Kobe Journal of Medical Sciences最新文献

{"title":"PARP3 Promotes SARS-CoV-2 Replication via Interaction with the Viral Nucleocapsid Protein.","authors":"Dewa Nyoman Murti Adyaksa, Aulia Fitri Rhamadianti, Lin Deng, Takayuki Abe, Chieko Matsui, Ikuo Shoji","doi":"10.24546/0100505590","DOIUrl":"10.24546/0100505590","url":null,"abstract":"<p><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exploits host cellular machinery to support its replication. Members of the host poly(ADP-ribose) polymerase (PARP) family regulate the DNA damage response and have been implicated in both antiviral and proviral processes. In this study, we investigated the potential role of PARP3 in SARS-CoV-2 replication in VeroE6/Rep3 cells. siRNA-mediated knockdown of PARP3 reduced viral subgenomic RNA (sgRNA) levels and reporter activity, whereas PARP3 overexpression enhanced these processes, suggesting that PARP3 promotes SARS-CoV-2 replication. In addition, PARP3 expression was increased in SARS-CoV-2-infected Calu-3 cells and in cells expressing SARS-CoV-2 nucleocapsid protein, suggesting that the nucleocapsid protein contributes to PARP3 upregulation during infection. Co-immunoprecipitation and immunofluorescence analyses revealed that PARP3 associates with the nucleocapsid protein and redistributes to the cytoplasm in nucleocapsid-expressing cells. Screening of a PARP inhibitor library identified venadaparib as a compound that reduced SARS-CoV-2 sgRNA levels and reporter activity in VeroE6/Rep3 cells with limited cytotoxicity under the condition tested. We further found that venadaparib reduced the interaction between PARP3 and the nucleocapsid protein. Molecular docking analysis further suggested that venadaparib can bind to the PARP3 catalytic domain. Collectively, these findings support a model in which PARP3 facilitates SARS-CoV-2 replication through its interaction with the viral nucleocapsid protein and suggest that venadaparib warrants further evaluation as a host-directed antiviral candidate.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"72 2","pages":"E105-E116"},"PeriodicalIF":0.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HBx Enhances the Nrf2/ARE-dependent Antioxidant Response by Promoting Nuclear Export and Downregulation of Bach1.","authors":"Muchamad Ridotu Solichin, Lin Deng, Hifdza Faza Felisha, Yeshua Putra Krisnugraha, Dewa Nyoman Murti Adyaksa, Auliana Hayu Kusumastuti, Safira Madaniyah, Chieko Matsui, Ikuo Shoji","doi":"10.24546/0100505589","DOIUrl":"10.24546/0100505589","url":null,"abstract":"<p><p>Hepatitis B virus (HBV) infection disrupts redox homeostasis in hepatocytes and is associated with the development of liver diseases. We previously reported that HBV activates the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway, a major cellular defense mechanism against oxidative stress. However, it remains unclear whether Bach1, a transcriptional repressor that antagonizes Nrf2, is involved in the HBV-induced activation of Nrf2/ARE pathway. In this study, we aimed to elucidate how HBV affects Bach1 expression and subcellular localization and how these changes contribute to activation of the Nrf2/ARE signaling pathway. ARE reporter assays revealed that Bach1 knockdown significantly enhanced HBx‑induced ARE activity, whereas Bach1 overexpression markedly attenuated it, indicating that Bach1 suppresses the HBx‑mediated antioxidant response. HBV infection and HBx expression reduced endogenous Bach1 protein levels without affecting Bach1 mRNA levels, suggesting post-transcriptional downregulation. Immunofluorescence and subcellular fractionation suggested that HBx contributes to HBV-induced Bach1 nuclear export. Co‑immunoprecipitation and immunofluorescence staining further demonstrated that HBx interacts with Bach1 in both the nucleus and cytoplasm. Notably, HBV infection upregulated the expression of NQO1, an Nrf2 target gene that was previously reported to contribute to HBx stabilization. In addition, Bach1 knockdown increased NQO1 and HBx protein levels. These findings suggest that Bach1 exerts an antiviral function by limiting Nrf2/ARE pathway activation and consequently restricting HBx stabilization. Collectively, our results suggest that HBx promotes nuclear export and downregulation of Bach1, thereby shifting the redox regulatory balance toward Nrf2 dominance, enhancing NQO1 expression, and stabilizing HBx protein.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"72 2","pages":"E89-E104"},"PeriodicalIF":0.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Implementation Model for Oncofertility Support in a Regional Cancer Center without an In-House Reproductive Medicine Unit.","authors":"Maho Azumi, Eri Okamoto, Akiko Uchida, Masahide Shiotani, Yoshito Terai","doi":"10.24546/0100505581","DOIUrl":"10.24546/0100505581","url":null,"abstract":"<p><strong>Purpose: </strong>Fertility loss related to cancer treatment can significantly affect quality of life among pediatric, adolescent, and young adult patients. Many regional cancer centers lack an in-house reproductive medicine unit, which creates barriers to timely fertility preservation (FP). To address this gap, our hospital established a multidisciplinary Oncofertility Working Group in collaboration with nearby reproductive centers. This study evaluated referral activities and outcomes after working group establishment and aimed to propose a feasible FP support implementation model for cancer centers without reproductive medicine units.</p><p><strong>Methods: </strong>We developed a standardized referral pathway and consultation checklist sheet in collaboration with a primary external reproductive center. We retrospectively analyzed consecutive patients referred for FP using consultation checklist sheets and medical records. Questionnaire surveys were conducted at working group launch and 4 years later to assess institutional changes.</p><p><strong>Results: </strong>Between April 2022 and September 2025, 45 patients (24 female and 21 male) were referred for FP. The median interval from referral to reproductive consultation was 2 days. FP was performed in 70.8% of female patients and 95.2% of male patients. Survey results showed a shift from department-dependent practices to a standardized referral system.</p><p><strong>Conclusion: </strong>Even in a regional cancer treatment cooperation base hospital without an in-house reproductive medicine unit, multidisciplinary coordination and structured external collaboration can deliver timely and practical FP support. This implementation model may help reduce regional disparities in oncofertility care, although further work should strengthen information sharing and long-term follow-up.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"72 2","pages":"E64-E76"},"PeriodicalIF":0.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct Tumor Suppression by Anti-Basigin Antibody and Enhancement of Macrophage-Mediated Cancer Cell Phagocytosis under SIRPα Blockade.","authors":"Yiyan Yang, Tomoko Takai, Naoya Hatano, Yoji Murata, Takashi Matozaki, Yoshimasa Maniwa, Takenori Kotani","doi":"10.24546/0100505582","DOIUrl":"10.24546/0100505582","url":null,"abstract":"<p><p>The transmembrane protein CD47 expressed on tumor cells suppresses Fcγ receptor-mediated antibody-dependent cellular phagocytosis (ADCP) through its interaction with signal regulatory protein α (SIRPα), a transmembrane protein expressed on phagocytic cells such as macrophages. Although blockade of the CD47-SIRPα interaction enhances the efficacy of tumor-targeting antibodies such as rituximab, its antitumor activity remains limited in cancers lacking defined tumor-associated antigens. In this study, we identified the membrane protein Basigin and SIRPα as broadly applicable therapeutic targets for cancer. We found that the 8H4 antibody, originally identified in the course of other research, recognized mouse Basigin, suppressed proliferation of diverse cancer cell types, and induced cancer cell death. Treatment with the 8H4 antibody indeed inhibited tumor growth in vivo. Moreover, combined treatment with the 8H4 antibody and an anti-SIRPα antibody that blocks the CD47-SIRPα interaction markedly enhanced macrophage-mediated ADCP against diverse cancer cell types in vitro. These results suggest that targeting Basigin, particularly in combination with SIRPα blockade, may provide a basis for the development of macrophage-mediated immunotherapies applicable to cancers in which tumor-associated antigens have not yet been identified.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"72 2","pages":"E77-E88"},"PeriodicalIF":0.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Rocuronium on Ischemia-reperfusion Injury and Intracellular ATP Consumption: A Randomized Controlled Trial.","authors":"Shinya Taguchi, Shohei Makino, Norihiko Obata, Satoshi Mizobuchi","doi":"10.24546/0100504858","DOIUrl":"10.24546/0100504858","url":null,"abstract":"<p><strong>Background: </strong>Muscle relaxants reduce \"total\" oxygen consumption, and 1.2 mg/kg of rocuronium has been shown to attenuate ischemia-reperfusion injury (IRI). Therefore, we herein investigated whether 0.9 mg/kg of rocuronium reduced \"local\" oxygen consumption and IRI indirectly by measuring changes in hypoxanthine (HPX), an indicator of intracellular adenosine triphosphate (ATP) consumption, and malondialdehyde (MDA), an indicator of IRI, respectively.</p><p><strong>Methods: </strong>This study was designed as a randomized controlled trial. Female patients aged 50-79 years old who were scheduled for elective knee arthroplasty under general anesthesia were recruited. After the collection of pre-ischemia blood samples, 0.9 mg/kg of rocuronium was administered to patients in group R and a placebo to those in group C 3 minutes before tourniquet inflation. Five minutes after tourniquet deflation, post-ischemia blood samples were collected. The primary outcome was the change in the concentration of MDA (Δ MDA) after ischemia.</p><p><strong>Results: </strong>Medians [interquartile ranges] for Δ MDA (μmol/L) in group R (n = 19) and group C (n = 18) were -0.47 [-1.25 to 0.13] and -0.58 [-0.67 to -0.28], respectively, with no significant difference (<i>p</i> = 0.796). Means ± standard deviations for Δ HPX (μmol/L) were 1.09 ± 0.70 and 1.71 ± 1.09 in groups R and C, respectively, and the difference between the groups was significant (<i>p</i> = 0.046).</p><p><strong>Conclusions: </strong>We were unable to confirm that 0.9 mg/kg of rocuronium attenuates IRI or postoperative quadriceps muscle weakness. While the present results suggest that rocuronium reduced intracellular ATP consumption, no clinically beneficial effects were observed.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"72 2","pages":"E52-E63"},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148473204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home Visits by Mother-Child Nurses to Concerned Mothers and Infants in Japan: Characteristics of Mothers and Infants Who Receive Continued Support.","authors":"Naoko Kawashita, Misa Shiomi, Rie Ikeda, Shinobu Nomachi, Yuka Okazaki, Akio Yamamoto, Hisako Izumi","doi":"10.24546/0100504448","DOIUrl":"10.24546/0100504448","url":null,"abstract":"<p><strong>Background: </strong>In Japan, postnatal care is delivered through follow-up home visits conducted by mother-child nurses in the community employed by local governments. During these visits, the nurses are responsible for promptly assessing the family's circumstances and mother's mental health and determining appropriate directions for ongoing support. This study aimed to determine the characteristics of mothers and children assessed by mother-child nurses in the community as needing ongoing support.</p><p><strong>Methods: </strong>In this qualitative study, participants were enrolled through convenience sampling. In total, 17 mother-child nurses in the community working at three Japanese local government health centres were surveyed through focus group interviews.</p><p><strong>Results: </strong>The characteristics of mothers and children requiring ongoing support generated 11 categories and 49 subcategories, which were organised into the following six classifications: physical factors of the mother, psychological and emotional factors, socioeconomic factors, social support factors, behavioural factors and physical factors of the child.</p><p><strong>Discussion: </strong>This study revealed that mother-child nurses in the community conducted comprehensive assessments of mothers and children. Understanding their multifaceted characteristics aids in early abuse detection, postpartum depression prevention and maternal mental health promotion. The findings reveal the importance of providing seamless support for mothers and infants, offering valuable insights for mother-child nurses in the community to consider in their care practices.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"72 1","pages":"E38-E51"},"PeriodicalIF":0.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Effect of TTF-1 Expression and Histopathology in the Patients with Advanced Lung Adenocarcinoma Treated with Immunochemotherapy.","authors":"Natsuhiko Iwamoto, Jun Yamada, Naoe Jimbo, Nanami Yamasaki, Yukihisa Hatakeyama, Tatsunori Kiriu, Kanoko Matsumura, Masahiro Katsurada, Keiko Okuno, Kyosuke Nakata, Motoko Tachihara","doi":"10.24546/0100504444","DOIUrl":"10.24546/0100504444","url":null,"abstract":"<p><strong>Objectives: </strong>The International Association for the Study of Lung Cancer (IASLC) proposed a grading system based on predominant histologic subtypes and reflecting prognosis. We previously reported that thyroid transcription factor-1 (TTF-1) expression levels and tumor cell proportion are useful predictors of immunochemotherapy for lung adenocarcinoma. Building upon our previous findings that TTF-1 negativity was associated with poorer outcomes in patients receiving immunochemotherapy, this study further investigated the relationship between TTF-1 expression and IASLC histologic subtypes, and analyzed progression-free survival (PFS) according to TTF-1 expression within each histologic subtype.</p><p><strong>Materials and methods: </strong>We used the same multicenter retrospective dataset as in our previous study, which was conducted between January 2019 and May 2023. TTF-1 was considered positive as a predictive factor of immunochemotherapy when staining showed high TTF-1 expression. The association between TTF-1 expression, histologic subtype, and mucus-producing components was evaluated.</p><p><strong>Results: </strong>Among 95 patients, the positivity rate for TTF-1 was 61.1%. The negative rate of TTF-1 in mucus-producing adenocarcinomas was significantly higher than that in non-mucus-producing adenocarcinomas (18/29 [62.1%] vs. 18/63 [28.6%]; p < 0.01). As per the analysis of IASLC grade 3, the median PFS of TTF-1 negative patients was significantly worse than that of positive patients (6.0 vs. 7.6 months, p = 0.035). Among patients with solid predominant patterns, the median PFS was significantly worse in the patients with TTF-1 negative than positive (5.2 vs. 8.5 months, p = 0.014).</p><p><strong>Conclusion: </strong>This study shows that the combination of histopathology and TTF-1 expression is a predictive factor in patients treated with combined immunochemotherapy.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"72 1","pages":"E20-E28"},"PeriodicalIF":0.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric Nutritional Risk Index Predicts Prognosis of Elderly Gastric Cancer Patients After Non-Curative Endoscopic Treatment.","authors":"Hitoshi Harada, Shingo Kanaji, Yutaka Sugita, Taro Ikeda, Yasufumi Koterazawa, Tomoaki Aoki, Yasunori Otowa, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Toshitatsu Takao, Masashi Yamamoto, Kimihiro Yamashita, Takeru Matsuda, Yuzo Kodama, Yoshihiro Kakeji","doi":"10.24546/0100504447","DOIUrl":"10.24546/0100504447","url":null,"abstract":"<p><p>Additional gastrectomy is usually performed after endoscopic submucosal dissection (ESD) for early gastric cancer diagnosed as \"non-curative\" according to the Japanese guidelines. However, the prognostic benefit of additional gastrectomy for the elderly with non-curative ESD is still debatable. The Geriatric Nutritional Risk Index (GNRI) is known as a prognostic value in elderly patients. This study aimed to clarify the advantages of GNRI as a prognostic indicator for elderly gastric cancer patients with non-curative ESD. A total of 120 elderly patients who underwent ESD for gastric cancer and diagnosed as non-curative resection according to the Japanese guidelines were retrospectively selected from the database of the Kobe University Hospital between January 2008 and March 2020. Their general condition, risk of lymph node metastasis, and nutritional status were evaluated retrospectively, and prognostic analysis was performed. After non-curative ESD, 48 patients underwent additional gastrectomy with lymph node dissection, and 72 patients were followed up with no additional treatment. In the follow-up group, patients with a high risk of lymph node metastasis had a significantly poorer prognosis. However, in the prognostic analysis of 120 cases, additional gastrectomy or follow-up were not independent prognostic factors. In the analysis of the additional gastrectomy group only, major nutrition-related risk of postoperative GNRI was an independent prognostic factor (95% CI: 0.01-0.25, P < 0.001). In elderly, the GNRI may be helpful as a prognostic indicator. Especially for elderly patients with poor nutritional status, additional gastrectomy might be considered only in cases of high risk of recurrence after non-curative ESD.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"72 1","pages":"E29-E37"},"PeriodicalIF":0.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Laparotomy and Percutaneous Intraperitoneal Lavage on Survival in a Cecal Slurry Peritonitis Model in Preterm Mice.","authors":"Yoshitomo Samejima, Shohei Yoshimura, Harunori Miyauchi, Yuichi Okata, Yuko Bitoh","doi":"10.24546/0100504291","DOIUrl":"10.24546/0100504291","url":null,"abstract":"<p><p>We aimed to compare survival rates in a 4-day-old mouse model of cecal slurry (CS)-induced bacterial peritonitis managed by laparotomy (LAP) or percutaneous peritoneal lavage (PPL). Four-day-old pups received intraperitoneal injections of CS to induce severe (3.0 g/gBW) or mild (1.0 g/gBW) peritonitis. Two hours later, pups underwent either LAP or PPL. Seven-day survival rates, perioperative body temperature (BT) changes, and postoperative ascites and plasma cytokine levels were assessed. In the severe peritonitis group, the 7-day survival rate tended to be higher in pups who underwent PPL than in those who underwent LAP (36.4% vs. 9.1%, <i>p</i> = 0.069). In the mild peritonitis group, survival rates were similar between treatments (83.3% vs. 72.7%, <i>p</i> = 0.53). The median perioperative BT change was significantly smaller in pups who underwent PPL for both the severe (-1.2℃ vs. -2.6℃, <i>p</i> < 0.01) and mild (-0.2℃ vs. -2.9℃, <i>p</i> < 0.01) peritonitis groups. Postoperative tumor necrosis factor levels were significantly lower in the PPL group compared with the LAP group under mild peritonitis (202 pg/ml vs. 443 pg/ml, <i>p</i> = 0.034). We established a novel 4-day-old PPL mouse model and identified PPL as a potential minimally invasive alternative that might help prevent perioperative hypothermia in the fatal peritonitis.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"72 1","pages":"E12-E19"},"PeriodicalIF":0.0,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transitional Care Support for Patients with Heart Failure: A Qualitative Study of Nursing Practices by Ward, Discharge Planning, and Visiting Nurses.","authors":"Miho Takahashi, Chiemi Taru, Atsuko Fukuda, Ikuko Miyawaki","doi":"10.24546/0100503457","DOIUrl":"10.24546/0100503457","url":null,"abstract":"<p><strong>Aim: </strong>This study explores the nursing practices of transitional care support for patients with heart failure performed by three different groups of nurses: 1) ward, 2) discharge planning, and 3) visiting nurses.</p><p><strong>Design: </strong>We conducted a qualitative, content analysis.</p><p><strong>Methods: </strong>Twelve ward nurses, four discharge planning nurses, and five visiting nurses were purposively sampled. Data were collected through semi-structured interviews and analyzed using content analysis.</p><p><strong>Results: </strong>Ward nurses implemented four practices, including \"Encourage patients to improve to prevent re-exacerbations\" and \"Share information with the home care team.\" Discharge planning nurses implemented four practices, including \"Communicate with the home care team to ensure the continued management of heart failure.\" Visiting nurses implemented three practices, including \"Make efforts to obtain test results and, based on physical signs, symptoms, and the pathological condition, detect signs of heart failure exacerbation.\"</p><p><strong>Conclusion: </strong>In transitional care support for patients with heart failure, the three different groups of nurses (ward, discharge planning, and visiting) must multilaterally share information on patients' pathological conditions, the progression of test results, and physical reactions during activities, while continuing to provide support for lifestyle adjustments.</p>","PeriodicalId":39560,"journal":{"name":"Kobe Journal of Medical Sciences","volume":"71 4","pages":"E154-E167"},"PeriodicalIF":0.0,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}