PD‐L1 expression by different scoring methods and different cutoff values and correlation with clinicopathological characteristics in gastric cancer: A retrospective study

IF 0.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Precision Medical Sciences Pub Date : 2023-01-21 DOI:10.1002/prm2.12094

Lixiang Si, Xiaohua Pan, Kang He, Ling Sun, Yajing Wang, Xinyu Xu, Jianwei Lu

引用次数: 0

Abstract

We retrospectively enrolled 325 gastric cancer (GC) patients to investigate the associations of programmed death ligand‐1 (PD‐L1) expression with clinicopathological characteristics by different scoring methods and different cutoff values. PD‐L1 expression was evaluated by the tumor proportion score (TPS) and the combined positive score (CPS). The positive rate of PD‐L1 TPS ≥1%, CPS ≥1, CPS ≥5 and CPS ≥10 in our study were 12.0%, 87.4%, 69.8% and 42.2%, respectively. Multivariate analysis showed that PD‐L1 CPS ≥5 was related to high expression of Ki67 (OR = 2.658, 95% CI: 1.401–5.045, p = .003) and pTNM staging (p = .033). PD‐L1 CPS ≥10 was correlated with larger tumor size (OR = 2.322, 95% CI: 1.052–5.127, p = .037) and lymph node metastasis (OR = 2.495, 95% CI: 1.293–4.814, p = .006). It is expected that these results can provide a reference for screening GC patients with high PD‐L1 expression level.

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不同评分方法、不同截止值PD‐L1表达与胃癌临床病理特征相关性的回顾性研究

我们回顾性纳入325例癌症（GC）患者，通过不同的评分方法和不同的临界值，研究程序性死亡配体-1（PD-L1）表达与临床病理特征的关系。通过肿瘤比例评分（TPS）和联合阳性评分（CPS）评估PD-L1的表达。在我们的研究中，PD-L1 TPS≥1%、CPS≥1、CPS≥5和CPS≥10的阳性率分别为12.0%、87.4%、69.8%和42.2%。多因素分析显示，PD-L1 CPS≥5与Ki67的高表达（OR=2.658，95%CI:1.401–5.045，p=0.003）和pTNM分期（p=0.033）有关。PD-L1 CPS≤10与较大的肿瘤大小（OR=2.322，95%CI:1.052–5.127，p=0.037）和淋巴结转移（OR=2.495，95%CI:12.93–4.814，p=0.006）有关。这些结果有望提供参考用于筛选具有高PD-L1表达水平的GC患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Precision Medical Sciences MEDICINE, RESEARCH & EXPERIMENTAL-

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审稿时长

15 weeks