Kobe Journal of Medical Sciences最新文献

{"title":"Spinal Muscular Atrophy: Advanced Version of Screening System with Real-Time mCOP-PCR and PCR-RFLP for SMN1 Deletion.","authors":"Emma Tabe Eko Niba,&nbsp;Mawaddah Ar Rochmah,&nbsp;Nur Imma Fatimah Harahap,&nbsp;Hiroyuki Awano,&nbsp;Ichiro Morioka,&nbsp;Kazumoto Iijima,&nbsp;Yasuhiro Takeshima,&nbsp;Toshio Saito,&nbsp;Kayoko Saito,&nbsp;Atsuko Takeuchi,&nbsp;Poh San Lai,&nbsp;Yoshihiro Bouike,&nbsp;Masafumi Matsuo,&nbsp;Hisahide Nishio,&nbsp;Masakazu Shinohara","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Spinal Muscular Atrophy (SMA) is a common autosomal recessive neuromuscular disease characterized by defects of lower motor neurons. More than 95% of SMA patients show homozygous deletion for the survival motor neuron 1 (SMN1) gene. For the screening of SMN1 deletion using dried blood spot (DBS), we developed a new combined system with real-time \"modified competitive oligonucleotide priming\"-polymerase chain reaction (mCOP-PCR) and PCR restriction fragment length polymorphism (PCR-RFLP). Although our real-time mCOP-PCR method is secured enough to be gene-specific, its amplification efficiency is not as good because the reverse primers carry a nucleotide mismatched with the sequence of the pre-amplified product. The mismatch has consequently been generated in the process of introducing a restriction enzyme site in the pre-amplified products for PCR-RFLP.</p><p><strong>Method: </strong>DBS samples of the subjects were stored at room temperature for a period of less than one year. Each subject had already been genotyped by the first PCR-RFLP using fresh blood DNA. SMN1/SMN2 exon 7 was collectively amplified using conventional PCR (targeted pre-amplification). Pre-amplified products were used as template in the real-time mCOP-PCR, and, on the other hand, were digested with DraI enzyme (PCR-RFLP). To improve the amplification efficiency of mCOP-PCR, one nucleotide change was introduced in the original reverse primers (SMN1-COP and SMN2-COP) to eliminate the mismatched nucleotide.</p><p><strong>Results: </strong>The real-time mCOP-PCR with a new primer (SMN1-COP-DRA or SMN2-COP-DRA) more rapidly and specifically amplified SMN1 and SMN2, and clearly demonstrated SMN1 deletion in an SMA patient. With the new primers, the amplification efficiencies of real-time mCOP-PCR were improved and the Cq values of SMN1 (+) and SMN2 (+) samples were significantly lowered.</p><p><strong>Conclusion: </strong>In the advanced version of our screening system for homozygous SMN1 deletion using DBS, the real-time mCOP-PCR with newly-designed reverse primers demonstrated the presence or absence of SMN1 and SMN2 within a shorter time, and the results were easily tested by PCR-RFLP. This rapid and accurate screening system will be useful for detection of newborn infants with SMA.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"65 2","pages":"E49-E53"},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012194/pdf/kobej-65-e49.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37557446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal Muscular Atrophy: New Screening System with Real-Time mCOP-PCR and PCR-RFLP for SMN1 Deletion.","authors":"Emma Tabe Eko Niba,&nbsp;Mawaddah Ar Rochmah,&nbsp;Nur Imma Fatimah Harahap,&nbsp;Hiroyuki Awano,&nbsp;Ichiro Morioka,&nbsp;Kazumoto Iijima,&nbsp;Yasuhiro Takeshima,&nbsp;Toshio Saito,&nbsp;Kayoko Saito,&nbsp;Atsuko Takeuchi,&nbsp;Poh San Lai,&nbsp;Yoshihiro Bouike,&nbsp;Masafumi Matsuo,&nbsp;Hisahide Nishio,&nbsp;Masakazu Shinohara","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Spinal Muscular Atrophy (SMA) is a common autosomal recessive neuromuscular disorder characterized by degeneration or loss of lower motor neurons. More than 95% of SMA patients show homozygous deletion for the survival motor neuron 1 (SMN1) gene. For the screening of SMN1 deletion, it is necessary to differentiate SMN1 from its highly homologous gene, SMN2. We developed a modified competitive oligonucleotide priming-PCR (mCOP-PCR) method using dried blood spot (DBS)-DNA, in which SMN1 and SMN2-specific PCR products are detected with gel-electrophoresis. Next, we added a targeted pre-amplification step prior to the mCOP-PCR step, to avoid unexpected, non-specific amplification. The pre-amplification step enabled us to combine mCOP-PCR and real-time PCR. In this study, we combined real-time mCOP-PCR and PCR-restriction fragment length polymorphism (PCR-RFLP) to develop a new screening system for detection of SMN1 deletion.</p><p><strong>Methods: </strong>DBS samples of the subjects were stored at room temperature for a period of less than one year. Each subject had already been genotyped by the first PCR-RFLP using fresh blood DNA. SMN1/SMN2 exon 7 was collectively amplified using conventional PCR (targeted pre-amplification), the products of which were then used as a template in the real-time PCR with mCOP-primer sets. To confirm the results, the pre-amplified products were subject to the second PCR-RFLP.</p><p><strong>Results: </strong>The real-time mCOP-PCR separately amplified SMN1 and SMN2 exon7, and clearly demonstrated SMN1 deletion in an SMA patient. The results of the real-time mCOP-PCR using DBS-DNA were completely consistent with those of the first and second PCR-RFLP analysis.</p><p><strong>Conclusion: </strong>In our new system for detection of SMN1 deletion, real-time mCOP-PCR rapidly proved the presence or absence of SMN1 and SMN2, and the results were easily tested by PCR-RFLP. This solid genotyping system will be useful for SMA screening.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"65 2","pages":"E44-E48"},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012196/pdf/kobej-65-e44.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37557445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nested PCR Amplification Secures DNA Template Quality and Quantity in Real-time mCOP-PCR Screening for SMA.","authors":"Yogik Onky Silvana Wijaya,&nbsp;Emma Tabe Eko Niba,&nbsp;Mawaddah Ar Rochmah,&nbsp;Nur Imma Fatimah Harahap,&nbsp;Hiroyuki Awano,&nbsp;Yasuhiro Takeshima,&nbsp;Toshio Saito,&nbsp;Kayoko Saito,&nbsp;Atsuko Takeuchi,&nbsp;Poh San Lai,&nbsp;Yoshihiro Bouike,&nbsp;Hisahide Nishio,&nbsp;Masakazu Shinohara","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Spinal Muscular Atrophy (SMA) is a common autosomal recessive disorder caused by SMN1 gene deletion. SMA has been considered an incurable disease. However, a newly-developed antisense oligonucleotide drug, nusinersen, brings about a good outcome to SMA patients in the clinical trials. Now, a screening for SMA is required for early diagnosis and early treatment so as to give a better clinical outcome to the patients. We have invented a new technology, mCOP-PCR, for SMA screening using dried blood spot (DBS) on the filter paper. One of the problems encountered in SMA screening is poor quality and quantity of DNA extracted from DBS.</p><p><strong>Methods: </strong>DNA was extracted from DBS of six individuals. Fresh blood DNA of each individual had already been genotyped using PCR/RFLP. The fragments including the sequence of SMN1/SMN2 exon 7 were pre-amplified with conventional PCR. To determine which pre-amplified product is a better template for the real-time mCOP-PCR, we did pre-amplification with a single PCR or pre-amplification with a nested PCR.</p><p><strong>Results: </strong>The real-time mCOP-PCR using pre-amplified products with a single PCR brought about ambiguous results in some SMN1-carrying individuals. However, the results of real-time mCOP-PCR following pre-amplification with a nested PCR were completely matched with those of PCR-RFLP.</p><p><strong>Conclusion: </strong>In our study on the real-time mCOP-PCR screening system for SMA, a nested PCR secured the DNA template quality and quantity, leading to unambiguous results of SMA screening.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"65 2","pages":"E54-E58"},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012193/pdf/kobej-65-e54.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37557447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Chronotype and Working Condition on Sleep Status and Health Related Quality of Life of Daytime Office Workers.","authors":"Yuh Sasawaki,&nbsp;Hideyuki Shiotani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Several companies in Japan introduced early working conditions (including recommendations on early morning work and prohibitions on nighttime overtime work) to decrease the number of long working hours at night. Nevertheless, individuals possess their own chronotype, i.e., their behavioral timing preference-be it morning or evening-that is associated with worker health. The purpose of this study was to investigate the influence of chronotype and working conditions on sleep and health related quality of life (HRQOL) using 126 daytime office workers who were classified as morning or evening type by their Morningness-Eveningness Questionnaire scores. We then compared morning and evening type workers' sleep variables (sleep onset/offset time and total sleep time), sleep quality (using the Japanese version of the Pittsburgh Sleep Quality Index), and HRQOL scores. Additionally, we compared the same sleep variables, sleep quality, and HRQOL scores of each chronotype category of worker under early and normal working conditions. As the results, evening type workers had late sleep onset/offset time, poor sleep quality, and low HRQOL (role-social component) compared to morning type workers. Furthermore, the evening type workers under early working conditions had earlier sleep onset/offset time and poorer sleep quality compared to those workers under normal working conditions. These results suggest that evening type workers in general have poor sleep and low HRQOL and those same workers under early working conditions, in particular, are associated with poor sleep quality. Therefore, in order to optimize worker health, we suggest that working conditions should be taken account of individual chronotypes.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"64 5","pages":"E189-E196"},"PeriodicalIF":0.0,"publicationDate":"2019-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668588/pdf/kobej-64-e189.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37318857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Treatment and Living Assistance Needed by Patients with Young-Onset Parkinson's Disease.","authors":"Yumi Iwasa,&nbsp;Izumi Saito,&nbsp;Chieko Fujii","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>This study assessed the symptoms, treatment, social systems use, and perception of living conditions of patients with young-onset Parkinson's disease (YOPD), and investigated the support needed by them.</p><p><strong>Method: </strong>Among the 252 people who completed our questionnaire, we defined YOPD patients as those diagnosed as young onset or those with onset at ≤40 years. The data were compared with others.</p><p><strong>Results: </strong>There were 24 patients with YOPD (9.5%) (average age: 61.7 years), with an average disease duration 6.4 years longer (p < 0.01) and time until diagnosis 0.7 years longer (p < 0.1) than those of other patients. This group took 1.6 times more types of medicines, and time to their next appointment was 8.6 days shorter than that of other patients (p < 0.05). Patients with YOPD had more pulsive walking and more sweating (p < 0.05), and more motor fluctuation (p < 0.1). More patients with YOPD had a physical disability certificate but felt they were not obtaining the required services (p < 0.05). 45.0% of the YOPD group wanted to work more, more used information and communication equipment (p < 0.05), and more felt their medications were adequate (p < 0.1).</p><p><strong>Conclusions: </strong>Increased awareness of YOPD is needed. YOPD patients have motor fluctuation because of the longer disease duration. Thus, the support of doctors and nurses, and frequent examination visits, are indispensable for controlling symptoms to achieve middle age developmental tasks. Increased support for care-giving, leisure-time activities, and work is also necessary and may help maintain the desire to work in this group.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"64 5","pages":"E180-E188"},"PeriodicalIF":0.0,"publicationDate":"2019-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668587/pdf/kobej-64-e180.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37318856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Questionnaire Survey for Bronchial Asthma in Elderly Care Facilities.","authors":"Haruko Shinke,&nbsp;Hiroshi Kamiryo,&nbsp;Kanoko Umezawa,&nbsp;Suya Hori,&nbsp;Kyosuke Nakata,&nbsp;Tatsuya Nagano,&nbsp;Nobuko Hazeki,&nbsp;Kazuyuki Kobayashi,&nbsp;Takashi Fukabori,&nbsp;Yoshihiro Nishimura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In developed countries such as North America, the decline in mortality from bronchial asthma has ceased since 2006. The decline in mortality rate is also decreasing in Japan, where about 1,500 asthma deaths have been reported. Among these, elderly people aged 65 years or over account for about 90% of cases. Therefore, the treatment of elderly patients with asthma is an important subject. However, few studies have been conducted on asthma in elderly patients. In this survey, we distributed a questionnaire to 253 elderly care facilities in Kobe, Japan. Ninety facilities responded, and 223 patients in 70 out of 90 facilities were diagnosed with asthma. Dry powder inhaler was the most commonly used dosage form of inhaled corticosteroids. Many facilities have patients who need some assistance during inhalation: only 60% of facilities reported that inhalation is performed accurately. While 31 facilities had patients with a history of hospitalization for asthma attacks, only 14 of these facilities were able to provide appropriate initial treatment. Many facilities have difficulty providing assistance with inhalation to elderly patients whose cognitive function has deteriorated. This survey highlights challenges experienced by care facilities in treating asthma in the elderly.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"64 5","pages":"E174-E179"},"PeriodicalIF":0.0,"publicationDate":"2019-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668589/pdf/kobej-64-e174.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37157031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional and Behavioral Problems of Pre-school Children with Autistic Spectrum Disorder Assessed by the Child Behavior Checklist 1½-5.","authors":"Irwanto,&nbsp;Muhamad Kahfi,&nbsp;Nining Febriyana,&nbsp;Sri Hartini,&nbsp;Satoshi Takada","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Children with Autism Spectrum Disorder (ASD) experience a significant disruption in the ability to communicate and interact socially. Early detection is important; the earlier the child is identified with ASD, the faster the intervention can begin. The Child Behavior Checklist (CBCL) is a screening tool capable of identifying various emotional and behavioral disorders. Research data on the use of the CBCL as a screening tool for ASD are still limited in Indonesia. The present study aimed to evaluate the CBCL's ability to detect emotional and behavioral problems in pre-school children with ASD.</p><p><strong>Methods: </strong>A cross sectional study was conducted in Surabaya, Indonesia. Children aged 1½-5 years old diagnosed with ASD, and typically developing (TD) children were enrolled using total sampling. The CBCL/1½-5 questionnaire for parents, consisting of 99 items, was used in this research to evaluate emotional and behavioral problems. Data were analyzed with the Independent-Sample T-test to compare the CBCL/1½-5 scale between ASD and TD children, while the proportion of gender was evaluated by a chi-square test with a 95% confidence interval.</p><p><strong>Results: </strong>Fifty children were included in this research, 25 with ASD and 25 TD. Seventy six percent (38) were male and 24% (12) were female. Six of the seven scales were significantly higher in ASD children than TD in the CBCL/1½-5. Children with ASD had higher internalization (p < 0.0001), externalization (p = 0.001), and total problem scores (p < 0.0001) when compared to TD children.</p><p><strong>Conclusion: </strong>The CBCL/1½-5 can significantly detect the emotional and behavioral problems in pre-school children with ASD.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"64 5","pages":"E170-E173"},"PeriodicalIF":0.0,"publicationDate":"2019-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668586/pdf/kobej-64-e170.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37157030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mothers'Breastfeeding-Related Durations and Nursing Management During the Early Postpartum Period in a Mixed Hospital Ward with an Obstetrics Department: A Prospective Observational Study.","authors":"Yukiko Mitsui,&nbsp;Izumi Saito","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to quantify duration of in-hospital breastfeeding (BF)-related activities in mothers after childbirth in a mixed ward-type hospital with an obstetrics department in Japan (hereafter, mixed ward).</p><p><strong>Methods: </strong>Twenty-two postpartum mothers (primiparous and multiparous) who had vaginal delivery in a mixed ward were instructed to wear radio beacons. A smartphone was placed in the BF room and detected the presence of a nearby beacon, 24 hours daily, measuring the number of hours a mother spent in the nursing room (defined as BF time [hereafter, BF-related duration]). BF-related duration included time spent for BF, diaper changes before and after BF, bottle feeding, and support from nurses. BF-related total hours during postpartum hospitalization were calculated. The effects of parity and each postpartum day number (postpartum days 1-4) on Daily BF-related duration were determined.</p><p><strong>Results: </strong>Percentage of total postpartum hospitalization time spent for BF-related duration was 21.6% and 19.9% for primiparous and multiparous mothers, respectively, with no significant difference between groups. BF-related duration was significantly different between parity group and postpartum day, with peaks on postpartum day 4 (387.7 minutes) and day 2 (318.0 minutes) for primiparous and multiparous groups, respectively. (F = 2.813, p = 0.048).</p><p><strong>Conclusion: </strong>Mothers spent 20% of their postpartum hospitalization period for BF-related activities. Individual support is necessary, especially for primiparous mothers, who spent more time than multiparous mothers for BF-related activities on postpartum day 4. In a mixed ward, postpartum mothers need a comfortable hospital environment in which midwives can dedicate themselves to mother-child dyad care.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"64 5","pages":"E160-E169"},"PeriodicalIF":0.0,"publicationDate":"2019-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668590/pdf/kobej-64-e160.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37157029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal Primary Small Bowel Volvulus Associated with Acute Gastric Dilatation Detected by Ultrasonography.","authors":"Sachiyo Fukushima,&nbsp;Kazumichi Fujioka,&nbsp;Mariko Ashina,&nbsp;Shohei Ohyama,&nbsp;Toshihiko Ikuta,&nbsp;Kosuke Nishida,&nbsp;Harunori Miyauchi,&nbsp;Yuichi Okata,&nbsp;Yuko Bitoh,&nbsp;Kenji Tanimura,&nbsp;Masashi Deguchi,&nbsp;Hideto Yamada,&nbsp;Kazumoto Iijima","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fetal intestinal volvulus is a rare condition, and fetal diagnosis of this disease is still challenging, especially in primary cases not accompanied by other comorbidities, such as intestinal malformations. Herein, we report a case of fetal primary small bowel volvulus associated with acute gastric dilatation detected by ultrasonography. We speculate that the mechanism of acute gastric dilatation in our case was peristatic malfunction of the whole intestine caused by a strangulated ileus resulting from fetal intestinal volvulus. In conclusion, acute gastric dilatation detected by fetal ultrasound can indicate the fetal intestinal volvulus.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"64 4","pages":"E157-E159"},"PeriodicalIF":0.0,"publicationDate":"2019-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347041/pdf/kobej-64-e157.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36925685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric Measurements of the Hip Bone in Turkish Adult Population.","authors":"Mehmet Demir,&nbsp;Emre Atay,&nbsp;Bülent Güneri,&nbsp;Halil Yilmaz,&nbsp;Muhammed Furkan Arpaci,&nbsp;Hatice Susar Güler,&nbsp;Özge Al,&nbsp;Tolga Ertekin,&nbsp;Mehtap Nisari,&nbsp;Erdoğan Unur","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Coxal bone paticipates in the formation of the pelvic skeleton. Anatomy knowledge on coxafemoral joint as well as careful history taking and physical examination are crucial in evaluation and management of disorders involving hip joint. The aims of the present study were to perform morphometric measurements of the human coxal bones, calculation of their articular surface areas and report the range of these parameters regarding Turkish adult population.</p><p><strong>Methods: </strong>Seventy-two dry human adult coxal bones (39 left and 33 right) from the Anatomy Departments of Erciyes University, Inonu University and Kahramanmaras Sutcu Imam University were measured using a caliper sensitive to 0.1 mm. Morphometric measurements were performed through 22 parameters determined. While 19 of these parameters were related to the distance between two points and thicknesses in various parts of the bone, the remaining three were related to the determination of articular surface areas. The articular surface areas of hip bone (facies auricularis (FA), facies lunata (FL) and facies symphsialis (FS)) were calculated with ImageJ software program.</p><p><strong>Results: </strong>The average values of facies auricularis area were 1659.04 ± 470.92 mm² and 1637.32 ± 460.15 mm² on the left and right coxal bones, respectively. No statistically significant difference was determined between the left and right coxal bone measurements (p > 0.05). We found a positive and significant correlation between articular surface areas of facies auricularis (FA), facies lunata (FL) and facies symphysialis (FS) and maximum width of ilium (rFA = 0.299, rFL = 0.276, rFS = 0.375, respectively and p < 0.05), and distance between spina ilica anterior superior and the upper edge of facies symphysialis (rFA = 0.268, rFL = 0.511, rFS = 0.482, respectively and p < 0.05).</p><p><strong>Conclusion: </strong>The distribution and mean values of coxal bone morphometric measurements usually differ between individuals and human populations. With this regard, orthopedic surgeons should be aware of the diversity in components of coxal bone dimensions although implants and hip prosthesis components of different sizes are manufactured. Safe routes and estimated distances should be considered during surgical procedures to avoid complications.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"64 4","pages":"E149-E156"},"PeriodicalIF":0.0,"publicationDate":"2018-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347039/pdf/kobej-64-e149.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36926277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}