Journal of Medical and Life Science最新文献_第2页

Efficacy and safety of Tenofovir Disoproxil Fumarate in Egyptian patients with chronic hepatitis B virus infection 富马酸替诺福韦酯对埃及慢性乙型肝炎病毒感染患者的疗效和安全性

Journal of Medical and Life Science Pub Date : 2024-02-05 DOI: 10.21608/jmals.2024.260653.1016

Othman Othman, Sahar Kamal

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Efficacy and safety of Tenofovir Disoproxil Fumarate in Egyptian patients with chronic hepatitis B virus infection 富马酸替诺福韦酯对埃及慢性乙型肝炎病毒感染患者的疗效和安全性

Journal of Medical and Life Science Pub Date : 2024-02-05 DOI: 10.21608/jmals.2024.260653.1016

Othman Othman, Sahar Kamal

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Evaluating the Anti-Obesity Effects of Chitosan in High-Fat Diet-Induced Obesity in Rat Model 评估壳聚糖对高脂饮食诱发肥胖大鼠模型的抗肥胖作用

Journal of Medical and Life Science Pub Date : 2024-01-13 DOI: 10.21608/jmals.2024.336113

Aml Ghoneim, Sara Abdou, Emad Elsehly, Eman Radwan, Aml Abdelrahman, Nada Badr

{"title":"Evaluating the Anti-Obesity Effects of Chitosan in High-Fat Diet-Induced Obesity in Rat Model","authors":"Aml Ghoneim, Sara Abdou, Emad Elsehly, Eman Radwan, Aml Abdelrahman, Nada Badr","doi":"10.21608/jmals.2024.336113","DOIUrl":"https://doi.org/10.21608/jmals.2024.336113","url":null,"abstract":"Background : Chitosan oligosaccharide (COS) exhibits hypolipidemic and anti-obesity properties. Nevertheless, it remains uncertain whether its efficiency exhibits sex-specific variations. Therefore, this study seeks to fill this gap, systematically evaluating the impact of chitosan oligosaccharides across genders under obesogenic conditions. Material and methods : 36 rats: 18 male, 18 female; split into 6 groups, each with equal male/female. G1 had a standard diet; G2 had a high-fat diet for 4 weeks, then standard for another 4 weeks; G3 had a high-fat diet for 4 weeks, then 500 mg/kg chitosan + standard diet for another 4 weeks. At the study's end, rats were euthanized, blood was collected for biochemical analysis, and liver tissues were excised for histological assessment. Results : Male rats on a high-fat diet displayed significantly elevated body weight, triglycerides, cholesterol, lactate dehydrogenase, ALT, AST, and total protein levels, coupled with noticeable liver damage compared to female rats. However, when treated with COS, male and female rats exhibited reduced weight, lowered triglycerides, cholesterol, lactate dehydrogenase, ALT, and AST levels, and improved liver function and structure. Interestingly, these therapeutic effects were more evident in female and male rats. Conclusion: The study found that COS administration to rats, especially females, reduced weight, and improved liver health, suggesting its potential gender-specific effects on a high-fat diet.","PeriodicalId":406966,"journal":{"name":"Journal of Medical and Life Science","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139530669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A pathochemical study to assess the level of vitamin B12 and magnesium in patients with type 1 and type 2 diabetes mellitus in Thi-Qar governorate. 一项病理化学研究，旨在评估 Thi-Qar 省 1 型和 2 型糖尿病患者体内维生素 B12 和镁的水平。

Journal of Medical and Life Science Pub Date : 2024-01-11 DOI: 10.21608/jmals.2024.335787

A. Alazbjee, N. Ali, Zainab farhan

{"title":"A pathochemical study to assess the level of vitamin B12 and magnesium in patients with type 1 and type 2 diabetes mellitus in Thi-Qar governorate.","authors":"A. Alazbjee, N. Ali, Zainab farhan","doi":"10.21608/jmals.2024.335787","DOIUrl":"https://doi.org/10.21608/jmals.2024.335787","url":null,"abstract":"Objective: In this research paper, we examine how treating patients with type 1 and type 2 diabetes with vitamin B12 and magnesium affects both insulin and non-insulin levels. The Glycated hemoglobin (HbA1c) marker, which is one of the fundamental and clinical markers to monitor in the control of type 2 diabetes mellitus patients (T2DM and type 1 diabetic mellitus), is also highlighted and discussed in this study. Methods: From February to March 2023, a cross-sectional study was done at the Medical Labs Research Center of Al-Hussein Teaching Hospital in Nasiriyah Governorate. Our research included 40 people with type 1 and type 2 diabetes. Before fasting, a physical examination, a thorough medical history, and blood samples were obtained. Following a 12-hour fast, all blood samples were collected. Results: Except for the B12 and Mg ++ levels being significantly higher in DM1 patients in both the first and second age groups and the third age group of DM1 patients being significantly lower at p. value 0.05, we conclude from this study's two-way ANOVA test and t-test that cumulative sugar is unaffected by age or type of sugar. Conclusions: Our findings indicate that both concentrations of B 12 and Mg ++ increased significantly in patients with DM 1 than DM 2 at p. value < 0.05. These findings call for more research on a wider population to look at the source of the deficit and the effectiveness of B12 supplementation in these patients.","PeriodicalId":406966,"journal":{"name":"Journal of Medical and Life Science","volume":"34 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139533887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the ameliorative role of ginger (Zingiber officinale) extract against carbon tetrachloride-induced hepatotoxicity in male albino rats 评估生姜（Zingiber officinale）提取物对雄性白化大鼠四氯化碳诱导的肝毒性的改善作用

Journal of Medical and Life Science Pub Date : 2023-11-16 DOI: 10.21608/jmals.2023.326295

Olfat Elghareeb, Hanem El-sherbiny, Najamul Nisa, Rania Abou-El-magd

{"title":"Evaluation of the ameliorative role of ginger (Zingiber officinale) extract against carbon tetrachloride-induced hepatotoxicity in male albino rats","authors":"Olfat Elghareeb, Hanem El-sherbiny, Najamul Nisa, Rania Abou-El-magd","doi":"10.21608/jmals.2023.326295","DOIUrl":"https://doi.org/10.21608/jmals.2023.326295","url":null,"abstract":"Background: One well-known hepatotoxin that is frequently used to cause acute toxic liver injury in a variety of experimental animals is carbon tetrachloride (CCl4). There have been suggestions that ginger (Zingiber officinale) offers great promise in alleviation of many diseases . Aim: The purpose of this study was to evaluate the ameliorative role of ginger extract (GE) against the liver damage induced by CCL4 in male rats. Material &methods: Thirty-two male adult albino rats were used in this study. The rats were divided into four groups (N=8): control group, GE-supplemented group (200mg / kg b.wt daily for consecutive 35 days), CCL4-treated group (2mg/kg b.wt/twice weekly for 5 weeks), and CCL4-intoxicated group followed by treatment with GE. Results : GE for consecutive 35 days significantly reduced the adverse effects of CCL4 toxicity on the levels of liver enzymes (ALT, AST, and ALP), total bilirubin, total protein, and albumin. The altered liver tissue antioxidants (SOD, CAT, and GPx) and MDA were significantly ameliorated on treatment with GE. Additionally, the liver histopathological alterations induced by CCL4 were markedly recurred on treatment with GE. Conclusion: Ginger extract has a potential ameliorative role against CCL4-induced adverse biochemical and histological alterations in the liver of male rats","PeriodicalId":406966,"journal":{"name":"Journal of Medical and Life Science","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139267836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EFFECT OF MAGNETIC WATER ON SOME ACTIVITIES OF HONEY BEES (Apis mellifera L.) in Jazan Province KSA 磁水对吉赞省蜜蜂某些活动的影响

Journal of Medical and Life Science Pub Date : 2023-08-17 DOI: 10.21608/jmals.2023.313283

Salama S. Salama, Abdel daim J., A. Saleh

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Study of Mitral Valve Insufficiency: A Systemic Review 二尖瓣功能不全的研究:一项系统综述

Journal of Medical and Life Science Pub Date : 2023-07-21 DOI: 10.21608/jmals.2023.309050

Haidar Alsaedi

引用次数: 0

Ameliorative effects of frankincense oil on rats treated with a minimum toxic dose of paracetamol 乳香油对小剂量扑热息痛大鼠的改善作用

Journal of Medical and Life Science Pub Date : 2023-07-17 DOI: 10.21608/jmals.2023.308224

Aml Talaat, Yomna A. Elgendy, Heba F. Mohamed, Nouran M Saed, Noran A. Abd Elrouf, Hend A. Elgendy, Hagar H. Elbalakousy, Nourhan N. El hantoshy, Mohammed S. Elmezaien, Youssef M. Sayed, Yosry El. Hekal, M. Gabr, Nada S. Badr

{"title":"Ameliorative effects of frankincense oil on rats treated with a minimum toxic dose of paracetamol","authors":"Aml Talaat, Yomna A. Elgendy, Heba F. Mohamed, Nouran M Saed, Noran A. Abd Elrouf, Hend A. Elgendy, Hagar H. Elbalakousy, Nourhan N. El hantoshy, Mohammed S. Elmezaien, Youssef M. Sayed, Yosry El. Hekal, M. Gabr, Nada S. Badr","doi":"10.21608/jmals.2023.308224","DOIUrl":"https://doi.org/10.21608/jmals.2023.308224","url":null,"abstract":"Paracetamol is a widely used analgesic and antipyretic drug, but its long-term usage has been associated with potential toxicity. The goal of this study was to investigate how frankincense oil prevents paracetamol toxicity. The study included twenty male albino rats divided into four groups: (G1) control, (G2) paracetamol, (G3) frankincense oil, and (G4) paracetamol + frankincense oil. For three days, 1000 mg/kg paracetamol was given orally, while frankincense oil was given orally at a dosage of 1000 mg/kg concurrently with paracetamol. Hematological parameters, lipid profile, cardiac markers, pancreatic function, blood antioxidant capacity, myeloperoxidase activity, blood, spleen, pancreas, heart, and lung histopathology were evaluated. Paracetamol caused oxidative stress, hematotoxicity, dyslipidemia, myocardial damage, pancreatic dysfunction, spleen alterations, and lung tissue damage. However, coadministration of paracetamol and frankincense oil protected against these effects by boosting antioxidant capacity, improving hematological parameters, preserving pancreatic function, enhancing lipid profiles, preserving spleen morphology, and preventing lung damage, likely due to the antioxidant properties of frankincense oil.","PeriodicalId":406966,"journal":{"name":"Journal of Medical and Life Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131208489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Biochemical and molecular mechanisms of Annona sp. fruits extract in Ehrlich ascites carcinoma-bearing mice 番荔枝果实提取物对埃利希腹水癌小鼠的生化及分子机制

Journal of Medical and Life Science Pub Date : 2023-07-15 DOI: 10.21608/jmals.2023.307798

K. El-Said, Fayza Ali, Amro E Mohamed

{"title":"Biochemical and molecular mechanisms of Annona sp. fruits extract in Ehrlich ascites carcinoma-bearing mice","authors":"K. El-Said, Fayza Ali, Amro E Mohamed","doi":"10.21608/jmals.2023.307798","DOIUrl":"https://doi.org/10.21608/jmals.2023.307798","url":null,"abstract":"Limitations of chemotherapeutic drugs for cancer treatment could be due to the lack of specificity, rapid drug metabolism, and harmful side effects. Therefore, finding new approaches in neoplastic cancer or targeting drugs depends on the pathways and characteristics of different tumor entities. Natural elements as anticancer agents are an effective strategy in the fight against cancer. This study investigated the biochemical and molecular mechanisms of Annona sp fruits extract (ASFE) in Ehrlich ascites carcinoma (EAC)-bearing mice. Seventy mice were divided into seven groups (n = 10) as follows: Gp1 was used as a negative control, from Gp2 to Gp7 were inoculated with 1 × 10 6 EAC-cells/mouse, then Gp2 left as EAC-bearing mice, Gp3 was injected with Cis (2 mg/kg), Gp4 was injected with ASFE (200 mg/kg), Gp5 was co-treated with Cis as Gp3 and ASFE as Gp4. Gp6 was injected with a low dose of Cis (0.5 mg/kg), and Gp7 was co-treated with a low dose of Cis as Gp6 and ASFE as Gp4. The body weight change percentages (b.wt%) were calculated. On day 14, all groups were sacrificed, the ascitic fluids were harvested, and the total tumor volume, count, and live and dead tumor cells were measured. The relative expression of P53, Bcl-2, BAX, and caspase-9 genes was determined in EAC cells by RT-PCR. Sera samples were collected for biochemical parameters assessment. Liver tissues were collected for the determination of oxidants/antioxidants biomarkers. The results showed that co-treatment of the high or low doses of Cis with ASFE led to synergistic effects via targeting apoptosis in EAC-cells that can significantly inhibit tumor growth, decrease liver dysfunctions induced by Cis and enhance the hepatic antioxidant status.","PeriodicalId":406966,"journal":{"name":"Journal of Medical and Life Science","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132567770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Hematological alterations in Egyptian farmers occupationally exposed to pesticides 职业接触农药的埃及农民血液学变化

Journal of Medical and Life Science Pub Date : 2023-07-13 DOI: 10.21608/jmals.2023.307496

Hany Desouky, N. Rizk, Huda Said, Reham Abd El-Azeem

{"title":"Hematological alterations in Egyptian farmers occupationally exposed to pesticides","authors":"Hany Desouky, N. Rizk, Huda Said, Reham Abd El-Azeem","doi":"10.21608/jmals.2023.307496","DOIUrl":"https://doi.org/10.21608/jmals.2023.307496","url":null,"abstract":"Background: Pesticides are agrochemicals extensively used all over the world for pest control and prevention, Egyptian farmers are occupationally exposed to many types of pesticides, making them at high risk for pesticide toxicity. Several studies have shown acute pesticide poisoning effects, but fewer have dealt with chronic pesticide toxicity, especially studies regarding pesticide's effects on hematological parameters. Objective: We aimed to evaluate hematological parameter changes related to long-term low-level pesticide exposure. Subjects and Methods: The blood samples were collected from 96 Egyptian farmers chronically exposed to mixed pesticides and 54 nonexposed controls. A Complete Blood Picture (CBC) was evaluated to explore the hematological indices alterations. Statistical analysis was conducted using IBM SPSS Statistics, version 25. Results: A significant decrease in hemoglobin, hematocrit, mean corpuscular volume, and mean corpuscular hemoglobin in addition to platelet count in the exposed farmers compared to the control, On the other hand, white blood cell count was significantly increased. Conclusion: Chronic occupational pesticide exposure of Egyptian farmers leads to a range of disorders in hematological indices. As an affordable and readily available test, the Complete Blood Picture can help in the chronic monitoring of farmers health status who are regularly exposed to pesticides.","PeriodicalId":406966,"journal":{"name":"Journal of Medical and Life Science","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129258535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0