{"title":"Introduction: Staging Justice in Early Modern France","authors":"M. Meere","doi":"10.1080/20563035.2020.1856573","DOIUrl":"https://doi.org/10.1080/20563035.2020.1856573","url":null,"abstract":"","PeriodicalId":40652,"journal":{"name":"Early Modern French Studies","volume":"42 1","pages":"108 - 115"},"PeriodicalIF":0.2,"publicationDate":"2020-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20563035.2020.1856573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41859144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"‘Neither Completely Guilty nor Completely Innocent’: Representing Injustice in Jean Racine’s Phèdre","authors":"M. Bizer","doi":"10.1080/20563035.2020.1856575","DOIUrl":"https://doi.org/10.1080/20563035.2020.1856575","url":null,"abstract":"The eponymous protagonist of Phèdre emerges as a true tragic heroine by exercising her own free will to commit wrong instead of being a mere victim of fate. Criticism focusing on injustice has tended to shine light on Thésée, denying Phèdre royal sovereignty just as French Salic law did to queens. By shifting the spotlight from Thésée to Phèdre, and from the idea of judgment as a means of redressing injustice to injustice resulting from the challenges of governance and self–governance in royal leaders, we will see that Phèdre's gender has tended to obscure the important connection between injustice and the exercise of monarchical power. The gender of the eponymous heroine of the play operates as a cover: by associating wrongdoing with a female monarch, a literal impossibility in France, Racine is able to delve into particularly controversial aspects of unjust governance as experienced in his day and age.","PeriodicalId":40652,"journal":{"name":"Early Modern French Studies","volume":"42 1","pages":"174 - 184"},"PeriodicalIF":0.2,"publicationDate":"2020-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20563035.2020.1856575","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46500949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"‘Cet autre moy’: Poetic Selves and Anterotic Friendships in Sixteenth-Century France","authors":"Vittoria Fallanca","doi":"10.1080/20563035.2020.1780388","DOIUrl":"https://doi.org/10.1080/20563035.2020.1780388","url":null,"abstract":"This article begins by considering a Complainte by the poet Philippe Desportes (1581) which contains the first recorded use of the substantive ‘self’ in French (‘cet autre moy’). Following Terence Cave (1999), it highlights the fact that it occurs in the context of Renaissance writings on friendship predominantly influenced by the ‘Aristotelian-Ciceronian model’. It proposes that alongside this well-established model of friendship, there is another, competing model, what it terms the ‘anterotic’ model based on the mythological figure of Anteros. The anterotic model is rooted in strife as well as mutuality, and evocatively captures the dynamics of the creation of poetic identity in sixteenth-century French writings, including the fraught relationship between poet and verse, and the struggle between originality, emulation and independence. Seen against this backdrop, the substantive ‘self’ reflects not so much ‘modern’ identity as we know it, but a poetic identity encapsulated in the complex doubleness of Anteros.","PeriodicalId":40652,"journal":{"name":"Early Modern French Studies","volume":"42 1","pages":"22 - 37"},"PeriodicalIF":0.2,"publicationDate":"2020-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20563035.2020.1780388","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46319465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Louis Daniel Lecomte (1655–1728): A Jesuit Commentator on Chinese Politics","authors":"Gwynedd Harley","doi":"10.1080/20563035.2020.1755134","DOIUrl":"https://doi.org/10.1080/20563035.2020.1755134","url":null,"abstract":"Louis Daniel Lecomte was one of five Jesuits sent to China in 1685, the missionaries' role, however, was not just evangelical. The Académie Royale des Sciences had provided a questionnaire to complete concerning China's arts and sciences: a significant difference from previous foreign missions. The Nouveaux Mémoires sur l'état présent de la Chine first published in 1696 provided an initial report of those aspects the Academie had requested. Lecomte, however, did not confine himself to the questionnaire and provided observations which gave a very interesting insight into both China and France's social, political and economic situation at the end of the seventeenth century. Information gleaned from texts like Lecomte's may have enhanced China's pivotal role in the formation of the ‘esprit philosophique’. In this article the author has chosen to consider Lecomte's very telling comments on China's political system with particular reference to the philosophy of government and the monarchy.","PeriodicalId":40652,"journal":{"name":"Early Modern French Studies","volume":"42 1","pages":"55 - 72"},"PeriodicalIF":0.2,"publicationDate":"2020-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20563035.2020.1755134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46268956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ronsard and the Ghost of Astyanax","authors":"Alice Roullière","doi":"10.1080/20563035.2020.1735054","DOIUrl":"https://doi.org/10.1080/20563035.2020.1735054","url":null,"abstract":"This article examines the emergence and transformation of Francion’s epic character in Ronsard’s works from 1550 to 1578. This study of Francion’s genesis in Ronsard’s works relies on the close reading of the variations of the ‘Ode de la paix’ and the beginning of the Franciade, as well as on the analysis of the myth’s reception before and after 1572. In the 1550 ‘Ode de la paix’, the memory of the Virgilian intertext directly undermines the epic hero’s identity since he is presented as Hector’s only son, who in the classical tradition is named Astyanax and dies in Troy. Drawing on the problematic memory of Astyanax, the author studies how Francion’s fragile identity illustrates the complexity of the Renaissance concept of imitation and the difficulty of creating a national myth for France.","PeriodicalId":40652,"journal":{"name":"Early Modern French Studies","volume":"42 1","pages":"2 - 21"},"PeriodicalIF":0.2,"publicationDate":"2020-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20563035.2020.1735054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46598102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editor’s Note","authors":"Timothy Chesters","doi":"10.1080/20563035.2020.1791409","DOIUrl":"https://doi.org/10.1080/20563035.2020.1791409","url":null,"abstract":"","PeriodicalId":40652,"journal":{"name":"Early Modern French Studies","volume":"42 1","pages":"1 - 1"},"PeriodicalIF":0.2,"publicationDate":"2020-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20563035.2020.1791409","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45747801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Human-Animal Debate and the Enlightenment Body Politic: Emilie Du Châtelet’s Reading of Mandeville’s Fable of the Bees","authors":"Elisabeth Wallmann","doi":"10.1080/20563035.2020.1775430","DOIUrl":"https://doi.org/10.1080/20563035.2020.1775430","url":null,"abstract":"This article rereads Bernard Mandeville’s infamous poem The Fable of the Bees: or, Private Vices Publick Benefits (1714; 1723; 1729) and Emilie du Châtelet’s French translation (1735-1738) in the context of the eighteenth-century debates around the differences between humans and animals. It argues that the considerable alterations to the text undertaken by Châtelet should be understood as a response to Mandeville’s vitalistic theories of physical and political bodies, and their implications for his theory of political economy. Through close readings of the two versions of the Fable, the article shows that Châtelet’s reworking circumvents the idea – central to Mandeville’s text – that all living bodies, whether human or animal, are interconnected systems animated by vital ‘spirits’. I thus use Mandeville’s and Châtelet’s texts as a window for exploring the implications of different positions in the debate on the animal-human hierarchy.","PeriodicalId":40652,"journal":{"name":"Early Modern French Studies","volume":"42 1","pages":"103 - 86"},"PeriodicalIF":0.2,"publicationDate":"2020-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20563035.2020.1775430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41647789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"‘Fantôme de devoir’: The Princesse de Clèves’s Haunting Duty","authors":"Benjamin Fancy","doi":"10.1080/20563035.2020.1775429","DOIUrl":"https://doi.org/10.1080/20563035.2020.1775429","url":null,"abstract":"This article explores the ways in which the characters of Marie-Madeleine de Lafayette's La Princesse de Clèves manipulate the conventions surrounding death in seventeenth-century France. It argues that Mme de Chartres prevents her daughter from participating in the traditional ceremonies surrounding death that were intended to comfort the living as much as the dying. In so doing, Mme de Chartres creates a sort of psychic ghost. One such manifestation of this ghost is the term ‘devoir,’ one that Mme de Chartres herself used in life. M. de Clèves's later death functions as a rewriting of Mme de Chartres's; it provides an opportunity for the princess to assert herself as an active participant in her husband's deathbed scene, a role which her mother had not previously allowed her to assume. This motivates the princess to retreat to a convent, where no one, not even the narrator, bears witness to her passing.","PeriodicalId":40652,"journal":{"name":"Early Modern French Studies","volume":"42 5-6","pages":"73 - 85"},"PeriodicalIF":0.2,"publicationDate":"2020-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20563035.2020.1775429","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41303238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Salvation in the Vernacular: The New Testament of Mons and Post-Tridentine Piety","authors":"Elizaveta Al-Faradzh","doi":"10.1080/20563035.2019.1672988","DOIUrl":"https://doi.org/10.1080/20563035.2019.1672988","url":null,"abstract":"In 1667, a group of intellectuals associated with the monastery of Port-Royal printed and distributed a new version of the New Testament in French. This article places their translation within the broader context of post-Tridentine devotional practices, and describes the polemics that followed the publication. The Port-Royal ideal of devotion placed the text of the Scriptures at its foundation. This ideal and its enactment in publishing an accessible Bible aroused criticism and drove Antoine Arnauld to publicly defend and justify the project. Critics condemned the doctrine of universal access to the Bible, the encouragement of women and simple people to read Scripture, and the very method of translation adopted by Port-Royal. The Port-Royal authors considered the ‘fidelity’ of a translation to require the resultant text to be easily intelligible. But the translators’ focus on accessibility was not limited to language; they pursued the publication of their work in a variety of formats to promote its distribution and use among a wide section of the literate society.","PeriodicalId":40652,"journal":{"name":"Early Modern French Studies","volume":"42 1","pages":"38 - 54"},"PeriodicalIF":0.2,"publicationDate":"2020-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20563035.2019.1672988","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48683327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fumin Xue, Chao An, Lixiang Chen, Gang Liu, Feifei Ren, Xinhua Guo, Haibin Sun, Lu Mei, Xiangdong Sun, Jinpeng Li, Youcai Tang, Xiuli An, Pengyuan Zheng
{"title":"4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment.","authors":"Fumin Xue, Chao An, Lixiang Chen, Gang Liu, Feifei Ren, Xinhua Guo, Haibin Sun, Lu Mei, Xiangdong Sun, Jinpeng Li, Youcai Tang, Xiuli An, Pengyuan Zheng","doi":"10.1186/s12964-019-0431-6","DOIUrl":"10.1186/s12964-019-0431-6","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer (GC) has high incidence and mortality worldwide. However, the underlying mechanisms that regulate gastric carcinogenesis are largely undefined. 4.1B is an adaptor protein found at the interface of membrane and the cytoskeleton. Previous studies demonstrated that 4.1B serves as tumor suppressor.</p><p><strong>Results: </strong>We showed that 4.1B expression was decreased or lost in most GC patients. The expression pattern of it was tightly correlated with tumor size, TNM stage and overall survival (OS). We further showed that 4.1B inhibited the proliferation of two GC cell lines, MGC-803 and MKN-45, by impeding the EGFR/MAPK/ERK1/2 and PI3K/AKT pathways. A similar phenotype was also observed in immortalized mouse embryonic fibroblasts (MEF) derived from wild type (WT) and 4.1B knock-out (BKO) mice. Additionally, immunofluorescence (IF) staining and Co-IP showed that protein 4.1B bound to EGFR. Furthermore, the FERM domain of 4.1B interacted with EGFR through the initial 13 amino acids (P13) of the intracellular juxtamembrane (JM) segment of EGFR. The binding of 4.1B to EGFR inhibited dimerization and autophosphorylation of EGFR.</p><p><strong>Conclusion: </strong>Our present work revealed that 4.1B plays important regulatory roles in the proliferation of GC cells by binding to EGFR and inhibiting EGFR function through an EGFR/MAPK/ERK1/2 pathway. Our results provide novel insight into the mechanism of the development and progression of GC.</p>","PeriodicalId":40652,"journal":{"name":"Early Modern French Studies","volume":"42 1","pages":"115"},"PeriodicalIF":8.2,"publicationDate":"2019-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72941507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"历史学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}