Egyptian Journal of Dermatology and Venereology最新文献

Evaluation of serum adiponectin and lipid profile in patients with acne vulgaris 寻常痤疮患者血清脂联素和血脂的评价

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Egyptian Journal of Dermatology and Venereology Pub Date : 2023-09-01 DOI: 10.4103/ejdv.ejdv_6_23

S. Alashry, Manar Sallam, Manar Hassan, Eman Saber

{"title":"Evaluation of serum adiponectin and lipid profile in patients with acne vulgaris","authors":"S. Alashry, Manar Sallam, Manar Hassan, Eman Saber","doi":"10.4103/ejdv.ejdv_6_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_6_23","url":null,"abstract":"Background Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit and is among the most common dermatological conditions worldwide. Adipokines are bioactive molecules secreted by adipocytes. Adiponectin is the most abundant adipokine. It has multiple properties, which includes sensitization of insulin, anti-inflammatory, and antiatherogenic effect. Objectives This study aims to evaluate serum adiponectin and lipid profile levels in patients with acne vulgaris and their correlation with each other and disease severity. Patients and methods This is a case-control study, conducted on a total of 90 patients with acne vulgaris and matched age, sex, and body mass index 70 healthy controls. Serum adiponectin and lipid profile levels were evaluated in all subjects. Results Total cholesterol (TC), total triglycrides (TG) and low density lipoprotein (LDL) were significantly higher in acne vulgaris cases, while high density lipoprotein (HDL) was statistically significant lower in cases compared to controls. Adiponectin concentration was significantly higher in acne vulgaris cases when compared to control group with positive correlations with female gender, disease severity, TC, LDL and significant negative correlation with HDL. Conclusions Adiponectin may play a role in the pathogenesis of acne vulgaris and may affect its severity. Evaluation of all acne patients for lipid profile and advice for healthy diets as an adjuvant method to acne treatment.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"208 - 211"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48750394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutathione S-transferase M1 and T1 gene polymorphisms in psoriasis patients: a pilot case-control study 银屑病患者谷胱甘肽s -转移酶M1和T1基因多态性:一项试点病例对照研究

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Egyptian Journal of Dermatology and Venereology Pub Date : 2023-09-01 DOI: 10.4103/ejdv.ejdv_5_23

Noha Z Tawfik, Hoda Abdallah, Mona Abdullah, Hagar Alshaarawy, M. Atwa

{"title":"Glutathione S-transferase M1 and T1 gene polymorphisms in psoriasis patients: a pilot case-control study","authors":"Noha Z Tawfik, Hoda Abdallah, Mona Abdullah, Hagar Alshaarawy, M. Atwa","doi":"10.4103/ejdv.ejdv_5_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_5_23","url":null,"abstract":"Background The exact etiology of psoriasis remains unknown; nevertheless, it has been found that oxidative stress plays a vital role. Among the multiple antioxidant enzymes, genetic polymorphisms in the Glutathione S-Transferases (GSTs) led to an imbalance in the antioxidant system, resulting in increased levels of reactive oxygen species. Accordingly, the polymorphism in these genes could increase the susceptibility to psoriasis. Objectives To assess the association between Glutathione S-Transferase M1 (GSTM1) and Glutathione S Transferase Theta-1 (GSTT1) gene polymorphisms in psoriasis patients compared to healthy controls. Methods A total of 200 participants, 100 psoriasis cases who were assessed by the Psoriasis Area and Severity Index (PASI), and 100 healthy controls were included. DNA extraction was done followed by multiplex PCR to detect genetic polymorphism in the GSTM1 and GSTT1 genes, Finally, the relation between the presence of polymorphism and the severity of psoriasis was estimated. Results The null genotype frequency of GSTM1 and GSTT1 was 76.0% and 58.0%, respectively among psoriasis patients, while it was 58.0% and 55.0%, respectively among healthy controls. There was a significantly higher risk for psoriasis in patients with the null genotype GSTM1 (OR=2.293) as compared to controls. On the other hand, there was no statistically significant relation between their polymorphisms and family history, psoriasis severity, and PASI score. Conclusion The null genotype GSTM1 could increase the risk of psoriasis susceptibility especially among males.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"200 - 207"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42910348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Royal jelly improved tramadol-induced testicular dysfunction in male albino rats 蜂王浆改善曲马多诱导的雄性白化大鼠睾丸功能障碍

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Egyptian Journal of Dermatology and Venereology Pub Date : 2023-09-01 DOI: 10.4103/ejdv.ejdv_47_22

Hassan Ibrahim, Nesreen Mostafa, A. Mawas, Atef Khalil, Eisa Hegazy

引用次数: 0

Syringocystadenoma papilliferum and leiomyoma of uterus 乳头状注射器囊腺瘤与子宫平滑肌瘤

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Egyptian Journal of Dermatology and Venereology Pub Date : 2023-09-01 DOI: 10.4103/ejdv.ejdv_3_23

Bushra Muna

引用次数: 0

Histoid leprosy, an unusual variant of leprosy - review of literature 组织型麻风病，一种不寻常的麻风病变体——文献综述

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Egyptian Journal of Dermatology and Venereology Pub Date : 2023-09-01 DOI: 10.4103/ejdv.ejdv_19_22

Soundarya Santhanakrishnaan, Manjumeena Dakshinamoorthy

引用次数: 0

Study of the epidemiologic characteristics of childhood vitiligo in Egyptian children 埃及儿童白癜风的流行病学特征研究

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Egyptian Journal of Dermatology and Venereology Pub Date : 2023-09-01 DOI: 10.4103/ejdv.ejdv_1_23

S. Aboeldahab, SarahEl-Sayed Mohammed, M. El-Hamd, Ramadan Saleh

{"title":"Study of the epidemiologic characteristics of childhood vitiligo in Egyptian children","authors":"S. Aboeldahab, SarahEl-Sayed Mohammed, M. El-Hamd, Ramadan Saleh","doi":"10.4103/ejdv.ejdv_1_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_1_23","url":null,"abstract":"Background Vitiligo during childhood is common. Pediatric vitiligo has a profound effect on the quality of life of both children and their parents. Aims and objectives To investigate the epidemiologic characteristics of vitiligo among Egyptian children. Patients and methods A cross-sectional study was conducted and included children of both sexes from birth to less than 18 years of age. The study included schools and maternity and childhood care centers in Sohag Governorate, Upper Egypt, during the period from March 2019 to February 2020. Complete demographic and clinical information of children with vitiligo were recorded. Dermatological examination of patients with vitiligo was done. Vitiligo area and severity index of patients was calculated. Results Of 2594 screened children, 18 (0.7%) had vitiligo. The median age of children with vitiligo was 12 (2–17) years. The age interval from 13 to less than 18 years accounted for 44.4% of vitiligo cases. Females cases of vitiligo were more prevalent (61.1%). Overall, 72.2% of patients with vitiligo were resident of rural areas. Of the 18 cases with childhood vitiligo, 83.3% of cases had a history of consanguineous marriage and 66.5% had vitiligo vulgaris. A proportion of cases related the exacerbation of the disease to exposure to psychological stress. Conclusions Childhood vitiligo was detected in 0.7% of pediatric population in Upper Egypt. The majority of cases with childhood vitiligo had a history a consanguineous marriage between the parents. Psychic trauma was identified as a potential exacerbating factor of childhood vitiligo.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"186 - 190"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44762858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium hypochlorite (0.1%) is a cost-effective and safe solution for trichomycosis (trichobacteriosis) axillaris: a novel use of an old solution 次氯酸钠（0.1%）是治疗腋窝毛霉菌病（毛细菌病）的一种成本效益高且安全的溶液：旧溶液的新用途

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Egyptian Journal of Dermatology and Venereology Pub Date : 2023-09-01 DOI: 10.4103/ejdv.ejdv_36_22

Muhammed Mukhtar

引用次数: 0

Hemostatic comedone extraction using a customized micropipette tip and topical hypertonic saline 使用定制的微移液管尖端和局部高渗盐水止血拔粉刺酮

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Egyptian Journal of Dermatology and Venereology Pub Date : 2023-09-01 DOI: 10.4103/ejdv.ejdv_35_22

Muhammed Mukhtar

引用次数: 0

Thymic stromal lymphopoietin: evaluating its role as a new marker related to presence of psoriasis vulgaris and its severity 胸腺基质淋巴生成素:评价其作为寻常型银屑病存在及其严重程度的新标志物的作用

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Egyptian Journal of Dermatology and Venereology Pub Date : 2023-09-01 DOI: 10.4103/ejdv.ejdv_7_23

H. Khaled, Y. Elghobashy, Enas M. El Sayed

{"title":"Thymic stromal lymphopoietin: evaluating its role as a new marker related to presence of psoriasis vulgaris and its severity","authors":"H. Khaled, Y. Elghobashy, Enas M. El Sayed","doi":"10.4103/ejdv.ejdv_7_23","DOIUrl":"https://doi.org/10.4103/ejdv.ejdv_7_23","url":null,"abstract":"Background Thymic stromal lymphopoietin (TSLP), a proallergic cytokine, and T cell-derived CD40 ligand (CD40L) may collaborate to increase the production of IL-23 in psoriasis patients. One key cytokine, IL-23, is responsible for the unwarranted immune response in psoriasis sufferers. Aim The current study aims to shed light on the possible role of TSLP as a novel biomarker related to presence of psoriasis vulgaris lesions and its severe forms with exclusion of people with atopic dermatitis, allergic rhinitis, rheumatoid arthritis, graft versus host disease (GVHD), blood diseases and patient on anticoagulant therapy as well as pregnant and lactating females. Patients and methods 40 subjects with psoriasis vulgaris participated in the current case-controlled research, whereas 40 healthy volunteers of similar age and gender served as the control group. The degree and extent of the illness were evaluated utilizing the psoriasis area and severity index (PASI) score. Serum was separated after blood samples from the venous blood of the subjects and control participants were taken. As soon as possible, the serum samples were frozen at −20°C. The Sandwich Enzyme-Linked Immunosorbant Assay (ELISA) was utilized to quantify serum TSLP. Results The case group’s serum TSLP levels rose statistically substantially more than those of the control group. In the cases group, there was a statistically strong positive relation between serum TSLP levels and PASI scores (P: < 0.001). There is a statistically strong positive relation between serum TSLP and patients’ age and illness duration, a statistically substantial rise in blood TSLP values in psoriatic arthritis patients and smokers. Conclusion Patients with psoriasis have higher serum TSLP levels, which are proportional to the disease’s severity.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":"43 1","pages":"212 - 219"},"PeriodicalIF":0.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45158007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic lupus erythematosus masquerading as gangrene - an infrequent presentation 伪装成坏疽的系统性红斑狼疮-罕见的表现

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Egyptian Journal of Dermatology and Venereology Pub Date : 2023-09-01 DOI: 10.4103/ejdv.ejdv_42_22

Aditi Singh

引用次数: 0