NowotworyPub Date : 2018-05-23DOI: 10.5603/NJO.2017.0054
E. Towpik, W. Wysocki
{"title":"The Nowotwory journal over the last 95 years (1923–2018)","authors":"E. Towpik, W. Wysocki","doi":"10.5603/NJO.2017.0054","DOIUrl":"https://doi.org/10.5603/NJO.2017.0054","url":null,"abstract":"Launching of the journal and its development One of the first global initiatives for publishing a periodical devoted to the fight against cancer arose in Poland back in 1906, when both Dr Mikołaj Rejchmann and Dr Józef Jaworski from Warsaw set up an Anti-Cancer Committee (Komitet do Walki z Rakiem). One of its aims was to launch a journal, however this proved impossible due to the unfavourable conditions prevailing at that time. When Poland regained its independence, organising anti-cancer policies again became a priority. In July 1921, an Polish Anti-Cancer Committee (Polski Komitet do Zwalczania Raka) in Warsaw came into being. Despite scant resources it rapidly and enthusiastically started its operations. This was reflected by publishing a journal entitled The Bulletin of the Polish Anti-Cancer Committee (Biuletyn Polskiego Komitetu do Zwalczania Raka). The first edition was published in 1923, whose editor was Dr Stefan Sterling-Okuniewski, MD. At that time, this really was a pioneering endeavour as there were only 5 other such journals dedicated solely to the anti-cancer campaign in the world: the German Zeitschrift für Krebsforschung (1903), the Japanese Gann (1907), the French Bulletin de l’Association Francaise pour l’Etude du Cancer (1909), the Italian Tumori (1911) and from the USA Journal of Cancer Research (1916)1. As a comparison, the","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"7 1","pages":"321-335"},"PeriodicalIF":0.0,"publicationDate":"2018-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85647035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2018-05-23DOI: 10.5603/NJO.2017.0062
R. Stec
{"title":"Should adjuvant therapy be used in patients with colorectal cancer in pathological stage II","authors":"R. Stec","doi":"10.5603/NJO.2017.0062","DOIUrl":"https://doi.org/10.5603/NJO.2017.0062","url":null,"abstract":"In meta-analyses and reliable randomised clinical trials, the most favourable therapeutic gain of adjuvant therapy of patients with colorectal cancer in stage II was estimated at 3% (in the majority of meta-analyses no statistical significance was). Considering the side effects, especially the mortality rate in chemotherapy (FOLFOX reached 0.5%, and in the case of 5-fluorouracil, the occurrence of toxicity grade 3 and 4, increased the risk of patient death by approximately 1%) seems to be questionable. Because of the lack confirmation of the effect of systemic treatment, an increase of the percentage of cured patients in the second stage has led to the development of several genetic tests determining the genetic signature of colorectal cancer. The aim of these tests is to identify the groups of patients that could potentially achieve the greatest benefit from adjuvant therapy. The most important tests are: “Oncotype DX”, “ColoPrint” and “GeneFx”. However, at the moment, there is no clear scientific evidence in favour of the standard use of adjuvant chemotherapy in patients with colon cancer in stage II.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"34 1","pages":"375-379"},"PeriodicalIF":0.0,"publicationDate":"2018-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75432481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2018-05-23DOI: 10.5603/NJO.2017.0059
Akash Gupta, Abdalla Saad Abdalla Al-Zawi, A. Naqvi, S. Salama, Emraga Abohamod, S. Alowami
{"title":"Malakoplakia in a colonic tubular adenoma: a unique case presentation","authors":"Akash Gupta, Abdalla Saad Abdalla Al-Zawi, A. Naqvi, S. Salama, Emraga Abohamod, S. Alowami","doi":"10.5603/NJO.2017.0059","DOIUrl":"https://doi.org/10.5603/NJO.2017.0059","url":null,"abstract":"Malakoplakia is an unusual characteristic inflammatory condition, it is distinctive feature is the presence of histiocytic cells with eosinophilic granular cytoplasm, often known as “von Hansemann’s histiocytes”, along with the pathognomonic siderocalcific Michaelis-Gutmann bodies (MGBs). We present a case of malakoplakia within a colonic adenoma seen against a background of Enterococcus infection. To our knowledge, this is a unique presentation which has not previous been described.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"5 1","pages":"365-369"},"PeriodicalIF":0.0,"publicationDate":"2018-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76388156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2018-05-23DOI: 10.5603/NJO.2017.0063
A. Deptała
{"title":"Should patients with stage II colon cancer be treated with adjuvant chemotherapy","authors":"A. Deptała","doi":"10.5603/NJO.2017.0063","DOIUrl":"https://doi.org/10.5603/NJO.2017.0063","url":null,"abstract":"Patients with stage II colon cancer, as defined by pTNM/AJCC 2017, when analysed with regards to the risk of recurrence and to DFS and OS prolongation with adjuvant chemotherapy, make up a heterogenous patient population. That is why, a qualified oncologist, who makes a decision to apply adjuvant chemotherapy, taking into consideration the patient’s well-being, should formulate a post-operative strategy, the main objective of which will be to minimise the risk of cancer recurrence and to prolong survival. The author of this paper believes that adjuvant chemotherapy should be provided for every patient in the very high risk group (IIC) and high risk group (IIA/IIB MSI-L/MSS and inadequate lymphadenectomy and BRAF mutation), and also in the group of intermediate risk of cancer recurrence (IIA/IIB MSI-L/MSS with an adequate scope of lymphadenectomy and BRAF mutation as well as IIA MSI-L/MSS with inadequate scope of lymphadenectomy and lack of BRAF mutation), after obtaining the patient’s informed consent. In a situation when an oncologist is unable to obtain the result of microsatellite instability or the BRAF gene mutation, it would be advisable to refer the patient to a centre which has access to such tests; this would allow the adjuvant chemotherapy to have optimum application, which would by all means translate into the improvement of the treatment results in patients with colon cancer.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"45 1","pages":"380-384"},"PeriodicalIF":0.0,"publicationDate":"2018-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75749994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2018-05-23DOI: 10.5603/NJO.2017.0061
W. Olszewski
{"title":"Is telepathology worth being developed","authors":"W. Olszewski","doi":"10.5603/NJO.2017.0061","DOIUrl":"https://doi.org/10.5603/NJO.2017.0061","url":null,"abstract":"In pathology, similarly to other branches of medicine, and in particular in the field of visualisation techniques, the use of image transmission via the Internet for diagnostic or consulting purposes is being introduced. One of the reasons for this is the limited number of specialists. Currently, three basic applications of this technique can be distinguished: telediagnostics, teleconsultations and teleconferences. In contrast to teleradiology where the basic subject of analysis is the image obtained by various visualisation techniques — in pathology, the basis is tissue or cell analysis. The evaluation of such material should be from the start in the hands of pathomorphologists. The transmitted image of the performed histological preparation may not be fully representative of the lesion being examined (cancer). In modern oncological pathomorphology, it is very often necessary to use special techniques such as immunohistology or molecular biology techniques to determine the proper diagnosis. Performing such tests requires direct access to tissue or cytological material. Telepathology can be used as part of consultations between reference centres. Modern telepathology techniques allow the use of these methods for training purposes, including the interactive participation of trainees.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"28 1","pages":"372-374"},"PeriodicalIF":0.0,"publicationDate":"2018-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78000673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2018-05-23DOI: 10.5603/NJO.2017.0056
D. Hempel, Joanna Mandrosz, M. Wojtukiewicz, T. Filipowski, E. Sierko
{"title":"Is AIO belly board device advantageous in all rectal cancer patients","authors":"D. Hempel, Joanna Mandrosz, M. Wojtukiewicz, T. Filipowski, E. Sierko","doi":"10.5603/NJO.2017.0056","DOIUrl":"https://doi.org/10.5603/NJO.2017.0056","url":null,"abstract":"Purpose. To compare the prone position on a flat table vs an “All in one” belly board device (AIO BBD) in rectal cancer patients (RCPs). Material and methods. Fifteen RCPs scheduled for irradiation were scanned in the two evaluated positions. After tomography, they completed a questionnaire concerning positioning. The dose-volume histograms (DVHs) for the small bowel and bladder were compared for both immobilization methods and setup accuracy was analyzed in electronic portal imaging devices (EPIDs) and X-ray volume imaging (XVI) procedures. Results. AIO BBD was accepted by the majority of RCPs and provided better DVHs for the small bowel than the prone position on a flat table. The setup reproducibility was within tolerance limit for patients with BMI ≤ 29 kg/m2. Patients with obesity regarded AIO BBD as uncomfortable and they presented mean setup shifts out of the tolerance limit in the Y axis — 5.9 mm. Conclusions. The AIO BBD should be recommended for RCPs, especially for those with BMI ≤ 29 kg/m2.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"16 1","pages":"342-348"},"PeriodicalIF":0.0,"publicationDate":"2018-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88994779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2018-02-22DOI: 10.5603/NJO.2017.0050
Ł. Kuncman, Malwina Pietrzykowska-Kuncman, J. Danielska, Jolanta Łuniewska-Bury, J. Fijuth
{"title":"Bone marrow sparing RT in era of immunotherapy","authors":"Ł. Kuncman, Malwina Pietrzykowska-Kuncman, J. Danielska, Jolanta Łuniewska-Bury, J. Fijuth","doi":"10.5603/NJO.2017.0050","DOIUrl":"https://doi.org/10.5603/NJO.2017.0050","url":null,"abstract":"Recent advances in the field of immunotherapy have changed the perception of cancer treatment to complex model with host immunity in the spotlight. Potential synergy of immunotherapy drugs [aiming cytotoxic T cell antigen 4 (CTLA-4) or programmed cell death-1/ligand (PD-1/PD-L1)] and radiotherapy (RT) have established basis for ongoing clinical trials testing combined treatment. It was shown that complete blood cell counts (CBC) parameters may correlate with cancer survival, toxicity and outcomes of treatment. Therefore, reduction of hematologic toxicity of cancer treatment may gain in significance. Modern dose delivery techniques compromise dose reduction in critical organs (like bone marrow — BM) with adequate irradiation of target volumes. In addition, usage of modern imaging like positron emission tomography (PET), magnetic resonance imaging (MRI) allows to divide the volume of BM to active and inactive one. In this review, we discuss the synergy of RT and immunity and techniques of Bone Marrow Sparing RT (BMS-RT).","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"25 1","pages":"301-307"},"PeriodicalIF":0.0,"publicationDate":"2018-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89305298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2018-02-22DOI: 10.5603/NJO.2017.0047
T. Nowikiewicz, W. Zegarski
{"title":"Current possibilities of peri-operative evaluation of the radicality of primary tumour resection in breast cancer patients treated with BCT (breast conserving treatment)","authors":"T. Nowikiewicz, W. Zegarski","doi":"10.5603/NJO.2017.0047","DOIUrl":"https://doi.org/10.5603/NJO.2017.0047","url":null,"abstract":"In accordance with the current standards of treatment of breast cancer patients, the application of breast conserving treatment (BCT) requires a radical resection of the tumour and post-operative radiotherapy. This means the necessity of obtaining tumour-free primary resection margins, i.e. without the presence of cancer tissue. In spite of the correct pre-operative diagnostic process and appropriate surgical treatment, in about 20–30% BCT cases, the tumour resection turns out to be not radical. The necessity of performing another surgery leads to the prolongation of the overall operative time and increases costs. A histopathological evaluation of the margin of the primary tumour resection performed on an immediate basis is not a standard procedure in patients undergoing BCT. In spite of the definite limitations of this method, its application may decrease the overall rate of revision surgeries. The paper discusses some other currently available possibilities of perioperative evaluation of the radicality of primary tumour resection in breast cancer patients treated with BCT.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"29 1","pages":"285-291"},"PeriodicalIF":0.0,"publicationDate":"2018-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78219211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2018-02-22DOI: 10.5603/NJO.2017.0049
G. Woźniak, Ł. Dolla, K. Slosarek, B. Bekman, T. Latusek, G. Głowacki
{"title":"Dynamic-arc respiratory-gated stereotactic radiotherapy — technique presentation","authors":"G. Woźniak, Ł. Dolla, K. Slosarek, B. Bekman, T. Latusek, G. Głowacki","doi":"10.5603/NJO.2017.0049","DOIUrl":"https://doi.org/10.5603/NJO.2017.0049","url":null,"abstract":"Main advancements in radiation treatment in recent years have included the introduction of dynamic techniques and 4D radiotherapy. The treatment of movable tumors relies on two important techniques: gating and tracking. The limitation of the former is the relatively short duration of the respiratory phase during which the radiation can be delivered and the need to teach the patient to breathe in accordance with the correct pattern. At the same time, certain clinical situations require the use of dynamic techniques. Intensity modulated radiotherapy (IMRT), combined with gantry rotation, forms the basis for the VMAT technique. The procedure usually takes a shorter time to complete than other dynamic techniques, which considerably improves patient comfort. The recently introduced True BeamTM accelerator employs all the latest innovations in terms of dose-rate modeling and respiratory gating.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"2 1 1","pages":"297-300"},"PeriodicalIF":0.0,"publicationDate":"2018-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78091444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2018-02-22DOI: 10.5603/NJO.2017.0048
M. Adamczyk, T. Piotrowski
{"title":"Respiratory motion and its compensation possibilities in the modern external beam radiotherapy of lung cancer","authors":"M. Adamczyk, T. Piotrowski","doi":"10.5603/NJO.2017.0048","DOIUrl":"https://doi.org/10.5603/NJO.2017.0048","url":null,"abstract":"The aim of this paper is to present a systematic review of the current characteristics and recent development of commercially available respiratory motion solutions and their compensation possibilities in the external beam radiotherapy treatment of lung cancer. The most commonly used X-ray and radiotherapeutic technologies are presented, as well as their division into pre-treatment methods and intra-treatment verification. The article discusses the most important technological achievements that allow radiation to be safely applied in the lung region and reports the potential advantages and limitations of each. Finally, it presents details concerning selected research trends and problems related to motion compensation.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"68 1","pages":"292-296"},"PeriodicalIF":0.0,"publicationDate":"2018-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89367111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}