：库蚊科）幼虫作为埃及 Burullus 湖水污染生物指标的可能性

Journal of Medical and Life Science Pub Date : 2024-06-01 DOI: 10.21608/jmals.2024.351977

Noura Toto, Shimaa S. Khattab, Samir El-Abbassy, Salwa A. El-Saidy

{"title":"The possibility of using Culex pipiens (Diptera: Culicidae) larvae as a bioindicator of water pollution in Burullus Lake, Egypt","authors":"Noura Toto, Shimaa S. Khattab, Samir El-Abbassy, Salwa A. El-Saidy","doi":"10.21608/jmals.2024.351977","DOIUrl":"https://doi.org/10.21608/jmals.2024.351977","url":null,"abstract":"The urgent environmental issue of heavy metal pollution in aquatic environments has brought attention to Burullus Lake due to its environmental and economic significance. Therefore, this study focused on using the third-instar larvae of Culex pipiens as bioindicators of metal pollution in two Burullus Lake sites: Al-Bughaz (site 1, reference) and the front of Drain 7 (site 2, polluted). The water physicochemical analysis confirmed site 2's higher pollution levels. Metal concentrations in water and larval midgut tissues from site 2 were significantly higher than in site 1. All biochemical parameters estimated in site 2's larval midgut tissues showed greater impacts compared to site 1. Concentration levels of malondialdehyde and metallothionein along with expression level of heat shock protein 70 were notably higher in site 2's larvae. Antioxidant biological markers, like reduced glutathione, superoxide dismutase, catalase, and glutathione peroxidase, as well as cytochrome P450 activity decreased significantly in site 2's larvae compared to the reference larvae from site 1. Analysis of DNA damage parameters in the midgut cells of site 2's larvae revealed significant rises in tail DNA%, tail length, and tail moment. DNA damage was increased in site 2's larvae due to migration of DNA fragments. Ultrastructure observations of site 2's larvae revealed structural alterations along the epithelial cells of midgut tissue like destroyed microvilli, an irregular nuclear envelope, vacuolated cytoplasm, increasing lysosomal bodies, disintegrated mitochondria, and the appearance of spherites and dense vesicles. In conclusion, C. pipiens larvae are reliable bioindicators for metal pollution in aquatic environments due to their sensitivity to metal bioaccumulation.","PeriodicalId":406966,"journal":{"name":"Journal of Medical and Life Science","volume":"86 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141231247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination Therapy with Vitamin D and Telmisartan to Suppress the Progression of Liver Fibrosis. 维生素 D 和替米沙坦联合疗法可抑制肝纤维化的进展

Journal of Medical and Life Science Pub Date : 2024-06-01 DOI: 10.21608/jmals.2024.278909.1020

Fatma Amer, Mahmoud El-rehany, Othman Othman

{"title":"Combination Therapy with Vitamin D and Telmisartan to Suppress the Progression of Liver Fibrosis.","authors":"Fatma Amer, Mahmoud El-rehany, Othman Othman","doi":"10.21608/jmals.2024.278909.1020","DOIUrl":"https://doi.org/10.21608/jmals.2024.278909.1020","url":null,"abstract":"Hepatic fibrosis is an improper wound repair response associated with various kinds of chronic liver injuries. It can be detected by over-deposition of diffuse ECM (Extracellular Matrix) and abnormal overgrowth of connective tissue, and it can progress to cirrhosis or hepatocellular carcinoma. Chronic liver diseases, which include liver fibrosis, have resulted in significant morbidity and mortality worldwide, and this trend is likely to continue. Although early liver fibrosis has been reported to be reversible, the exact mechanism of reversal is unidentified, and there is a lack of effective therapy for liver fibrosis. Vitamin D is essential for maintaining the metabolism of bone and calcium balance. Unexpectedly new evidence indicates that vitamin D has a protective function toward hepatic fibrosis. Telmisartan has been shown to have a positive effect on hepatic fibrosis markers in various pathological contexts. This review focused on summarizing the effect of vitamin D and telmisartan on the progression of hepatic fibrosis and updating their present impact on fibrosis. Telmisartan and vitamin D reduce fibrosis in hepatic stellate cells by inhibiting the production of profibrogenic genes.","PeriodicalId":406966,"journal":{"name":"Journal of Medical and Life Science","volume":"63 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141231386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPARATIVE STUDY OF IMMUNOHISTOCHEMICAL EXPRESSION OF GP88 AND Cath-D AS PROGNOSTIC MARKERS AND CORRELATION WITH PATHOLOGICAL AND HISTOLOGICAL PARAMETERS IN HUMAN BREAST CANCER 人类乳腺癌中作为预后标志的 GP88 和 Cath-D 的免疫组织化学表达及其与病理和病史参数的相关性比较研究

Journal of Medical and Life Science Pub Date : 2024-04-08 DOI: 10.21608/jmals.2024.349436

S. Al-Qadasi, M. Yahia, SaeedSamah Mohamed, R. Sultan

引用次数: 0

Impact of Essential Oils (Orange Peels) on Ehrlich Ascites Carcinoma Against Cardiac Damage in Female Mice 精油（橘皮）对雌性小鼠艾氏腹水癌和心脏损伤的影响

Journal of Medical and Life Science Pub Date : 2024-03-02 DOI: 10.21608/jmals.2024.266129.1018

Ahmed Hasan, Haneen Hameed, Mohanad Hussein, A. Abbood, Assala Jawad, Marwa mahmoud Nada

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Giant bladder stones : Cases from a Late Consultation 巨型膀胱结石：晚期会诊病例

Journal of Medical and Life Science Pub Date : 2024-02-19 DOI: 10.21608/jmals.2024.264753.1017

Reda Tariqi, Abdelmounim Boughaleb, Hamza El Abidi, Adam El Aboudi, I. Boualaoui, Ahmed Ibrahimi, Hachem El Sayegh, Yassine Nouini

引用次数: 0