Cohesive Journal of Microbiology & Infectious Disease最新文献_第6页

The Novel Coronavirus Outbreak, A risk of Pandemic and A Challenge to the World 新型冠状病毒爆发，大流行的风险，对世界的挑战

Cohesive Journal of Microbiology & Infectious Disease Pub Date : 2020-08-12 DOI: 10.31031/cjmi.2020.03.000579

N. Khan

{"title":"The Novel Coronavirus Outbreak, A risk of Pandemic and A Challenge to the World","authors":"N. Khan","doi":"10.31031/cjmi.2020.03.000579","DOIUrl":"https://doi.org/10.31031/cjmi.2020.03.000579","url":null,"abstract":"Recently the outbreak of novel coronavirus-19 in China has caused a worldwide panic. The center of viral attack was the people in Wuhan city of China and then spread rapidly all over the world. This review aims to highlight the current issue of novel Coronavirus-19 (COVID-19) to evaluate the present knowledge about human causalities its economic effects, and treatment. In this regard, a detailed layout of viral infections is discussed in the light of literature. The results of this review stated that the novel Coronavirus-19 infected humans with severe loss in days. This pandemic caused world recession by significantly hitting the world economy. Due to lacking any specific vaccine or antiviral therapies against this virus, it has affected 213 countries of the world. Currently, the severity of this viral disease is observed in the US and Europe. While in developing countries, a higher infection rate was reported in Iran, India, and Pakistan. This virus infected 16 million people around the world with 645,627 deaths. The quick discovery of drug treatment has become a global challenge for the response of the COVID-19 outbreak. Therefore, it is important to develop an effective vaccine against nCoV-19 to control the spread of disease","PeriodicalId":406162,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126871384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stealth Adapted Viruses with Genetically Unstable Rhesus Monkey Cellular Sequences A Possible Forerunner of Complex Human Illnesses 具有遗传不稳定的恒河猴细胞序列的隐身适应病毒可能是复杂人类疾病的先驱

Cohesive Journal of Microbiology & Infectious Disease Pub Date : 2020-08-10 DOI: 10.31031/cjmi.2020.03.000578

W. J. Martin

{"title":"Stealth Adapted Viruses with Genetically Unstable Rhesus Monkey Cellular Sequences A Possible Forerunner of Complex Human Illnesses","authors":"W. J. Martin","doi":"10.31031/cjmi.2020.03.000578","DOIUrl":"https://doi.org/10.31031/cjmi.2020.03.000578","url":null,"abstract":"The production of human virus vaccines in virus-contaminated cultured animal cells provides the opportunity for genetic alterations in the respective vaccine and culture-contaminating viruses. Poliovirus vaccines were previously produced in kidney cell cultures from cytomegalovirus infected rhesus and African green monkeys. Viruses can undergo an immune evasion process termed stealth adaptation. It involves the deletion or mutation of the genes coding for the relatively few virus components that are normally targeted by the cellular immune system. As earlier reported, additional genetic sequences of cellular and bacterial origin can be incorporated into replicating stealth adapted viruses. This article confirms the incorporation of rhesus monkey genome-derived genetic sequences in certain stealth adapted viruses cultured from patients with the chronic fatigue syndrome (CFS). The virus-incorporated cellular-derived sequences differ slightly from the originating cellular sequences reflecting mutational changes and genetic instability. Ongoing mutations are also apparent in the minor differences in the genetic sequences seen in similar PCR products generated from the cultures of the two different CFS patients. Mutated human cellular genome-derived genetic sequences were also detected in the culture from one of the CFS patients. This is consistent with homologous recombination between human sequences and the virus-incorporated monkey cellular sequences. The transmission of genetically unstable, replicating monkey genomic sequences to humans and the potential of further transmission of mutated human genetic sequences between humans, warrants the attention of Public Health officials. The findings also question the continuing use of cultured animal cells to generate virus vaccines for human use.","PeriodicalId":406162,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133879370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Preparation of the Dermal Mucoadhesive Film Containing Mupirocin 含莫匹罗星真皮黏附膜的制备

Cohesive Journal of Microbiology & Infectious Disease Pub Date : 2020-07-15 DOI: 10.31031/cjmi.2020.03.000576

M. Darbandi

引用次数: 0

COVID-19 Pandemic Simulation Studies on the Transmissibility COVID-19大流行传播性模拟研究

Cohesive Journal of Microbiology & Infectious Disease Pub Date : 2020-04-28 DOI: 10.31031/cjmi.2020.03.000574

Hyunjo Kim

{"title":"COVID-19 Pandemic Simulation Studies on the Transmissibility","authors":"Hyunjo Kim","doi":"10.31031/cjmi.2020.03.000574","DOIUrl":"https://doi.org/10.31031/cjmi.2020.03.000574","url":null,"abstract":"be critical for the response to the COVID-19 outbreak. In order to assess their threat to humans, we explored to infer the potential hosts of coronaviruses using a dual-model approach with discriminant model achieved high accuracies in leave-one-out cross-validation of training data consisting of standard representative coronaviruses [34-37]. Predictions on chosen additional coronaviruses precisely conformed to conclusions or speculations by other researchers. The novel coronavirus disease 19 (COVID-19) is rapidly spreading with a rising death toll and transmission rate reported in high income countries rather than in low income countries. The overburdened healthcare systems and poor disease surveillance systems in resource-limited settings may struggle to cope with this COVID-19 outbreak and this calls for a tailored strategic response for these settings. Here, we recommend blockchain Abstract COVID-19 was identified as the causative virus of pneumonia based on unknown etiology. COVID-19 has multiple characteristics distinct from other infectious diseases, including high infectivity during incubation, time delay between real dynamics and daily numbers of confirmed cases, and the intervention effects of quarantine and control measures. Public health concerns are being paid globally on how many people are infected and suspected reach to pandemics. Therefore, it is urgent to develop a mathematical model to estimate the transmissibility and dynamic of the transmission of the virus.","PeriodicalId":406162,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125033419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disinfection of Mycotic Species Isolated from Cases of Bovine Mastitis Showing Antifungal Resistance 牛乳腺炎分离菌种抗真菌性消毒研究

Cohesive Journal of Microbiology & Infectious Disease Pub Date : 2020-03-19 DOI: 10.31031/cjmi.2020.03.000571

Elaine Meade, M. Savage, M. Slattery, M. Garvey

引用次数: 1

Comparison of Ultrabio HIV DNA PCR and Gag Real-Time PCR Assays for Total Hiv-1 DNA Quantification Ultrabio HIV DNA PCR与Gag Real-Time PCR测定HIV -1总DNA的比较

Cohesive Journal of Microbiology & Infectious Disease Pub Date : 2020-03-10 DOI: 10.31031/cjmi.2020.03.000572

Cong-hui Yu, W. Jiankun, Tuofu Zhu, C. Yuan, Sheng-zhang Li

{"title":"Comparison of Ultrabio HIV DNA PCR and Gag Real-Time PCR Assays for Total Hiv-1 DNA Quantification","authors":"Cong-hui Yu, W. Jiankun, Tuofu Zhu, C. Yuan, Sheng-zhang Li","doi":"10.31031/cjmi.2020.03.000572","DOIUrl":"https://doi.org/10.31031/cjmi.2020.03.000572","url":null,"abstract":"Total HIV-1 DNA has been shown to reflect reservoir size in HIV-1 infected individuals and correlate with viral rebound time after therapy interruption. Quantification of total HIV-1 DNA level may be used to study and evaluate reservoir elimination therapies. There is currently no FDA approved HIV-1 DNA quantification assay available. The performance of a research uses only kit, Ultrabio HIV DNA quantification kit, was compared to a commonly used laboratory qPCR method targeting the gag region (GAG PCR). The limit of detection (LOD) and precision was evaluated with serially diluted 8E5/LAV DNA. LOD of Ultrabio Kit and GAG PCR was determined to be 4 and 25 copies/reaction, respectively. The Ultrabio Kit showed less variation when HIV-1 DNA concentration was lower than 20 copies/reaction. Twenty-six HIV-1 infected patients’ PBMCs samples were quantified by both methods and the Ultrabio kit showed higher sensitivity. GAG PCR was unable to detect 2 of the samples while Ultrabio Kit was able to detect all. Both 2 samples had undetectable viral load. The quantified HIV DNA copies/million cells of the 24 detected samples by both methods showed good correlation, r=0.91. The difference was within one log.","PeriodicalId":406162,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128316499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global Clinical Epidemiology of Carbapenem- Resistant Enterobacteriaceae Bacteremia and Association with Mortality: Systematic Review and Meta-Analysis 碳青霉烯耐药肠杆菌科菌血症的全球临床流行病学及其与死亡率的关系:系统回顾和荟萃分析

Cohesive Journal of Microbiology & Infectious Disease Pub Date : 2020-02-20 DOI: 10.31031/cjmi.2020.03.000569

Wu Menglu, L. Qiuxia, Zhong Hong, Zou Hua, Huang Shifeng

{"title":"Global Clinical Epidemiology of Carbapenem- Resistant Enterobacteriaceae Bacteremia and Association with Mortality: Systematic Review and Meta-Analysis","authors":"Wu Menglu, L. Qiuxia, Zhong Hong, Zou Hua, Huang Shifeng","doi":"10.31031/cjmi.2020.03.000569","DOIUrl":"https://doi.org/10.31031/cjmi.2020.03.000569","url":null,"abstract":"Objectives: This study was aimed to systematically review published data to evaluate the clinical epidemiology, to explore the risk factors for the acquisition of CRE bacteremia among hospitalized patients and to find out their association with mortality. Methods: The reports concerning the CRE bacteremia in hospitalized adult patients among the published literature before May 2019 were identified by a systematic search of Pubmed, EMBASE and Cochrane. Summary odds ratios(OR) were calculated using random effects models, and study quality was assessed using a modified Newcastle-Ottawa scale. Results: Totally 573 literatures were retrieved out, and we identified 42 studies to calculate the statistically significant pooled odds ratio, of which 22 papers describing factors for CRE-BSIs morbidity and 26 papers for mortality. Previous antibiotic exposure (OR 7.71; 95% CI 2.82-21.08; I-squared=87%), following by mechanical ventilation (OR 4.54; 95% CI 2.55, 8.08; I-squared=78%) and admission to ICU (OR 4.17; 95% CI 3.02-5.76; I-squared=72%) device generated the highest pooled estimate for CRE-BSIs morbidity. Underlying diseases or conditions lead to an unfortunate ending for patients with CRE-BSI. Appropriate empirical therapy contributed to reduce mortality for CRE-BSIs, and the use of ceftazidime-avibactam, lower Pitt bacteremia score or APACHE2 score were also relevant to control mortality. Conclusion: The worldwide morbidity and mortality for CRE-BSIs are high. We should standardize medical practices, optimize the therapeutic approach, timely monitor relevant indicators to control hospital outbreaks.","PeriodicalId":406162,"journal":{"name":"Cohesive Journal of Microbiology & Infectious Disease","volume":"669 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123382591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling the Transmission Dynamics of LASSA Outbreaks in Nigeria States 模拟尼日利亚各州拉沙病暴发的传播动力学

Cohesive Journal of Microbiology & Infectious Disease Pub Date : 2020-02-19 DOI: 10.31031/cjmi.2020.03.000568

S. Oluwafemi Oyamakin, Tolulope Samuel Adeyina

引用次数: 0

Observable Variations in Serum Toll Like Receptors (TLR4) as an Adjunct for Detection of Asymptomatic Neisseria Gonorrhoea Infection Amongst Sexually Active Women in Osun State, Nigeria 尼日利亚奥逊州性活跃妇女血清Toll样受体(TLR4)作为检测无症状淋病奈瑟菌感染的辅助手段的可观察变化

Cohesive Journal of Microbiology & Infectious Disease Pub Date : 2020-02-11 DOI: 10.31031/cjmi.2020.03.000566

I. N. Isaiah

引用次数: 0

Cellular and Bacterial Genetic Sequences in Monkey-Derived Stealth Adapted Viruses 猴源性隐身适应病毒的细胞和细菌基因序列

Cohesive Journal of Microbiology & Infectious Disease Pub Date : 2020-02-11 DOI: 10.31031/cjmi.2020.03.000567

W. John Martin