Kobe Journal of Medical Sciences最新文献_第2页

A High Fibrosis-4 Index is Associated with a Reduction in the Estimated Glomerular Filtration Rate in Non-obese Japanese Patients with Type 2 Diabetes Mellitus. 高纤维化-4 指数与非肥胖的日本 2 型糖尿病患者估计肾小球滤过率降低有关。

Kobe Journal of Medical Sciences Pub Date : 2024-04-30 DOI: 10.24546/0100489395

Hiroyuki Inoue, Shun-Ichiro Asahara, Fumihiko Nakamura, Yoshiaki Kido

{"title":"A High Fibrosis-4 Index is Associated with a Reduction in the Estimated Glomerular Filtration Rate in Non-obese Japanese Patients with Type 2 Diabetes Mellitus.","authors":"Hiroyuki Inoue, Shun-Ichiro Asahara, Fumihiko Nakamura, Yoshiaki Kido","doi":"10.24546/0100489395","DOIUrl":"10.24546/0100489395","url":null,"abstract":"Liver fibrosis is associated with non-alcoholic fatty liver disease (NAFLD), and one of the most important risk factors for NAFLD is type 2 diabetes (T2DM). The Fibrosis-4 (FIB-4) index, a noninvasive liver fibrosis score, has been found to be useful for estimating liver fibrosis. Because individuals with non-obese NAFLD were recently reported to be metabolically unhealthy and have a higher risk of T2DM than individuals with obese NAFLD, we hypothesized that the clinical factors related to a high FIB-4 index would differ between non-obese and obese Japanese T2DM patients. Accordingly, we examined the relationship between clinical factors and the FIB-4 index in non-obese and obese Japanese patients with T2DM. We divided 265 patients into two groups by BMI level - a non-obese group (n = 149) and an obese group (n = 116) - and examined the correlation between the FIB-4 index and clinical parameters. Single regression analysis revealed that a high FIB-4 index was correlated with a reduction in the estimated glomerular filtration rate and hypertension in the non-obese group. Importantly, multiple regression analysis showed that only a reduction in the estimated glomerular filtration rate was significantly associated with a high FIB-4 index in the non-obese group. These results demonstrated that non-obese T2DM patients with a high FIB-4 index might be at risk of kidney dysfunction. Our findings may enable the more appropriate treatment of T2DM patients based on BMI level.","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"70 1","pages":"E39-E45"},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Rare Variants Affecting Multiple Pathways in Japanese Patients with Palindromic Rheumatism. 影响日本双相风湿病患者多条通路的罕见遗传变异。

Kobe Journal of Medical Sciences Pub Date : 2024-04-30 DOI: 10.24546/0100489391

Taketo Kawara, Koji Inoue, Shunichi Shiozawa, Kayo Osawa, Koichiro Komai

{"title":"Genetic Rare Variants Affecting Multiple Pathways in Japanese Patients with Palindromic Rheumatism.","authors":"Taketo Kawara, Koji Inoue, Shunichi Shiozawa, Kayo Osawa, Koichiro Komai","doi":"10.24546/0100489391","DOIUrl":"10.24546/0100489391","url":null,"abstract":"Palindromic rheumatism (PR) is a type of cryptogenic paroxysmal arthritis. Several genes may be involved in PR pathogenesis; however, conducting comprehensive case-control genetic studies for PR poses challenges owing to its rarity as a disease. Moreover, case-control studies may overlook rare variants that occur infrequently but play a significant role in pathogenesis. This study aimed to identify disease-related genes in Japanese patients with PR using whole-genome sequencing (WGS) and rare-variant analysis. Genomic DNA was obtained from two familial cases and one sporadic case, and it was subjected to WGS. WGS data of 104 healthy individuals obtained from a public database were used as controls. We performed data analysis for rare variants on detected variants using SKAT-O, KBAC, and SKAT, and subsequently defined significant genes. Significant genes combined with variants shared between the cases were defined as disease-related genes. We also performed pathway analysis for disease-related genes using Reactome. We identified 2,695,244 variants shared between cases; after excluding polymorphisms and noise, 74,640 variants were detected. We identified 540 disease-related genes, including 1,893 variants. Furthermore, we identified 32 significant pathways. Our results indicate that the detected genes and pathways in this study may be involved in PR pathogenesis.","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"70 1","pages":"E26-E38"},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of a Self-directed Social Resources Study Program on Negative Symptoms and Quality of Life in Schizophrenia Outpatients: A Randomized Controlled Trial. 自我导向的社会资源研究计划对精神分裂症门诊患者的消极症状和生活质量的影响：随机对照试验

Kobe Journal of Medical Sciences Pub Date : 2024-04-01 DOI: 10.24546/0100488377

Yuko Nishimura, Kayano Yotsumoto, Takeshi Hashimoto

{"title":"Impacts of a Self-directed Social Resources Study Program on Negative Symptoms and Quality of Life in Schizophrenia Outpatients: A Randomized Controlled Trial.","authors":"Yuko Nishimura, Kayano Yotsumoto, Takeshi Hashimoto","doi":"10.24546/0100488377","DOIUrl":"10.24546/0100488377","url":null,"abstract":"To clarify whether a self-directed study program on social resources improves negative symptoms, quality of life (QOL), and social participation among outpatients with schizophrenia. Eighty-six participants were randomly divided into intervention and control groups. In addition to the usual day programs, the intervention group participated in a self-directed study program on social resources once a week for eight weeks. The control group participated only in the usual day programs. Negative symptoms and QOL were assessed at baseline and post-intervention using the Positive and Negative Syndrome Scale (PANSS) and the WHO Quality of Life-BREF (WHOQOL-BREF), respectively. Social participation was also assessed. After the intervention, there were no significant differences in the PANSS negative symptoms and WHOQOL-BREF total scores between the two groups. Within-group, PANSS negative symptom scores significantly improved in the intervention group (p < 0.05), but not in the control group. The WHOQOL-BREF physical health subscale scores improved significantly only in the intervention group (p < 0.05). Social participation remained unchanged between the intervention and control groups. The results suggest that a self-directed study program on social resources may be useful for improving negative symptoms and physical QOL in outpatients with schizophrenia. The findings highlight the potential of such interventions to bridge the existing gap in psychosocial rehabilitation strategies for this population.","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"70 1","pages":"E15-E21"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HELLP Syndrome at 20 Gestational Weeks Managed Using the Mississippi Protocol: A Case Report. 使用密西西比方案治疗妊娠 20 周 HELLP 综合征：病例报告。

Kobe Journal of Medical Sciences Pub Date : 2024-04-01 DOI: 10.24546/0100488386

Naohisa Masuko, Kenji Tanimura, Masayuki Tanaka, Akiko Uchida, Ryosuke Takahashi, Hitomi Imafuku, Masashi Deguchi, Yoshito Terai

{"title":"HELLP Syndrome at 20 Gestational Weeks Managed Using the Mississippi Protocol: A Case Report.","authors":"Naohisa Masuko, Kenji Tanimura, Masayuki Tanaka, Akiko Uchida, Ryosuke Takahashi, Hitomi Imafuku, Masashi Deguchi, Yoshito Terai","doi":"10.24546/0100488386","DOIUrl":"10.24546/0100488386","url":null,"abstract":"Hemolysis, elevated liver enzyme levels, and low platelet count (HELLP) syndrome is one of the most severe complications of hypertensive disorders of pregnancy. HELLP syndrome occurring before 22 gestational weeks (GWs) is extremely rare, and patients prevalently exhibit underlying maternal diseases or fetal abnormalities. Here, we report the case of a pregnant woman who had HELLP syndrome at 20 GWs without any obvious underlying maternal diseases or fetal abnormalities. A 38-year-old pregnant woman was referred to Kobe University Hospital from another hospital at 19 + 5/7 GWs for hypertension, proteinuria, generalized edema, and fetal growth restriction. She was diagnosed with partial HELLP syndrome according to the Mississippi classification at 20 + 2/7 GWs. The patient was managed following the Mississippi protocol, including intravenous dexamethasone, magnesium sulfate, and antihypertensive drugs. She received intensive blood pressure and laboratory data monitoring using an arterial line and additional treatments, including platelet transfusion, intravenous haptoglobin infusion, and human atrial natriuretic peptide. The pregnancy ended in an induced delivery at 20 + 3/7 GWs, and she was discharged without complications 10 days postnatal. We performed laboratory tests for diagnosing underlying diseases but identified no obvious underlying diseases. This report indicates that early and intensive treatment of patients with HELLP syndrome occurring before 22 GWs according to the Mississippi protocol may enable clinicians to complete pregnancy termination without maternal complications and provide useful information to clinical practitioners in perinatal medicine.","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"70 1","pages":"E22-E25"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Disparities in Applied Force on Maxillary Incisors Among Novices During Laryngoscopy Using a High-Fidelity Simulator: A Prospective Observational Study. 使用高保真模拟器进行喉内镜检查时，新手上颌切牙所受力的性别差异：一项前瞻性观察研究。

Kobe Journal of Medical Sciences Pub Date : 2024-02-29 DOI: 10.24546/0100486397

Yuko Ono, Kazuaki Shinohara, Jiro Shimada, Jun Sugiyama, Shigeaki Inoue, Joji Kotani

{"title":"Sex Disparities in Applied Force on Maxillary Incisors Among Novices During Laryngoscopy Using a High-Fidelity Simulator: A Prospective Observational Study.","authors":"Yuko Ono, Kazuaki Shinohara, Jiro Shimada, Jun Sugiyama, Shigeaki Inoue, Joji Kotani","doi":"10.24546/0100486397","DOIUrl":"10.24546/0100486397","url":null,"abstract":"Endotracheal intubation (ETI) is a common and crucial intervention. Whether the performance of ETI differs according to the sex of the laryngoscopist remains unclear. The aim of this study was to assess sex disparities in markers of ETI performance among novices using a high-fidelity simulator. This prospective observational study was conducted from April 2017 to March 2019 in a public medical university. In total, 209 medical students (4th and 5th grade) without clinical ETI experience were recruited. Of the 209 students, 64 (30.6%) were female. The participants used either a Macintosh direct laryngoscope or C-MAC video laryngoscope in combination with a stylet or gum-elastic bougie to perform ETI on a high-fidelity simulator. The primary endpoint was the maximum force applied on the maxillary incisors during laryngoscopy. The secondary endpoint was the time to ETI. The implanted sensors in the simulator automatically quantified the force and time to ETI. The maximum force applied on the maxillary incisors was approximately 30% lower in the male than female group for all laryngoscopes and intubation aids examined (all P < 0.001). Similarly, the time to ETI was approximately 10% faster in the male than female group regardless of the types of laryngoscopes and intubation aids used (all P < 0.05). In this study, male sex was associated with a lower maximum force applied on the maxillary incisors during both direct and indirect laryngoscopy performed by novices. A clinical study focusing on sex differences in ETI performance is needed to validate our findings.","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"69 4","pages":"E151-E158"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11006240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spiritual Support to Improve Women's Mental Health after Miscarriage and Stillbirth: A Qualitative Study in Japan. 为流产和死产后妇女提供精神支持以改善其心理健康：日本的一项定性研究。

Kobe Journal of Medical Sciences Pub Date : 2024-02-08 DOI: 10.24546/0100486284

Yuko Endo, Izumi Saito

{"title":"Spiritual Support to Improve Women's Mental Health after Miscarriage and Stillbirth: A Qualitative Study in Japan.","authors":"Yuko Endo, Izumi Saito","doi":"10.24546/0100486284","DOIUrl":"10.24546/0100486284","url":null,"abstract":"Problem: Miscarriage and stillbirth can severely impact maternal mental well-being.Background: In Japan, local municipalities must prepare systems to provide mental and social-spiritual support to women after miscarriage or stillbirth.Objective: To elucidate what spiritually supports the mental health of women who have experienced miscarriages and stillbirths.Methods: This analysis included 25 women who had experienced miscarriage or stillbirth at least one month previously and participated in self-help group meetings at least twice. Data were collected from March 2020 to March 2021 using two narrative interviews and questionnaires.Findings: The mothers led their lives \"together\" with their children. They derived spiritual support from others, such as \"the presence of someone who is living now after having experienced anguish\" and \"others who acknowledge the presence of my child and me as a mother. \" Further elements of the support included \"resigning myself to face my grief\" and \"strong links to deceased children. \" While facing their grief by accepting that this anguish cannot be replaced [with anything else] and resigning themselves to reality, their bond to their child is strengthened.Conclusion: What women perceive as support after a miscarriage or stillbirth will be an important clue to care.","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"70 1","pages":"E1-E14"},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of EGFR and p16 in Squamous Cell Carcinoma of External Auditory Canal. 外耳道鳞状细胞癌中表皮生长因子受体和 p16 的表达

Kobe Journal of Medical Sciences Pub Date : 2024-01-31 DOI: 10.24546/0100486232

Yasuyuki Kajimoto, Hirotaka Shinomiya, Natsumi Uehara, Masanori Teshima, Takeshi Fujita, Akinobu Kakigi, Yoshinori Imamura, Naomi Kiyota, Daisuke Miyawaki, Ryohei Sasaki, Hidehito Kimura, Ken-Ichi Nibu

{"title":"Expression of EGFR and p16 in Squamous Cell Carcinoma of External Auditory Canal.","authors":"Yasuyuki Kajimoto, Hirotaka Shinomiya, Natsumi Uehara, Masanori Teshima, Takeshi Fujita, Akinobu Kakigi, Yoshinori Imamura, Naomi Kiyota, Daisuke Miyawaki, Ryohei Sasaki, Hidehito Kimura, Ken-Ichi Nibu","doi":"10.24546/0100486232","DOIUrl":"10.24546/0100486232","url":null,"abstract":"The expression of EGFR and p16 in the external auditory canal squamous cell carcinoma (EACSCC) and their impacts on oncological outcomes were not well studied. Seventeen-one consecutive patients who were treated for EACSCC at Kobe University Hospital from 1995 to 2018 were enrolled in this study. The expression of EGFR, and p16 were evaluated and their impacts on oncological outcomes were statistically analyzed. Positive expression of EGFR was observed in 62 patients (87%). Strong positive expression of p16 were observed in 18 patients (32.4%), and weakly positive expression in 30 patients (42.3%), respectively. While the number of the patients with negative EGFR expression were limited, all the surgically treated patients with negative EGFR expression have been alive without disease. In the patients with T3 & T4a EACSCC, prognosis of the patients with positive p16 expression EACSCC tended to be better than those with negative p16 expression. These results suggest the clinical significance of EGFR and p16 expressions in the patients with advanced EACSCC to predict oncological outcomes.","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"69 4","pages":"E144-E150"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11006239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Intervention for Control of Clinical Symptom in Patients with Systemic Metal Allergy: A Single Center Randomized Controlled Clinical Study. 控制全身性金属过敏患者临床症状的饮食干预：单中心随机对照临床研究》。

Kobe Journal of Medical Sciences Pub Date : 2024-01-31 DOI: 10.24546/0100486230

Reiko Mikajiri, Atsushi Fukunaga, Makoto Miyoshi, Noriaki Maeshige, Ken Washio, Taro Masaki, Chikako Nishigori, Ikuko Yamamoto, Akiyo Toda, Michiko Takahashi, Shun-Ichiro Asahara, Yoshiaki Kido, Makoto Usami

{"title":"Dietary Intervention for Control of Clinical Symptom in Patients with Systemic Metal Allergy: A Single Center Randomized Controlled Clinical Study.","authors":"Reiko Mikajiri, Atsushi Fukunaga, Makoto Miyoshi, Noriaki Maeshige, Ken Washio, Taro Masaki, Chikako Nishigori, Ikuko Yamamoto, Akiyo Toda, Michiko Takahashi, Shun-Ichiro Asahara, Yoshiaki Kido, Makoto Usami","doi":"10.24546/0100486230","DOIUrl":"10.24546/0100486230","url":null,"abstract":"Patients with eczema with a systemic metal allergy, such as nickel (Ni), cobalt (Co), chromium (Cr), and tin (Sn), should pay attention to symptomatic exacerbation by excessive metal intake in food. However, dietary intervention for systemic metal allergy can be difficult. In this study, we evaluated the effect of dietary intervention by a registered dietitian on clinical symptoms in patients with a systemic metal allergy. Forty-four patients with cutaneous symptoms who were diagnosed with a metal allergy were randomly assigned to the dietary intervention group (DI group, n = 29) by a registered dietitian or the control group (C group, n = 15). The DI group was individually instructed by a registered dietitian how to implement a metal-restricted diet and then evaluated 1 month later. Dermatologists treated skin lesions of patients in both groups. Skin symptoms assessed by the Severity Scoring of Atopic Dermatitis (SCORAD) index, blood tests, and urinary metal excretion were evaluated. The DI group showed decreased Ni, Co, Cr, and Sn intake (all P ≤ 0.05), and an improved total SCORAD score, eczema area, erythema, edema/papulation, oozing/crust, excoriation, lichenization and dryness after 1 month of intervention compared with before the intervention (all P ≤ 0.05). However, the C group showed decreased Ni and Sn intake and an improved oozing/crust score (all P < 0.05). It showed the effective reduction of dietary metal intake controls dermatitis due to a metal allergy. In conclusion, dietary intervention by a registered dietitian is effective in improving skin symptoms with a reduction in metal intake.","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"69 4","pages":"E129-E143"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11006241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significance of Serum Leucine-rich Alpha-2 Glycoprotein as a Diagnostic Marker in Pediatric Inflammatory Bowel Disease. 血清富亮氨酸甲-2糖蛋白作为小儿炎症性肠病诊断标志物的意义

Kobe Journal of Medical Sciences Pub Date : 2024-01-24 DOI: 10.24546/0100486228

Shohei Yoshimura, Yuichi Okata, Makoto Ooi, Tomoko Horinouchi, Serena Iwabuchi, Yasuyuki Kameoka, Aya Watanabe, Atsushi Kondo, Kotaro Uemura, Yuichiro Tomioka, Yoshitomo Samejima, Yumiko Nakai, Kandai Nozu, Yuzo Kodama, Yuko Bitoh

{"title":"Significance of Serum Leucine-rich Alpha-2 Glycoprotein as a Diagnostic Marker in Pediatric Inflammatory Bowel Disease.","authors":"Shohei Yoshimura, Yuichi Okata, Makoto Ooi, Tomoko Horinouchi, Serena Iwabuchi, Yasuyuki Kameoka, Aya Watanabe, Atsushi Kondo, Kotaro Uemura, Yuichiro Tomioka, Yoshitomo Samejima, Yumiko Nakai, Kandai Nozu, Yuzo Kodama, Yuko Bitoh","doi":"10.24546/0100486228","DOIUrl":"10.24546/0100486228","url":null,"abstract":"Serum leucine-rich alpha-2 glycoprotein (LRG) has been utilized for adult inflammatory bowel disease (IBD); however, its efficacy in pediatric IBD remains unknown. The aim of this study was to compare the diagnostic accuracy of serum LRG for pediatric IBD with that of current inflammatory markers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). This retrospective case-control study included pediatric patients, aged <16 years, who underwent colonoscopy and/or esophagogastroduodenoscopy between April 2017 and March 2022. All eligible patients were divided into two groups: patients with IBD, diagnosed with ulcerative colitis and Crohn's disease, and non-IBD controls. The optimal cut-off value of serum LRG for IBD diagnosis was determined from receiver operating characteristic analysis, and diagnostic accuracy of serum LRG was compared to serum ESR and CRP. A total of 53 patients (24 with IBD and 29 non-IBD controls) met the inclusion criteria. The cut-off value of serum LRG for IBD diagnosis was determined to be 19.5 μg/ml. At this cut-off value, serum LRG had a positive predictive value (PPV) of 0.80 and negative predictive value (NPV) of 0.88. In contrast, PPV and NPV were 0.78 and 0.70 for serum ESR and 0.82 and 0.72 for serum CRP, respectively. Serum LRG can be a potential diagnostic marker for pediatric IBD, with higher diagnostic accuracy than that of the conventional serum markers ESR and CRP.","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"69 4","pages":"E122-E128"},"PeriodicalIF":0.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11006238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Outcome of Mandibular Distraction Osteogenesis in Infants with Severe Pierre Robin Sequence in Vietnam. 越南严重Pierre Robin序列婴儿下颌牵张成骨的结果。

Kobe Journal of Medical Sciences Pub Date : 2023-11-16 DOI: 10.24546/0100485260

Dang Hoang Thom, Vu Ngoc Lam, Tran Thiet Son

{"title":"The Outcome of Mandibular Distraction Osteogenesis in Infants with Severe Pierre Robin Sequence in Vietnam.","authors":"Dang Hoang Thom, Vu Ngoc Lam, Tran Thiet Son","doi":"10.24546/0100485260","DOIUrl":"10.24546/0100485260","url":null,"abstract":"The purpose of this study was to provide the experience of a single center with mandibular distraction osteogenesis (MDO) in Pierre Robin Sequence (PRS) patients. A longitudinal research analysis was conducted to identify PRS patients who underwent MDO at Vietnam National Children's Hospital between 2019 and 2021. The following criteria were used to determine inclusion: 1) those pediatric patients with PRS who were not well handled with conservative therapy, 2) those who received MDO with internal mandibular distractors, and 3) no previous treatment elsewhere. Demographic data, postoperative complications, and surgical results were all evaluated. The inclusion criteria were met by 73 patients. There were no difficulties associated with our distraction strategy. The majority of individuals with tracheostomies were successfully decannulated, and the remainder were able to avoid tracheostomies. Using MDO in PRS is an effective technique to avoid future airway issues. The success rate was lower and the complication rate higher for patients who had a tracheotomy before distraction and for those who underwent distraction at an age older than 2 months. The presence of laryngomalacia, gastric reflux disease, cardiac abnormalities, and GI anomalies did not increase the likelihood of MDO failure in PRS patients.","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"69 3","pages":"E115-E121"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138452765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0