Proceedings of the 8th World Congress on New Technologies最新文献_第7页

The Effect of Age on Gene Therapy Efficacy for RPE65 Leber’s Congenital Amaurosis: A Pooled Analysis 年龄对RPE65 Leber先天性黑朦基因治疗疗效的影响:一项汇总分析

Proceedings of the 8th World Congress on New Technologies Pub Date : 2022-08-01 DOI: 10.11159/icbb22.009

Megan Tian, S. Bhatia

{"title":"The Effect of Age on Gene Therapy Efficacy for RPE65 Leber’s Congenital Amaurosis: A Pooled Analysis","authors":"Megan Tian, S. Bhatia","doi":"10.11159/icbb22.009","DOIUrl":"https://doi.org/10.11159/icbb22.009","url":null,"abstract":"- Leber’s congenital amaurosis (LCA) is an inherited retinal disease that leads to severe vision loss from birth. Gene therapy for LCA caused by mutations in the RPE65 gene has been discovered to be a promising treatment, and one treatment (Luxturna) has received FDA approval. Within the current body of clinical trials, there is little consensus on whether age has any effect on treatment efficacy and outcomes. This pooled analysis aims to discern the effect of age on changes in visual function in patients undergoing adeno-associated virus mediated gene therapy for RPE65-LCA. The PubMed database was searched for papers describing the results of RPE65 gene therapy on patients with LCA, and data were pooled from 5 selected studies. Linear regression of age on percent change from baseline visual acuity in treated eyes was conducted on the pooled data from one, two, and three years post-treatment. Linear regression of age on change from baseline retinal thickness in treated eyes was conducted on the pooled data at one year post-treatment. At 1 year, a s tatistically significant linear regression equation of age versus visual acuity was found (α = 0.05, n = 78, F(1, 76) = 7.3152, p = 0.0084). At the same time point, a statistically significant linear regression equation of age versus change in r etinal thic kness was not found (α = 0.05, n = 50, F(1, 48) = 0.07756, p = 0.7818). Age appears to be a statistically significant predict or of improvements in visual acuity, but not of retinal degeneration. Younger age appears to be associated with greater improvements in vision. However, the age predictive effect is only visible in the first year after treatment, and may be attributed to the decline in long-term data availability. Future analysis using a larger sample size is needed to evaluate the effect after one year.","PeriodicalId":394576,"journal":{"name":"Proceedings of the 8th World Congress on New Technologies","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130199325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fog Capture and Its Potential Use Irrigation and Human Consumption, Lima - Peru 雾捕获及其潜在用途灌溉和人类消费，利马-秘鲁

Proceedings of the 8th World Congress on New Technologies Pub Date : 2022-08-01 DOI: 10.11159/icepr22.165

V. León, Alexi Delgado, Noemí Herrera, Kiara Aguirre, Estefany Valverde, Edson Palacios

{"title":"Fog Capture and Its Potential Use Irrigation and Human Consumption, Lima - Peru","authors":"V. León, Alexi Delgado, Noemí Herrera, Kiara Aguirre, Estefany Valverde, Edson Palacios","doi":"10.11159/icepr22.165","DOIUrl":"https://doi.org/10.11159/icepr22.165","url":null,"abstract":"– Fog catchers could be an alternative to make up for the lack of water in shanty towns, either for irrigation or human consumption. These have demonstrated average catchments of up to 9 l/m 2 /d generated during the winter, and technologies such as baked clay filters can treat any type of water showing high efficiency in the elimination of pathogens, metals and other contaminants. Therefore, the present investigation aimed (1) to determine the volume of water generated by 2 standard fog catchers, (2) to evaluate the quality of collected water with potential use in irrigation, and (3) to evaluate the quality of collected water treated by baked clay filters with potential use for human consumption. Results show that the maximum collected water volume for the two fog catchers are 17.1 l/m 2 /d and 21.1 l/m 2 /d respectively. Characterization of the directly captured fog water sample can be used in irrigation without restriction. Fog water captured and filtered through a clay filter meet maximum permissible limits for human consumption according to peruvian regulations, except for fluoride (1.50 mg F - /L) and pH (10). However, it’s suggested to treat the water with another alternative. Species recommended for shanty towns are Molle serrano ( Schinus molle ), Tara ( Caesalpinia spinosa ) and Tipa ( Tipuana tipu ) because they can adapt to extreme conditions of aridity and stress, and require low amounts of water.","PeriodicalId":394576,"journal":{"name":"Proceedings of the 8th World Congress on New Technologies","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125780930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The Non-Saponin Fraction Of Korean Red Ginseng Prevents Sarcopenia By Maintaining Immune Homeostasis In Old C57BL/6J Mice 红参非皂苷部位通过维持免疫稳态预防老年C57BL/6J小鼠肌少症

Proceedings of the 8th World Congress on New Technologies Pub Date : 2022-08-01 DOI: 10.11159/icbb22.001

Boo-Yong Lee, Hyun-ji Oh, Heegu Jin

{"title":"The Non-Saponin Fraction Of Korean Red Ginseng Prevents Sarcopenia By Maintaining Immune Homeostasis In Old C57BL/6J Mice","authors":"Boo-Yong Lee, Hyun-ji Oh, Heegu Jin","doi":"10.11159/icbb22.001","DOIUrl":"https://doi.org/10.11159/icbb22.001","url":null,"abstract":"Background The non-saponin fraction (NSF) of Korean red ginseng is a powder in which saponin is eliminated from red ginseng concentrate by fractionation. In this study, we investigated the effect of NSF on age-associated sarcopenia in old C57BL/6J mice. Young (3–6-month-old) and old (20–24-month-old) C57BL/6J mice were orally administered NSF (50 or 200 mg/kg/day) every day for 6 weeks. Throughout the oral treatment period, body weight and grip strength were assessed once a week. After sacrifice, hindlimb muscles were cut out and used for western blotting and hematoxylin and eosin staining to examine the impacts of NSF on sarcopenia and inflammation/oxidative stress. Flow cytometry analysis was conducted to investigate the effect of NSF on immune homeostasis. Blood samples were collected, and the serum levels of insulin-like growth factor 1, pro-inflammatory cytokines, and glutathione were measured. NSF significantly increased muscle strength, mass, and fiber size in old mice. NSF recovered age-associated disturbance of immune homeostasis by retaining CD11b+F4/80+ macrophages and regulating inflammatory biomarkers. NSF also inhibited the age-induced expression of oxidative stress factors. Thus, NSF diminished conventional low-grade chronic inflammatory/oxidative factors, which are the major source of sarcopenia. effects in aged C57BL/6J mice. NSF is a promising restorative agent that could be used to improve sarcopenia in the elderly.","PeriodicalId":394576,"journal":{"name":"Proceedings of the 8th World Congress on New Technologies","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132790528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Performance Nanogenerators for Energy Harvesting and Sensing Applications 用于能量收集和传感应用的高性能纳米发电机

Proceedings of the 8th World Congress on New Technologies Pub Date : 2022-08-01 DOI: 10.11159/icnfa22.003

Dayan Ban

{"title":"High Performance Nanogenerators for Energy Harvesting and Sensing Applications","authors":"Dayan Ban","doi":"10.11159/icnfa22.003","DOIUrl":"https://doi.org/10.11159/icnfa22.003","url":null,"abstract":"Nanogenerators convert ubiquitously-available mechanical energy to electrical energy and thus attracted tremendous interests in past 15 years. By exploring novel materials and device structures, the performance of nanogenerators have been improved significantly and the applications of nanogenerators have been extended to different areas. In this talk, I will present the latest progress in nanogenerator research in past few years, including piezoelectric nanogenerators (PENGs) based on one-dimensional (1D)/ two-dimensional (2D) hybrid zinc oxide nanostructures; PENGs based on selfassembled highly ordered porous perovskite/polyvinylidene fluoride (PVDF) composite films; devices employed 2D organic-inorganic hybrid perovskite nano-sheets with superior transverse piezoelectricity, to name a few. A highly integrated uniaxial tristate hybrid nanogenerator was also demonstrated by using Inorganic-organic perovskite/polymer nano-composite. A self-powered multi-broadcasting wireless sensing system was realized with an all-in-one triboelectric nanogenerator. A nanogenerator-based self-powered sensor with deep learning technique was developed for intelligent sound monitoring and identification.","PeriodicalId":394576,"journal":{"name":"Proceedings of the 8th World Congress on New Technologies","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131444949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promoting of Environmental Education via Outdoor Activities in Finland: Clean Games case 芬兰通过户外活动促进环境教育:清洁运动会案例

Proceedings of the 8th World Congress on New Technologies Pub Date : 2022-08-01 DOI: 10.11159/icepr22.167

T. Samarina, Anna Belenikhina, O. Laatikainen

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Analysis of the effectiveness of the system improving water quality in the WOPR facility 该系统改善WOPR设施水质的效果分析

Proceedings of the 8th World Congress on New Technologies Pub Date : 2022-08-01 DOI: 10.11159/icepr22.178

Bogna Buta, M. Wiatkowski, P. Tomczyk, Łukasz Gruss, Witold Skorulski

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A Glance at Biobased and Sustainable Aromatic Polymers for Coatings and Binders 涂料和粘合剂用生物基和可持续芳香族聚合物概述

Proceedings of the 8th World Congress on New Technologies Pub Date : 2022-08-01 DOI: 10.11159/icnfa22.001

S. Caillol

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Self-closing Micro-Cuff for Neural Recording in the Locust 用于蝗虫神经记录的自闭微袖带

Proceedings of the 8th World Congress on New Technologies Pub Date : 2022-08-01 DOI: 10.11159/icnf22.131

Hasti Sajedi, Navjot S. Randhawa, Dharam Parikh, H. Fotowat, F. Gabbiani, J. Wolfe

{"title":"Self-closing Micro-Cuff for Neural Recording in the Locust","authors":"Hasti Sajedi, Navjot S. Randhawa, Dharam Parikh, H. Fotowat, F. Gabbiani, J. Wolfe","doi":"10.11159/icnf22.131","DOIUrl":"https://doi.org/10.11159/icnf22.131","url":null,"abstract":"- We have developed a self-wrapping flexible cuff electrode for recording electrical activity on the descending contralateral movement detector (DCMD) neuron of the locust. First, a gold film is sputtered onto a monoaxially oriented polycarbonate membrane. Then, the resulting bilayer film is cut into individual strips parallel to the machine direction of the polycarbonate film. Thermally shrinking the polycarbonate at 155 0 C actuates the curl. This method can be used to fabricate controlled diameters between 50-250 µm; diameter is controlled by thickness of the two layers and the temperature and duration of the heat shrinking process. The cuffs are self-closing, and do not require suturing for attachment to a nerve. The cuffs are carefully unrolled, a gold film deposited, and a plasma-deposited, ion-sensitive resist applied. A stencil mask is then used to define the metallization lines by 50 kV He + ion beam proximity lithography. Ion milling transfers the resist pattern to the metal film. Conformality of the resist and large depth-of-field of the lithography are key to high resolution patterning on these non-flat substrates. The dielectric overcoat is a layer of exposed resist, which simplifies the opening of the contact windows, and provides excellent biocompatibility.","PeriodicalId":394576,"journal":{"name":"Proceedings of the 8th World Congress on New Technologies","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122228230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Environmental Impact Of An Informal Settlement On A Headwater Area At High-Risk Of Erosion In Brazil 非正式定居点对巴西水土流失高风险源头地区的环境影响

Proceedings of the 8th World Congress on New Technologies Pub Date : 2022-08-01 DOI: 10.11159/icepr22.141

Maria Thereza Fonseca, Samuel L. L. Silva2, J. Ferreira, R. Nunes, Hugo Paula, J. Cruz, A. Nunes, R. Santos, Juni Cordeiro, L. Saenz, E. Vieria, R. Coelho, M. Scotti

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Photochemical Characteristics of Radish (Raphanus sativus) Leaf Grown under Different Nitrogen (N) Fertilization 不同氮肥条件下萝卜叶片光化学特性的研究

Proceedings of the 8th World Congress on New Technologies Pub Date : 2022-08-01 DOI: 10.11159/icepr22.138

Tae-seon Eom, Seong-ju Lee, Ye-Bin Hwang, Tae Wan Kim

{"title":"Photochemical Characteristics of Radish (Raphanus sativus) Leaf Grown under Different Nitrogen (N) Fertilization","authors":"Tae-seon Eom, Seong-ju Lee, Ye-Bin Hwang, Tae Wan Kim","doi":"10.11159/icepr22.138","DOIUrl":"https://doi.org/10.11159/icepr22.138","url":null,"abstract":"Radish is a nutritionally balanced vegetable and has a short growing period, so it is cultivated all over the world. [1] Radish, one of the crops with a lot of fertilizer requires a greater amount of nitrogen (N) than phosphorus (P) and potassium (K) during the growing season. [2] Nitrogen is an essential element for plant growth, and it has a high chlorophyll content and productivity enhancement effect in the body, so proper fertilization is required for radish cultivation. [3] [4] In this study, growth health was evaluated by using radish growth investigation and photochemical reaction analysis by nitrogen fertilization level. Radish was cultivated from September to November 2021 at the farm affiliated with Hankyong University (Anseong-si, Gyeonggi-do). Nitrogen (urea) treatment was performed three times at 5 levels (0kg N ha-1, 117kg N ha-1, 234kg N ha-1, 468kg N ha-1, 968kg N ha-1) (basis, 1st fertilization, 2nd fertilization), and the control was based on 234kg N ha-1. Chlorophyll fluorescence analysis was measured after 30 minutes of dark treatment of leaves using Fluorpen FP-100 (PSI, Czech).","PeriodicalId":394576,"journal":{"name":"Proceedings of the 8th World Congress on New Technologies","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132046232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0