{"title":"Treatment of conjunctival squamous cell carcinoma: balancing disease eradication with minimising treatment-induced morbidity","authors":"Cameron A McLintock, J. McKelvie, S. Hamada","doi":"10.35119/MYJO.V2I4.122","DOIUrl":"https://doi.org/10.35119/MYJO.V2I4.122","url":null,"abstract":"A 41-year-old male presented with a large non-pigmented lesion on the ocular surface involving 8 clock hours of limbus, bulbar conjunctiva, and palpebral conjunctiva. Incisional biopsy confirmed poorly differentiated conjunctival squamous cell carcinoma (SCC). It was staged as a T3, N0, M0 lesion. Treatment was with surgical excision, amniotic membrane transplant, and buccal mucosa graft. Three weekly cycles of 0.04% mitomycin C were administered postoperatively. Six months following excision, although there was no evidence of residual conjunctival SCC, the patient suffered from poor vision, significant pain, and diplopia due to severe dry eye, limbal stem cell deficiency, and symblepharon.This case illustrates the difficult clinical decisions which confront the clinician when treating conjunctival SCC, particularly with balancing the need to eradicate the disease to prevent local invasion and metastatic spread on the one hand and minimising ocular morbidity on the other.","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128045093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adeline I. Low, Y. L. Neoh, Siu Wan Foo, Azida Juana Kadir
{"title":"Leber’s hereditary optic neuropathy","authors":"Adeline I. Low, Y. L. Neoh, Siu Wan Foo, Azida Juana Kadir","doi":"10.35119/MYJO.V2I4.88","DOIUrl":"https://doi.org/10.35119/MYJO.V2I4.88","url":null,"abstract":"Leber’s hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease caused by several point mutations in mitochondrial DNA. We present the case of a healthy 12-year-old Chinese boy who presented with bilateral, painless, subacute loss of central vision (more severe in the left eye the than right eye) for 1 week. No abnormalities were detected on magnetic resonance imaging of the brain and orbit. Serial Humphrey visual field tests initially showed a centrocaecal scotoma that worsened progressively. Cerebrospinal fluid samples and blood investigations showed normal results. A trial of steroid therapy was commenced with not much improvement in the patient’s vision. A blood sample was then sent for LHON genetic testing and a mitochondrial DNA (mtDNA) G11778A pathogenic mutation was detected. The same mutation was also present in the patient’s mother.","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132087525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From my laptop","authors":"L. A. Ahmad Tajudin","doi":"10.35119/myjo.v2i1.134","DOIUrl":"https://doi.org/10.35119/myjo.v2i1.134","url":null,"abstract":"","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125502618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li Chun, Jelinar Mohamed Noor, N. Ramli, Ch’ng Tun Wang, Gan Hui
{"title":"Efficacy of selective laser trabeculoplasty in primary open-angle glaucoma: HKL experience, one-year results","authors":"Li Chun, Jelinar Mohamed Noor, N. Ramli, Ch’ng Tun Wang, Gan Hui","doi":"10.35119/myjo.v1i3.54","DOIUrl":"https://doi.org/10.35119/myjo.v1i3.54","url":null,"abstract":"Introduction: Selective laser trabeculoplasty (SLT) has been demonstrated to lower intraocular pressure (IOP) and reduce the number of topical medications used in patients with primary open-angle glaucoma (POAG). \u0000Purpose: The purpose of our study was to investigate the sustainability and efficacy of SLT in treating POAG at one year following laser. To our knowledge, this is one of the first studies to be published based on local data in Malaysia. \u0000Study design: This was a retrospective study conducted in a specialist eye clinic, Hospital Kuala Lumpur, from July 2017 until January 2019. Data was collected from the medical notes of the patients. \u0000Materials and methods: The study recruited cases of POAG patients who were using topical antiglaucoma medications. Inclusion criteria were patients with unilateral or bilateral POAG aged 50 years and above. Exclusion criteria were secondary open-angle glaucoma and all forms of angle-closure glaucoma. Patients who had undergone trabeculectomy or glaucoma drainage devices were excluded in our study. A single session of 360° SLT using a Q-switched Nd:YAG laser with an initial energy of 0.8 mJ was performed. IOP and number of antiglaucoma medications were recorded at prestudy, 1 week, 1 month, 3 months, 6 months, and 12 months. \u0000Results: In 17 eyes, mean prestudy IOP was 19.3 ± 3.3 mmHg while on 2.18 ± 0.7 eye drops. At 12 months after SLT, mean IOP was 13.3 ± 3.5 mmHg while on 1.88 ± 0.9 IOP-lowering eye drops. This represented a 31% reduction of IOP compared to prestudy levels. However, the reduction of number of medications was not statistically significant. \u0000Conclusion: A single session of 360° SLT treatment for POAG patients is able to lower IOP by 31% at one year following laser. SLT is a safe and effective procedure for reducing IOP. It may be used as adjuvant therapy, especially in noncompliant patients; patients who have difficulty applying topical eye drops or who are intolerant to topical medication.","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128421619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Yoo, Yong Meng Hsien, Mushawiahti Mustapha, J. Hamzah
{"title":"23-G trocar-assisted cyclopexy: scleral sparing method as a new modality for large cyclodialysis repair","authors":"I. Yoo, Yong Meng Hsien, Mushawiahti Mustapha, J. Hamzah","doi":"10.35119/myjo.v1i3.63","DOIUrl":"https://doi.org/10.35119/myjo.v1i3.63","url":null,"abstract":"Cyclodialysis cleft results from separation of longitudinal ciliary muscle fibres from the scleral spur. The separation increases the uveoscleral outflow, leading to severe hypotony. Complexity in managing such condition relies on the extent of the injury and its collateral damage. We reported an alternative method of surgical repair for large cyclodialysis. The procedure was less invasive utilizing a scleral sparing technique. A 66-year-old gentleman presented with severe blunt trauma injury to the globe secondary to shuttlecock injury while playing badminton. He presented with a vision of hand motion. There was hyphaema (filling up half of the anterior chamber), complete posterior dislocation of the crystalline lens, and minimal vitreous haemorrhage. Posterior globe rupture was excluded with further imaging of the orbit. Despite significant amount of hyphaema, intraocular pressure (IOP) remained low several days post injury. Further investigations revealed the presence of almost 270° of cyclodialysis. Surgical repair was indicated. In order to avoid an extensive cut on the sclera, the treating surgeon decided to explore a less invasive method utilizing a small gauge vitrectomy trocar. The main instruments used were the trocar, a straight prolene needle, and a bent 25-G needle. The direction of trocar insertion plays a pivotal role in bringing the detached ciliary body back to its original position. The simplified technique did not require the creation of a scleral flap or direct visualization of the ciliary body. The technique was fast and less invasive, with early improvement of IOP post intervention.","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126627976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Population-based study on axial ocular dimensions and corneal astigmatism","authors":"K. M. Kamal","doi":"10.35119/myjo.v1i3.98","DOIUrl":"https://doi.org/10.35119/myjo.v1i3.98","url":null,"abstract":"As cataract surgery has evolved over 50 years, there have been changes in the current clinical ophthalmic practice to improve safety and efficacy in order to achieve perfect postoperative outcomes. Since the 1990s, technological advances such as ocular biometry, phacoemulsification, and intraocular lens (IOL) formulas, as well as many others, have undergone numerous incremental upgrades aiming to produce predictable and reproducible quality results. However, the financial burden of adopting all these proven yet costly technologies in ophthalmological practice, especially in rural areas, has to be justified. In this issue, an epidemiological study on ocular biometrics conducted by the Ministry of Health at the Kuala Pilah Cluster Program has shed some light on a possible strategy to incorporate advanced tools and technology into our public service.","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115927805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Wen, Teo Shee Kiang, M. Ami, Mushawiahti Mustapha, Tang Seng Fai
{"title":"A surgical cause of pseudopapilledema","authors":"C. Wen, Teo Shee Kiang, M. Ami, Mushawiahti Mustapha, Tang Seng Fai","doi":"10.35119/myjo.v1i3.34","DOIUrl":"https://doi.org/10.35119/myjo.v1i3.34","url":null,"abstract":"We report a case of vitreopapillary traction mimicking optic disc swelling in a 73-year-old female with pseudophakia in the left eye and satisfactory postoperative vision of 6/6 and N5 two years prior. She presented with insidious onset of blurred vision in her left eye for two months. She was referred to Universiti Kebangsaan Malaysia Medical Centre (UKMMC) for further investigations of apparent optic disc swelling in the left eye by a general ophthalmologist. Her left eye vision was 6/18, pinhole 6/12, with near vision at N6. There was no relative afferent pupillary defect and anterior segment examination was normal. Examination of the posterior segment revealed a pink optic disc with blurred and elevated margins without hyperaemia. Vessels of the optic nerve head appeared normal and a lamellar macular hole was present with dull foveal reflex clinically. Right eye examination was normal. Optical coherence tomography (OCT) of the left eye using the raster line scan showed vitreopapillary traction surrounding the optic disc and vitreomacular traction (VMT) with lamellar macular hole. The patient was counselled for surgical release of VMT, however, she opted for conservative management. \u0000Peripapillary vitreoretinal traction is a rare cause of pseudo-optic disc swelling. Thorough fundus examination with the help of OCT is crucial in making a prompt diagnosis, preventing unnecessary investigations, and evaluating other retinal pathologies which may benefit from treatment. \u0000 ","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123053025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An atypical presentation of ANCA-associated retinal vasculitis in a young Malay woman","authors":"Jin Yi Yap, Mohtar Ibrahim, Zunaina Embong","doi":"10.35119/myjo.v1i3.60","DOIUrl":"https://doi.org/10.35119/myjo.v1i3.60","url":null,"abstract":"We describe a case of antineutrophil cytoplasmic antibody (ANCA)-associated retinal vasculitis in a 21-year-old previously healthy Malay woman, who presented to us with complaints of sudden painless loss of vision in her left eye. Her vision upon presentation was counting fingers and her fundus examination showed retinal vasculitis and ischemic changes. Fundus fluorescein angiography showed leakage from the vasculitic retinal vessels, resulting in macular oedema. All investigations were normal, except that a full blood test showed eosinophilia and an autoimmune screening revealed positive perinuclear staining-ANCA, which led us to diagnose ANCA-associated retinal vasculitis. The patient was comanaged with the rheumatology team. She was started on a high-dose intravenous steroid followed by a tapering dose of an oral steroid. Improvement was noted from the resolution of macular oedema evident on optical coherence tomography of the macula. However, vision remained poor and unchanged.","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"201 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127322495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Infectious keratitis: findings from a retrospective review in the central zone of Sarawak","authors":"Koay Jiah Bou, Tan Teng Siew, C. Wei, T. L. Mun","doi":"10.35119/myjo.v1i3.61","DOIUrl":"https://doi.org/10.35119/myjo.v1i3.61","url":null,"abstract":"Introduction: Infectious keratitis is caused by inflammation of the cornea from an infectious pathogen that usually results in corneal scarring. It is a major cause of visual impairment globally. The management of infectious keratitis is challenging, and unfortunately, there is no proper study on this issue in the central zone of Sarawak to date. \u0000Purpose: To identify the demographic characteristics, risk factors, and etiological agents of patients with infectious keratitis in Sibu Hospital, Sarawak, Malaysia. \u0000Design of the study: Retrospective study. \u0000Materials and methods: Data were collected and reviewed from medical records of all patients with infectious keratitis in Sibu Hospital from January 2013 up to May 2018. \u0000Results: A total of 139 patients (143 eyes/cases) were included in the study. The average age of affected individuals was 47.39 years. The most frequently affected patients fell within the age group of 21-30 years (18.9%). The male-to-female ratio was 1.65:1, with 61.5% of patients being males and 38.5% being females. Seventy-four cases were noted to have predisposing factors before the manifestation of symptoms. The commonest predisposing factors were ocular trauma (55.4%), followed by contact lens wear (29.7%), recent ocular surgery (13.5%), and a recent history of swimming (7.4%). At least one pathogen was isolated in 63.1% of the 38 cases that were tested for corneal scraping culture and sensitivity. Pseudomonas aeruginosa was identified as the most common causative pathogen in our study. \u0000Conclusion: Ocular injury stood out as the most common risk factor for infectious keratitis in this study and Pseudomonas aeruginosa was the most common etiological pathogen. A good grasp of local epidemiology and microbial profile of infectious keratitis is essential in aiding and guiding the management of infectious keratitis in hopes of better outcomes for all affected patients. \u0000 ","PeriodicalId":405983,"journal":{"name":"Malaysian Journal of Ophthalmology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123700307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}