Diagnostic Histopathology最新文献_第9页

Update on classification, diagnosis and management of columnar cell lesions of the breast 乳腺柱状细胞病变的最新分类、诊断和处理方法

Diagnostic Histopathology Pub Date : 2024-02-01 DOI: 10.1016/j.mpdhp.2023.11.003

Charles Adewole, Soha El Sheikh

{"title":"Update on classification, diagnosis and management of columnar cell lesions of the breast","authors":"Charles Adewole, Soha El Sheikh","doi":"10.1016/j.mpdhp.2023.11.003","DOIUrl":"10.1016/j.mpdhp.2023.11.003","url":null,"abstract":"<div><p><span><span><span><span>Columnar cell lesions (CCLs) are clonal alterations of the terminal duct lobular unit (TDLU) characterised by enlarged, variably dilated acini lined by columnar epithelial cells. They encompass a spectrum of morphological changes ranging from columnar cell change to columnar </span>cell hyperplasia with or without atypia. With the increasing uptake of the breast cancer screening programme and wider use of </span>mammography, more and more of these lesions are identified with associated calcifications, leading to an increasing number of biopsies being obtained that show these changes. In this review, we describe the historic concepts behind the evolution of the terminology of CCLs, and give an update on the diagnostic criteria, </span>immunohistochemistry, and molecular genetics of these lesions. Their relation to </span>breast carcinoma<span> and current management strategies are also discussed. With the relatively recent classification scheme for these lesions, the recognition and study of CCLs is more standardised, and the role of these lesions as potential breast cancer risk factors will become more evident.</span></p></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 2","pages":"Pages 123-131"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139021480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory conditions of the oral mucosa 口腔粘膜炎症

Diagnostic Histopathology Pub Date : 2024-01-12 DOI: 10.1016/j.mpdhp.2023.12.003

Philip A Atkin, Syed A Khurram, Adam V Jones

引用次数: 0

Metastatic neuroendocrine tumour of the orbit 眼眶转移性神经内分泌肿瘤

Diagnostic Histopathology Pub Date : 2024-01-11 DOI: 10.1016/j.mpdhp.2023.12.006

Harriet Hunter, Mike Thomas

引用次数: 0

Differential diagnosis of sinonasal tumours with emphasis given to undifferentiated malignancy, spindle cell lesions and tumours with divergent differentiation 鼻窦肿瘤的鉴别诊断，重点是未分化恶性肿瘤、纺锤形细胞病变和分化不同的肿瘤

Diagnostic Histopathology Pub Date : 2024-01-10 DOI: 10.1016/j.mpdhp.2023.12.002

Brendan I Conn, Grant Stenhouse, Anne Chambers

{"title":"Differential diagnosis of sinonasal tumours with emphasis given to undifferentiated malignancy, spindle cell lesions and tumours with divergent differentiation","authors":"Brendan I Conn, Grant Stenhouse, Anne Chambers","doi":"10.1016/j.mpdhp.2023.12.002","DOIUrl":"10.1016/j.mpdhp.2023.12.002","url":null,"abstract":"<div><p><span>The number and range of tumour types that present in the sinonasal tract is staggering. The most recent WHO classification of head and neck tumours (5</span><sup>th</sup><span> edition) attempts to simplify the issue by focusing on tumours that typically present in this anatomical site (with exclusion of lesions occuring elsewhere in the body). Even then, there are 24 discrete entities described; many of which have sub-variants and well documented histological pitfalls. In this mini-symposium we demonstrate 3 challenging cases from our routine practice that have required consideration of a broad range of entities in the differential diagnosis. The article is laid out in 3 sections covering undifferentiated malignancies<span>, spindle cell lesions and tumours with divergent differentiation respectively. Sinonasal tumours may show considerable histological overlap between entities, and this is illustrated by the fact that many entities described in this article fall into more than one of the categories and some are even present in all three. In each section we recommend a methodical approach with careful consideration of the histological features in combination with appropriate ancillary studies in order to render as accurate a diagnosis as possible.</span></span></p></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 3","pages":"Pages 145-159"},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139454765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibro-osseous lesions of the jaws 颌骨纤维骨病损

Diagnostic Histopathology Pub Date : 2024-01-04 DOI: 10.1016/j.mpdhp.2023.12.004

Hannah Crane, Hannah Walsh, Keith D Hunter

引用次数: 0

A diagnostic approach to small round cell epithelial and neuroepithelial tumours of the sinonasal tract 鼻窦鼻道小圆细胞上皮和神经上皮肿瘤的诊断方法

Diagnostic Histopathology Pub Date : 2024-01-01 DOI: 10.1016/j.mpdhp.2023.12.005

Shraddha Adamane, Justin Weir

引用次数: 0

Acral keratoderma and sudden death 口腔角化症和猝死

Diagnostic Histopathology Pub Date : 2023-11-11 DOI: 10.1016/j.mpdhp.2023.10.007

Kira Süßmuth, Clemens Metze, Vinzenz Oji, Heiko Traupe, Jürgen Sindermann, Eric Schulze-Bahr, Dieter Metze

{"title":"Acral keratoderma and sudden death","authors":"Kira Süßmuth, Clemens Metze, Vinzenz Oji, Heiko Traupe, Jürgen Sindermann, Eric Schulze-Bahr, Dieter Metze","doi":"10.1016/j.mpdhp.2023.10.007","DOIUrl":"10.1016/j.mpdhp.2023.10.007","url":null,"abstract":"<div><p>Carvajal syndrome (MIM605676) is a cardiocutaneous disease with non-epidermolytic palmoplantar keratosis (PPK), hair anomalies (woolly hair or hypotrichosis) and dilated cardiomyopathy (DCM). Autosomal recessive inherited mutations in the <em>desmoplakin (DSP)</em> gene are causative for this disorder. Cardiac involvement may lead to heart failure and sudden cardiac death. Since this may require pacemaker and heart transplantation, early diagnosis and cardiologic screening is of great importance. We present a diagnostic case with typical but also hidden symptoms of Carvajal syndrome and its clinical follow up. A skin biopsy showed hyperkeratosis, acanthosis and “acantholysis of the desmosomal-type” as defined by hypereosinophilic epidermal keratinocytes, widening of the intercellular spaces and partial loss of the intercellular bridges in the suprabasal layers. Vesiculation, blistering, crusting and stronger inflammation were absent. We would like to point out the importance of a diagnostic skin biopsy and discuss the histologic differential diagnoses of acantholysis of the desmosomal-type.</p></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 1","pages":"Pages 77-80"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1756231723001676/pdfft?md5=0e38f4c28ed069efeb653c4d271993de&pid=1-s2.0-S1756231723001676-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135664980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An etiology-focused overview of vulvar and penile squamous cell carcinoma and its precursors: similarities, differences and emerging concepts 外阴和阴茎鳞状细胞癌及其前兆的病因学概述：相似之处、不同之处和新概念

Diagnostic Histopathology Pub Date : 2023-11-11 DOI: 10.1016/j.mpdhp.2023.10.002

Michelle Schneider, Jennifer Crimmins, Angelica Selim

引用次数: 0

Melanocytic lesions of the conjunctiva: an up-to-date review 结膜黑色素细胞病变：最新综述

Diagnostic Histopathology Pub Date : 2023-11-06 DOI: 10.1016/j.mpdhp.2023.10.005

Carli P. Whittington, Scott C. Bresler, Caroline Simon, Carol L. Shields, Rajiv M. Patel

{"title":"Melanocytic lesions of the conjunctiva: an up-to-date review","authors":"Carli P. Whittington, Scott C. Bresler, Caroline Simon, Carol L. Shields, Rajiv M. Patel","doi":"10.1016/j.mpdhp.2023.10.005","DOIUrl":"10.1016/j.mpdhp.2023.10.005","url":null,"abstract":"<div><p>The conjunctiva is a thin mucous membrane covering the anterior portion of the eye. Similar to the skin, the conjunctiva has normal resident melanocytes along the basal layer of the epithelium and these cells can give rise to melanocytic neoplasms of the conjunctiva. A variety of pigmented tumors can involve the conjunctiva, ranging from benign to malignant. Given the sensitive anatomic location and potential for some conjunctival melanocytic lesions to progress to melanoma, timely clinical recognition and correct histologic diagnosis of these tumors are essential in order to initiate the appropriate treatment and optimize outcomes. Clinicopathologic correlation is a vital step in this process. In this review article, the authors aim to provide an up-to-date concise, yet detailed, summary of the clinical, histopathologic, and molecular findings as well as a brief mention of management options for each type of conjunctival melanocytic lesion that may be encountered by pathologists and dermatopathologists.</p></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"30 1","pages":"Pages 37-59"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1756231723001652/pdfft?md5=39363945ff27da08ee0fc2a1282d11ff&pid=1-s2.0-S1756231723001652-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135509487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clear cell sarcoma: a rare cause of a lump in the foot 透明细胞肉瘤：脚部肿块的罕见病因

Diagnostic Histopathology Pub Date : 2023-11-03 DOI: 10.1016/j.mpdhp.2023.10.008

Steven WG Nottley, Nischalan Pillay

引用次数: 0