International Journal of Hepatobiliary and Pancreatic Diseases最新文献

{"title":"Antiplatelet therapy after pancreaticoduodenectomy with portal vein resection as the optimal preventative strategy for maintaining primary vein patency","authors":"Meshka K Anderson, Ryan C Pickens, Joshua Davis, Erin H Baker, John B Martinie, D. Vrochides","doi":"10.5348/100096z04ma2021ra","DOIUrl":"https://doi.org/10.5348/100096z04ma2021ra","url":null,"abstract":"","PeriodicalId":40532,"journal":{"name":"International Journal of Hepatobiliary and Pancreatic Diseases","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71032109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare cause of hemobilia: Metastatic melanoma of the gallbladder","authors":"Meera L Chandrananth, M. Cullinan","doi":"10.5348/100091z04mc2020ci","DOIUrl":"https://doi.org/10.5348/100091z04mc2020ci","url":null,"abstract":"Introduction: Gallbladder melanoma is an extremely rare entity, even more so in living patients, as many remain asymptomatic. Patients usually present with symptoms resembling acute cholecystitis, however here we present a case of metastatic melanoma of the gallbladder presenting with hemobilia.\u0000 Case Report: An 82-year-old lady with a history of skin cancer excisions, including melanoma, many years ago, presented with anemia of unknown origin. A computed tomography (CT) scan was performed, demonstrating a gallbladder mass and hemobilia. She successfully underwent open cholecystectomy, partial liver resection, and lymph node dissection, which on histopathology, demonstrated metastatic melanoma. She remains disease free eight months later.\u0000 Conclusion: Although melanoma of the gallbladder is rare, in patients with a past history of melanoma, a high index of suspicion should be maintained if there are concerning signs, such as anemia, without a clear cause. With early identification and surgical intervention, a patient’s survival rate can be optimized.","PeriodicalId":40532,"journal":{"name":"International Journal of Hepatobiliary and Pancreatic Diseases","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2020-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45805464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum negative immunoglobulin G4-associated cholangiopathy mimicking hilar cholangiocarcinoma: A case report and review","authors":"Nwaduru Chinedu, C. Thomas, P. Anjana","doi":"10.5348/100087z04cn2020cr","DOIUrl":"https://doi.org/10.5348/100087z04cn2020cr","url":null,"abstract":"Introduction: Immunoglobulin G4-associated cholangiopathy (IAC) is a systemic manifestation of IgG4-related diseases manifesting with an increased serum level of IgG4. Immunoglobulin G4-associated cholangiopathy often has a robust clinical response to steroid therapy, however making a diagnosis can be difficult as the cholangiographic features may resemble that of cholangiocarcinoma with varying immunological profiles. In the absence of features suggestive of malignancy, a high index of suspicion for the disease should be maintained, even in the presence of normal serum levels of IgG4. Case Report: In this case report, the diagnosis of IAC was made following cholangiographic imaging, along with the presence of retroperitoneal fibrosis and thickened urothelia, although serum IgG4 levels were within normal limits. The resolution of biliary strictures following a trial of steroid therapy further confirmed the diagnosis. Conclusion: Immunoglobulin G4associated cholangiopathy requires a combination of clinical, serological, histopathological, and radiological features in order to make a clear diagnosis. A trial of steroid therapy in the event of an unclear clinical presentation further helps in differentiating IAC from hilar cholangiocarcinoma. Chinedu Nwaduru1, Thomas Couri2, Anjana Pillai2 Affiliations: 1Medical Student, College of Medicine, University College Hospital, Queen Elizabeth Road, P.O. Box 200212, Ibadan, Nigeria; 2Department of Medicine, University of Chicago Medicine, 5844 S. Maryland Avenue, Chicago, Illinois 60637, USA. Corresponding Author: Chinedu Nwaduru, College of Medicine, University College Hospital, Queen Elizabeth Road, P.O. Box 200212, Ibadan, Nigeria; Email: alexanderelvis200@gmail.com Received: 21 January 2020 Accepted: 24 March 2020 Published: 07 April 2020 PEER REVIEWED | OPEN A CE S","PeriodicalId":40532,"journal":{"name":"International Journal of Hepatobiliary and Pancreatic Diseases","volume":" ","pages":"1"},"PeriodicalIF":0.1,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44700704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life after repair of iatrogenic bile duct injury of postcholecystectomy Filipino patients","authors":"E. Crisostomo, P. Hector, R. Anthony","doi":"10.5348/100086z04ca2020ra","DOIUrl":"https://doi.org/10.5348/100086z04ca2020ra","url":null,"abstract":"Aims: The estimated incidence of bile duct injuries (BDIs) has increased ranging from 0.4% to 0.7% since global recognition of laparoscopic cholecystectomy as a standard procedure. Bile duct injuries are associated with increased morbidity and mortality, as well as substantial health care costs, and malpractice litigation claims. This study aims to determine the quality of life (QoL) of Filipino patients after repair of BDIs incurred from their previous laparoscopic or open cholecystectomies. Methods: A total of 22 patients post-repair of BDIs and 22 ageand sex-matched patients who had unremarkable cholecystectomies from 1997 to 2017 were recruited for this study. The patients were requested to answer a survey on QoL using RAND 36-Item Health Survey 1.0, a validated survey which includes a multi-item scale that assesses eight health concepts. Results: Patients with BDIs had lower scores in all domains compared to non-BDI group. Physical functioning and role limitations due to physical health are statistically significant (p values 0.0473 and 0.0025). Conclusion: The effect of BDI is considerable and bears an impact on a patient’s health and well-being. Physical functioning and Crisostomo E Arcilla, Jr., MD1, Hector Paolo A Zamora, MD2, Anthony R Perez3 Affiliations: 1Chairman, Department of Surgery, University of the Philippines College of Medicine and Philippine General Hospital, Philippines; 2Surgical Resident, Manila Doctors Hospital, Philippines; 3Associate Professor, Department of Surgery, University of the Philippines College of Medicine and Philippine General Hospital, Philippines. Corresponding Author: Anthony R Perez, Associate Professor, Department of Surgery, University of the Philippines College of Medicine and Philippine General Hospital, Philippines; Email: tonyperez92@yahoo.com Received: 16 October 2019 Accepted: 24 January 2020 Published: 11 February 2020 role limitations due to physical health were identified to be impaired among these patients and these factors should be assessed during long-term follow-up.","PeriodicalId":40532,"journal":{"name":"International Journal of Hepatobiliary and Pancreatic Diseases","volume":" ","pages":"1"},"PeriodicalIF":0.1,"publicationDate":"2020-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45890642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary pancreatic metastasis from a primary breast carcinoma: A case report","authors":"Crisostomo E Arcilla, Hector Paolo A Zamora, A. Perez","doi":"10.5348/100085z04ca2020cr","DOIUrl":"https://doi.org/10.5348/100085z04ca2020cr","url":null,"abstract":"Breast cancer is the most frequent cancer among women. Common sites of metastatic involvement of breast cancer, in order of frequency, are bone, lung, pleura, soft tissues, and liver. Isolated metastasis to the pancreas from a primary breast cancer is a rare occurrence. Presented herein is a case of a 55-year-old female patient postmastectomy for breast carcinoma who developed signs and symptoms of obstructive jaundice secondary to a pancreatic head mass. It was documented to be metastatic from the primary breast cancer and was managed surgically to relieve the biliary obstruction.","PeriodicalId":40532,"journal":{"name":"International Journal of Hepatobiliary and Pancreatic Diseases","volume":"10 1","pages":"1"},"PeriodicalIF":0.1,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41434862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of Mirizzi syndrome during the pandemic in a COVID 19 referral center: Report of a case from a developing country","authors":"Brent Andrew G Viray, Crisostomo E Arcilla, Anthony R Perez, Vincent Nestor A Venida, Emmanuel T Limpin","doi":"10.5348/100093z04bv2020cr","DOIUrl":"https://doi.org/10.5348/100093z04bv2020cr","url":null,"abstract":"Mirizzi syndrome (MS) is a rare complication of gallstone disease Surgical management may be complex, depending on the type of Mirizzi, and may range from simple cholecystectomy to a hepaticojejunostomy A 39-year-old female diagnosed previously to have gallstones was admitted in the Philippine General Hospital (PGH), a tertiary COVID 19 referral center presenting with obstructive jaundice, right upper quadrant pain and fever Hepatobiliary ultrasonography demonstrated a markedly distended gallbladder with a stone at the Hartmann's pouch A diagnosis of Mirizzi syndrome with cholangitis was made The patient was managed with broad spectrum antibiotics and scheduled for surgery No further imaging or endoscopy was requested due to the limitations brought about by the pandemic Upon a negative COVID 19 polymerase chain reaction (COVID 19 PCR) test result she underwent surgery, subtotal cholecystectomy, intraoperative cholangiography, and choledochoplasty No perioperative complications were noted This patient patient care while limiting risks from COVID 19 both to the patient and the health care team This case demonstrates the need to address issues brought about by the pandemic resulting in limitations in resources, added risk of morbidity to patients, and increased level of technical difficulty particularly in biliary surgery","PeriodicalId":40532,"journal":{"name":"International Journal of Hepatobiliary and Pancreatic Diseases","volume":"10 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71032055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological difference between invasive pancreatic duct cancer and distal bile duct cancer of the pancreas head after pancreaticoduodenectomy","authors":"M. Ikeguchi, K. Endo","doi":"10.5348/100090z04mi2020ra","DOIUrl":"https://doi.org/10.5348/100090z04mi2020ra","url":null,"abstract":"Aims: The only curative treatment for patients with invasive pancreatic duct cancer (IPDC) and distal bile duct cancer (DBDC) of the pancreas head is pancreaticoduodenectomy (PD). However, the clinicopathological difference between IPDC and DBDC after PD has not been thoroughly discussed. In this study, we retrospectively analyzed the clinical and pathological difference between IPDC and DBDC in patients who underwent PD. Methods: Sixty-six patients who underwent curative PD were enrolled (IPDC, n = 35; DBDC, n = 31). Preoperative, intraoperative, and postoperative parameters and pathological factors (stages, lymph node metastasis, lymphatic invasion, vascular invasion, and perineural invasion) were compared. Results: Jaundice was frequently detected and preoperative biliary drainage was frequently performed in patients with DBDC (60.5% and 90.3%, respectively). Additionally, the preoperative serum total bilirubin concentration and C-reactive protein/albumin ratio were higher in patients with DBDC than IPDC. As a result, the occurrence of postoperative pancreatic fistula occurred more frequently in patients with DBDC. In contrast, lymph node metastasis, lymphatic invasion, and vascular invasion were detected more frequently in patients with IPDC. The overall 5-year survival rate of the 35 patients with IPDC (13.4%) was much worse than that of the 31 patients with DBDC (52.3%, p < 0.001). Masahide Ikeguchi1, Kanenori Endo2 Affiliations: 1Department of Surgery, Kitaoka Hospital, 10315 Meiji-machi, Kurayoshi, Japan; 2Department of Surgery, Tottori Prefectural Central Hospital, 730 Ezu, Tottori, Japan. Corresponding Author: Masahide Ikeguchi, MD, Department of Surgery, Kitaoka Hospital, 1031-5 Meiji-machi, Kurayoshi 682-0887, Japan; Email: m-ikeguchi@kitaokahp.jp Received: 07 May 2020 Accepted: 27 June 2020 Published: 07 August 2020 RE ARCH ARTICLE PEER REVIEWED | OPEN A CE S Conclusion: The oncological characteristics of IPDC are much different from those of DBDC. More effective treatment should be started in patients with IPDC as soon as possible.","PeriodicalId":40532,"journal":{"name":"International Journal of Hepatobiliary and Pancreatic Diseases","volume":"10 1","pages":"1"},"PeriodicalIF":0.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71032307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute pancreatitis in a patient with COVID-19: A case report","authors":"M. Kolhe, Praveen Sharma, S. Anikhindi, N. Bansal, Munish Saachdeva, A. Arora","doi":"10.5348/100092z04mk2020cr","DOIUrl":"https://doi.org/10.5348/100092z04mk2020cr","url":null,"abstract":"Introduction: The world is in the middle of the COVID-19 global pandemic Case load is rising on exponential rate and we have already crossed 20 million mark Typical presenting feature of COVID-19 is asymptomatic/mild or symptoms/acute respiratory illness and death Gastrointestinal (GI) manifestations are common like loose stools, nausea, and abdominal pain Case Report: A case of a 19-year-old girl without previous comorbidities presented with typical symptoms of COVID-19 During hospital stay she developed abdominal pain and diagnosed severe pancreatitis All common causes of acute pancreatitis were ruled out by doing relevant investigations Her pancreatitis was severe and required percutaneous drainage of necrotic material She was discharged after prolonged hospital stay even after her negative COVID test Conclusion: Atypical presentation of COVID-19 is increasing with increasing case load Abdominal pain in a patient with COVID should be evaluated for acute pancreatitis and be treated accordingly to lessen morbidity and mortality","PeriodicalId":40532,"journal":{"name":"International Journal of Hepatobiliary and Pancreatic Diseases","volume":"16 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71032464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel surgical technique for the management of biliary-enteric anastomotic strictures","authors":"Malek A. Al-Omari, S. Smadi","doi":"10.5348/100089z04ta2020ra","DOIUrl":"https://doi.org/10.5348/100089z04ta2020ra","url":null,"abstract":"","PeriodicalId":40532,"journal":{"name":"International Journal of Hepatobiliary and Pancreatic Diseases","volume":"1 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71032246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative HBsAg titers in relation to disease progression and serum markers of iron metabolism among chronic hepatitis B patients","authors":"N. Yılmaz, H. Cam","doi":"10.5348/100088z04ny2020ra","DOIUrl":"https://doi.org/10.5348/100088z04ny2020ra","url":null,"abstract":"Aims: To investigate quantitative hepatitis B surface antigen (HBsAg) titers in relation to disease progression and serum markers of iron metabolism in chronic hepatitis B (CHB) patients. Methods: A total of 99 treatment-naïve CHB patients [median (min/max) age: 39.0 (17–66) years, 61.6% were males] with HBsAg positivity for at least six months were included in this study. Data on patient demographics, quantitative HBsAg titers (IU/mL), liver enzymes, hepatitis B virus (HBV) DNA levels, fibrosis stage, necroinflammatory scores and serum iron parameters including serum Fe (μg/dL), total iron binding capacity (TIBC; μg/dL), transferrin saturation (%), and ferritin (ng/mL) were recorded and compared with respect to gender and age (median age <40 years vs. ≥40 years). Results: Serum Fe (78.2 ± 29.5 vs. 111.7 ± 36.8 μg/dL, p = 0.001), transferrin saturation [0.2 (0.1–0.5) vs. 0.3 (0.1–1.0) %, p < 0.001], and ferritin [27 (3.9–298) vs. 100 (31– 994) ng/mL, p < 0.001] levels were significantly lower in females than in males. Quantitative HBsAg titers were correlated with age negatively in males overall (r = –0.328, p < 0.001) and positively in females >40 years of age (r = 0.722, p < 0.001). In females, quantitative HBsAg titers were positively with fibrosis stage (r = 0.491, p = 0.002), necroinflammatory grade (r = 0.235, p = 0.049), and ferritin (r = 0.288, p = 0.011) regardless of the age. In males, HBsAg titers were Nimet Yilmaz1, Hakan Çam2 Affiliations: 1Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterology, University of Sanko, Gaziantep, Turkey; 2Private Meydan Health Institutions, Private Uncali Meydan Hospital, Division of Gastroenterology, Antalya, Turkey. Corresponding Author: Nimet Yilmaz, Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterology, University of Sanko, Gaziantep, Turkey; Email: drnimet23@ hotmail.com Received: 01 January 2020 Accepted: 04 March 2020 Published: 20 May 2020 RE ARCH ARTICLE PEER REVIEWED | OPEN A CE S positively correlated with fibrosis stage (r = 0.501, p = 0.003), necroinflammatory grade (r = 0.471, p = 0.007), and HBV DNA (r = 0.313, p = 0.012) as well as with aspartate aminotransferase (AST) (r = 0.284, p = 0.021) and alanine aminotransferase (ALT) (r = 0.265, p = 0.031) only in those >40 years of age. Conclusion: In conclusion, our findings revealed lower serum iron parameters and association of quantitative HBsAg with ferritin levels in females and significant association of quantitative HBsAg with hepatitis markers in females regardless of age and in males after 40 years of age. Our findings also emphasize the likelihood of the more direct role of HBV-related liver injury rather than HBV infection per se in disturbed iron metabolism among female CHB patients and stronger association of HBsAg titers with HBV DNA and liver enzymes in males after 40 years of age.","PeriodicalId":40532,"journal":{"name":"International Journal of Hepatobiliary and Pancreatic Diseases","volume":"10 1","pages":"1"},"PeriodicalIF":0.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71031548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}