Nowotwory最新文献_第6页

Survival analysis of patients with locally advanced non-small cell lung cancer treated at the Nu-Med Radiotherapy Center in Elbląg 在Nu-Med放射治疗中心Elbląg治疗的局部晚期非小细胞肺癌患者的生存分析

Nowotwory Pub Date : 2020-07-27 DOI: 10.5603/njo.2020.0028

Marcin Kurowicki, K. Osowiecka, S. Nawrocki, Łukasz Cieśliński, B. Szostakiewicz, A. Badzio

引用次数: 0

Gut microbiota and neoplastic diseases of the gastrointestinal tract 肠道菌群与胃肠道肿瘤疾病

Nowotwory Pub Date : 2020-07-27 DOI: 10.5603/njo.2020.0030

A. Pilśniak, U. Dworzecka, E. Otto-Buczkowska

{"title":"Gut microbiota and neoplastic diseases of the gastrointestinal tract","authors":"A. Pilśniak, U. Dworzecka, E. Otto-Buczkowska","doi":"10.5603/njo.2020.0030","DOIUrl":"https://doi.org/10.5603/njo.2020.0030","url":null,"abstract":"The term “microbiome” is used to describe the substantial number and diverse spectrum of microorganisms that inhabit the body. It plays an essential role in health conditions and diseases. Recent years have brought a further intensification of experimental studies on the impact of the microbiome on the human body, particularly with the aim of identifying and clarifying this impact. Many studies indicate that diet, lifestyle and drugs can affect the composition of the intestinal microflora, which, in turn, can modulate the development and progression of gastrointestinal tract tumors. It is suspected that the gut microbiome plays a significant role in the formation of gastrointestinal tumors. On the other hand, the role of the intestinal microflora in inhibiting the processes of oncogenesis suggests that this mechanism may be used to prevent and treat gastrointestinal cancer. Using probiotics to modify the microbiome may be beneficial in cancer therapy and may be used as a supportive treatment for classic cancer therapies such as chemotherapy, radiotherapy and surgical treatment. Intestinal microbiome analysis can be potentially used to develop non-invasive diagnostic tests. These tests could be useful as new protective markers for colorectal cancer, or as prognostic markers and predictive markers of response to treatment, especially immunotherapy.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"60 1","pages":"150-152"},"PeriodicalIF":0.0,"publicationDate":"2020-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74109616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does the type of a centre in which the resection of extensive tumours of the limbs and truck is performed, affect the patients’ survival? 切除肢体和肢体广泛肿瘤的中心类型是否会影响患者的生存?

Nowotwory Pub Date : 2020-07-27 DOI: 10.5603/njo.2020.0032

P. Drozdowski, Ł. Krakowczyk, A. Maciejewski

引用次数: 0

Pulmonary toxicities of immune checkpoint inhibitors 免疫检查点抑制剂的肺毒性

Nowotwory Pub Date : 2020-06-16 DOI: 10.5603/njo.2020.0023

M. Knetki-Wróblewska, J. Domagała-Kulawik

{"title":"Pulmonary toxicities of immune checkpoint inhibitors","authors":"M. Knetki-Wróblewska, J. Domagała-Kulawik","doi":"10.5603/njo.2020.0023","DOIUrl":"https://doi.org/10.5603/njo.2020.0023","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of many malignancies. Toxicities of immunotherapy are variable, can involve almost every organ, therefore appropriate diagnosis and management of Immune Related Adverse Events (irAEs) is important. Immune-mediated pneumonitis is an uncommon, but potentially life-threatening toxicity of ICIs. Pre-existing lung disease, a history of lung radiotherapy, age > 70 years and male gender are suggested as the risk factors of pneumonitis. Dyspnoea, dry cough, fever and chest pain are typical symptoms. Diagnostic algorithms recommend radiological investigation with a chest computed tomography scan. Additional diagnostic procedures – such as pulse oximetry, spirometry, measurement of carbon monoxide diffusing capacity, bronchoscopy with BAL may be helpful. The therapeutic approach is determined by the intensity of the symptoms and CT findings. Corticosteroids and antibiotics are the drugs of choice. Hospitalisation is necessary in severe cases, and other forms of immunosuppression (infliximab, mycophenolate mofetil) may be considered. Continuation of immunotherapy can be considered with caution in patients with G1-2 toxicity, when clinical improvement was achieved and steroids were tapered.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"27 1","pages":"105-110"},"PeriodicalIF":0.0,"publicationDate":"2020-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87815575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on the epidemiology, imaging and therapy of brain metastases 脑转移的流行病学、影像学和治疗的最新进展

Nowotwory Pub Date : 2020-06-16 DOI: 10.5603/njo.2020.0024

Maciej Mielczarek, Anna Kubica, Mateusz Szylberg, K. Zielińska, Jakub Przybył, Agata Sierzputowska, M. Harat

{"title":"An update on the epidemiology, imaging and therapy of brain metastases","authors":"Maciej Mielczarek, Anna Kubica, Mateusz Szylberg, K. Zielińska, Jakub Przybył, Agata Sierzputowska, M. Harat","doi":"10.5603/njo.2020.0024","DOIUrl":"https://doi.org/10.5603/njo.2020.0024","url":null,"abstract":"Introduction. The incidence of brain metastases (BM) is rapidly increasing, with most cases occurring in patients aged 50–80 years and in 10–40% of patients with systemic neoplastic disease. The Graded Prognostic Assessment (GPA) is the most impartial prognostic method, according to which the average survival rate of patients with brain metastases is only 7.18 months. Purpose. To present a systematic review of the currently available evidence-based literature on the epidemiology, diagnosis, and treatment of BM. Methods. The authors searched PubMed up to March 2020 using the phrases “brain metastases”, “brain metastasis surgery”, and “brain metastases treatment”, which returned 65 citations. Conclusions. The choice of imaging and therapy for brain metastases remains a significant clinical problem. MRI, including T1, T1 + C, T2, FLAIR, and SWI sequences, is the most sensitive method for solitary BM detection, while other techniques such as spectroscopy, perfusion imaging, or fractional anisotropy contribute to diagnosis precision and neurological deficit avoidance in cases eligible for surgery. According to current treatment algorithms, three main methods are used to manage BM: surgery, chemotherapy, and radiotherapy, depending on the expected effect and the patient’s clinical condition. Surgery is most often used, offering neurological deficit remission in 60 to 90% of patients. Most chemotherapeutics do not cross the blood-brain barrier, so immunotherapy with antibodies such as pembrolizumab and ipilimumab, as well as antineoplastic vaccines, are a promising therapeutic prospect.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"19 1","pages":"111-117"},"PeriodicalIF":0.0,"publicationDate":"2020-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80085805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Surgical anatomy of the breast revisited 乳房的外科解剖重述

Nowotwory Pub Date : 2020-03-03 DOI: 10.5603/njo.2020.0005

W. Wysocki, G. Libondi, A. Juszczak

引用次数: 2

Malignant granular cell tumor of the lumbar region – a case report and review of the criteria for diagnosis 腰椎恶性颗粒细胞瘤1例报告及诊断标准回顾

Nowotwory Pub Date : 2020-03-03 DOI: 10.5603/njo.2020.0007

O. Stanowska, T. Morysiński, P. Rutkowski, A. Klimczak, A. Szumera-Ciećkiewicz

引用次数: 0

What was supposed to be the role of a coordinator of oncological treatment, and what is it really like? 肿瘤治疗协调员的角色应该是什么，它到底是什么样的?

Nowotwory Pub Date : 2020-03-03 DOI: 10.5603/njo.2020.0001

K. Osowiecka, M. Rucińska, A. Andrzejczak, E. Żarłok, Iwona Chrostek, S. Nawrocki

{"title":"What was supposed to be the role of a coordinator of oncological treatment, and what is it really like?","authors":"K. Osowiecka, M. Rucińska, A. Andrzejczak, E. Żarłok, Iwona Chrostek, S. Nawrocki","doi":"10.5603/njo.2020.0001","DOIUrl":"https://doi.org/10.5603/njo.2020.0001","url":null,"abstract":"Introduction. Due to the multidisciplinary nature of oncological treatment, it is necessary to coordinate it properly. In response to this need, an idea emerged to create a new profession in the system of oncological care, the so-called oncological treatment coordinator. The aim of the study was to assess the actual role of coordinators in hospitals in Poland. Material and methods. The study was carried out by means of a questionnaire among persons employed as coordinators and persons who act as coordinators within additional duties. Results. The study involved 95 coordinators from various centers in Poland, half of which were recruited on purpose as coordinators. Less than half (40%) have received training on their work. The main task of the coordinators is to ensure that the documentation related to the patient’s Diagnostic and Oncological Treatment Card (DiLO) is complete, to set appointments for diagnostic tests and visits to doctors’ offices and to cooperate with medical statistics departments. Only half of the coordinators inform or provide non-medical support to the patient. Coordinators face very different difficulties in their work. Conclusions. Coordinators are a valuable professional group in the Polish oncological care system. However, there is a lack of clearly defined tasks, systematic training and support.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"110 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79261447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should adjuvant radiotherapy be used in patients with early stage Hodgkin’s lymphoma? A vote for yes 早期霍奇金淋巴瘤患者是否应该使用辅助放疗?投赞成票

Nowotwory Pub Date : 2020-03-03 DOI: 10.5603/njo.2020.0006

E. Łata-Woźniak, A. Łacko

引用次数: 0

Adjuvant radiation therapy after immediate implant-based breast reconstruction 乳房植体重建后的辅助放射治疗

Nowotwory Pub Date : 2020-03-03 DOI: 10.5603/njo.2020.0004

J. Socha

引用次数: 0