Current Journal of Neurology最新文献_第10页

A retrospective study of the safety and efficacy of rituximab in Iranian patients with myasthenia gravis: A single-center experience. 利妥昔单抗治疗伊朗重症肌无力患者安全性和有效性的回顾性研究:单中心经验

IF 0.7

Current Journal of Neurology Pub Date : 2022-04-04 DOI: 10.18502/cjn.v21i2.10492

Bentolhoda Ziaadini, Narges Karimi, Akram Panahi, Ali Asghar Okhovat, Farzad Fatehi, Shahriar Nafissi

{"title":"A retrospective study of the safety and efficacy of rituximab in Iranian patients with myasthenia gravis: A single-center experience.","authors":"Bentolhoda Ziaadini, Narges Karimi, Akram Panahi, Ali Asghar Okhovat, Farzad Fatehi, Shahriar Nafissi","doi":"10.18502/cjn.v21i2.10492","DOIUrl":"10.18502/cjn.v21i2.10492","url":null,"abstract":"Background: This retrospective cohort study was conducted to evaluate the efficacy and tolerance of rituximab (RTX) for the management of myasthenia gravis (MG). Methods: This retrospective cross-sectional study was conducted on 61 patients with refractory and non-refractory MG who received RTX. The Myasthenia Gravis Activities of Daily Living (MG-ADL) profile was used to assess MG symptoms and their effects on daily activities at the start of RTX and in the last follow-up. The Myasthenia Gravis Foundation of America Post-Intervention Status (MGFA-PIS) scale has been used as an outcome measure after treatment with RTX in the 12th month and the last follow-up. Results: The mean age of the patients was 40.31 ± 13.53 years (range: 15-78 years). Of 61 patients, eight (13.1%) were double seronegative, 29 (47.5%) had anti-acetylcholine receptor (AChR+) antibody, and 24 (39.3%) had anti-muscle-specific tyrosine kinase antibody (MuSK+). According to the mean rank table, the results of this study showed that the drug was more effective in improving the symptoms of MuSK+ patients compared to the other two groups (P = 0.006). The mean MG-ADL was 4.86 ± 1.83 before treatment and 1.51 ± 2.02 in the last follow-up visit. Paired t-test showed a significant association between MG-ADL before and after treatment in the last visit [t(55): 11.30, 95% confidence interval (CI): 2.79-3.99, P = 0.001)]. Conclusion: This retrospective study showed a considerable effect of RTX as induction therapy in patients with MG, especially those with MuSk+ MG.","PeriodicalId":40077,"journal":{"name":"Current Journal of Neurology","volume":"21 1","pages":"91-97"},"PeriodicalIF":0.7,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49049813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral border zone infarctions: An etiologic study. 脑边界区梗死的病因研究

IF 0.7

Current Journal of Neurology Pub Date : 2022-01-05 DOI: 10.18502/cjn.v21i1.9353

Mazyar Hashemilar, Parla Tohidi, Nasrin Forghani, Elyar Sadeghi-Hokmabadi, Ehsan Sharifipour

{"title":"Cerebral border zone infarctions: An etiologic study.","authors":"Mazyar Hashemilar, Parla Tohidi, Nasrin Forghani, Elyar Sadeghi-Hokmabadi, Ehsan Sharifipour","doi":"10.18502/cjn.v21i1.9353","DOIUrl":"10.18502/cjn.v21i1.9353","url":null,"abstract":"Background: Cerebral border zone infarctions (BZIs) are a subtype of acute ischemic stroke that occur at the junction between two major cerebral arterial territories. Internal and external BZIs are defined based on the known patterns in brain magnetic resonance imaging (MRI). However, the etiology and pathophysiology of these two types of BZI are still debated. This study aimed to determine the etiologic differences of two types of BZI to guide tailor appropriate treatment strategies for these patients. Methods: In this prospective study, patients with BZIs were enrolled from patients with acute ischemic stroke admitted to the hospitals affiliated with Tabriz University of Medical Sciences, Tabriz, Iran, from 2017 to 2019. Appropriate clinical and laboratory workups were applied to determine possible etiologies of ischemic stroke according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification system. Results: The study included 106 patients with BZI, 53 patients in each group. Both types of BZI were more frequent in males. However, there was no significant difference between the two types concerning sex, age, and profile of major stroke risk factors. The results showed no correlation between the type of BZI and hemodynamic factors (P = 0.086). However, large artery atherosclerosis (LAA) was the most frequent etiology within each subtype of BZI; LAA in internal (P = 0.016) and cardioembolism (P = 0.046) in external BZI were more frequent etiologic subtypes of cerebral infarction. Conclusion: LAA might be the most common etiology for internal and external cerebral BZIs. Cardioembolism might have a more important etiologic role in the external subtype.","PeriodicalId":40077,"journal":{"name":"Current Journal of Neurology","volume":"21 1","pages":"1-6"},"PeriodicalIF":0.7,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46226603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Validation of myasthenia gravis activity of daily living questionnaire: Persian version. 重症肌无力日常生活活动问卷的验证：波斯语版

IF 0.5

Current Journal of Neurology Pub Date : 2022-01-05 DOI: 10.18502/cjn.v21i1.9360

Shahriar Faghani, Ali Asghar Okhvat, Narges Karimi, Mana Moassefi, Seyed Farzad Maroufi, Shahriar Nafissi, Farzad Fatehi

{"title":"Validation of myasthenia gravis activity of daily living questionnaire: Persian version.","authors":"Shahriar Faghani, Ali Asghar Okhvat, Narges Karimi, Mana Moassefi, Seyed Farzad Maroufi, Shahriar Nafissi, Farzad Fatehi","doi":"10.18502/cjn.v21i1.9360","DOIUrl":"10.18502/cjn.v21i1.9360","url":null,"abstract":"Background: The 8-item myasthenia gravis activity of daily living (MG-ADL) questionnaire is a valid and reliable instrument for evaluating myasthenia gravis (MG)-associated disability. This study aims to assess its validity and reliability in the Iranian population. Methods: A total number of 58 patients with MG were qualified for the examination. All 58 patients completed the Persian translation of 15-item Myasthenia Gravis Quality of Life (MG-QOL15) and MG-ADL questionnaires initially, and 30 filled out the MG-ADL questionnaire 2 to 4 weeks after the initial visit. Pearson correlation coefficient of questionnaires, internal consistency using Cronbach's alpha (α), and test-retest repeatability of the questionnaire were evaluated. Results: The Pearson correlation coefficient of Persian versions of MG-QOL and MG-ADL was 0.93 (P < 0.01). The Persian MG-ADL showed satisfactory internal consistency (Cronbach's α = 0.89) and test-retest reliability (r = 0.99, P < 0.01). Conclusion: The Persian MG-ADL is a valid and reliable questionnaire for the determination of activities of daily life in Iranian patients with MG.","PeriodicalId":40077,"journal":{"name":"Current Journal of Neurology","volume":"21 1","pages":"35-39"},"PeriodicalIF":0.5,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41438042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous screening for antibodies to myelin oligodendrocyte glycoprotein and aquaporin-4 in patients with optic neuritis using cell-based assay. 细胞法同时筛选视神经炎患者髓鞘少突胶质细胞糖蛋白和水通道蛋白-4抗体

IF 0.7

Current Journal of Neurology Pub Date : 2022-01-05 DOI: 10.18502/cjn.v21i1.9359

Durgadevi Parthasarathy, Kulandai Lily Therese, Selvakumar Ambika, Selvi Krishnan, Durga Priyadarshini Santhakumar

{"title":"Simultaneous screening for antibodies to myelin oligodendrocyte glycoprotein and aquaporin-4 in patients with optic neuritis using cell-based assay.","authors":"Durgadevi Parthasarathy, Kulandai Lily Therese, Selvakumar Ambika, Selvi Krishnan, Durga Priyadarshini Santhakumar","doi":"10.18502/cjn.v21i1.9359","DOIUrl":"10.18502/cjn.v21i1.9359","url":null,"abstract":"Background: This study was aimed to test simultaneous detection of antibodies to myelin oligodendrocyte glycoprotein (MOG)/aquaporin4 (AQP4) in serum samples of patients with clinically-diagnosed optic neuritis (ON), by fixed cell-based immunofluorescence assay (CBIFA). Methods: The study involved 237 serum samples of patients with ON which were tested for MOG and AQP4 antibodies using fixed CBIFA kit which utilizes AQP4 or MOG protein transfected cells as a substrate. Results: Of 237 serum samples, 22 (9%) were positive for AQP4, 66 (28%) were positive for MOG, and 138 (58%) were negative for both AQP4 and MOG antibodies. 11 (5%) patients with clinically-diagnosed multiple sclerosis (MS) were negative for both antibodies. None of the samples were positive for both AQP4 and MOG. Among 237, 132 women [18 (13.6%) and 37 (28%)] and 105 men [4 (3.8%) and 29 (27.6%)] were positive for AQP4/MOG antibodies and remaining percentage belonged to double negative and MS. Seropositivity rate was higher in women than men. Antibodies to MOG were significantly higher than AQP4 antibodies and evenly found in all age groups. There was no ambiguous result encountered in the study. Conclusion: In this study, the seropositivity for antibodies to MOG is more than AQP4 antibody in patients with ON. Fixed CBIFA is a useful tool for laboratory diagnosis of ON in the clinical setting of neuro-ophthalmology to plan the next line of treatment management effectively.","PeriodicalId":40077,"journal":{"name":"Current Journal of Neurology","volume":"21 1","pages":"29-34"},"PeriodicalIF":0.7,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44183316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natalizumab-induced thrombocytopenia: A case report. 那他单抗致血小板减少症1例报告

IF 0.7

Current Journal of Neurology Pub Date : 2022-01-05 DOI: 10.18502/cjn.v21i1.9363

Amirreza Azimi, Zohreh Abna, Fereshteh Ghadiri, Farzad Mehrabi

引用次数: 1

Assessment of computed tomography perfusion RAPID estimated core volume accuracy in patients following thrombectomy. 计算机断层扫描灌注快速评估取栓后患者核心容量的准确性

IF 0.7

Current Journal of Neurology Pub Date : 2022-01-05 DOI: 10.18502/cjn.v21i1.9356

Riwaj Bhagat, Allison Muha, Kerri Remmel, Wei Liu

{"title":"Assessment of computed tomography perfusion RAPID estimated core volume accuracy in patients following thrombectomy.","authors":"Riwaj Bhagat, Allison Muha, Kerri Remmel, Wei Liu","doi":"10.18502/cjn.v21i1.9356","DOIUrl":"10.18502/cjn.v21i1.9356","url":null,"abstract":"Background: Computed Tomography Perfusion (CTP) maps ischemic core volume (CV) and penumbra following a stroke; however, its accuracy in early symptom onset is not well studied. We compared the accuracy of CTP RAPID estimated CV with diffusion weighted imaging (DWI) infarct volume (IV) in patients following thrombectomy. Methods: Charts of anterior circulation large vessel occlusion post-thrombectomy cases with thrombolysis in cerebral infarction (TICI) 2b/3 reperfusion from 2017 to 2019 were reviewed. CTP time was dichotomized as 0-3 hours and ≥ 3 hours from the last known normal (LKN) cognition. The volumetric difference (VD), defined as DWI IV minus CTP CV, core volume overestimation (CVO), defined as CTP CV minus DWI IV and Alberta stroke programme early CT score (ASPECTS) were calculated. Large CV was defined as ≥ 50 ml CV. Modified Rankin Score (mRS) at 90 days were reviewed. We performed independent sample t-test and Spearman correlation coefficient test. Results: Total cases (n) were 61. In < 3 hours window from LKN (n = 27), the mean VD was 58.3 ± 0.1 ml (P = 0.990) and CVO (n = 11; 40.7%) was 39.6 ± 35.7 ml (P = 0.008). Mean large CV (n = 8) was 78.3 ± 25.4 ml with median ASPECTS of 8 [interquartile range (IQR) = 6.5-9.0] and median mRS at 90 days of 2 (IQR = 0.8-3.3). In ≥ 3 hours window from LKN (n = 34), CVO (n = 5) was uncommon and large CV had median mRS at 90 days of 5 (IQR = 4.0-6.0). Conclusion: CTP more frequently overestimates CV in patients who are < 3 hours from LKN. The treated patients with large CV in < 3 hours and > 3 hours had good and poor functional outcomes, respectively.","PeriodicalId":40077,"journal":{"name":"Current Journal of Neurology","volume":"21 1","pages":"17-22"},"PeriodicalIF":0.7,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43060431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diet and disease-related outcomes in multiple sclerosis: A systematic review of clinical trials. 多发性硬化症的饮食和疾病相关结果:临床试验的系统回顾

IF 0.7

Current Journal of Neurology Pub Date : 2022-01-05 DOI: 10.18502/cjn.v21i1.9362

Mohammad Hossein Harirchian, Elmira Karimi, Sama Bitarafan

{"title":"Diet and disease-related outcomes in multiple sclerosis: A systematic review of clinical trials.","authors":"Mohammad Hossein Harirchian, Elmira Karimi, Sama Bitarafan","doi":"10.18502/cjn.v21i1.9362","DOIUrl":"10.18502/cjn.v21i1.9362","url":null,"abstract":"Background: A growing number of clinical trials have investigated the role of diet in multiple sclerosis (MS) patients. We systematically reviewed the literature for clinical trials to assess the impact of different kinds of diets on MS-related outcomes. Methods: We searched MEDLINE, EMBASE, and Web of Science for relevant studies published before July 2019. The clinical trials included a defined dietary intervention and MS outcomes, including fatigue, relapse rate (RR), quality of life (QOL), and disability. Results: In the present review, 15 trials on 669 MS patients were included. The 2 plant-based diet trials, 1 was low-fat and the other was low-calorie, included in the review showed a large effect (ES: 0.6 to 0.7) on fatigue compared to the regular diet. The other plant-based diet was a low-protein diet and showed moderate to large effects on disability and RR compared to the Western diet. Moreover, 2 studies showed the clinically meaningful effects of the ketogenic diet (KD) on QOL and disability compared to the regular diet. In addition, 2 studies compared fish oil (FO) to placebo and found a small effect on disability (ES: 0.1 to 0.3). There were 2 studies that evaluated evening primrose oil and hemp seed oil and showed medium to large effect (ES: 0.7 to 1.5) on RR compared to olive oil. Finally, we found 2 studies that showed high flavonoid cocoa had a moderate effect (ES: 0.4) on fatigue and a small effect (ES: 0.04) on QOL compared to low flavonoid cocoa. Conclusion: Plant-based diet is a backbone for dietary recommendations in MS patients although low-fat, low-calorie, and KD diets with the addition of fish oil, vegetable oil, and flavonoids could be helpful.","PeriodicalId":40077,"journal":{"name":"Current Journal of Neurology","volume":"21 1","pages":"52-63"},"PeriodicalIF":0.7,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43656995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The prevalence and major determinants of non-compliance with anti-seizure medication among children. 儿童不遵守抗癫痫药物的流行率和主要决定因素

IF 0.7

Current Journal of Neurology Pub Date : 2022-01-05 DOI: 10.18502/cjn.v21i1.9358

Ladan Afsharkhas, Shabnam Zamani, Azita Tavasoli, Babak Zamani, Atefeh Talebi

{"title":"The prevalence and major determinants of non-compliance with anti-seizure medication among children.","authors":"Ladan Afsharkhas, Shabnam Zamani, Azita Tavasoli, Babak Zamani, Atefeh Talebi","doi":"10.18502/cjn.v21i1.9358","DOIUrl":"10.18502/cjn.v21i1.9358","url":null,"abstract":"Background: A wide range of adherence to the use of anti-seizure medications has been reported among children with the disease, and accordingly, various factors on the degree of adherence to the drug have been reported. But in our society, there is no clear picture of drug adherence and related factors among children with seizures. We evaluated the frequency of adherence to anti-seizure medication as well as related factors. Methods: This cross-sectional study was conducted on 120 children with epilepsy who referred to Ali Asghar Hospital in Tehran, Iran, during 2019 and 2020. Along with demographic characteristics, adherence to antiepileptic medications was assessed by the Modified Morisky Scale (MMS). Results: The overall frequency of adherence to anti-seizure medications among children was reported to be about 41.7%. Among all baseline characteristics, much higher adherence was revealed in patients with educated parents. The rate of drug adherence in children with a history of perinatal morbidities was much lower than in other patients. The type of seizure could also affect the rate of drug adherence as the highest and the lowest adherence was found concerning focal impaired awareness seizure (57.1%) and atonic seizures (11.1%) indicating a significant difference (P = 0.022). The most common causes of non-adherence to treatment were expressing inability to treat the patient (23.0%), parents' forgetfulness to give medicine to the child (18.3%), and not taking medication when traveling or leaving home (16.7%). Conclusion: The lower level of education of the parents, type of seizure, as well as the presence ofunderlying perinatal morbidity in the child can predict non-compliance with anticonvulsant medication regimens among affected children.","PeriodicalId":40077,"journal":{"name":"Current Journal of Neurology","volume":"21 1","pages":"23-28"},"PeriodicalIF":0.7,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46329672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain, heart, and sudden death. 大脑，心脏和猝死

IF 0.5

Current Journal of Neurology Pub Date : 2022-01-05 DOI: 10.18502/cjn.v21i1.9361

Shahram Oveisgharan, Fariborz Ghaffarpasand, Peter Sörös, Mustafa Toma, Nizal Sarrafzadegan, Vladimir Hachinski

{"title":"Brain, heart, and sudden death.","authors":"Shahram Oveisgharan, Fariborz Ghaffarpasand, Peter Sörös, Mustafa Toma, Nizal Sarrafzadegan, Vladimir Hachinski","doi":"10.18502/cjn.v21i1.9361","DOIUrl":"10.18502/cjn.v21i1.9361","url":null,"abstract":"During the past 30 years, rate of coronary artery disease (CAD), as the main cause of sudden death (SD), has decreased more than rate of SD. Likewise, cause of SD remains elusive in not a trivial portion of its victims. One possible reason is attention to only one organ, the heart, as the cause of SD. In fact, SD literature focuses more on the heart, less on the brain, and seldom on both. A change is required. In this paper, we first review the pathological findings seen in heart autopsies of SD victims after psychological stressors such as physical assault victims without internal injuries. Then, we summarize new studies investigating brain areas, like the insula, whose malfunctions and injuries are related to SD. Next, we review prototypes of neurological diseases and psychological stressors associated with SD and look at heart failure (HF)-related SD providing evidence for the brain-heart connection. Finally, we propose a new look at SD risk factors considering both brain and heart in their association with SD, and review strategies for prevention of SD from this perspective.","PeriodicalId":40077,"journal":{"name":"Current Journal of Neurology","volume":"21 1","pages":"40-51"},"PeriodicalIF":0.5,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41789842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors predisposing patients with temporal lobe epilepsy to seizure cluster. 颞叶癫痫患者易发癫痫的因素

IF 0.7

Current Journal of Neurology Pub Date : 2022-01-05 DOI: 10.18502/cjn.v21i1.9355

Marjan Asadollahi, Faezeh Maghsudloo, Leila Simani, Hossein Pakdaman

{"title":"Factors predisposing patients with temporal lobe epilepsy to seizure cluster.","authors":"Marjan Asadollahi, Faezeh Maghsudloo, Leila Simani, Hossein Pakdaman","doi":"10.18502/cjn.v21i1.9355","DOIUrl":"10.18502/cjn.v21i1.9355","url":null,"abstract":"Background: We aimed to identify the potential risk factors associated with seizure clusters in patients with temporal lobe epilepsy (TLE). Methods: This retrospective cross-sectional study was performed on all the consecutive patients with TLE, who were admitted to the Epilepsy Monitoring Unit (EMU), Loghman-Hakim Hospital, Tehran, Iran. Seizure cluster was defined as three or more habitual seizures occurring within 24 hours, in over 50% of ictal events, with inter-seizure interval of less than 8 hours. The patients' demographic data, epilepsy duration, seizure frequency, frequency of interictal epileptiform discharges (IEDs), and brain magnetic resonance imaging (MRI) findings were collected. Results: Among a total number of 124 patients with TLE, 62 (50.0%) patients reported seizure clusters. In addition, 44 (37.9%), 42 (36.2%), and 30 (25.9%) patients had normal-appearing brain MRI, mesial temporal sclerosis (MTS), and other brain pathologies, respectively. In terms of IEDs frequency, 35 (29.4%), 43 (36.1%), 17 (14.3%), and 24 (20.2%) patients had respectively frequent, occasional, rare, and no spikes in one-hour of interictal scalp electroencephalography (EEG) recording. In our study, seizure clusters were not associated with the epilepsy duration (P = 0.100), the amount of IEDs (P = 0.764), or MRI findings (P = 0.112). Conclusion: In patients with TLE, seizure clustering had no correlation with the epilepsy duration, the amount of IEDs, or brain MRI findings.","PeriodicalId":40077,"journal":{"name":"Current Journal of Neurology","volume":"21 1","pages":"12-16"},"PeriodicalIF":0.7,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9527866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47631752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0