Precision Medical Sciences最新文献_第3页

Metrology and visualization analysis of literatures related to tumor immunotherapy based on CiteSpace 基于CiteSpace的肿瘤免疫治疗相关文献计量与可视化分析

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Precision Medical Sciences Pub Date : 2023-03-28 DOI: 10.1002/prm2.12099

Weidong Ma, Zhi-yun Xu, Qianwei Wang, Zhenzhong Zhang, Derong Tang, Jianqiang Zhao

{"title":"Metrology and visualization analysis of literatures related to tumor immunotherapy based on CiteSpace","authors":"Weidong Ma, Zhi-yun Xu, Qianwei Wang, Zhenzhong Zhang, Derong Tang, Jianqiang Zhao","doi":"10.1002/prm2.12099","DOIUrl":"https://doi.org/10.1002/prm2.12099","url":null,"abstract":"To explore the development of global tumor immunotherapy in the past 20 years, and analyze the research status, hotspots and trends to provide theoretical support for subsequent research. CiteSpace 5.6.R2 software were used to analyze 290 articles related to tumor immunotherapy research from the Web of Science core data set from 2000 to 2019. CiteSpace was used to draw related visual maps and tables of coauthors, cooperating countries, cooperating institutions, literature and journal co‐citation, keyword co‐occurrence, and cluster analysis. The total amount of papers published in the field of tumor immunotherapy research has gradually increased. After receiving the Nobel Prize in Physiology or Medicine in 2018, the number of papers published in the field of research in tumor research reached 20. We found that the United States has the largest number of papers in all countries and China ranks 6. “Proceedings of the National Academy of Sciences of the United States of America,” “Journal of Immunology,” “Cancer Research,” “New England Journal of Medicine,” “Blood” is the top five core academic journals in this field. Cancer, disease, and tumor necrosis factor are the three keywords with the highest highlighting intensity. Comprehensive analysis shows that the coauthors, co‐institutions, and co‐cited journals of the literature are mostly concentrated in the United States. The rise of immunotherapy provides a new direction for tumor treatment. From 2018 to 2019, the number of literatures on tumor immunotherapy worldwide increased sharply. Immunotherapy combined with specific diseases is the current research frontier and hotspot.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"159 - 169"},"PeriodicalIF":0.5,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41619933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application and effect evaluation of case management nursing practice mode in patients with precision radiotherapy for nasopharyngeal carcinoma 病例管理护理实践模式在鼻咽癌精准放疗中的应用及效果评价

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Precision Medical Sciences Pub Date : 2023-03-04 DOI: 10.1002/prm2.12096

Xiaodong Li, D. Xu, Shuchang Lou, Jun Li

{"title":"Application and effect evaluation of case management nursing practice mode in patients with precision radiotherapy for nasopharyngeal carcinoma","authors":"Xiaodong Li, D. Xu, Shuchang Lou, Jun Li","doi":"10.1002/prm2.12096","DOIUrl":"https://doi.org/10.1002/prm2.12096","url":null,"abstract":"To explore the application and effect evaluation of case management nursing practice mode in patients with nasopharyngeal carcinoma receiving precision radiotherapy. Fifty patients with nasopharyngeal carcinoma diagnosed for the initial treatment in our hospital from February 2020 to October 2020 were selected as the control group and 50 patients with the same condition in the same period were selected as the experimental group. The experimental group was trained by nurses to implement case management nursing practice mode for nasopharyngeal cancer patients; in the control group, nasopharyngeal cancer patients were treated with general nursing routine, such as health education and discharge guidance before chemotherapy and radiotherapy. Compared with the control group, self‐care ability and patient satisfaction of experimental group were improved to a certain extent, and the differences were statistically significant (p < .05). The nursing practice mode of case management is suitable for patients with cancer and chronic diseases. The mode can provide continuous and high‐quality nursing for patients, improve patients' self‐care ability, satisfaction with hospitalization, and so forth, and thus is worthy of clinical application.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"76 - 82"},"PeriodicalIF":0.5,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45011598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of pharmacogenomic and pharmacomicrobiomic data for personalized medicine 整合药物基因组和药物微生物组数据，实现个性化用药

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Precision Medical Sciences Pub Date : 2023-03-01 DOI: 10.1002/prm2.12095

M. Shamsuzzaman, T. Ahsan, Hadisur Rahman, K. C. Das, Salimullah

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Issue Information 问题信息

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Precision Medical Sciences Pub Date : 2023-03-01 DOI: 10.1002/prm2.12058

引用次数: 0

PD‐L1 expression by different scoring methods and different cutoff values and correlation with clinicopathological characteristics in gastric cancer: A retrospective study 不同评分方法、不同截止值PD‐L1表达与胃癌临床病理特征相关性的回顾性研究

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Precision Medical Sciences Pub Date : 2023-01-21 DOI: 10.1002/prm2.12094

Lixiang Si, Xiaohua Pan, Kang He, Ling Sun, Yajing Wang, Xinyu Xu, Jianwei Lu

引用次数: 0

The role of receptor‐type protein tyrosine phosphatases in cancer 受体型蛋白酪氨酸磷酸酶在癌症中的作用

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Precision Medical Sciences Pub Date : 2023-01-02 DOI: 10.1002/prm2.12090

Zhengyuan Lv, Tianming Wang, Xin Cao, Mengting Sun, Yuan Qu

引用次数: 0

A narrative medicine‐based training program increases the humanistic care quality of new nurses in cancer hospital 以叙述医学为基础的培训计划提高了癌症医院新护士的人文关怀质量

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Precision Medical Sciences Pub Date : 2023-01-01 DOI: 10.1002/prm2.12091

Ning-Jung Lu, Zhuyue Ma, Yanyan Shi, Shanshan Yao, Liuliu Zhang, Jingyi Shan, Liying Zhai, Caiyu Li, F. Cheng

{"title":"A narrative medicine‐based training program increases the humanistic care quality of new nurses in cancer hospital","authors":"Ning-Jung Lu, Zhuyue Ma, Yanyan Shi, Shanshan Yao, Liuliu Zhang, Jingyi Shan, Liying Zhai, Caiyu Li, F. Cheng","doi":"10.1002/prm2.12091","DOIUrl":"https://doi.org/10.1002/prm2.12091","url":null,"abstract":"With the change of medical model, the cancer nurses should not only pay attention to patients' physical pain, but also patients' psychological distress, which requires cancer nurses to have a high quality of humanistic care. This study aims to explore the humanistic care quality of new nurses in cancer hospital and effects of the narrative medicine‐based training program on the new nurses of cancer hospital. A total of 101 new nurses in a cancer hospital received the narrative medicine‐based training in 2020. Before and after the training, they were investigated with humanistic care quality questionnaire and empathy ability questionnaire. The course included narrative therapy overview, narrative medicine overview, narrative nursing, psychological nursing cases of cancer patients, and so on. After training, the total score of the humanistic care and quality empathy ability increased significantly, and the comparison was statistically significant. The total score of empathy after the training (98.44 ± 2.23) was higher than the score before the training (86.35 ± 7.53) (p < .05). The total score of humanistic care quality after the training (184.45 ± 14.34) was higher than the score before the training (161.45 ± 15.45) (p < .01). The scores of all dimensions were statistically significant. The narrative medicine‐based training program could increase the empathy ability of the new cancer nurses and improve the humanistic care quality. This program is suitable for clinical promotion and application. The study findings could have implications for medical institute to increase the humanistic care quality of new nurses.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"32 - 37"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43159744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

ALKBH5 involves in osteosarcoma tumor progression by mediating Notch signaling ALKBH5通过介导Notch信号参与骨肉瘤的肿瘤进展

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Precision Medical Sciences Pub Date : 2023-01-01 DOI: 10.1002/prm2.12093

Dagui Chen, Jiebing Zhao, H. Tian, Fusheng Shang, Jianjun Feng

{"title":"ALKBH5 involves in osteosarcoma tumor progression by mediating Notch signaling","authors":"Dagui Chen, Jiebing Zhao, H. Tian, Fusheng Shang, Jianjun Feng","doi":"10.1002/prm2.12093","DOIUrl":"https://doi.org/10.1002/prm2.12093","url":null,"abstract":"ALKBH5 is the major demethylase of ribonuclease m6A and exerts these multiple biological functions in cancer. In this study, we mainly explore the use of ALKBH5 in the development and progression of osteosarcoma and elucidate the potential molecular mechanisms by which it functions. Relative to human osteoblast cell lines (NHOst), we detected ALKBH5 expression in osteosarcoma cell lines (HOS, U2OS, and MG‐63) by RT‐PCR and western blot. By overexpression and knockout of ALKBH5 gene, to observe the effect of ALKBH5 on apoptosis, invasion and epithelial‐mesenchymal transition (EMT) of osteosarcoma cells, as well as the effect of Notch signaling pathway. We found that ALKBH5 was significantly higher in osteosarcoma cell lines than in osteoblastic cell lines. In addition, ALKBH5 overexpression promoted the proliferation, migration, and invasion of osteosarcoma cells, and simultaneously activated Notch signaling pathway and up‐regulated E‐cadherin protein. Knockout of ALKBH5 inhibited these effects in osteosarcoma cells. It was also found that up‐regulation of ALKBH5 could promote the proliferation of osteosarcoma cells in vitro and in vivo. ALKBH5 can be involved in osteosarcoma development through Notch signaling pathway regulation. ALKBH5 is therefore expected to be a new target in the treatment of osteosarcoma.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"38 - 45"},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46111533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report of hypocalcemia after chemotherapy with albumin‐bound paclitaxel 白蛋白结合紫杉醇化疗后低钙1例报告

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Precision Medical Sciences Pub Date : 2022-12-18 DOI: 10.1002/prm2.12092

Zhongchao Wang, Huanfeng Zhu, Jing Wu, M. Du, Wen-jie Guo, Z. Dai

引用次数: 0

A novel N7‐methylguanosine‐related long noncoding RNAs signature for predicting prognosis and immune microenvironment in gastric cancer patients 一种新的N7-甲基鸟苷相关长非编码RNA信号用于预测癌症患者的预后和免疫微环境

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Precision Medical Sciences Pub Date : 2022-12-01 DOI: 10.1002/prm2.12087

Peisen Guo, Panpan Wang, Limin Liu, Peixi Wang, Zhi-Jun Qu, Zengli Yu, Nan Liu

{"title":"A novel N7‐methylguanosine‐related long noncoding RNAs signature for predicting prognosis and immune microenvironment in gastric cancer patients","authors":"Peisen Guo, Panpan Wang, Limin Liu, Peixi Wang, Zhi-Jun Qu, Zengli Yu, Nan Liu","doi":"10.1002/prm2.12087","DOIUrl":"https://doi.org/10.1002/prm2.12087","url":null,"abstract":"Long noncoding RNA (lncRNA) may act as a biomarker to predict the overall survival (OS) of cancer patients. This study is to explore the prognostic signature of gastric cancer based on N7‐methylguanosine‐related lncRNAs to evaluate the prognosis and immune status of patients. The lncRNAs were identified by co‐expression analysis, univariate and, stepwise multivariate Cox regression. Then, patients were divided into the high‐ and low‐risk groups. Time‐dependent receiver operating characteristics, log‐rank test, principal component analysis, and nomogram were used to analyze the risk model. Finally, different immune status between the two groups was revealed by gene set enrichment/variation analysis (GSEA/GSVA), CIBERSORTx, and ESTIMATE algorithm. The difference in tumor mutation burden and drug sensitivity between the two groups was also explored. Three lncRNAs (LINC00412, REPIN1‐AS1, and RPH3AL‐AS1) were employed to construct the prognostic model. The OS rate of the high‐risk group was lower than the low‐risk group. GSEA and GSVA indicated this model was associated with immune‐related function, such as negative regulation of humoral immune response. Furthermore, the relative fractions of regulatory T cells, activated NK cells, and so forth, were significantly higher in the high‐risk group. And ESTIMATE revealed the different immune scores between the two groups. Finally, six compounds were screened out as candidate therapy drugs, and the prognostic model revealed higher performance than TP53 mutation status. The prognostic signature was competent in predicting the prognosis of gastric cancer and the immune microenvironment, which could guide individualized treatment for gastric cancer in the clinic.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"11 1","pages":"195 - 208"},"PeriodicalIF":0.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49294097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0