Disease and Molecular Medicine最新文献

{"title":"Glutathione S-transferase and Catalase gene polymorphisms with Type 2 diabetes mellitus. -","authors":"P. Vats, H. Chandra, M. Banerjee","doi":"10.5455/DMM.20131027101207","DOIUrl":"https://doi.org/10.5455/DMM.20131027101207","url":null,"abstract":"Background and Aim: Antioxidant enzymes such as glutathione S-transferases (GSTs) and catalase (CAT) play important roles in cellular defense by detoxifying various toxic substrates and can be used as important biomarkers for T2DM. The aim of the present work was to study the association of GST and CAT gene polymorphism with T2DM cases and controls in north Indian population. \u0000Materials and Methods: Polymorphic GST gene isoforms, GSTM1, T1 and P1 were investigated in 201 healthy control subjects and 204 T2DM cases while CAT -21A/T polymorphism in 186 controls and 189 T2DM cases. Genotypes were analyzed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotype distribution and allelic frequencies were compared between patients and controls. Mean values and odds ratio (OR) with 95% confidence interval (CI) were calculated using SPSS software (version 15.0). \u0000Results: Biochemical parameters showed highly significant association with T2DM (P","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122159047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telomeres: Implications for The Future -","authors":"M. Yunce, Y. Bez","doi":"10.5455/DMM.20140715073457","DOIUrl":"https://doi.org/10.5455/DMM.20140715073457","url":null,"abstract":"Telomeres are located at the ends of chromosomes and contain proteins and tandem repeats of DNA hexanucleotides. This DNA repeats shorten with each cell division, and the telomere length is an indicator of how many divisions the cell has undergone so far. So, telomere length is a sign of several biological pathways in many different era of medicine. Psychiatric disorders are good candidates and have not been fully understood in terms of the telomeres and its association with them. This review will give a sense of importance of telomere length in the era of medicine, hematology, and psychiatry. This hot topic will be deeply discussed in this review.","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134122940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Intraoperative Management of Bleeding with Application of Ankaferd Blood Stopper in a Patient Undergoing Gastrointestinal Surgery","authors":"M. A. Türkoğlu, A. Tanoğlu, Y. Beyazıt, E. Bostancı","doi":"10.5455/dmm.20141027120140","DOIUrl":"https://doi.org/10.5455/dmm.20141027120140","url":null,"abstract":"Dear Editor, Excess intraoperative bleeding still remains a major complication following surgery, resulting in increased morbidity and mortality. Approaches for controlling intraoperative bleeding include vein ligation, tissue glue, locally eff ective vasoconstrictor agents, mechanical compression, electrocoagulation, freezing, diathermy, laser, ultrasonic wave, and local hemostatic substances (1). Although all of these modalities have diff erent rates of success, there is an ongoing intensive search for the novel techniques or treatments that are eff ective, safe and “potentially life-saving” in the distinct settings of intraoperative bleedings. In this setting Ankaferd blood stopper (ABS) may become an eff ective alternative hemostatic agent for distinct states of bleedings that are resistant to conventional anti-hemorrhagic measurements (2). Herein, we would like to present the fi rst reported case of intraoperative bleeding due to gastrointestinal surgery that was successfully controlled with intraoperative ABS application. An 80-year-old woman who had undergone a gastrojejunostomy operation four years earlier for stomach cancer was admitted to our Emergency Service due to constipation, abdominal distention, nausea, and vomiting. The abdomen was tender and swollen with peritoneal signs. The biological assessment revealed leukocytosis of 12100/mm3 with normal blood chemistry. Plain abdominal radiograph showed multiple airfl uid levels without any free gas under the diaphragm. Abdominal ultrasound revealed small bowel herniation through a skin defect at previous incision site. The patient underwent a surgical operation with a diagnosis of incarcerated hernia. Intraoperative exploration showed a 3 cm stricture due to adhesions and herniation with no signs of ischemic fi ndings at distal jejunum. After intestinal decompression towards stomach, hemorrhagic aspiration material was noted. For that reason, a 5 cm transaxial gastrotomy incision was performed. An oozing bleeding on the anastomosis line with multiple bleeding sites in the stomach that thought to be from acute erosive gastritis was seen. Due to the multifocal nature of the bleeding, we fi rst tried dilute epinephrine saline irrigation to the bleeding area. Unfortunately, the bleeding did not stop, and we decided to use 20 ml of ABS for to control bleeding that resulted with success in after 2 min (Figure 1). After being sure that bleeding was stopped gastrotomy line was sutured. Post-operative follow-up of the patient was uneventful. The patient was discharged after 6 days from the operation. ABS is an herbal extract used as a topical hemostatic agent in traditional Turkish medicine. It comprises a standardized mixture of fi ve plants; Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia offi cinarum, and Urtica dioica that has been approved in the management of dental surgery bleeding and external hemorrhages in Turkey (3). Each of these plants has certain eff ects on the endoth","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132325615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case considering utilization of potent antiviral agents in a hepatitis B virus-infected patient with high viral load receiving immunosuppressive therapy -","authors":"E. Karagoz, L. Gorenek, A. Ulçay, V. Turhan, A. Acar, H. Erdem, O. Oncul","doi":"10.5455/DMM.20160323124934","DOIUrl":"https://doi.org/10.5455/DMM.20160323124934","url":null,"abstract":"In this case, we present a follicular non-Hodgkin lenfoma patient whose liver enzymes increased after withdrawal of chemotherapy and afterward hepatitis B virus (HBV) reactivation was occurred despite HBV surface antigen was negative before immunosuppressive therapy.","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114366679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heme oxygenase as a molecule changing traffic light from red (heme) to green (biliverdin)","authors":"O. Ozcan","doi":"10.5455/DMM.20130612072702","DOIUrl":"https://doi.org/10.5455/DMM.20130612072702","url":null,"abstract":"Author affiliations: Department of Biochemistry, GMMA Haydarpaşa Training Hospital Istanbul, Turkey DOI: 10.5455/dmm.20130612072702 Correspondence to: ozcanmd@gmail.com (Ö. Özcan) Heme oxygenase (HO), which presents in all life forms from algae to human, is a vital and important enzyme because of its relationship with oxygen and its product carbon monoxide (CO). After its discovery in 1968(1), it has been realized that HO might have important functions beyond recycling heme. By degrading heme molecule to biliverdin, it also produces equimolar amounts of iron (Fe+2) and CO, which is a colorless, odorless diatomic gas like nitric oxide (NO) (Figure). Its similarity to NO is not only of their physicochemical but also functional properties. Since CO also behaves as a neurotransmitter and makes its action through both cyclic guanosine monophosphate (cGMP) dependent","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134187640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative sensory testing in type 1 diabetic patients with painful and painless diabetic neuropathy","authors":"A. Alahmar","doi":"10.5455/DMM.20160720024110","DOIUrl":"https://doi.org/10.5455/DMM.20160720024110","url":null,"abstract":"The mechanism underlying the development of painful diabetic neuropathy (DN) is unknown. The aim of this study was to compare quantitative sensory testing (QST) characteristics of patients with painful and painless DN and to correlate QST measures with DN pain. Fifty type 1 diabetic patients with DN (30 with painful DN and 20 with painless DN) and 32 age-matched non-diabetic controls were included in this study. For all patients and controls, a detailed assessment of DN was performed which comprised McGill visual analogue scale (McGill VAS) for pain, neuropathy symptom profile and neuropathy disability score (NDS), quantitative sensory testing in form of cold, warm and vibration perception thresholds, nerve conduction studies (NCS), deep-breathing hear rate variability and Neuropad staining scores. Measures of QST, NCS and DB-HRV were correlated with McGill VAS for pain. There were no significant differences in cold, warm and vibration perception thresholds, NCS, DB-HRV and Neuropad scores between patients with painful and painless DN. Cold (r=-0.57, P=0.005), warm (r=0.47, P=0.026) and DB-HRV (r=0.50, P=0.023), however, correlated significantly with McGill VAS scores of pain. In conclusion, Quantitative sensory testing is a helpful tool to identify small nerve fibres damage of DN, correlates with pain intensity but cannot differentiate between painful and painless DN. Both central and peripheral neural injury could be implicated in the genesis of DN pain.","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115175629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocardia abscessus-Associated Subcutaneous Infection in a Patient with Non-Hodgkin’s Lymphoma -","authors":"A. Karakaş, A. Kilic, C. Artuk, M. Akçaer, D. Tok, Y. Yurttaş, O. Coskun, B. Beşirbellioğlu","doi":"10.5455/DMM.20160626070853","DOIUrl":"https://doi.org/10.5455/DMM.20160626070853","url":null,"abstract":"This paper describes primary subcutaneous infection caused by Nocardia abscessus in a 60-year-old male patient with the history of non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. The patient was presented with pain and swelling in his left thigh for 45 days. Soft tissue ultrasonography showed a heterogeneous and hypoechoic mass consistent with an abscess. Gram-positive and branched filamentous bacilli, along with neutrophils, were identified in Gram-stained smears of the pus. The pus culture was pos itive for Gram-positive bacilli, which identified as N. abscessus. Initially, the patient was treated with trimethoprim-sulfamethoxazole (TMP-SMX). Due to insufficient clinical re -sponse, ceftriaxone was added for 2 weeks. Then, the patient was prescribed a 3-month course of TMP-SMX. It is important to start appropriate and effective treatment as soon as possible in patients with immunosuppression.","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126805782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Clinical Relevance of Bacterial Colonization in Patients With Suspected Viral Respiratory Tract Infection By Using Multiplex PCR Method","authors":"V. Turhan, G. Mert, A. Kilic, Haijing Li, S. Susan, C. Stratton, Yi-Wei Tang","doi":"10.5455/DMM.20130122062607","DOIUrl":"https://doi.org/10.5455/DMM.20130122062607","url":null,"abstract":"Numerous viral and bacterial pathogens have been reported causing acute respiratory tract infection (ARTI). Nasopharyngeal swab (NPS) specimens from 351 patients (278 children, 73 adults) with suspected upper and lower ARTI were submitted during the study period from Jan. 2005 to Dec. 2006. Organism-specific nucleic acids were detected using TemPlex technology (ResPlex I and II, Genaco Biomedical Products, Huntsville, AL). Amplified products were identified using a suspension array for multiplex detection performed on a Luminex 100 instrument (Luminex, Austin, TX). A total of 221 viral and bacterial respiratory agents were detected in 148 patients (135 [48.5%] of the 278 children and 13 [17.8%] of the 73 adults) with suspected ARTI. A single respiratory pathogen was detected in 89 patients [25.35%], whereas mixed infection with two or three pathogens was found in 59 [16.8%] of 351 suspected patients. S. pneumonia was the most frequently isolated strain (54 [15.3%] of 351 patients), followed by H. influenzae (37 [10.5%]), rhinoviruses (35 [9.9%]), influenza A virus (23 [6.5%]), enteroviruses (19 [5.4%]), hMPV (14 [3.9%]), PIV-1 (12 [3.4%]), PIV-3 (11 [3.1%]), RSV (10 [2.8%]), and influenza B virus (6 [1.7%]). Mixed infections were more frequent in children (56 [20.1%] of 278) than adult patients (3 [4.1%] of 73 patients). The detection rate of the bacteria peaked in the spring season (37 [40.6%] of 91 bacteria), followed by winter (24 infections), autumn (18 infections) and summer (12 infections). The prevalence of co-infection is ~40%, finding a much higher incidence of co-infection with more than one agent than that reported previously.","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130848562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"St John's Wort in the Treatment of Major Depression Disorder","authors":"S. Bhat, A. Wani, A. Ara","doi":"10.5455/DMM.20150117084951","DOIUrl":"https://doi.org/10.5455/DMM.20150117084951","url":null,"abstract":"","PeriodicalId":399572,"journal":{"name":"Disease and Molecular Medicine","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127432764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}