Open Access Journal of Biogeneric Science and Research最新文献

{"title":"Learning Difficulties and Reading Comprehension in the First Grades of Primary School","authors":"T. Antonis","doi":"10.46718/jbgsr.2022.10.000255","DOIUrl":"https://doi.org/10.46718/jbgsr.2022.10.000255","url":null,"abstract":"This paper is a study on the concept of learning disabilities and reading comprehension. Specifically, it studies the learning difficulties and the reading ability in terms of the school performance of the students of the first grades of primary school. Aim: In our work we try to analyze and present the following topics: Method: We followed the most up-to-date literature on the subject Conclusions: Learning difficulties can also cause emotional problems in children as they feel that they are lagging behind compared to the rest of the class. Our goal is to include children with learning disabilities in the classroom by adapting the lesson to the children and not the children in it. Our main concern should be the valid and timely diagnosis of difficulties and effective intervention to address them.","PeriodicalId":405266,"journal":{"name":"Open Access Journal of Biogeneric Science and Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126993651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marine Drugs as a Valuable Source of Natural Biomarkers Used in the Treatment of Alzheimer’s Disease","authors":"U. NATH U","doi":"10.46718/jbgsr.2022.10.000253","DOIUrl":"https://doi.org/10.46718/jbgsr.2022.10.000253","url":null,"abstract":"Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder. Current approved drugs may only ameliorate symptoms in a restricted number of patients and for a restricted period of time. Currently, there is a translational research challenge into identifying the new effective drugs and their respective new therapeutic targets in AD and other neurodegenerative disorders. In this review, selected examples of marine-derived compounds in neuro degeneration, specifically in AD field are reported. The emphasis has been done on compounds and their possible relevant biological activities. The proposed drug development paradigm and current hypotheses should be accurately investigated in the future of AD therapy directions.","PeriodicalId":405266,"journal":{"name":"Open Access Journal of Biogeneric Science and Research","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115427959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forest Biodiversity Degradation: Assessment of Deforestation in Ohaji Egbema Forest Reserve, Imo State, Nigeria Using GIS Approach","authors":"Egbuche Christian Toochi","doi":"10.46718/jbgsr.2022.10.000252","DOIUrl":"https://doi.org/10.46718/jbgsr.2022.10.000252","url":null,"abstract":"This research is focused on a spatial analysis of a reserved forest deforestation over a period of time using a GIS approach in Ohaji Egbema Local Government Area Imo state, Nigeria. It aimed at assessing and analyze deforestation in Ohaji Egbema forest reserve and examined the possible effects of deforestation on the forest environment. The assessment concentrated on when and where have forestlands changed in the reserved forest programmed within the period of 1984 - 2040 forecast. The key objectives were to assess the impact of land use and land cover changes on forest cover for the past 36 years, while sub objectives were dedicated to achieve in mapping out different land cover in Ohaji Egbema forest reserve, to assess land cover changes in the forest reserve susceptible to long term degradation from 1984 to 2020 of about 20 years. To evaluate forest loss in the area for the past 36years, and to predict the state of the land cover (forest) for the next 20 years (2040). Primary and secondary data employed using (200 ground truth points) were systematically collected from four different LULC classes in the study area using geographical positioning system (GPS), the secondary data (Satellite Landsat Imageries of 1984, 2002 and 2020) of the study area was acquired. The imageries were processed, enhanced and classified into four LULC classes using supervised classification in Idrisi and ArcGis software Ground truth points were utilized to assess the accuracy of the classifications. The data collected was analyzed in tables and figures and represented with a bar chart and pie chart graphs. Results showed that forest land, built up, grassland and water body were the four LULC classified in the study area. Kappa coefficient values of 91%, 85% and 92% for 1984, 2002 and 2020 respectively shows the accuracy of the classifications. Classifying the land uses into built-up and forest lands revealed that the built-up lands constantly rose while the forest lands kept dropping. The built-up lands increased by 49.30% between 1984 and 2000, 50.00% between 2002 and 2020 and 28.40% between 2020 and 2040 at the expense of the forest portion of the area which fell by 33.88% between 1984 and 2000,46.45% between 2002 and 2020, and 49.22% between 2020 and 2040. Increase in population, per capita income, and land use activities and by extension urban expansion were found to be the major factors causing deforestation in the forest reserve, it is likely that in the nearest future the remaining forest lands would be gradually wiped out and consequently the environmental crisis would be aggravated. Based on the findings of the study, there is need to urgently limit and control the high rate of deforestation going on in Ohaji Egbema forest reserve and embark on tree replanting campaigns without delay. There is need and recommended that a higher quality satellite imagery that offers up to 4m resolution should be used and a forest relic analysis should be conducted.","PeriodicalId":405266,"journal":{"name":"Open Access Journal of Biogeneric Science and Research","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115301083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wilms’s Tumor Gene Mutations: Loss of Tumor Suppresser Function: A Bioinformatics Study","authors":"Uzma Jabbar","doi":"10.46718/jbgsr.2022.10.000250","DOIUrl":"https://doi.org/10.46718/jbgsr.2022.10.000250","url":null,"abstract":"Introduction: Mutation in the Wilms’s Tumor (WT1) gene product has been detected in both sporadic and familial cases suggesting that alteration in WT1 may disrupt its normal function. The study aims to find the protagonist amino acid in WT1 proteins by mutating these residues with other amino acids. Material and Methods: The 3D modeling approach by MODELLER 4 was utilized to build a homology of WT1 proteins. Quality of the WT1 model was verified by predicting 10 models of WT1 and hence selecting the best one. Stereochemistry of model was evaluated by PROCHECK. Mutational studies were done by WHAT IF. Five human WT1 mutations were modeled which were Lys371→Ala371, Ser415→Ala415, Cys416→Ala416, His434→Asp434 and His434→Arg434. Result: Based on active side of WT1 protein and its role in DNA binding mutation. No significant change was observed when Lys371 was mutated to Ala371, Ser415 was mutated to Ala415. Significant change was observed in Cys416 mutated to Ala416. In mutant Ala416, loss of coordination with the metal ion Zn was also predicted. In case of Mutants His434→Asp434, there was a loss of coordination of metal ion (Zn203) with mutant Asp434. In case of mutant His434→Arg434, there was a loss of Zn203 coordination with Arg434. His434 does not interact directly with any DNA base, whereas mutated Arg434 is predicted to interact directly with DNA base. Conclusion: It is concluded that mutation of amino acid residue Cys416→Ala416, His434→Asp434 and His434→Arg434 may lose the proto-oncogenic function of WT1.","PeriodicalId":405266,"journal":{"name":"Open Access Journal of Biogeneric Science and Research","volume":"36 24","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113974863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Advantages of Peritoneal Dialysis over Hemodialysis","authors":"Sami Bahçebaşı","doi":"10.46718/jbgsr.2022.10.000251","DOIUrl":"https://doi.org/10.46718/jbgsr.2022.10.000251","url":null,"abstract":"Although kidney transplantation is the definitive treatment of kidney failure, for many reasons, most of patients need dialysis treatment. Despite significant advantages of PD over HD, HD commonly used modality all over the world. PD patients have better survival relative to HD patients in the first year of dialysis. A recent study has shown that the risk of all-cause mortality and infection death were higher in the unplanned HD group than in the unplanned PD group during 1-year follow up. Because of prolonged and gentle removal of body fluids and toxins ,PD reduces the risk of hemodynamic instability. Therefore, PD may be preferred in the treatment of critically ill patients with acute kidney injury (AKI) or end-stage renal disease (ESRD). In a study compared PD with continuous renal replacement therapy in critically ill patient with AKI. Patients in the PD group had lower mortality rate at 28 days, less complication of infections and faster recovery of renal function. Therefore, PD can be applied effectively and safely in critically ill patients with AKI and requiring dialysis. PD confers better quality of life (autonomy, flexibility, avoidance of regular hospital visits for the patients and relatives, travel easily, more free time). PD can be done while sleeping, this allowing patient to travel and do daily activities. PD preserves the residual renal function over HD. PD has freedom of pain in vascular access sites from repeated cannulation for HD and preserves this sites for the future HD. PD has significant economic advantage over HD globally. There is no need for a large number of healthcare workers, dialysis machines, protective equipment and clean water in PD. A meta-analysis has shown that pretransplant","PeriodicalId":405266,"journal":{"name":"Open Access Journal of Biogeneric Science and Research","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125297407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene Editing via Integrase Enzyme","authors":"U. Masood","doi":"10.46718/jbgsr.2022.10.000249","DOIUrl":"https://doi.org/10.46718/jbgsr.2022.10.000249","url":null,"abstract":"","PeriodicalId":405266,"journal":{"name":"Open Access Journal of Biogeneric Science and Research","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133671007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Cell Tumor of the Distal Tibia and Fibula (Rare Location)","authors":"Mohamed Hamid Awadelseid","doi":"10.46718/jbgsr.2022.10.000248","DOIUrl":"https://doi.org/10.46718/jbgsr.2022.10.000248","url":null,"abstract":"","PeriodicalId":405266,"journal":{"name":"Open Access Journal of Biogeneric Science and Research","volume":"2011 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128877818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of Award-Winning Research to the Visibility of Science on a University Campus","authors":"Raquel de la Cruz Soriano","doi":"10.46718/jbgsr.2022.10.000247","DOIUrl":"https://doi.org/10.46718/jbgsr.2022.10.000247","url":null,"abstract":"This article presents the experience in the preparation and presentation of results to the call for awards of the Ministry of Science, Technology and Environment, evidence of the impact achieved. The methods of science were applied such as: analysis and synthesis, historical and logical, hypothetical deductive; within the empirical ones: observation, document review, interview, training actions, conducting scientific sessions, giving conferences and joint elaboration. The scientific results with the potential to opt for the call were determined by reviewing documents, interviewing teachers-researchers, holding scientific sessions on the subject and giving lectures on the methodological procedure.","PeriodicalId":405266,"journal":{"name":"Open Access Journal of Biogeneric Science and Research","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121519988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What was and was not agreed at COP26 In Glasgow, UK in November 2021","authors":"K. Openshaw","doi":"10.46718/jbgsr.2021.10.000246","DOIUrl":"https://doi.org/10.46718/jbgsr.2021.10.000246","url":null,"abstract":"","PeriodicalId":405266,"journal":{"name":"Open Access Journal of Biogeneric Science and Research","volume":"89 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132531089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant Lung Abscess and Endometritis in a Woman with Turner Syndrome in","authors":"Maryam m Hashemi","doi":"10.46718/jbgsr.2021.10.000244","DOIUrl":"https://doi.org/10.46718/jbgsr.2021.10.000244","url":null,"abstract":"Objective: To report a rare case of Turner syndrome (TS) in postpartum period in COVID-19 era. Case Report: A 27-year-old woman with TS and twin pregnancy referred for preterm premature rupture of membranes (PPROM) and severe anemia. Hysterotomy was done in this case and after that, she presented a persistent fever. PCR result for COVID-19 was negative. She had hemoptysis and anti-tuberculosis drugs were given. Lung abscess was diagnosed and right lobectomy was performed. Regardless of it, the fever continued and hysterectomy were carried out. Despite of this, fever continued. Finally, after 57 days, the patient was discharged.The patient was followed up for three months and she was afebrile and had no cough. Conclusion: Women with TS are cases with multiple problems and it is necessary to mitigate them. In COVID-19 era, some of postpartum complications in these patients are like to COVID-19 symptoms and make their management difficult. Clinicians should consider life-threatening risks in these patients before recommending and using assisted reproductive techniques (ART), especially in more than one embryo transfer.","PeriodicalId":405266,"journal":{"name":"Open Access Journal of Biogeneric Science and Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114799720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}