Malaysian Journal of Ophthalmology最新文献_第9页

Association between HLA-DRB1*04 and Malay patients with Vogt-Koyanagi-Harada syndrome in Malaysia: A case-control study HLA-DRB1*04与马来西亚Vogt-Koyanagi-Harada综合征患者的关系:一项病例对照研究

Malaysian Journal of Ophthalmology Pub Date : 2019-05-30 DOI: 10.35119/myjo.v1i2.11

Alvernia M Samy, N. Ngah, Safinaz Binti Mohd Khialdin, N. Azli, Noor Hamidah Hussin, Azrena Anee

{"title":"Association between HLA-DRB1*04 and Malay patients with Vogt-Koyanagi-Harada syndrome in Malaysia: A case-control study","authors":"Alvernia M Samy, N. Ngah, Safinaz Binti Mohd Khialdin, N. Azli, Noor Hamidah Hussin, Azrena Anee","doi":"10.35119/myjo.v1i2.11","DOIUrl":"https://doi.org/10.35119/myjo.v1i2.11","url":null,"abstract":"Introduction: Vogt-Koyanagi-Harada (VKH) is an autoimmune disorder affecting melanocyte-containing tissues. Major histocompatibility complex, class II, DR beta1 (HLA-DRB1)*04 and its suballele HLA-DRB1*0405 were found to be associated with VKH in many studies.Purpose: To determine the association of HLA-DRB1*04 and its suballele HLADRB1*0405 with VKH patients of Malay descent.Materials and methods: A case control study was conducted among VKH patients of Malay ethnicity attending Ophthalmology Clinic, Hospital Selayang, Malaysia from December 2016 to December 2017. HLA-DRB1*04 allele-specific typing was performed on 14 Malay patients with VKH and 14 healthy controls using the polymerase chain reaction sequence-specific primer method. The data was then analysed using Fisher’s Exact test.Results: The frequency of HLA-DRB1*04 was noted to be higher in patients (42.9%) compared to controls (14.3%), but was not statistically significant (p = 0.209). The frequency of suballele HLA-DRB1*0405 was also increased in patients (42.9%) vscontrols (7.1%); however, the results were not significant (p = 0.077).Conclusion: In conclusion, although the findings were not statistically significant, the increased frequency of both HLA-DRB1*04 and its suballele HLA-DRB1*0405 may suggest a possible cause for the development of VKH among Malay patients.","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131181090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low density lipoprotein receptor (LDLR) gene and ocular manifestation in Malay patients with familial hypercholesterolaemia 马来家族性高胆固醇血症患者的低密度脂蛋白受体(LDLR)基因和眼部表现

Malaysian Journal of Ophthalmology Pub Date : 2019-05-30 DOI: 10.35119/myjo.v1i2.18

A. Liza-Sharmini, Nor Idahriani Muhammad Nur, A. Al-khateeb, Wan-Hazabbah Wan Hitam, Zilfalil Bin Alwi

{"title":"Low density lipoprotein receptor (LDLR) gene and ocular manifestation in Malay patients with familial hypercholesterolaemia","authors":"A. Liza-Sharmini, Nor Idahriani Muhammad Nur, A. Al-khateeb, Wan-Hazabbah Wan Hitam, Zilfalil Bin Alwi","doi":"10.35119/myjo.v1i2.18","DOIUrl":"https://doi.org/10.35119/myjo.v1i2.18","url":null,"abstract":"Introduction: Corneal arcus and eyelid xanthelasma are the common ocular findings but not exclusively found in familial hypercholesterolaemia (FH) patients. Low density lipoprotein receptor (LDLR) gene is the one of the most common genes investigated in FH. There is no study predicting ocular manifestations with genetic variations of the LDLR gene.Purpose: To associate common ocular manifestations of FH and LDLR gene in Malays.Material and methods: A cross-sectional study involving 50 unrelated Malay patients with FH were recruited. FH was diagnosed based on Dutch Lipid Clinic Network diagnostic criteria. The right eye was examined for eyelid xanthelasma and corneal arcus, while mean retinal nerve fibre layer thickness (RNFL) was assessed using Heidelberg retinal tomography II. Venepuncture was performed and genomic deoxyribonucleotide acid (DNA) was extracted. LDLR gene variations were screened using denaturing high-performance liquid chromatography and confirmed through DNA sequencing.Results: Corneal arcus was detected in 86.0% of patients, while eyelid xanthelasma was detected in 2.0% of patients. Mean RNFL thickness was 254.16 μm (SD: 60.67 μm). LDLR gene variations were identified in 32 patients (64.0%), including 5 mutations and 9 single nucleotide polymorphisms (SNPs). Two novel mutations were detected: c.1705+117T>G and p.Asp139His. There was significant association between genotype frequency of LDLR variations c.940+36G>A, p.Glu201Lys and p.Asp304Asn with FH, p.Glu201Lys with corneal arcus, and p.Cys255Ser and c.1705+117T>G with mean RNFL thickness.Conclusion: LDLR gene variations were not uncommon in Malay patients with FH. Two novel variations, c.1705+117T>G and p.Asp139His, were identified. LDLR gene is a potential predictor genetic marker for corneal arcus in Malay patients with FH. c.1705+117T>G is associated with thinner mean RNFL thickness.","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117149727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Role of HLA-DRB1*04 in Malay patients with Vogt-Koyanagi-Harada syndrome HLA-DRB1*04在马来Vogt-Koyanagi-Harada综合征患者中的作用

Malaysian Journal of Ophthalmology Pub Date : 2019-05-30 DOI: 10.35119/myjo.v1i2.68

V. Menezo, Simon R. J. Taylor

{"title":"Role of HLA-DRB1*04 in Malay patients with Vogt-Koyanagi-Harada syndrome","authors":"V. Menezo, Simon R. J. Taylor","doi":"10.35119/myjo.v1i2.68","DOIUrl":"https://doi.org/10.35119/myjo.v1i2.68","url":null,"abstract":"In this issue of the Malaysian Journal of Ophthalmology, Alvernia et al. report the results of their study into the association between HLA-DRB1*04 and Vogt-Koyan-agi-Harada (VKH) syndrome in patients of Malay descent. VKH is a useful condition on which to focus this type of study as, unlike many types of uveitis, it has validated international diagnostic criteria. 1,2 VKH is also among the most common causes of uveitis in Asia, where it accounts for almost one-third of all causes of panuveitis. The combination of a genetic predisposition, including HLA haplotype as well as other genetic polymorphisms, and environmental factors is generally held responsible for the breakdown of tolerance and the development of autoimmunity in many disease entities. However, with the exception of acute anterior uveitis and HLA-B27, there is a disappointing lack of correlation between clinical phenotype, disease outcome, and HLA haplotype in uveitis. This lack of clarity also applies to VKH: there are distinct HLA associations across different ethnic populations, as has been shown in Hispanic and Japanese VKH patients with their HLA-DRB1*01 and *0405 associations; similarly, whilst VKH shares almost identical phenotypical and histopathological findings with sympathetic ophthalmia, and both share an association with HLA-DR1*0405 subtypes, they have completely different precipi-tating disease triggers.","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"261 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116235664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The right eye abducens nerve palsy as a cranial neuropathy of dengue fever: The benefit of corticosteroids in an unusual dengue sequela 右眼展神经麻痹作为登革热的颅神经病变:皮质类固醇在不寻常的登革热后遗症中的益处

Malaysian Journal of Ophthalmology Pub Date : 2019-05-30 DOI: 10.35119/myjo.v1i2.25

M. A. Majid

{"title":"The right eye abducens nerve palsy as a cranial neuropathy of dengue fever: The benefit of corticosteroids in an unusual dengue sequela","authors":"M. A. Majid","doi":"10.35119/myjo.v1i2.25","DOIUrl":"https://doi.org/10.35119/myjo.v1i2.25","url":null,"abstract":"Dengue fever is very common in tropical climate countries and the number of reported cases in Malaysia shows an increasing trend recently, according to the Malaysian Clinical Practice Guidelines. Although dengue fever is common, cranial nerve mononeuropathy is a very rare manifestation in relation to other neurological-associated syndromes. We report a rare case of cranial mononeuropathy of dengue fever in Malaysia and highlight the option of steroid usage as an alternative treatment to hasten the neurological recovery. The patient, a 25-year-old healthy policeman, presented with symptomatic viral fever, which was serologically confirmed as dengue fever. He developed acute-onset binocular diplopia, which was secondary to right eye isolated abducens nerve palsy during the critical phase of dengue fever. His visual acuity was 6/6 in both eyes with slightly restricted abduction of the right eye, consistent with right abducens nerve palsy, which was confirmed with a Hess test. There was corresponding diplopia over the right paracentral visual field. Urgent contrasted brain imaging was done, which ruled out the life-threatening intracranial pathology; therefore, a diagnosis of possible subclinical inflammatory changes causing sixth nerve palsy was made. Subsequently, he was treated with intravenous methylprednisolone 500 mg daily for 3 days and regained full extraocular muscle movement after 1 week. Oral steroid was not initiated. In conclusion, although the isolated unilateral cranial mononeuropathy may improve spontaneously within a certain period of time, a short course of systemic corticosteroids may be considered to hasten the recovery, as it has a favourable outcome.","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127501324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ocular biometry and refractive changes post sutureless vitrectomy surgery 无缝线玻璃体切除术后眼生物测量和屈光变化

Malaysian Journal of Ophthalmology Pub Date : 2019-05-30 DOI: 10.35119/myjo.v1i2.12

Raja Nor Farahiyah Raja Othman

{"title":"Ocular biometry and refractive changes post sutureless vitrectomy surgery","authors":"Raja Nor Farahiyah Raja Othman","doi":"10.35119/myjo.v1i2.12","DOIUrl":"https://doi.org/10.35119/myjo.v1i2.12","url":null,"abstract":"Introduction: Pars plana vitrectomy (PPV) without endotamponade should not induce significant change to the refractive status of the eye. However, several studies have reported minor refractive changes after plain vitrectomy. Purpose: To compare the changes in refraction following PPV and to examine the biometry parameters that may affect the refractive change.Materials and methods: In this prospective cohort study, patients who were listed for 23-gauge 3-port PPV without buckling or silicone oil tamponade were enrolled between December 2015 and September 2017. Autorefraction, keratometry, anterior chamber depth (ACD), and axial length (AL) were measured preoperatively and three months postoperatively.Results: This study involved 41 eyes from 38 patients. The mean spherical equivalent (SE) before PPV was -1.08 dioptres (D), (standard deviation (SD) 2.18), which changed to a mean of -1.88 D (SD 2.20) postoperatively. The mean SE change was -0.80 D (SD 1.61, 95% confidence interval (CI) -1.31 to 0.30 D, P = 0.003). The median astigmatism before PPV was 0.69 D (Interquartile range (IQR) 0.69 D) reduced to 0.66 D (IQR 0.60 D) after PPV (P = 0.882). Median ACD preoperatively was 3.55 mm (IQR 0.76 mm) and reduced postoperatively to 3.44 mm (IQR 0.67 mm), (P = 0.028). The median AL was 23.36 mm (IQR 1.42 mm) and 23.48 mm (IQR 1.56 mm) before and after PPV, respectively, (P = 0.029). No significant SE change was found between phakic and pseudophakic groups (P = 0.155).Conclusion: Patients experience myopic shift post plain PPV, possibly due to the reduction of ACD. The ACD tended to be shorter in the pseudophakic group, suggesting that the myopic shift in the phakic group may be a result of the development of nuclear sclerosis cataract.","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"94 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120872575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Bilateral optic perineuritis associated with p-ANCA vasculitis 双侧视神经周围炎伴p-ANCA血管炎

Malaysian Journal of Ophthalmology Pub Date : 2019-05-30 DOI: 10.35119/myjo.v1i2.21

I. Yoo, Yong Meng Hsien, Mushawiahti Mustapha, J. Hamzah

引用次数: 2

A report on the postoperative outcome of MyIOL603YP implantation in Hospital Melaka 马六甲医院MyIOL603YP植入术后疗效报告

Malaysian Journal of Ophthalmology Pub Date : 2019-05-30 DOI: 10.35119/myjo.v1i2.8

Khavigpriyaa Kalaichelvam

引用次数: 0

Sweet disaster: use of honey-based eye drops as an alternative treatment for vernal keratoconjunctivitis 甜蜜的灾难：使用蜂蜜眼药水作为治疗虹膜炎的替代疗法

Malaysian Journal of Ophthalmology Pub Date : 2019-05-30 DOI: 10.35119/myjo.v1i2.10

Kenneth Teow Kheng Leong, Rebecca Jennifer Mary Louis, Lai Yin Peng, R. Alias, Safinaz Mohd Khialdin

引用次数: 0

Axial ocular dimensions and corneal astigmatism: The Kuala Pilah Cluster Cataract Study 轴向眼尺寸与角膜散光:吉隆坡丛集性白内障研究

Malaysian Journal of Ophthalmology Pub Date : 2019-05-09 DOI: 10.35119/myjo.v1i3.46

P. Raman, Nur Hanis Yusri, Syed Alsagoff Ahmed Daiyallah, P. D. Sivagurunathan, Khairul Husnaini Mohd Khalid

{"title":"Axial ocular dimensions and corneal astigmatism: The Kuala Pilah Cluster Cataract Study","authors":"P. Raman, Nur Hanis Yusri, Syed Alsagoff Ahmed Daiyallah, P. D. Sivagurunathan, Khairul Husnaini Mohd Khalid","doi":"10.35119/myjo.v1i3.46","DOIUrl":"https://doi.org/10.35119/myjo.v1i3.46","url":null,"abstract":"Introduction: The Kuala Pilah Cluster Project involves Kuala Pilah Hospital as the lead hospital and the Jempol Hospital and Tampin Hospital as the district hospitals, serving as a single entity to provide ophthalmology services to the local population. \u0000Purpose: To evaluate the distribution of ocular biometric parameters and corneal astigmatism in patients presenting for cataract surgery within the Kuala Pilah Cluster Hospital System. \u0000Study design and methods: A cross-sectional study conducted on 273 consecutive patients presented for cataract surgery between January and June 2017. Ocular biometry measurements, including axial length (AXL), lens thickness (LT), and anterior chamber depth (ACD) of each right eye were measured using immersion A-scan ultrasound. Keratometric (K) readings were obtained via auto keratometer. \u0000Results: The mean values for AXL, ACD, and LT were 23.40 ± 0.90 mm, 3.17 ± 0.49 mm, and 4.45 ± 0.96 mm, respectively. The average K-reading was 44.40 ± 1.59 D, with a mean corneal astigmatism of 0.82 ± 0.62 D. In this population, the females have significantly shorter AXL and ACD, but steeper K compared to the males (P < 0.001). The local Malays have higher AXL and ACD values compared to the Chinese and Indians. A total of 35.5% patients exhibited a corneal astigmatism greater than 1 D. The magnitude of preoperative astigmatism positively correlated with age (P < 0.001). \u0000Conclusions: Ocular dimensions vary with gender and race in cataract patients from the Kuala Pilah cluster population. The probability of a patient requiring astigmatic correction increases with age. The average profile of ocular biometric data and corneal astigmatism may help local ophthalmologists to predict intraocular lens selections prior to cataract outreach projects.","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130943076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cap-puncturing mechanism for ophthalmic postoperative antibiotic eye drops: friend or foe? 眼科术后抗生素滴眼液的帽穿刺机制:是好是坏?

Malaysian Journal of Ophthalmology Pub Date : 2019-05-09 DOI: 10.35119/myjo.v1i3.33

C. Wen, Yong Meng Hsien, M. Ami, R. A. Nasaruddin, M. Bastion, J. Hamzah

{"title":"Cap-puncturing mechanism for ophthalmic postoperative antibiotic eye drops: friend or foe?","authors":"C. Wen, Yong Meng Hsien, M. Ami, R. A. Nasaruddin, M. Bastion, J. Hamzah","doi":"10.35119/myjo.v1i3.33","DOIUrl":"https://doi.org/10.35119/myjo.v1i3.33","url":null,"abstract":"A retrospective case series highlights two cases of postoperative endophthalmitis, in which similar improper technique of puncturing the antibiotic bottle with a nonsterile needle was noted. \u0000Patient A, a 65-year-old man with three weeks’ history of uneventful combined cataract and pars plana vitrectomy (PPV) presented with acute painful right eye and vision blurring from 6/12 to 1/60 for two days. Examination showed severe anterior chamber activity and hazy fundal view. B-scan showed dense vitritis. Vitreous sampling revealed gram positive cocci, but no culture growth. Patient B, a 69-year-old man presented with three days’ history of right painful red eye and vision dropped to light perception following an uneventful cataract surgery. Examination showed severe anterior chamber activity with hypopyon, raised intraocular pressure, and no fundal view. B-scan detected dense vitritis with loculation. Vitreous sampling cultured Pseudomonas aeruginosa in Patient B. In both cases, the patients reported piercing the generic topical ciprofloxacin 0.3% bottle tip with a nonsterile needle instead of the prescribed method of using the sterile, inner aspect of the bottle cap. However, the cultures of the bottle contents were negative in both cases. Both patients received intravitreal, topical, and systemic antibiotics and subsequently underwent PPV. Patient A recovered vision to baseline, while Patient B recovered to counting finger vision. \u0000The cap-puncturing mechanism for eye drop bottles is designed to maintain the sterility of the contents. However, this may backfire when patients do not understand the prescribed technique. We postulate that this improper technique predisposed the two cases to endophthalmitis. ","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128331755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0