Phytotherapie最新文献_第3页

En direct du Congrès international d’aromathérapie et de phytothérapie appliquées Phyt’Arom (Grasse 2019) 来自国际应用芳香疗法和植物疗法大会phyt ' arom (Grasse 2019)的现场直播

Phytotherapie Pub Date : 2019-10-01 DOI: 10.3166/phyto-2019-0205

P. Goetz

引用次数: 0

Effects of Papaya Leaf Extract (Carica papaya L.) on Cellular Proliferation and Apoptosis in Cervical Cancer Mice Model 木瓜叶提取物对癌症小鼠模型细胞增殖和凋亡的影响

Phytotherapie Pub Date : 2019-10-01 DOI: 10.3166/PHYTO-2018-0096

Yuly Peristiowati, Y. Puspitasari, Indasah

{"title":"Effects of Papaya Leaf Extract (Carica papaya L.) on Cellular Proliferation and Apoptosis in Cervical Cancer Mice Model","authors":"Yuly Peristiowati, Y. Puspitasari, Indasah","doi":"10.3166/PHYTO-2018-0096","DOIUrl":"https://doi.org/10.3166/PHYTO-2018-0096","url":null,"abstract":"This study is aimed at analyzing the anticancer properties of papaya leaf extract, specifically the inhibition of cell proliferation and apoptotic induction through nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and p53 pathways. Twenty-five mice (Mus musculus), aged 2 months and weighing 20–30 g, was injected with 0.5 mg dexamethasone for 7 days. The mice were then injected intracutaneously with 1 ml of HeLa cells (8 × 106 HeLa cells/microliter). The mice were divided into five groups (5 each): negative control (P1) (5% CMC-Na, sodium carboxymethyl cellulose), treatment II (225 mg/kg BW (body weight) papaya leaves methanol extract), treatment III (450 mg/kg BW), treatment IV (750 mg/kg BW), and treatment PV (2 mg alcohol anticancer drug). Papaya leaf extract treatments were applied for 2 weeks. Then, the tumor tissue was isolated for hematoxylin and eosin staining. Immunohistochemical imaging was used to detect Ki-67, caspase-3, NF-κB, and p53 expression. Further analysis was undertaken using the ImmunoRatio software program. The results indicated that administration of papaya leaf methanol extract significantly increased the expression of NF-κB and p53 at a dose of 450 mg/kg BW. Our results also showed that the mice treated with 450 mg of papaya leaf extract per kg of BW (P3) had the largest increase of caspase-3 expression compared to the negative control group. Papaya leaf ethanol extract decreased the cancer cell proliferation index and increased apoptosis of cancer cells in animal models of cervical cancer; it may also work to increase NF-kB expression and expression of the p53 gene.","PeriodicalId":39888,"journal":{"name":"Phytotherapie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41734734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparative Chemical Profile of Lavandula stoechas L. Essential Oils Isolated from Flowers and Leaves Native to Algeria 从原产于阿尔及利亚的花和叶中分离的薰衣草精油的化学成分比较

Phytotherapie Pub Date : 2019-10-01 DOI: 10.3166/PHYTO-2018-0103

B. Barhouchi, S. Aouadi, A. Abdi

{"title":"Comparative Chemical Profile of Lavandula stoechas L. Essential Oils Isolated from Flowers and Leaves Native to Algeria","authors":"B. Barhouchi, S. Aouadi, A. Abdi","doi":"10.3166/PHYTO-2018-0103","DOIUrl":"https://doi.org/10.3166/PHYTO-2018-0103","url":null,"abstract":"This study is aimed at the extraction and chemical analysis of the essential oils of the leaves and flowers of Lavandula stoechas L growing in northeastern Algeria. The hydrodistilled oils isolated from leaves (0.75%) and flowers (0.6%) were characterized by fifty-two and sixtyfour compounds, respectively. Gas chromatography–mass spectrometry (GC-MS) analysis demonstrated that both organs revealed the presence of fenchone and camphor as the major compounds. However, the highest percentage of fenchone (52.7%) was observed in the flowers oil; whereas, the percentage of camphor (25.94%) was significantly higher in the leaves oil in comparison with its content in flowers oil (15.52%). Other predominant compounds in leaves and flowers oils were, respectively, as follows: 1.8-cineole (4.84% and 4.02%), camphene (4.55% and 3.23%), bornyl acetate (3.06% and 4.43%), α-terpinolene (1.09% and 1.45%), viridiflorol (1.51% and 1.39%), and α- pinene (0.5% and 1.5%). The quantitative and qualitative data proved that the chemical profile of both organs of Lavandula stoechas native to Algeria was approximately close. The oil chemical composition is susceptible to the influence of environmental factors (soil, climate). The biological activity (antimicrobial and antioxidant) of the two oils from Lavandula stoechas L., native to this Algerian region is under study.","PeriodicalId":39888,"journal":{"name":"Phytotherapie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49649673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Diarrhée(s) 腹泻(s)

Phytotherapie Pub Date : 2019-10-01 DOI: 10.3166/phyto-2019-0204

P. Goetz

引用次数: 0

Composition chimique et propriétés antioxydante et antimicrobienne de l’huile essentielle d’Origanum floribundum Munby Origanum floribundum Munby精油的化学成分、抗氧化和抗菌性能

Phytotherapie Pub Date : 2019-10-01 DOI: 10.3166/PHYTO-2019-0115

F. Boulaghmen, C. Chaouia, F. Saidi

{"title":"Composition chimique et propriétés antioxydante et antimicrobienne de l’huile essentielle d’Origanum floribundum Munby","authors":"F. Boulaghmen, C. Chaouia, F. Saidi","doi":"10.3166/PHYTO-2019-0115","DOIUrl":"https://doi.org/10.3166/PHYTO-2019-0115","url":null,"abstract":"L’objectif du travail est l’étude de la composition chimique de l’huile essentielle (HE) d’Origanum floribundum Munby, ainsi que l’évaluation de son activité antioxydante et antimicrobienne. L’analyse de la composition chimique réalisée par chromatographie phase gazeuse couplée à la spectrométrie de masse a permis d’identifier 27 composés représentant 99,8 % de la composition totale, dont le composant majoritaire est le p-cymène à 53,4 %. Les résultats de l’activité antimicrobienne de l’HE ont montré qu’elle présente un large spectre d’action vis-à-vis de tous les microorganismes testés, ainsi qu’un effet bactéricide et fongicide puissant. La zone d’inhibition la plus importante (50,67 ± 0,58 mm) a été observée chez Candida albicans et la plus faible chez Pseudomonas aeruginosa (13,33 ± 1,44 mm). L’activité d’inhibition du radical DPPH (2,2- diphényl-1-picrylhydrazyle) à 600, 800 et 1 000 mg/l par l’HE est comparable à l’hydroxytoluène butylé (BHT) et au tocophérol (vitamine E), antioxydants de référence, elle reste inférieure aux concentrations de 100, 200 et 400 mg/l avec une valeur IC50 de 500,71 ± 16,97 mg/l. Le pouvoir réducteur de l’HE d’origan aux concentrations (100, 200, 400, 600, 800 et 1 000 mg/l) est légèrement inférieur aux antioxydants de référence retenus pour cette étude.","PeriodicalId":39888,"journal":{"name":"Phytotherapie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45530865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Composition and Anti-inflammatory Effect of the Common Myrtle’s (Myrtus communis L.) Essential Oil Growing Wild in Algeria 阿尔及利亚野生杨梅精油的成分及抗炎作用

Phytotherapie Pub Date : 2019-08-08 DOI: 10.3166/phyto-2019-0180

M. Touaibia

引用次数: 2

Ah ! les vacances champêtres

Phytotherapie Pub Date : 2019-08-01 DOI: 10.3166/phyto-2019-0192

P. Goetz

引用次数: 0

Phytothérapie de bronchopneumopathies chroniques 慢性支气管肺病的植物疗法

Phytotherapie Pub Date : 2019-08-01 DOI: 10.3166/phyto-2019-0190

P. Goetz

引用次数: 1

Effet synergique d’extraits de cannelle et de canneberge sur l’inhibition de l’adhésion d’Escherichia coli uropathogène aux cellules épithéliales de la vessie 肉桂和蔓越莓提取物对抑制尿路致病大肠杆菌粘附膀胱上皮细胞的协同作用

Phytotherapie Pub Date : 2019-08-01 DOI: 10.3166/PHYTO-2019-0178

A. Leblanc, C. Blondeau, S. Holowacz, C. Langlois, L. Haddioui

引用次数: 0

Analgesic, Anti-inflammatory and Antihyperlipidemic Activities ofKnema attenuata, an Endemic Plant of Southern India 印度南部特有植物衰减Knema的镇痛、抗炎和抗高脂血症活性

Phytotherapie Pub Date : 2019-08-01 DOI: 10.3166/PHYTO-2018-0098

V. Chandra, K. Chandrashekar, P. Shama, C. Shastry

{"title":"Analgesic, Anti-inflammatory and Antihyperlipidemic Activities ofKnema attenuata, an Endemic Plant of Southern India","authors":"V. Chandra, K. Chandrashekar, P. Shama, C. Shastry","doi":"10.3166/PHYTO-2018-0098","DOIUrl":"https://doi.org/10.3166/PHYTO-2018-0098","url":null,"abstract":"The analgesic, anti-inflammatory and antihyperlipidemic activities ofKnema attenuata(Myristicaceae), one of the ingredients of ‘Ashwagandhadhi nei (medicated ghee)’ used in the treatment of spleen disorders according to the Ayurvedic herbal medicine tradition are investigated using suitable in vivo models such as hot plate method, tail immersion test, carrageenan-induced paw oedema assay and Triton X-100-induced hyperlipidemic assay. The seed and aril (a fleshy to hard structure which develops from the funicle or ovule after fertilisation and encloses all or part of the seed) extracts were used. Both the extracts showed significant dose dependent analgesic activity up to 400 mg/kg. The dose dependent ethanolic extract of aril exhibited higher latency to hot plate and tail withdrawal reflex proving its analgesic property. Anti-inflammatory activity was demonstrated after 3 h of oedema induction. The paw volume (ml) decreased from 1.36 ± 0.05 in control to 0.73 ± 0.02 and 0.78 ± 0.02 respectively in groups treated with ethanol extract of aril and seed. The extracts of seed and aril administered at a dose of 400 mg/kg lowered the serum TC (total cholesterol), TG (triglycerides), LDL (low density lipoprotein) and VLDL (very low density lipoprotein) compared to hyperlipidemic groups. A significant decrease in the atherogenic index (a strong marker to predict the risk of atherosclerosis and coronary heart disease) was observed in animals supplemented withKnema attenuatawhich suggests an athero protective/ cardio protective potential of this plant extract. We conclude that ethanolic extract ofKnema attenuatahas significantly good analgesic, anti-inflammatory and antihyperlipidemic activity. It could be a new source of natural analgesic agent and an alternative natural source of antiinflammatory and cardio protective agents.","PeriodicalId":39888,"journal":{"name":"Phytotherapie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49360549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1