P Corral, A Lavalle Cobo, M F Arrupe, L Schreier, G Matta, N F Renna
{"title":"[Design and rationale: Observational Study of the Argentine Group for the Study of Lipoprotein (a)].","authors":"P Corral, A Lavalle Cobo, M F Arrupe, L Schreier, G Matta, N F Renna","doi":"10.1016/j.hipert.2024.07.005","DOIUrl":"https://doi.org/10.1016/j.hipert.2024.07.005","url":null,"abstract":"<p><strong>Introduction: </strong>Elevated levels of Lipoprotein(a) [Lp(a)] have been linked to increased cardiovascular risk globally. However, comprehensive studies on Lp(a) levels and their impact on cardiovascular health in Argentina are lacking. The Argentine Group for the Study of Lipoprotein (a) [GAELp(a)] aims to address this gap through an observational study designed to evaluate the prevalence and consequences of elevated Lp(a) levels in the Argentine population.</p><p><strong>Methods: </strong>The GAELp(a) study will recruit participants from diverse regions across Argentina. Eligible individuals will undergo comprehensive assessments, including demographic data collection, medical history review, and laboratory analyses to measure Lp(a) levels. The study will employ rigorous statistical analyses to explore the association between elevated Lp(a) levels and cardiovascular outcomes, considering potential confounding variables.</p><p><strong>Results: </strong>Anticipated outcomes of the GAELp(a) study include a detailed characterization of Lp(a) levels within the Argentine population and their correlation with cardiovascular diseases. By elucidating these relationships, the study aims to provide valuable insights into the prevalence and impact of elevated Lp(a) on cardiovascular health in Argentina.</p><p><strong>Conclusion: </strong>The GAELp(a) observational study holds promise for enhancing our understanding of Lp(a)-related cardiovascular risk in Argentina. Findings from this study may contribute to the development of targeted interventions, clinical guidelines, and public health policies aimed at reducing cardiovascular morbidity and mortality associated with elevated Lp(a) levels. Through collaborative efforts, the GAELp(a) study seeks to advance cardiovascular research and improve healthcare outcomes in Argentina.</p>","PeriodicalId":39403,"journal":{"name":"Hipertension y Riesgo Vascular","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efecto de diferentes bebidas alcohólicas sobre la presión arterial","authors":"","doi":"10.1016/j.hipert.2024.07.003","DOIUrl":"10.1016/j.hipert.2024.07.003","url":null,"abstract":"","PeriodicalId":39403,"journal":{"name":"Hipertension y Riesgo Vascular","volume":"41 4","pages":"Pages 270-271"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Delucchi, D. Fernández, M. Sorini, P. Reisin, M. Scarabino, P. Rodríguez
{"title":"Diferencia de presión arterial entre brazos: mediciones consecutivas versus simultáneas en pacientes hipertensos tratados y controlados","authors":"A. Delucchi, D. Fernández, M. Sorini, P. Reisin, M. Scarabino, P. Rodríguez","doi":"10.1016/j.hipert.2024.06.005","DOIUrl":"10.1016/j.hipert.2024.06.005","url":null,"abstract":"<div><div>The inter-arm difference (IAD) of systolic blood pressure (SBP) is associated with higher cardiovascular risk. We compared simultaneous and consecutive recordings in measuring IAD of SBP, and evaluated reproducibility between visits. 143 hypertensive patients (63.8<!--> <!-->±<!--> <!-->9.5 years, 51.7% women) treated and controlled with stable antihypertensive medication for a period of ≥<!--> <!-->3 months were included. Blood pressure (BP) in both arms was measured simultaneously and consecutively with an automatic oscillometric device, in two visits. The IAD of the simultaneous SBP was significantly lower compared to the consecutive one, both in the first (3.51<!--> <!-->±<!--> <!-->4.1 vs. 4.40<!--> <!-->±<!--> <!-->3.7<!--> <!-->mmHg; <em>P</em> <!--><<!--> <!-->.01) and in the second visit (3.62<!--> <!-->±<!--> <!-->3.5 vs. 5.69<!--> <!-->±<!--> <!-->5.1<!--> <!-->mmHg; <em>P</em> <!--><<!--> <!-->.001). When the IAD of SBP was categorized as ≥<!--> <!-->10 or <<!--> <!-->10<!--> <!-->mmHg, the reproducibility between visits was insignificant in both simultaneous measurements and consecutive measurements. The frequency of initial dominance was similar between the left and right arm in simultaneous ones (46.2 vs. 43.3%), and greater in the right arm in consecutive ones (55.2 vs. 38.5). The persistence of dominance between both visits was significantly higher when SBP was measured simultaneously (54.4% vs. 45.5%; <em>P</em> <!--><<!--> <!-->.01). Our study shows that to define the arm with the highest BP, simultaneous measurements are preferable. In treated and controlled hypertensive patients, the poor persistence of initial dominance between visits requires us to review the recommendation of recording, during follow-up, the BP in the arm where it was highest on the first visit.</div></div>","PeriodicalId":39403,"journal":{"name":"Hipertension y Riesgo Vascular","volume":"41 4","pages":"Pages 232-239"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M.J. Vallejo Herrera , V. Vallejo Herrera , V. Márquez Pérez , F. Serrano Puche , I. Vegas Vegas
{"title":"Feocromocitoma como simulador de patología cardiaca","authors":"M.J. Vallejo Herrera , V. Vallejo Herrera , V. Márquez Pérez , F. Serrano Puche , I. Vegas Vegas","doi":"10.1016/j.hipert.2024.04.006","DOIUrl":"10.1016/j.hipert.2024.04.006","url":null,"abstract":"<div><div>Pheochromocytomas are rare neuroendocrine tumors that can present as hypertensive crises or serious cardiac and cerebrovascular complications that endanger the patient's life.</div><div>Two unusual cases of adrenergic crises induced by pheochromocytoma with cardiovascular manifestations are presented, one with multiple complications/multiorgan failure, fatal outcome and definitive diagnosis in the <em>post mortem</em> autopsy, and another with a satisfactory evolution after diagnosis and appropriate treatment.</div></div>","PeriodicalId":39403,"journal":{"name":"Hipertension y Riesgo Vascular","volume":"41 4","pages":"Pages 260-263"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Calor nocturno e incidencia de ictus","authors":"","doi":"10.1016/j.hipert.2024.07.002","DOIUrl":"10.1016/j.hipert.2024.07.002","url":null,"abstract":"","PeriodicalId":39403,"journal":{"name":"Hipertension y Riesgo Vascular","volume":"41 4","pages":"Pages 268-269"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Alvarez , L. Peñailillo , P. Ibacache-Saavedra , D. Jerez-Mayorga , C. Campos-Jara , D.C. Andrade , G.V. Guimarães , E. Gomes-Ciolac , P. Delgado-Floody , M. Izquierdo , A.N. Gurovich
{"title":"Six weeks of a concurrent training therapy improves endothelial function and arterial stiffness in hypertensive adults with minimum non-responders","authors":"C. Alvarez , L. Peñailillo , P. Ibacache-Saavedra , D. Jerez-Mayorga , C. Campos-Jara , D.C. Andrade , G.V. Guimarães , E. Gomes-Ciolac , P. Delgado-Floody , M. Izquierdo , A.N. Gurovich","doi":"10.1016/j.hipert.2024.07.001","DOIUrl":"10.1016/j.hipert.2024.07.001","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to examine the effects of a six-week of concurrent training using high-intensity interval plus resistance training on flow-mediated dilation and pulse wave velocity in hypertensive, elevated blood pressure, or normotensive. A secondary goal was to analyze the inter-individual variability.</div></div><div><h3>Methods</h3><div>A randomized controlled clinical trial was executed with 60 adult participants distributed across six groups: three control groups of hypertensive, elevated blood pressure, or normotensive and other three experimental hypertensive, elevated blood pressure, and normotensive groups, each comprising <em>n</em> <!-->=<!--> <!-->10 individuals. Participants underwent a six-week intervention of concurrent exercise using high-intensity interval plus resistance training three-weekly. Flow mediated dilation and pulse wave velocity and secondary vascular assessments were conducted before and after the intervention.</div></div><div><h3>Results</h3><div>The hypertensive exercise group exhibited a significant increase in flow mediated dilation (<em>Δ</em>+7.7%; <em>p</em> <!-->=<!--> <!-->0.003) and a reduction in pulse wave velocity (<em>Δ</em>−1.2<!--> <!-->m<!--> <!-->s<sup>−1</sup>; <em>p</em> <!--><<!--> <!-->0.0001). The normotensive exercise group also showed a significant increase in flow mediated dilation (<em>Δ</em>+8.4%, <em>p</em> <!-->=<!--> <!-->0.002).</div></div><div><h3>Conclusion</h3><div>The six-week concurrent exercise using high-intensity interval plus resistance training protocol, characterized by its clinical time-efficiency, was effective in improving endothelial function, as demonstrated by increased flow mediated dilation, and in reducing arterial stiffness, indicated by decreased pulse wave velocity.</div></div>","PeriodicalId":39403,"journal":{"name":"Hipertension y Riesgo Vascular","volume":"41 4","pages":"Pages 240-250"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Dutta , V. Chaudhary , A.K. Gupta , K. Murti , S. Kumari , D. Dhir , S. Meenakshi , C. Ahuja , B. Sharma , B. Pal
{"title":"Prevalence of depression in hypertensive patients and its associated factors in India: A systematic review and meta-analysis","authors":"A. Dutta , V. Chaudhary , A.K. Gupta , K. Murti , S. Kumari , D. Dhir , S. Meenakshi , C. Ahuja , B. Sharma , B. Pal","doi":"10.1016/j.hipert.2024.05.003","DOIUrl":"10.1016/j.hipert.2024.05.003","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension is a prevalent health challenge in India, with a bidirectional link to depression. Recognizing the prevalence of depression among hypertensive patients and associated factors are important for better health outcomes.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in PubMed, Embase<span>, Scopus, and Google Scholar databases to identify relevant studies. R software was used for analysis, employing a random effects model with a 95% confidence interval. Subgroup analyses were done to explore sources of heterogeneity within the included studies.</span></div></div><div><h3>Results</h3><div>The prevalence of depression among hypertensive patients in India was 39.8% (95% CI: 28.6; 52.1). Despite a higher prevalence observed in South region (44.7%) compared to North (26.9%), the difference was not significant (<em>p</em> <!-->=<!--> <!-->0.39). Studies utilizing different assessment scales and varying sample sizes yielded similar prevalence. However, a temporal trend analysis indicated a higher prevalence in studies published between 2020 and 2023 (52.6%) compared to those published between 2016 and 2019 (35.5%) (<em>p</em> <!-->=<!--> <!-->0.03). Major factors associated with depression included lower socioeconomic status, low education level, female gender, uncontrolled hypertension, and COVID-19 related factors.</div></div><div><h3>Conclusions</h3><div>A significant proportion of hypertensive patients suffer from depression. Therefore, screening for depression in hypertensive patients is essential to improve hypertension management in India.</div></div>","PeriodicalId":39403,"journal":{"name":"Hipertension y Riesgo Vascular","volume":"41 4","pages":"Pages 217-225"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Álvarez-González , J. Espíldora-Hernández , M.A. Sánchez-Chaparro
{"title":"Más allá de la hipercoagulabilidad en la enfermedad celíaca","authors":"C. Álvarez-González , J. Espíldora-Hernández , M.A. Sánchez-Chaparro","doi":"10.1016/j.hipert.2024.06.002","DOIUrl":"10.1016/j.hipert.2024.06.002","url":null,"abstract":"<div><div>In celiac disease (CD) there is a state of hypercoagulability and multiple factors have been found that may be involved. Cases of association of CD and antiphospholipid síndrome (APS) have been described and several observational studies have found an increase in antiphospolipid antibodies (AAF) in patients with CD, so both entities may be interrelated, increasing the risk of thrombotic events. A descriptive case of a patient who is simultaneusly diagnosed with CD and APS is presented.</div></div>","PeriodicalId":39403,"journal":{"name":"Hipertension y Riesgo Vascular","volume":"41 4","pages":"Pages 264-267"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Martín-Enguix , J.C. Aguirre Rodríguez , M. Guisasola Cárdenas , M.N. Generoso Torres , A. Hidalgo Rodríguez , M. Sánchez Cambronero , A. González Bravo
{"title":"Prescripción de antihipertensivos en personas con diabetes tipo 2 en Andalucía y recomendaciones SEH-LELHA 2022: evaluación del coste y uso","authors":"D. Martín-Enguix , J.C. Aguirre Rodríguez , M. Guisasola Cárdenas , M.N. Generoso Torres , A. Hidalgo Rodríguez , M. Sánchez Cambronero , A. González Bravo","doi":"10.1016/j.hipert.2024.06.004","DOIUrl":"10.1016/j.hipert.2024.06.004","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to analyze the prescription of antihypertensive drugs in patients with type 2 diabetes (T2D) in Andalusia, comparing it with the SEH-LELHA 2022 guidelines, and to assess the direct cost of these treatments.</div></div><div><h3>Materials and methods</h3><div>A multicentric, cross-sectional, and descriptive study was conducted with 385 T2D patients. Participants were randomly selected from the patient lists of 120 primary care physicians from Andalusia. Inclusion criteria included a diagnosis of T2D and complete clinical records for the year 2022. Demographic data and drug prescription information were collected, with the average cost per patient being calculated.</div></div><div><h3>Results</h3><div>The mean age of the subjects was 70.72 years, with 53.51% being male. A total of 70.9% of the patients were taking antihypertensive drugs, the most common being ACE inhibitors/ARBs (70.9%), diuretics (70.1%), beta-blockers (40.0%), and calcium channel blockers (20.0%). Each patient took an average of 2.46<!--> <!-->±<!--> <!-->1.06 antihypertendsive, and fixed association of 2 or more antihypertensive drugs were used by 40.9% of the studied patients. The annual cost per patient was 141.45<!--> <!-->€/year.</div></div><div><h3>Conclusions</h3><div>The study reveals strong adherence to the SEH-LELHA 2022 guidelines among physicians in Andalusia regarding the of antihypertensives for T2D patients, with a significant preference for Renin-Angiotensin System blockers, diuretics, and beta-blockers. However, a notable deviation in prescription practices was observed with the frequent choice of doxazosin over spironolactone, despite the latter being the recommended option for resistant hypertension. Although the overall expenditure on antihypertensives is moderate, their cost-effectiveness is enhanced by the efficacy of these treatments in preventing cardiovascular complications.</div></div>","PeriodicalId":39403,"journal":{"name":"Hipertension y Riesgo Vascular","volume":"41 4","pages":"Pages 226-231"},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}