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Egyptian Journal of Dermatology and Venereology最新文献

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Seminal Endoglin in infertile men with varicocele, a cohort study 患有精索静脉曲张的不育男性的精液内胚胎蛋白，一项队列研究
IF 0.4
Egyptian Journal of Dermatology and Venereology Pub Date : 2024-04-18 DOI: 10.4103/ejdv.ejdv_46_23
Samy Hanafy, T. Mostafa, Heba Abd-Elhameed, L. Rashed, E. M. Akl
{"title":"Seminal Endoglin in infertile men with varicocele, a cohort study","authors":"Samy Hanafy, T. Mostafa, Heba Abd-Elhameed, L. Rashed, E. M. Akl","doi":"10.4103/ejdv.ejdv_46_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_46_23","url":null,"abstract":"\u0000 \u0000 Varicocele is considered a common and correctable cause of male infertility. This is established by the improvement of sperm parameters after surgical correction. Endoglin (Eng) is presented in two forms, a membrane and soluble forms, and the equilibrium between these forms depends on the oxidative status. Eng is linked to several pathological conditions common in varicocele as hypoxia and apoptosis.\u0000 \u0000 \u0000 \u0000 This study aimed to evaluate the seminal level of soluble Eng in infertile oligoasthenoteratozoospermic (OAT) men associated with varicocele.\u0000 \u0000 \u0000 \u0000 Sixty men were enrolled in this study. They were divided into two groups: infertile OAT men with varicocele and healthy fertile men as a control group. These participants were subjected to complete history taking, clinical and genital examination, semen analysis, and assessment of soluble Eng pre- and 6 months after the surgical intervention.\u0000 \u0000 \u0000 \u0000 The results showed a significant elevation of seminal soluble Eng in infertile OAT men associated with varicocele than in fertile control. Six months postsurgical correction, there was a significant improvement in semen parameters accompanied by a significant decrease in the seminal level of soluble Eng.\u0000 \u0000 \u0000 \u0000 It was concluded that seminal soluble Eng is elevated in infertile OAT men linked to varicocele concurrent with the negative effect on sperm parameters. The surgical correction of varicocele in these cases shows significant improvement in these criteria.\u0000","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140687322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of angiogenesis and inflammatory pathways by glycyrrhizic acid 甘草酸调节血管生成和炎症途径
IF 0.4
Egyptian Journal of Dermatology and Venereology Pub Date : 2024-04-18 DOI: 10.4103/ejdv.ejdv_39_23
Doaa D. Mohamed, H. Mahrous, Hany Khalil, Ibrahim A. Ibrahim, Dalia D. Mohamed, Omar S. Keshk, Alaa H. Nada, A. I. Maksoud
{"title":"Regulation of angiogenesis and inflammatory pathways by glycyrrhizic acid","authors":"Doaa D. Mohamed, H. Mahrous, Hany Khalil, Ibrahim A. Ibrahim, Dalia D. Mohamed, Omar S. Keshk, Alaa H. Nada, A. I. Maksoud","doi":"10.4103/ejdv.ejdv_39_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_39_23","url":null,"abstract":"Skin cancer accounts for most malignancies across the globe. They are primarily divided into melanoma and nonmelanoma skin malignancies. Nonmelanoma skin cancer includes basal cell carcinoma and squamous cell carcinoma. Glycyrrhetinic acid (GA) is a bioactive compound extracted from licorice that exhibits an inhibition effect on various cancers. GA has been reported to have in vitro cytotoxic effects on several human cancer cells. However, reports on the mode of action and detailed mechanism of GA in vitro in skin cancer disease are limited. Hence, GA’s effect on the human skin cell line BJ and MCC13 was investigated. MTT assay showed that GA had cytotoxic effects on MCC13 cells but was non-toxic to the normal cells of BJ in a time-dose dependent manner. GA also inhibited the angiogenic sprouting of new blood vessels in tumor progression. In gene expression assay, GA induces mitochondrial apoptosis through the induction and inhibition of Cytochrome C and Bcl2 respectively. In conclusion, GA is a potent candidate to induce apoptosis and concurrently inhibit the invasion, migration, and angiogenesis of the MCC13 cell line through increasing TNF-alpha concentration resulting in the necroptotic pathway induction.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loss of follow-up of HIV patients from an HIV clinic during COVID-19 outbreak period: what are the reasons? 在 COVID-19 疫情爆发期间，一家艾滋病诊所失去了对艾滋病患者的随访：原因何在？
IF 0.4
Egyptian Journal of Dermatology and Venereology Pub Date : 2024-04-18 DOI: 10.4103/ejdv.ejdv_27_23
P. Sookaromdee, V. Wiwanitkit
{"title":"Loss of follow-up of HIV patients from an HIV clinic during COVID-19 outbreak period: what are the reasons?","authors":"P. Sookaromdee, V. Wiwanitkit","doi":"10.4103/ejdv.ejdv_27_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_27_23","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140688319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letterer–Siwe disease: a case of multisystem Langerhans cell histiocytosis 莱特-西韦病：一例多系统朗格汉斯细胞组织细胞增生症病例
IF 0.4
Egyptian Journal of Dermatology and Venereology Pub Date : 2024-04-18 DOI: 10.4103/ejdv.ejdv_18_23
Jigna Patel, Dharmender Jairam, Kajal G. Kansara, Tejasvi Patel, Bela J. Shah
{"title":"Letterer–Siwe disease: a case of multisystem Langerhans cell histiocytosis","authors":"Jigna Patel, Dharmender Jairam, Kajal G. Kansara, Tejasvi Patel, Bela J. Shah","doi":"10.4103/ejdv.ejdv_18_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_18_23","url":null,"abstract":"Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is an idiopathic uncommon haematological condition affecting infants and young children but can occur at any age group characterized by clonal proliferation of abnormal Langerhans cells. Langerhans cells express an immunophenotype positive for S100 protein, CD1a and Langerin (CD207). Here we present a case of 2-year-old male patient presented with a multiple raw area associated with oozing, bleeding and crusted lesions were present over scalp, trunk and post-auricular areas. Radiographic examination revealed multiple osteolytic bone involvement. Histopathological examination revealed Langerhans cell histiocytosis. Immunophenotyping was positive for vimentin, CD1a, and S100. Based on radiological, histological and immunophenotyping findings suggestive of multisystem LCH. The purpose of this report is to describe a rare case of LCH in the 2-year-old male child with multisystem LCH involving skin, soft tissue and bones and to discuss clinical, radiological and histopathological features of LCH.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryotherapy in chronic plaque psoriasis: an effective therapeutic modality 慢性斑块状银屑病的冷冻疗法：一种有效的治疗方式
IF 0.4
Egyptian Journal of Dermatology and Venereology Pub Date : 2024-04-18 DOI: 10.4103/ejdv.ejdv_38_23
Rajiv Kumar, Mohita Mahajan, B. B. Mahajan
{"title":"Cryotherapy in chronic plaque psoriasis: an effective therapeutic modality","authors":"Rajiv Kumar, Mohita Mahajan, B. B. Mahajan","doi":"10.4103/ejdv.ejdv_38_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_38_23","url":null,"abstract":"\u0000 \u0000 Psoriasis is a common, chronic, inflammatory, and proliferative condition of the skin in which both genetic and environmental factors have a critical role. Various topical and systemic drugs which are given as rotational and sequential therapies are commonly prescribed as treatment. However, these are often not effective in prolonging the remission of chronic plaque psoriasis.\u0000 \u0000 \u0000 \u0000 To assess the therapeutic efficacy of cryotherapy in chronic plaque psoriasis.\u0000 \u0000 \u0000 \u0000 A prospective study on 50 patients with chronic plaque psoriasis was undertaken. Patients were treated with six consecutive sessions of cryotherapy at weekly intervals and further followed-up for another 6 weeks.\u0000 \u0000 \u0000 \u0000 It was observed that among 128 plaques of psoriasis vulgaris, 63 (49%) plaques showed G5 improvement while 40 (73%) among 55 plaques of palmoplantar psoriasis had G5 improvement. Thus, palmoplantar lesions responded better as compared with cutaneous lesions.\u0000 \u0000 \u0000 \u0000 Cryotherapy using nitrous oxide as cryogen has been proven to be an effective therapeutic modality not only for treatment but also for prolonging the remission in localized plaque psoriasis.\u0000","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of topical silymarin 0.7%, dual toning and chemical peels (SeQuenCe protocol) for lichen planus pigmentosus in Indian skin 外用水飞蓟素 0.7%、双重调理和化学换肤（SeQuenCe 方案）联合治疗印度皮肤扁平苔藓色素沉着症
IF 0.4
Egyptian Journal of Dermatology and Venereology Pub Date : 2024-04-18 DOI: 10.4103/ejdv.ejdv_30_23
Rajat Kandhari
{"title":"Combination of topical silymarin 0.7%, dual toning and chemical peels (SeQuenCe protocol) for lichen planus pigmentosus in Indian skin","authors":"Rajat Kandhari","doi":"10.4103/ejdv.ejdv_30_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_30_23","url":null,"abstract":"","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma 无细胞淋巴瘤激酶阴性无细胞大细胞淋巴瘤
IF 0.4
Egyptian Journal of Dermatology and Venereology Pub Date : 2024-04-18 DOI: 10.4103/ejdv.ejdv_17_23
Shraddha Kote, Samruddhi Chopkar, B. Supekar, J. Mukhi
{"title":"Anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma","authors":"Shraddha Kote, Samruddhi Chopkar, B. Supekar, J. Mukhi","doi":"10.4103/ejdv.ejdv_17_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_17_23","url":null,"abstract":"Anaplastic large-cell lymphoma (ALCL) is a non-Hodgkin T-cell lymphoma characterized by persistent expression of CD 30 antigen that represents 2–3% of non-Hodgkin lymphoma (NHL). ALCL may present as a primary cutaneous disease or systemic disease with secondary cutaneous involvement. World Health Organization (WHO) classifies ALCL into ALK-positive and ALK-negative ALCL. ALK-negative ALCL shows poor response on treatment and has a bad prognosis. We report locally aggressive and metastasizing primary cutaneous anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma in a 58-year-old female, due to its paucity of literature.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermoscopy of Nevus Comdonicus 痣的皮肤镜检查
IF 0.4
Egyptian Journal of Dermatology and Venereology Pub Date : 2024-04-18 DOI: 10.4103/ejdv.ejdv_20_23
Shirin S. Gawali, B. Supekar, J. Mukhi
{"title":"Dermoscopy of Nevus Comdonicus","authors":"Shirin S. Gawali, B. Supekar, J. Mukhi","doi":"10.4103/ejdv.ejdv_20_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_20_23","url":null,"abstract":"Nevus sebaceous or comedo naevus is a rare benign hamartoma of the folliculo-sebaceous unit. It is characterized by bundles of papules having dilated follicular openings and keratinous plugs within. We report a case of nevus comedonicus diagnosed based on clinical-histopathological & dermoscopic findings in a 12-year-old male child treated who showed mild improvement with topical retinoids.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yellow diode laser 577 nm versus neodymium-doped yttrium aluminum garnet laser (Nd:Yag) in treating onychomycosis: A comparative study 黄色二极管激光器 577 nm 与掺钕钇铝石榴石激光器 (Nd:Yag) 在治疗甲癣方面的比较研究：比较研究
IF 0.4
Egyptian Journal of Dermatology and Venereology Pub Date : 2024-04-18 DOI: 10.4103/ejdv.ejdv_52_23
Hazem L. Abdel-Aleem, Khaled M. Tawfik, Amaal A. Mofarreg, A. Y. Badran
{"title":"Yellow diode laser 577 nm versus neodymium-doped yttrium aluminum garnet laser (Nd:Yag) in treating onychomycosis: A comparative study","authors":"Hazem L. Abdel-Aleem, Khaled M. Tawfik, Amaal A. Mofarreg, A. Y. Badran","doi":"10.4103/ejdv.ejdv_52_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_52_23","url":null,"abstract":"\u0000 \u0000 Laser treatment signifies a safe option for managing Onychomycosis precisely in the presence of contraindication for antifungal drug use. Yellow Diode laser 577 nm has proved efficacy for managing different dermatological conditions as; vascular lesions, skin innovation and hair elimination. Nonetheless, it not yet been evaluated for treating Onychomycosis.\u0000 \u0000 \u0000 \u0000 We aimed to evaluate the efficacy of Yellow Diode laser 577 nm in treating Onychomycosis and to compare the result with the use of long-pulsed Neodymium-doped Yttrium Aluminum Garnet (Nd:Yag) 1064 nm laser.\u0000 \u0000 \u0000 \u0000 Thirty patients diagnosed clinically and mycologically as having Onychomycosis were recruited. The right side of the treated hand was subjected to treatment by Yellow Diode laser 577 nm, while the left side of the treated hand was subjected to treatment by of long-pulsed Nd:Yag 1064 nm laser. All patients received 6 sessions (1 month apart). The results were evaluated clinically using the Onychomycosis Severity Index (OSI), photographically and mycologically.\u0000 \u0000 \u0000 \u0000 Complete recovery in the side treated by Yellow Diode laser 577 nm was observed in 7 (23.3%) patients, while the side treated by long-pulsed Nd:Yag 1064 nm laser showed complete recovery in 4 patients (13.3%), with significant difference between both sides (p value=0.015*).\u0000 \u0000 \u0000 \u0000 Yellow Diode laser 577 nm is an effective safe and well-tolerated treatment option for managing Onychomycosis. It has proved better effectiveness than long-pulsed Nd;Yag 1064 nm laser in treating Onychomycosis.\u0000","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140686997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum neopterin level in psoriatic patients treated with acitretin or narrowband ultraviolet B or both 接受阿昔曲汀或窄带紫外线 B 或两者治疗的银屑病患者的血清蝶呤水平
IF 0.4
Egyptian Journal of Dermatology and Venereology Pub Date : 2024-04-18 DOI: 10.4103/ejdv.ejdv_53_23
E. Hegazy, M. E. El Taieb, Abd A. M. Eliew, Ali Younis, Ahmed K. Ibrahim, Fatma E. A. Elfatah, H. Ibrahim
{"title":"Serum neopterin level in psoriatic patients treated with acitretin or narrowband ultraviolet B or both","authors":"E. Hegazy, M. E. El Taieb, Abd A. M. Eliew, Ali Younis, Ahmed K. Ibrahim, Fatma E. A. Elfatah, H. Ibrahim","doi":"10.4103/ejdv.ejdv_53_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_53_23","url":null,"abstract":"\u0000 \u0000 A biological indicator of cellular immunity is neopterin. In certain studies, psoriasis patients had higher serum, and urine neopterin levels, which were reduced following therapy.\u0000 \u0000 \u0000 \u0000 To evaluate the effect of acitretin versus narrowband ultraviolet B (NB-UVB) and combinations of them on psoriasis vulgaris and correlate it with neopterin level\u0000 \u0000 \u0000 \u0000 In this case-control research, a total of 120 respondents (30 healthy volunteers) served as the control group, in addition to 90 psoriasis patients randomly allocated into three equal groups: group (I): 30 patients received Acitretin for 3 months. Group (II): 30 patients were treated with NB-UVB. Group (III): 30 patients received Acitretin and NB-UVB (3 sessions/week) for 3 months. Serum neopterin levels were measured pre- and post-treatment. All patients were clinically and photographically evaluated using the Psoriasis Area and Severity Index (PASI) score. The study was registered at clinicaltrial.com. Approval numbers: NCT05401006 and date of registration: 1/6/2022.\u0000 \u0000 \u0000 \u0000 In this study, statistically significant higher serum neopterin levels have been found in psoriatic patients than healthy controls. We found a significant decrease in PASI scores in all groups. The relative reduction percentage in the PASI score was substantially different between groups (P<0.001). The highest decrease percentage in PASI score was reported in group III compared with group II (NB-UVB) and group I (Acitretin group), (P<0.001). The median s. neopterin levels after treatment varied substantially among the three groups (P<0.001).\u0000 \u0000 \u0000 \u0000 When compared with healthy controls, serum neopterin levels in psoriatic patients were substantially greater (P<0.05).\u0000","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140686869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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