巨细胞动脉炎：常规诊疗中并不简单的诊断方法

Diagnostic Histopathology Pub Date : 2024-10-07 DOI:10.1016/j.mpdhp.2024.09.006

Dilek Taze, Kathryn J Griffin, Aruna Chakrabarty

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引用次数: 0

摘要

我们讨论了一名 70 岁女性的病例，她因颞部头痛和视力障碍急性就诊。她开始服用大剂量糖皮质激素，随后进行的颞动脉活检发现肉芽肿性炎症波及颞动脉各层，证实了巨细胞动脉炎（GCA）的疑似诊断。目前，诊断 GCA 有四种有效的组织学模式。尽管如此，对于没有表现出 "经典 "组织学特征的微妙病例，GCA 的诊断仍然具有挑战性。目前，经验丰富的病理学家对 GCA 诊断中 TAB 切片观察到的炎症的诊断特征和分类缺乏共识。最近的研究试图统一 GCA 诊断的最低报告标准，但国际上仍存在争议，因此有必要在这一领域开展进一步的工作。

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Giant cell arteritis: a not-so-straightforward diagnosis in routine practice

We discuss the case of a 70-year-old female who presented acutely with temporal headache and vision disturbance. She was commenced on high dose glucocorticosteroids and a subsequent temporal artery biopsy revealed granulomatous inflammation affecting all layers of the temporal artery, confirming the suspected diagnosis of giant cell arteritis (GCA). At present, there are four validated histological patterns for the diagnosis of GCA. Nonetheless, the diagnosis of GCA remains challenging in subtle cases which do not show the “classic” histological features. There is currently a lack of agreement among experienced pathologists regarding the diagnostic features and classification of inflammation observed in TAB sections in the diagnosis of GCA. Recent research has attempted to standardize the minimum reporting criteria for the diagnosis of GCA however international controversy remains, justifying further work in this field.

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来源期刊

Diagnostic Histopathology Medicine-Pathology and Forensic Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.