Precision Medical Sciences最新文献_第2页

The application of metabolomics toward idiopathic pulmonary fibrosis and potential metabolomic value of diverse samples in interstitial lung diseases 代谢组学在特发性肺纤维化中的应用及其在肺间质性疾病中不同样本的潜在代谢组学价值

Precision Medical Sciences Pub Date : 2023-05-29 DOI: 10.1002/prm2.12106

Mingtao Liu, Zhangkai J. Cheng, Mingshan Xue, Runpei Lin, Teng Zhang, Baoqing Sun

{"title":"The application of metabolomics toward idiopathic pulmonary fibrosis and potential metabolomic value of diverse samples in interstitial lung diseases","authors":"Mingtao Liu, Zhangkai J. Cheng, Mingshan Xue, Runpei Lin, Teng Zhang, Baoqing Sun","doi":"10.1002/prm2.12106","DOIUrl":"https://doi.org/10.1002/prm2.12106","url":null,"abstract":"Abstract Interstitial lung diseases (ILDs), also known as diffuse lung diseases, pose a significant challenge to the respiratory health of individuals worldwide. Among these conditions, idiopathic pulmonary fibrosis (IPF) is one of the most prevalent, contributing substantially to morbidity and mortality. However, IPF is characterized by high heterogeneity, presenting a substantial obstacle to clinical program development and scientific research due to significant variations in disease progression, treatment response, and prognosis. Recent advances in metabolomics have enabled the identification of specific biochemical pathways and disease biomarkers, offering a beacon of hope for patients afflicted with various diseases. Remarkably, metabolomics has made significant strides in ILDs, particularly in IPF. Metabonomics, a branch of life science, provides an in‐depth analysis of metabolic pathways and the specific biological molecular composition of omics, obtained primarily from biological samples such as serum, plasma, pleural effusion, bronchoalveolar lavage fluid, lung surgical biopsy samples, urine, feces, sputum, and cerebrospinal fluid. In this review, we aim to provide a comprehensive overview of the application of metabolomics in ILDs, with a particular focus on IPF. By summarizing the current state of research in this field, we hope to shed light on the latest advances, challenges, and opportunities that metabolomics can provide in managing ILDs.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135792679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR‐643 suppresses cell invasion and radioresistant of lung cancer through RAF1 miR - 643通过RAF1抑制肺癌细胞侵袭和放射耐药

IF 0.5

Precision Medical Sciences Pub Date : 2023-05-24 DOI: 10.1002/prm2.12102

H. Tian, K. Ding, Zhongchao Wang, L. Yin, Jianzhong Wu, Xia He

{"title":"miR‐643 suppresses cell invasion and radioresistant of lung cancer through RAF1","authors":"H. Tian, K. Ding, Zhongchao Wang, L. Yin, Jianzhong Wu, Xia He","doi":"10.1002/prm2.12102","DOIUrl":"https://doi.org/10.1002/prm2.12102","url":null,"abstract":"RAF1 (c‐raf) has been known as an important tumor‐promoter in many cancers. However, the regulatory mechanisms affecting RAF1 expressions are rarely reported. This study aimed to predict the candidate miRNAs of RAF1 gene and verify their functions in the progression of lung cancer. The expression of miR‐643 was detected by reverse transcription polymerase chain reaction (RT‐PCR). A dual‐luciferase report system was used to verify the relationship between miR‐643 and RAF1. RT‐PCR and Western blot were used to analyze the regulatory relationship between miR‐643 and RAF1. Transwell chamber, scratch, and monoclonal tests showed that miR‐643 affected the proliferation, migration, and radiosensitivity of H1299 and A549 cells by targeting the RAF1 gene. The expression of miR‐643 in lung cancer cells was lower than that in the bronchial epithelioid cells (CRL‐2741), and luciferase reporter experiment confirmed that miR‐643 targeted RAF1. MiR‐643 overexpression decreased the RAF1 expression, thereby decreasing cell migration, proliferation, and radiation resistance through the AKT/nuclear factor‐κB pathway. miR‐643 in lung cancer cells could inhibit cell proliferation, invasion, and metastasis and increase the radiosensitivity by downregulating RAF1.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"113 - 120"},"PeriodicalIF":0.5,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41860154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of cuproptosis‐related subtypes and tumor microenvironment characteristics in colon cancer 癌症铜中毒相关亚型的鉴定及肿瘤微环境特征

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Precision Medical Sciences Pub Date : 2023-05-21 DOI: 10.1002/prm2.12101

Hao Han, Ye Jin, Haihao Yan, Zheng Liu

{"title":"Identification of cuproptosis‐related subtypes and tumor microenvironment characteristics in colon cancer","authors":"Hao Han, Ye Jin, Haihao Yan, Zheng Liu","doi":"10.1002/prm2.12101","DOIUrl":"https://doi.org/10.1002/prm2.12101","url":null,"abstract":"Cuproptosis is a form of regulated cell death, which is characterized by the lethal accumulation of excessive copper in cells. However, its role in colon adenocarcinoma (COAD) remains elusive. Our study aimed to decipher the biological function of cuproptosis‐related genes (CRGs) in patients with COAD. The expression data were obtained from The Cancer Genome Atlas, while the Gene Expression Omnibus database was used to verify the results. A total of eight differentially expressed CRGs were selected from patients with COAD. Subsequently, patients were stratified into three subtypes with distinct clinical and biological features. In view of the huge differences in the prognosis between subtypes A and C, we selected them for further study, including the variations in clinical progressions, oncogenic pathways, and immune cell infiltration. For the sake of better evaluation, we also established a cuproptosis index (CI) to quantify the heterogeneity of CRGs expression. Enrichment analysis showed that the high‐CI group was enriched in immune activation pathways. Meanwhile, the immunosuppressive cell infiltration and immune checkpoints were elevated in the high‐CI group. The CI we constructed had its predicting function in different clinical groups. Besides, we noticed that CRGs, especially CDKN2A, were closely related to the clinical progression in patients with COAD and immune cell infiltration in tumors. Moreover, CDKN2A could become a potential novel target for immunotherapy in the setting of COAD.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"83 - 94"},"PeriodicalIF":0.5,"publicationDate":"2023-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49256532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solute carrier family 35 member D3 promotes colorectal cancer progression through AMPK signaling pathway 溶质载体家族35成员D3通过AMPK信号通路促进结直肠癌的进展

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Precision Medical Sciences Pub Date : 2023-05-17 DOI: 10.1002/prm2.12108

Xinyue Wang, Ya Lu, Yuan Zhang, Jianzhong Wu, Rong Ma, Jifeng Feng

{"title":"Solute carrier family 35 member D3 promotes colorectal cancer progression through AMPK signaling pathway","authors":"Xinyue Wang, Ya Lu, Yuan Zhang, Jianzhong Wu, Rong Ma, Jifeng Feng","doi":"10.1002/prm2.12108","DOIUrl":"https://doi.org/10.1002/prm2.12108","url":null,"abstract":"This article is aim to investigate the functional role and potential regulatory mechanisms of solute carrier family 35 member D3 (SLC35D3) in colorectal cancer. Beyond analyzing databases, western blot was used to detect and verify the expression of SLC35D3. Cell proliferation and invasion or migration ability were detected by CCK‐8, EdU, and Transwell assays. Animal experiments were conducted to verify if the biological function of SLC35D3 in vivo is consistent with that in vitro. Beyond SLC family pathway enrichment analysis, the relationship between SLC35D3 and metabolic pathway AMPK was explored using co‐immunoprecipitation and western blot. SLC35D3 is highly expressed in colorectal cancer (CRC) tissue. The overexpression or down regulation of SLC35D3 has been shown to promote or inhibit the biological functions of colorectal cancer, and similar experimental results can be verified in vivo experiments. Based on the high correlation between the SLC family and metabolic pathways, we chose the metabolic‐related AMPK pathway as the subject of our research. Co‐immunoprecipitation and protein analysis demonstrated that SLC35D3 may bind to AMPK molecules and regulate the AMPK pathway of colorectal cancer cells. Based on the above facts, SLC35D3 promotes colorectal cancer progression through regulating AMPK signaling pathway.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"121 - 129"},"PeriodicalIF":0.5,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45996755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell‐free DNA integrity correlates with lymph node metastasis and predicts short‐term postoperative recurrence in patients with proximal gastric carcinoma after curative gastrectomy 无细胞DNA完整性与淋巴结转移相关，并预测根治性胃切除术后近端胃癌患者术后短期复发

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Precision Medical Sciences Pub Date : 2023-05-08 DOI: 10.1002/prm2.12105

Xu Zhang, Qingshan Hu, Lian K. Chen, P. Shao, Jian Wang

{"title":"Cell‐free DNA integrity correlates with lymph node metastasis and predicts short‐term postoperative recurrence in patients with proximal gastric carcinoma after curative gastrectomy","authors":"Xu Zhang, Qingshan Hu, Lian K. Chen, P. Shao, Jian Wang","doi":"10.1002/prm2.12105","DOIUrl":"https://doi.org/10.1002/prm2.12105","url":null,"abstract":"The predictive value of cell‐free DNA (cfDNA) integrity for lymph node metastasis and short‐term postoperative recurrence in patients with proximal gastric carcinoma (PGC) after curative gastrectomy remains unclear. From August 2019 to March 2021, the cfDNA integrity was assessed in 107 patients with proximal gastric carcinoma who underwent total gastrectomy (TG). The correlation between cfDNA integrity and lymph node metastasis was inspected, and the optimal cutoff value of cfDNA integrity for lymph node metastasis was determined. Meanwhile, the cfDNA integrity was identically detected in 91 proximal gastric cancer patients receiving proximal gastrectomy (PG), as well as 41 heathy individuals. The diagnostic value of cfDNA integrity for short‐term postoperative recurrence was assessed in both cohorts. The cfDNA integrity in healthy control was significantly higher than that in TG (p < .001) and PG (p = .0003) cohorts, but not statistically different between the latter two (p = .540). In the TG cohort, the cfDNA integrity was closely correlated to lymph node metastasis. Using the cutoff value of 0.873, the patients were stratified into the cfDNA integrity high and low groups; low cfDNA integrity was associated with a shorter disease free survival (DFS) both in the TG (p = .011) and PG (p = .041) cohorts. Moreover, cfDNA integrity was assessed to possess the most predictive value for postoperative recurrence by ROC curves in both cohorts. Therefore, the cfNDA integrity may correlate with lymph node metastasis in patients with PGC, and predict short‐term recurrence after curative gastrectomy.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"170 - 176"},"PeriodicalIF":0.5,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44494938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hair and urine lead, cadmium, nickel, and arsenic levels in children with attention‐deficit hyperactivity disorder: A case–control study in a tertiary care hospital in eastern India 注意缺陷多动障碍儿童毛发和尿液中的铅、镉、镍和砷水平:印度东部一家三级医院的病例对照研究

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Precision Medical Sciences Pub Date : 2023-05-04 DOI: 10.1002/prm2.12103

Saurav Nayak, S. Sahu, Joseph John, Suravi Patra

{"title":"Hair and urine lead, cadmium, nickel, and arsenic levels in children with attention‐deficit hyperactivity disorder: A case–control study in a tertiary care hospital in eastern India","authors":"Saurav Nayak, S. Sahu, Joseph John, Suravi Patra","doi":"10.1002/prm2.12103","DOIUrl":"https://doi.org/10.1002/prm2.12103","url":null,"abstract":"Attention‐deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention and/or hyperactivity–impulsivity. It is one of the most widespread neurodevelopmental conditions and has compound etiopathogenesis involving both environmental and genetic factors. Though the role of heavy metals on ADHD has been implicated but is less studied. Hair and urine are two non‐invasive methods which can substitute blood as a method of monitoring and assessing heavy metal levels. Twenty‐four cases of ADHD and their age matched healthy children (24) were taken as controls. Hair and urine samples were analyzed for lead, cadmium, nickel, and arsenic using inductively coupled plasma optical emission spectrometry (ICP‐OES) after acid digestion and extraction. The levels of heavy metals were significantly higher in cases; lead (p = .004, .003), cadmium (p = .020, <.001), and nickel (p = .016, <.001) of the hair and urine samples, respectively. Arsenic was below the limit of detection for all the samples. Hence, in conclusion, the heavy metal levels in hair and urine were significantly higher in ADHD cases as compared to their healthy counterparts.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"153 - 158"},"PeriodicalIF":0.5,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46315473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information 问题信息

IF 0.5

Precision Medical Sciences Pub Date : 2023-05-01 DOI: 10.1002/prm2.12059

引用次数: 0

Impact of body mass index on the circulating levels of nitric oxide metabolites in clinicopathological features from women with breast cancer 体重指数对乳腺癌女性临床病理特征中一氧化氮代谢物循环水平的影响

IF 0.5

Precision Medical Sciences Pub Date : 2023-04-27 DOI: 10.1002/prm2.12104

Pâmella Aparecida Ferreira Fagotti, Matheus Iago Oliveira Colleto, Mariane Okamoto Ferreira, Vitor Teixeira Maito, Bruno Vinicius Campestrini, T. B. Scandolara, Janoário Athanázio de Souza, D. Rech, Janaína Carla da Silva, Fernanda Mara Alves, Vanessa Jacob Victorino, D. Venturini, C. Panis

{"title":"Impact of body mass index on the circulating levels of nitric oxide metabolites in clinicopathological features from women with breast cancer","authors":"Pâmella Aparecida Ferreira Fagotti, Matheus Iago Oliveira Colleto, Mariane Okamoto Ferreira, Vitor Teixeira Maito, Bruno Vinicius Campestrini, T. B. Scandolara, Janoário Athanázio de Souza, D. Rech, Janaína Carla da Silva, Fernanda Mara Alves, Vanessa Jacob Victorino, D. Venturini, C. Panis","doi":"10.1002/prm2.12104","DOIUrl":"https://doi.org/10.1002/prm2.12104","url":null,"abstract":"To investigate the clinical meaning of systemic nitric oxide metabolites (NOx) by comparing eutrophic and overweight/obese patients with breast cancer, considering clinical factors determinant of disease prognosis. A total of 61 women diagnosed with breast cancer were included in the study. NOx estimative was performed on plasma samples using the cadmium–copper‐Griess method. It was then categorized according to the age at diagnosis, body mass index, menopausal status, tumor histological features, molecular subtype lymph nodal invasion, and emboli presence, considering p ≤ 0.05 as significant. A significant augment was observed in NOx levels from overweight patients carrying Luminal B tumors concerning the Luminal B eutrophic ones. There was a considerable reduction in NOx levels in eutrophic postmenopausal patients compared to the overweight postmenopausal ones. Patients bearing tumor sizes between 2 and 5 cm in the eutrophic group had lower levels of NOx, concerning the overweight patients carrying tumors of the same size interval. Circulating NOx levels change significantly according to the trophic‐adipose status of breast cancer patients, and it is further affected by prognostic factors related to poor disease prognosis.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"62 - 68"},"PeriodicalIF":0.5,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43082759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of serum lipids and BMI in China patients with primary pterygium 血脂和BMI在原发性翼状胬肉患者中的作用

IF 0.5

Precision Medical Sciences Pub Date : 2023-04-02 DOI: 10.1002/prm2.12097

Yu‐ying Sun, Wei‐peng Liang, Yanzhang Zeng, Shu-Ai Luo, Chun-Yu Huang, Yu-Ying Liu

{"title":"The role of serum lipids and BMI in China patients with primary pterygium","authors":"Yu‐ying Sun, Wei‐peng Liang, Yanzhang Zeng, Shu-Ai Luo, Chun-Yu Huang, Yu-Ying Liu","doi":"10.1002/prm2.12097","DOIUrl":"https://doi.org/10.1002/prm2.12097","url":null,"abstract":"To study the role of Body Mass Index (BMI) and serum lipid profile molecules, as well as their derivative indexes in primary pterygium patients. The patient group consisted of 110 patients with primary pterygium diagnosed in our center between January 2019 and December 2020, while the control group consisted of 144 healthy persons of similar age and sex diagnosed during the same time period. The BMI, serum lipid profile molecules and their derivative indexes of both groups were analyzed retrospectively. In the patient group, 62 patients were overweight or obesity and 104 patients with dyslipidemia. Among them, body mass index (BMI), serum triglycerides (TG), total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (Apo‐B) levels were significantly higher than those in the control group (p < 0.05). The difference in Apo‐B/ApoAl ratio, TC/LDL‐C ratio, HDL‐C/LDL‐C ratio was statistically significant (p < 0 .05), while the serum high‐density lipoprotein cholesterol (HDL‐C), apolipoprotein A1 (ApoA1) and TG/LDL‐C ratio were not significantly different in the patient group compared with control group (p > 0.05). Logistic analysis indicated that obesity, TC and HDL‐C/LDL‐C ratio are independent risk factors influencing the onset of pterygium (p < .05). BMI and serum lipid level are both significantly associated with primary pterygium. Obesity and abnormal serum lipid metabolism are independent risk factors for pterygium and play a critical role in the development of pterygium. Obesity and serum lipid level can significantly affect clinical management of pterygium. These characteristics are simple to use in clinical practice and may aid in the identification of pterygium high‐risk populations.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"69 - 75"},"PeriodicalIF":0.5,"publicationDate":"2023-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48862995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CircSMARCA5 functions as a potential biomarker for clinicopathology and therapy in solid tumors: A systematic review and meta‐analysis CircSMARCA5作为实体瘤临床病理和治疗的潜在生物标志物:一项系统综述和荟萃分析

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Precision Medical Sciences Pub Date : 2023-03-29 DOI: 10.1002/prm2.12100

Chaomin Pan, Zhuoyu Ding, Jingping Dai, Li Yang, Yiyi Wei, Xinke Wang

{"title":"CircSMARCA5 functions as a potential biomarker for clinicopathology and therapy in solid tumors: A systematic review and meta‐analysis","authors":"Chaomin Pan, Zhuoyu Ding, Jingping Dai, Li Yang, Yiyi Wei, Xinke Wang","doi":"10.1002/prm2.12100","DOIUrl":"https://doi.org/10.1002/prm2.12100","url":null,"abstract":"Circular RNAs (circRNAs) have been implicated in cancer proliferation, migration, and invasion. Among various circRNAs, circSMARAC5 attracted our great attention. The research aimed at broadening the knowledge on circSMARCA5 and exploring its function in clinicopathology and therapy in solid tumors. The incorporated research was explored via Web of Science, PubMed, Embase, and Cochrane Library, consisting of 1048 patients. This study was calculated using STATA 12.0 and Review Manager 5.3 software. Clinicopathological characteristics and therapeutic targets were analyzed using pooled odd ratios (ORs) with 95% confidence intervals (CIs). And the ceRNA network of circSMARCA5 was constructed via Cytoscape 3.9.0. Eventually, there were eight studies included in conducting clinicopathological characteristics and four literature used in exploring therapeutic targets. Patients with low expression of circSMARCA5 were closely associated with gender (OR = 1.367, 95% CI = 1.003–1.862, p = .048) and pathological differentiation (OR = 1.627, 95% CI = 1.130–2.343, p = .009). Among these modulating axes, the most commonly microRNA was miR‐432. In the near future, circSMARCA5 may be a promising diagnostic biomarker and a new therapeutic target.","PeriodicalId":40071,"journal":{"name":"Precision Medical Sciences","volume":"12 1","pages":"144 - 152"},"PeriodicalIF":0.5,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47870861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0