IMMUNOHISTOCHEMICAL EXPRESSION OF ESTROGEN RECEPTORS AS PROGNOSTIC MARKER AND CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN HUMAN ENDOMETRIAL ADENOCARCINOMA

Abstract

In human steroid-sensitive tissue, Estrogen receptors (ERs) have been demonstrated at the mRNA and/or protein levels by using molecular biology and immunohistochemistry techniques. Estrogen receptors are present in endometrial hyperplasia and neoplastic endometrium. The present work aimed to compare the expression of ER as a prognostic biomarker in human endometrial adenocarcinoma versus benign tumors and normal endometrial tissues as well as their correlation with different pathological and histological parameters. The immunohistochemical technique was used to examine the expression of ER in normal, benign as well as in endometrial adenocarcinoma. Present results showed higher expression of ER in endometrial adenocarcinoma compared to normal and benign endometrial tissues.