Physics of Life Reviews最新文献_第8页

Computational models of peripersonal space representation 个人空间表征的计算模型

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-09-01 Epub Date: 2025-07-03 DOI: 10.1016/j.plrev.2025.07.002

Tommaso Bertoni , Ishan-Singh J. Chauhan , Jean-Paul Noel , Andrea Serino

{"title":"Computational models of peripersonal space representation","authors":"Tommaso Bertoni , Ishan-Singh J. Chauhan , Jean-Paul Noel , Andrea Serino","doi":"10.1016/j.plrev.2025.07.002","DOIUrl":"10.1016/j.plrev.2025.07.002","url":null,"abstract":"<div><div>Peripersonal space (PPS) is the region of space near the body, the multisensory interface where interactions with the environment predominantly occur. This space is represented by a specialized neural system that integrates tactile and external stimuli as a function of their distance from the body. Previous studies uncovered plastic and dynamical properties of PPS representation, links between PPS encoding and higher-level cognitive functions (e.g., social cognition), as well as its alterations in neurological and psychiatric disorders. These findings have expanded the definition of PPS and have led to the development of an array of computational models of PPS, addressing the <em>why</em> and <em>how</em> of PPS encoding. Although computational models are crucial for advancing our mechanistic and functional understanding of PPS representation, no prior work has reviewed these models. Here, we address this gap by analysing computational models of PPS, and proposing a taxonomy to classify them based on their level of description, capacity to reproduce empirical findings, and ability to generate novel predictions. This effort leads us to propose that PPS may be best understood as a system that detects spatiotemporal regularities in body-environment interactions, in order to predict potential future interactions. Hence, we suggest re-defining PPS as a unified spatiotemporal field that integrates not only spatial dimensions, but also temporal ones.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"54 ","pages":"Pages 128-140"},"PeriodicalIF":13.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-order interaction modeling of tumor-microenvironment crosstalk for tumor growth 肿瘤生长中肿瘤-微环境串扰的高阶相互作用模型

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-09-01 Epub Date: 2025-05-16 DOI: 10.1016/j.plrev.2025.05.007

Jincan Che , Yu Wang , Li Feng , Claudia Gragnoli , Christopher Griffin , Rongling Wu

{"title":"High-order interaction modeling of tumor-microenvironment crosstalk for tumor growth","authors":"Jincan Che , Yu Wang , Li Feng , Claudia Gragnoli , Christopher Griffin , Rongling Wu","doi":"10.1016/j.plrev.2025.05.007","DOIUrl":"10.1016/j.plrev.2025.05.007","url":null,"abstract":"<div><div>Signaling interactions between cancer cells and nonmalignant cells in the tumor microenvironment (TME) are believed to influence tumor progression and drug resistance. However, the genomic machineries mediating such an influence remain elusive, making it difficult to determine therapeutic targets on the tumor and its microenvironment. Here, we argue that a computational model, derived from the integration of evolutionary game theory and ecosystem theory through allometric scaling law, can chart the genomic atlas of high-order interaction networks involving tumor cells, TME, and tumor mass. We assess the application of this model to identify the causal influence of gene-induced tumor-TME crosstalk on tumor growth. The findings demonstrate that cooperation and competition between tumor cells and their infiltrating microenvironment promote or inhibit tumor growth in diverse ways. We identify specific genes that govern this promotion or inhibition, which can be used as genetic targets to alter tumor growth. This model opens up a new avenue to precisely infer the genomic underpinnings of tumor-TME interactions and their impact on tumor progression from any omics data.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"54 ","pages":"Pages 11-23"},"PeriodicalIF":13.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights from tradition: Comment on “Can arts-based interventions improve health? A conceptual and methodological critique” by Martin Skov and Marcos Nadal 来自传统的见解：评论“基于艺术的干预措施能改善健康吗？”马丁·斯科夫（Martin Skov）和马科斯·巴布（Marcos bbb）的《概念和方法论批判》

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-09-01 Epub Date: 2025-07-05 DOI: 10.1016/j.plrev.2025.07.007

Sloka Iyengar

引用次数: 0

Bridging dynamical systems theory and cross-species experimental validation: Comment on “Entrainment by transcranial alternating current stimulation: Insights from models of cortical oscillations and dynamical systems theory” by M. Madadi Asl and A. Valizadeh 桥接动力系统理论和跨物种实验验证：对M. Madadi Asl和A. Valizadeh合著的《经颅交流电刺激引起的带动：来自皮质振荡模型和动力系统理论的见解》的评论

IF 14.3 1区生物学

Physics of Life Reviews Pub Date : 2025-09-01 Epub Date: 2025-08-12 DOI: 10.1016/j.plrev.2025.08.004

Xinchen Li , Changhong Han , Yanmin Liu , Peng Ji

引用次数: 0

Creative cures or wishful thinking? The case for rigor in arts-based interventions: Comment on “Can arts-based interventions improve health? A conceptual and methodological critique” by Martin Skov and Marcos Nadal 创意疗法还是一厢情愿？基于艺术的干预措施的严谨性：评论“基于艺术的干预措施能改善健康吗？”马丁·斯科夫（Martin Skov）和马科斯·巴布（Marcos bbb）的《概念和方法论批判》

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-09-01 Epub Date: 2025-06-19 DOI: 10.1016/j.plrev.2025.06.002

Dirk B. Walther

引用次数: 0

To enhance or not to enhance: A debate about cognitive enhancement from a psychological and neuroscientific perspective 增强或不增强：从心理学和神经科学的角度对认知增强的争论

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-09-01 Epub Date: 2025-05-14 DOI: 10.1016/j.plrev.2025.05.002

Sandra Grinschgl , Manuel Ninaus , Guilherme Wood , Aljoscha C. Neubauer

{"title":"To enhance or not to enhance: A debate about cognitive enhancement from a psychological and neuroscientific perspective","authors":"Sandra Grinschgl , Manuel Ninaus , Guilherme Wood , Aljoscha C. Neubauer","doi":"10.1016/j.plrev.2025.05.002","DOIUrl":"10.1016/j.plrev.2025.05.002","url":null,"abstract":"<div><div>The enhancement of humans’ core cognitive abilities–such as intelligence–is a frequently debated topic in scientific and public discourse. Different enhancement methods such as cognitive trainings, smart drugs, and brain stimulation techniques have been proposed and tested to enhance human’s cognition. In this narrative review, we summarize the main psychological and neuroscientific findings regarding those cognitive enhancement methods. We thereby distinguish passive (e.g., smart drugs) and active enhancement methods (e.g., working memory training)–which require different levels of agency. While for both forms of enhancement there is no (or only little) empirical evidence on their effectiveness to improve overall cognitive abilities, passive methods entail severe risks. Thus, we criticize promoting an overly optimistic view on especially passive enhancement. Furthermore, we highlight which individuals might be willing to enhance themselves, related motivational aspects of cognitive enhancement, and ethical considerations thereof. To raise awareness for the (in)effectiveness and risks of passive and active enhancement, we propose a category framework that distinguishes cognitive enhancement from clinical methods to treat disorders or diagnosed deficits and introduces important dimensions thereof. Finally, we present open questions for psychological and neuroscientific research which should become part of enhancement debates. Taken together, our narrative review provides a broad overview and critical assessment of enhancement-related topics such as effectiveness and risks of enhancement methods, motivational aspects to apply enhancement, and societal implications of cognitive enhancement.</div></div>","PeriodicalId":403,"journal":{"name":"Physics of Life Reviews","volume":"54 ","pages":"Pages 58-77"},"PeriodicalIF":13.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From seeing X-ray sparks to sparking neural circuits 从看到x射线火花到激发神经回路

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-09-01 Epub Date: 2025-07-10 DOI: 10.1016/j.plrev.2025.07.011

Ge Wang

引用次数: 0

Bioelectrics for healthy and food-secure lives: Reply to comments on “Advances in pulsed electric stimuli as a physical method for treating liquid foods” 用于健康和食品安全生活的生物电：对“脉冲电刺激作为处理液体食品的物理方法的进展”评论的答复

IF 13.7 1区生物学

Physics of Life Reviews Pub Date : 2025-09-01 Epub Date: 2025-07-11 DOI: 10.1016/j.plrev.2025.07.010

Farzan Zare , Negareh Ghasemi , Nidhi Bansal , Hamid Hosano

引用次数: 0

The paradox of the self-studying brain: Timescales, self-representation, and roots of consciousness. Reply to comments on 'The paradox of the self-studying brain' 自我学习大脑的悖论：时间尺度、自我表现和意识的根源。回复“自学大脑的悖论”评论