Disease and Molecular Medicine最新文献_第2页

Secondary syphilis and HIV co-infection: a case report - 二期梅毒合并HIV感染1例报告

Disease and Molecular Medicine Pub Date : 2016-06-30 DOI: 10.5455/DMM.20160707102329

A. Inci, S. Ceylan, B. Mete

引用次数: 0

Severe manifestation of psoriasis in a HIV infected patient: a case report - 1例HIV感染者出现严重银屑病表现:1例报告

Disease and Molecular Medicine Pub Date : 2015-12-01 DOI: 10.5455/DMM.20160104101140

A. Gunduz, Nihal Aslı Küçükünal, D. Sevgi, Ahsen Oncul, Okan Derin, Ali Seydi Alpay, Ahmet Sanlı Konuklar, N. Uzun, I. Dokmetas

{"title":"Severe manifestation of psoriasis in a HIV infected patient: a case report -","authors":"A. Gunduz, Nihal Aslı Küçükünal, D. Sevgi, Ahsen Oncul, Okan Derin, Ali Seydi Alpay, Ahmet Sanlı Konuklar, N. Uzun, I. Dokmetas","doi":"10.5455/DMM.20160104101140","DOIUrl":"https://doi.org/10.5455/DMM.20160104101140","url":null,"abstract":"The human immunodeficiency virus (HIV) epidemic in Turkey reveals a slow progression and at the end of November 2015, the total official number was reported to be 11,109 cases. Approximately 90% of HIV patients develop some type of skin disease. Especially patients with psoriasis and HIV infection often present with more severe and treatment-refractory cutaneous disease. Herein, we describe a case of a patient with previously known psoriasis worsened by HIV infection. A 37-year-old housewife was admitted to our clinic with previously known psoriasis worsened during the last two years with conversion to erythrodermic psoriasis which was not controlled even by PUVA, methotrexate and systemic cyclosporine. The patient had positive HIV antibody test. HIV RNA viral load was 120.000 copy/ml and CD4 count 88/ mm3 . She also had oral candidiasis and Pneumocystis jirovecii pneumonia. The patient received antiretroviral treatment including tenofovir/emtricitabine and lopinavir/ritonavir. Symptoms resolved gradually within one month with almost complete impovement of her erythrodermic psoriasis. . Four years later the patient was still on tenofovir/emtricitabine and lopinavir/ritonavir without concomitant spesific psoriasis treatment. Psoriasis manifestations can be severe in AIDS patients. Clinicians face diagnostic and therapeutic difficulties when psoriasis coexists with HIV infection. The HIV test should be considered in patients affected by severe erythrodermic psoriasis and resistant to conventional and biological treatments.","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116210176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in patients with non-alcoholic fatty liver disease 非酒精性脂肪肝患者血清基质金属蛋白酶-9及金属蛋白酶-1组织抑制剂的表达

Disease and Molecular Medicine Pub Date : 2015-06-01 DOI: 10.5455/DMM.20150424065705

T. Akyol, A. Tanoğlu, Y. Yazgan, A. Coşar, U. Berber, M. Kaplan

{"title":"Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in patients with non-alcoholic fatty liver disease","authors":"T. Akyol, A. Tanoğlu, Y. Yazgan, A. Coşar, U. Berber, M. Kaplan","doi":"10.5455/DMM.20150424065705","DOIUrl":"https://doi.org/10.5455/DMM.20150424065705","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed countries. NAFLD may progress to non-alcoholic steatohepatitis (NASH) and cirrhosis. Emerging evidence suggests that NAFLD is the hepatic manifestation of metabolic syndrome (MetS). NAFLD is closely linked to MetS, with a significant increase in cardiovascular risk. Several matrix metalloproteinases (MMPs) and tissue inhibitors ofMMPs (TIMPs) play important roles in the pathophysiology of atherosclerosis and liver fibrosis. In this study, we investigated the usefulness of serum metalloproteinases as noninvasive markers of NAFLD. 46 patients with NAFLD and twenty-six healthy controls were enrolled into the study, in Gulhane Military Medical Academy, Haydarpasa Training Hospital. Liver biopsies were performed on all patients with NAFLD and histopathological evaluations were made by an experienced pathologist. All NAFLD patients were divided into 2 subgroups according to MetS status using ATP III criteria. MMP-9 and TIMP-1 were studied in serum samples of all groups. Results were compared between both groups and subgroups. In this study, the NAFLD and control groups did not differ significantly on MMP-9, TIMP-1, and TIMP-1/MMP-9 ratio (p>0.05). However, we found a significant relationship between the HOMA and TIMP-1 (p<0.05). Moreover, MMP-9 and TIMP-1/MMP-9 levels were significantly correlated with waist circumference (p<0.05). Our findings are not sufficient to suggest that MMP-9, TIMP-1, and TIMP-1/MMP-9 ratio might be used as noninvasive biochemical diagnostic tests among NAFLD patients.","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133866271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Importance of Adipokines in Alzheimer’s Disease - 脂肪因子在阿尔茨海默病中的重要性

Disease and Molecular Medicine Pub Date : 2015-06-01 DOI: 10.5455/DMM.20150710120954

S. Ay, F. Deniz, K. Baskoy, A. Yonem

引用次数: 0

CD4+CD25+ Regulatory T cells and CD8+CD28- Suppressor Cells in Cancer Patients Older than Seventy Years - CD4+CD25+调节性T细胞和CD8+CD28-抑制细胞在70岁以上癌症患者中的作用

Disease and Molecular Medicine Pub Date : 2015-06-01 DOI: 10.5455/dmm.20150505110228

B. Karagöz, O. Bilgi, Alpaslan Özgün, Levent Emirzeoğlu, T. Tunçel, S. Çelik

{"title":"CD4+CD25+ Regulatory T cells and CD8+CD28- Suppressor Cells in Cancer Patients Older than Seventy Years -","authors":"B. Karagöz, O. Bilgi, Alpaslan Özgün, Levent Emirzeoğlu, T. Tunçel, S. Çelik","doi":"10.5455/dmm.20150505110228","DOIUrl":"https://doi.org/10.5455/dmm.20150505110228","url":null,"abstract":"Objective: Immunosenescence is an important aspect in elderly cancer patients. In aging, T cell dysfunction and increasing CD4+CD25+ Regulatory T (Treg) cells have been reported. However, the status of these cells has not been uncovered so far in elderly cancer patients. In this study, we aimed to investigate Treg cells, CD8+CD28- suppressor cells, and other lymphocyte subpopulations in elderly cancer patients. Materials and Methods: Seventy-five cancer patients were included in the study. Data were obtained from our previous three studies about Treg, suppressive cells and other lymphocyte populations of breast, gastric and lung cancer patients. Total CD4+CD25+ Treg cells, CD8+CD28- suppressor cells, CD8+ memory cells, CD8+ naive cells, Natural Killer (NK) cells, CD8+ and CD4+ T cells had been investigated by flow cytometry. The parameters were compared between in patients over and under the age of seventy. Results: Eighteen patients were older than 70 years of age and fifty-seven patients were not. The percentage of CD4+CD25high cells in CD4+ T cells were higher in elderly cancer patients than control patients (smaller than 70 years old) (13.01%±6.59% vs. 8.43%±5.01%; p:0.02). CD8+CD28- suppressor cells in lymphocytes were similar in both groups (18.12%±7.73% vs 18.03%±8.33%; p:0.97). NK cells were elevated in elderly patients. CD8+ memory cells, CD8+ naive cells, CD8+ T cells, and CD4+ T cells were not different between groups. Conclusion: Our data suggest that CD4+CD25+ Treg cells are increased in elderly cancer patients, but not CD8+CD28- suppressor cells. This may be a cause of age-related immunosuppression in cancer patients.","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126577309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emphysematous Cholecystitis: A Rare Complication of Hepatitis A Virus Infection - 肺气肿性胆囊炎:甲型肝炎病毒感染的罕见并发症

Disease and Molecular Medicine Pub Date : 2015-03-02 DOI: 10.5455/DMM.20150217101206

A. Karakaş, C. Artuk, O. Coskun, H. C. Gul, G. Mert, C. Eyigün

引用次数: 0

Clinical significance of OXA-10-type ESBL producing MDR Pseudomonas aeruginosa - oxa -10型ESBL产生耐多药铜绿假单胞菌的临床意义

Disease and Molecular Medicine Pub Date : 2015-03-02 DOI: 10.5455/DMM.20150217101131

S. Şenbayrak, F. Kolaylı, A. Inan, G. Albayrak, S. Aksaray, H. Vahaboğlu

引用次数: 0

Diffusion-Weighted MRI Predicts Prognosis in Hypoglycemic Encephalopathy: Case Report 弥散加权MRI预测低血糖性脑病的预后:1例报告

Disease and Molecular Medicine Pub Date : 2015-03-02 DOI: 10.5455/dmm.20150115041324

G. Halac, Gulsen Kocaman, Ç. Deniz, S. Tuncel, T. Asil

引用次数: 0

Adipose-derived mesenchymal stem cells in wound healing: A clinical review 脂肪源性间充质干细胞在伤口愈合中的应用:临床综述

Disease and Molecular Medicine Pub Date : 2014-12-31 DOI: 10.5455/DMM.20150120123357

G. Uzun, A. Yapici, Yasin Ilgaz

引用次数: 1

Successfull Treatment of Ventriculitis Caused by Extensively Drug Resistant (XDR) Acinetobacter Baumannii with Intraventriculer Colistin Administration: Report of Two Cases - 脑室内注射粘菌素成功治疗广泛耐药鲍曼不动杆菌引起的脑室炎2例报告

Disease and Molecular Medicine Pub Date : 2014-12-31 DOI: 10.5455/DMM.20141205051323

G. Karaahmetoglu, Cem Atabey, O. Oncul, Ali Kıvanç Topuz, V. Turhan, A. Acar, L. Gorenek

{"title":"Successfull Treatment of Ventriculitis Caused by Extensively Drug Resistant (XDR) Acinetobacter Baumannii with Intraventriculer Colistin Administration: Report of Two Cases -","authors":"G. Karaahmetoglu, Cem Atabey, O. Oncul, Ali Kıvanç Topuz, V. Turhan, A. Acar, L. Gorenek","doi":"10.5455/DMM.20141205051323","DOIUrl":"https://doi.org/10.5455/DMM.20141205051323","url":null,"abstract":"Acinetobacter baumanni, is an important nosocomial infection pathogen has emerged worldwide and can causes life-threatening hospital acquired infections, particularly in intensive care units. After post neurosurgical operations or procedures, this pathogen consists with central nervous system infections, also. Resistance mechanism of these pathogens against broad-spectrum antimicrobials is the challenging problem and limited penetration of antibiotics to achieve therapeutic concentrations in cerebrospinal fluid (CSF) has been still controversial issue. Here we report two cases who had ventriculitis after external ventricular drainage placement procedures. Both of CSF of two cases yielded extensively drug resistant A. baumannii. Traditional intravenous (IV) treatment did not eradicate pathogen exactly, at first. Adjunctive colistimetat sodium every 12 h (10 mg/kg/day) by the route of intraventricular (IVT) was admitted and CSF sterilization was achieved thereafter. The option of IVT colistin administration must be considered with IV antibiotherapy to provide satisfactory treatment of those complicated CNS infections.","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114650644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0