Medical Journal of Malaysia最新文献

{"title":"The mediating effect of mental health status between self-system and sexual risk behaviour among university students in Malaysia.","authors":"S M Azlan, F Mohamad, A I N Mohd Nazan, R Dahlan, K N Kamaruddin, N A Shibraumalisi, S N Syed Mohamad, I Z Ismail, H Kadir Shahar, N H Shamsuddin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Young adults' engagement in sexual risk behaviour (SRB) is a growing concern worldwide. Addressing this issue is crucial as it can lead to various detrimental effects on individuals, including psychological, behavioural, and, in severe cases, suicidal tendencies and mortality. This nationwide study aimed to determine the mediating roles of depressive, anxiety, and stress symptoms in the relationship between adverse childhood experiences (ACE), religiosity, knowledge on sexuality, attitude towards premarital sex, and SRB among young Malaysian adults using structural equation modelling (SEM).</p><p><strong>Materials and methods: </strong>A quantitative, cross-sectional design was employed in this study. Respondents were recruited from June to December 2021 among students attending higher education institutions in Malaysia. Institutions were sampled using stratified random sampling and the respondents were selected via convenience sampling. Data were collected via an online survey that inquired about respondents' socio-demographic characteristics, ACE, religiosity, knowledge on sexuality, attitude towards premarital sex, mental health status (MHS), and engagement in SRB. The data were analysed using SPSS version 27 for descriptive analysis, and SPSS AMOS version 27 for structural equation modelling (SEM) analysis.</p><p><strong>Results: </strong>A total of 1171 respondents were recruited in this study. From the SEM analysis, the proposed model indicated a good fit, and it explained 26% of the SRB variance. There was a partial mediation effect of the relationship between ACE on SRB through MHS (p<0.05), as well as religiosity on SRB through MHS (p<0.05). There was no significant mediation effect was found for the other variables.</p><p><strong>Conclusion: </strong>This study highlighted the mediation effect of MHS between ACE on SRB, as well as between religiosity and SRB. Apart from addressing ACE and religiosity of the young adults, MHS should also need to be explored when dealing with SRB issues and vice versa. Preventive measures should be considered at younger stage to prevent high risk behaviour among young adults.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":"80 2","pages":"183-190"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between statin use and depression among diabetic patients in Seremban: a cross-sectional study.","authors":"S V Pannir, Z F Zakaria, K V Surendren, Y S Kok, Q L Phua, Q H Roslan, R H Singh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Statins are one of the most commonly used drugs in primary care. Both hyperlipidaemia and diabetes have independently shown statistically significant association with depression. Conversely, patients with depression have also been shown to have increased comorbidity with and poorer control of both diabetes and hyperlipidaemia.</p><p><strong>Materials and methods: </strong>A retrospective cross-sectional study was conducted for about 7 months (from 23 January 2024 to 9 August 2024) among adult Type 2 diabetic patients in the non-communicable disease section of Seremban Health Clinic to determine the association between statin use and depression. The data was collected via interviewerguided questionnaire that consisted of 5 sections: Section A (Participant Information), Section B (Depression, Anxiety and Stress Scale 21 [DASS-21]), Section C (Beliefs about Medicines Questionnaire [BMQ]), Section D (Malaysia Medication Adherence Assessment Tool [MyMAAT]) and Section E (Patient Health Questionnaire-9 [PHQ-9]). Consecutive patients that met inclusion and exclusion criteria who consent to be involved in the study were sampled. Although the ideal sample size that was required is 242, only 82 participants were enrolled in this study. These participants were also part of the Seremban Diabetes cohort study.</p><p><strong>Results: </strong>Since only 82 participants consented to be part of this study, the response rate was 33.9%. About 25% of patients had depression. As the statin dosage intensity increased, the prevalence of depression also increased but this was not statistically significant. Based on Pearson's chi square test, only stress (p<0.001), anxiety (p=0.002), beliefs about medicines (p=0.010) and marital status (p=0.039) had a statistically significant association with depression. Upon adjusted logistic regression of the 4 factors (marital status, stress, anxiety and belief about medicines), only stress (OR 14.000, 95% CI 2.682 - 73.076, p=0.002) was statistically significant.</p><p><strong>Conclusion: </strong>The association between depression and statin use among patients with Type 2 diabetes mellitus is not statistically significant. Further studies are needed to confirm the cause of depression in this group of patients.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":"80 2","pages":"191-198"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of computer vision syndromes among students during COVID-19 lockdown - a single school study in Malaysia.","authors":"J Y Liew, P T Yong, H N Lee, A V P Loo, V Subrayan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>To determine the frequency of computer vision syndromes among students during COVID-19 lockdown in Malaysia.</p><p><strong>Materials and methods: </strong>This is a cross-sectional survey study. A total of 145 subjects studied in secondary school and pre-university programme were involved in this study. An exploratory survey questionnaire was used to assess the symptoms of computer vision syndromes encountered by the students and their electronic device usage behavior before and during fully remote learning started.</p><p><strong>Results: </strong>Average time spent by students on outdoor activities reduced from one to two hours per day (40.7%) to less than an hour per day (56.6%) after fully remote learning. Average time spent on entertainment activities using electronic devices increased from one to two hours per day (38.6%) to four hours and above per day (40.0%) after fully remote learning. The majority of time spent on school assignments using electronic devices increased from one to two hours (44.8%) to three to four hours per day (33.8%) after fully remote learning. Increased frequency of students experienced eye pain (44.1%), eye fatigue (57.2%), headache (56.6%), eye itchiness (18.6%), glare (31.7%), dry eye (40.0%), blurry vision (31.7%) and double vision (7.6%) after fully remote learning began.</p><p><strong>Conclusion: </strong>An observed increase frequency of computer vision syndrome was noted in relation to the reduction of time spent on outdoor activities and increased usage of electronic devices for entertainment activities and completing school assignment during COVID-19 lockdown in Malaysia.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":"80 2","pages":"235-244"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring psychosocial needs of young women with breast cancer in a country with crisis: a mixed-methods study.","authors":"S Hasan, K S Chew, R V Vincent, S S L Wong","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Previous research conducted in politically stable countries showed that the diagnosis and treatment of breast cancer among young women can be very distressing and devastating and may result in a lot of unmet psychosocial needs affecting their quality of life. This study aimed to address the psychosocial needs of young women with breast cancer in war-torn Syria.</p><p><strong>Materials and methods: </strong>A mixed-methods explanatory sequential design was employed in this study. Initially, a quantitative survey was conducted for 3 months from May to July 2022 on 167 young women using the Psychological Needs Inventory to identify their psychosocial needs. Secondly, a qualitative, semi-structured interview was conducted for 6 months from July to December 2022 with 11 participants to explore the challenges faced in meeting these needs.</p><p><strong>Results: </strong>The quantitative results showed that three items, \"Help with financial matters\", \"Advice about food and diet\", and \"Help with transport\", were identified as significant unmet psychosocial needs. All three items fall within the category of practical needs. The qualitative results identified five themes: (1) challenges of adequate information needs with five subthemes (inadequate communication with the health professionals, lack of educational programs and awareness campaigns, inadequate number of nurses, need for nutritionists, and effects of unmet informational needs); (2) psychological challenges with five subthemes (uncertainty of the future, fear concerning the children, fear of death, treatment-related effects and the loss of a woman's identity, and inadequate psychosocial care); (3) financial challenges with 2 subthemes (treatment not available and expensive, low incomes and high cost of living); (4) social influences with 2 subthemes (society's view and stigma, lack of marriage choices); and (5) environmental stressors with 2 subthemes (stressful hospital environment and situational factors).</p><p><strong>Conclusion: </strong>These psychosocial needs identified were found to align with Maslow's hierarchy of needs, underscoring a cascading effect of the Syrian crisis across various dimensions of well-being. Young breast cancer women living in countries with crises have high levels of unmet psychosocial needs.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":"80 2","pages":"153-160"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating CCL2 and TNF-α into the Framingham Risk Score for cardiovascular risk prediction: a cross-sectional study in a Malaysian cohort.","authors":"A Nurul Izzati, A M Fatin Syazwani, F Kahar, M A Amrina, M P Izzudin, S G Sazlina, M N Sabariah","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiovascular diseases (CVDs) are the leading cause of death worldwide, significantly contributing to increased healthcare costs and deteriorated health. In Malaysia, CVDs account for 20.79% of deaths in government hospitals. Key risk factors include high blood sugar levels, elevated blood pressure, and increased cholesterol levels. Atherosclerosis frequently serves as the underlying condition for coronary heart disease (CHD), with CCL2 and TNF-α playing a crucial role in recruiting immune cells to inflammation sites. Early diagnosis of CVDs risk is important for preventing severe complications. This crosssectional study aims to investigate the relationship between biomarker CCL2 and TNF-α expression levels and Framingham Risk Score (FRS) categories in a Malaysian cohort.</p><p><strong>Materials and methods: </strong>A total of 333 patients from the Family Medicine Specialist Clinic at Hospital Sultan Abdul Aziz Shah were recruited between March 2022 and February 2023. Blood samples were taken after a 12-hour fasting period, and levels of fasting blood sugar (FBS), triglycerides (TG), total cholesterol (TC), HDL cholesterol, and LDL cholesterol were measured. 150 plasma samples were randomly selected for cytokine analysis of CCL2 and TNF-α using the Human Magnetic Luminex Assay. Patients' cardiovascular risk was assessed using the FRS calculator. The Kruskal-Wallis test was used to analyze the relationship between cytokine levels and FRS categories, followed by a post hoc test with Bonferroni correction. A logistic regression model was implemented to assess the independent effects of these variables.</p><p><strong>Results: </strong>The results demonstrated a significant association between the level of chemokines CCL2 and proinflammatory TNF-α, and FRS categories (low-risk, moderate-risk, and high-risk). CCL2 levels were notably higher in the high-risk group, as were TNF-α levels, with both biomarkers showing increasing trends with higher risk categories, (p<0.001, effect size=0.32) and (p<0.001, effect size-0.29), respectively. Multiple logistic regression analysis showed that dyslipidaemia, FBS, and TNF-α remained significant after adjusting for other variables. Specifically, dyslipidaemia had lower odds of being in the high-risk group (AOR: 0.04), while FBS (AOR: 3.19) and TNF-α (AOR: 1.18).</p><p><strong>Conclusion: </strong>This study highlights the potential of CCL2 and TNF-α as biomarkers for CVDs risk assessment. Integrating these biomarkers into CVDs risk prediction models may enhance the precision of identifying individuals at elevated risk. However, the study's cross-sectional design and small sample size for cytokine analysis constrain the findings. Future research should explore the long-term predictive value of these cytokines in larger, longitudinal cohorts and explore more advanced techniques for improving CHD risk prediction models.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":"80 2","pages":"133-140"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a time series prediction modelling for dengue in Kota Kinabalu, Sabah.","authors":"N Md Taib, A Atil, R Dapari, M R Hassan, P D Kunasagran, S M I R M Zali, Z A Azhar, S S S A Rahim","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Dengue is a major public health issue, with 3,900,000 people living in 129 dengue-endemic countries globally facing a risk of contracting dengue fever. Dengue incidence in Sabah is among the highest in Malaysia. In 2022, Kota Kinabalu District reported 22% of the total number of dengue cases in Sabah. The objective of this study was to develop a prediction model for dengue incidence using meteorological, entomological, and environmental parameters in Kota Kinabalu, Sabah.</p><p><strong>Materials and methods: </strong>An ecological study was conducted from 2016 to 2021 using the dengue database and meteorological data. The forecasting model for dengue incidence was performed with R software using the seasonal autoregressive integrated moving average (SARIMA) model. The model was fitted based on the reported weekly incidence of dengue from 2016 to 2020 and validated using data collected between January and December 2021.</p><p><strong>Results: </strong>SARIMA (1,1,1) (1,1,0)52 with the external regressor maximal temperature, Aedes index, and vacant lot were the models with minimal measurement errors, as indicated by the Mean Absolute Error (MAE) values of 3.04, Root Mean Squared Error (RMSE) of 4.43, and Akaike Information Criterion (AIC) of 1354.82.</p><p><strong>Conclusions: </strong>The predicted values in 2021 accurately forecasted the capability to serve as an early warning system for proactive dengue measures. This information is deemed valuable to healthcare administrators for enhancing the level of preparedness.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":"80 2","pages":"161-167"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and outcomes of out-of-hospital cardiac arrest cases responded by emergency medical services across three states in Malaysia.","authors":"A K Sarah, M S Mohd Sidqi, J Md Noor, K D Wong, K M Umul, M Y Low, B Y Chia, F S A Sharifah, A W Mahathar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>IOut-of-hospital cardiac arrest (OHCA) is globally a critical, time-sensitive emergency with varying outcomes. In Asia, the Pan Asian Resuscitation Outcome Study reported survival rates between 0.5% to 8.5%. We aim to describe the characteristics and outcomes of OHCA cases responded to by Emergency Medical Services (EMS) across several cities in Sarawak, Penang and Klang Valley in Malaysia.</p><p><strong>Materials and methods: </strong>This retrospective observational study analysed EMS data from Sarawak, Penang and Klang Valley from 2010 to 2019. All OHCA cases where EMS performed cardiopulmonary resuscitation (CPR) were included, regardless of age or aetiology. The primary outcome was survival to hospital admission with the secondary outcome a return of spontaneous circulation (ROSC) prior to Emergency Department arrival.</p><p><strong>Results: </strong>A total of 2,435 OHCA cases were analysed. Median patient age was 58 years, 70% of them are male with 63% had underlying medical conditions, with hypertension being the most common. Out of all cases, 71% of arrests occurred at home, 60% witnessed. Median time from arrest to 999 call was 20 minutes, median time for ambulance arrival thereafter is 17 minutes. Bystander CPR rate was 38%, bystander Automated External Defibrillator (AED) use 1.5- 2.6%. Detection of shockable rhythm on first analysis by EMS was 3.9 to 7.7%. Overall survival to admission rate was 4.76%. ROSC rate before Emergency Department arrival was 2.8%. Survival to admission among bystander-witnessed arrests with shockable rhythm was 14.7%.</p><p><strong>Conclusion: </strong>Survival to admission rates for OHCA patients in the studied Malaysian regions (1.3-6.7%) are lower compared to some Asian countries. Areas for improvement include reducing time from arrest to 999 calls, decreasing time to EMS arrival, and increasing bystander CPR and AED use rates. Implementing the Utstein ten-step implementation strategy, focusing on community-based interventions and improving EMS response, could potentially enhance survival rates in Malaysia.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":"80 2","pages":"147-152"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-diabetic and anti-microbial activity of aspalathus linearis and syzygium aromaticum formulation mediated zinc oxide nanoparticles.","authors":"R V Geetha, K Shwetha, R Annika, S Rajeshkumar, M Pradeep, A Jayasree","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Zinc oxide nanoparticles (ZnO NPs) exhibit a wide range of biomedical applications majorly used as antiinflammatory, anti-cancer, anti-diabetic, and anti-microbial activity and other biomedical applications because they show less toxicity and are very compatible. Zinc metal is an inorganic and essential element in the human body at the trace level. ZnO NPs are also GRAS substances (Generally Recognized As Safe). This study's main objective is synthesizing zinc oxide nanoparticles using red tea & clove mediated herbal formulation and screening for its antimicrobial, and anti-diabetic properties.</p><p><strong>Materials and methods: </strong>Red tea and clove-mediated ZnO NPs were synthesized using the green synthesis method. The anti-microbial activity was tested against oral pathogens using the agar well diffusion method, while the anti-diabetic activity was estimated using the alpha-amylase inhibitory assay method by using red tea and clovemediated ZnO NPs.</p><p><strong>Results: </strong>ZnO NPs were successfully synthesized using red tea and clove-formulated extract. The synthesized ZnO NPs using Aspalathus linearis (red tea) and Syzygium aromaticum (clove) mediated ZnO NPs were characterized using UV visible spectrophotometry and SEM (Scanning Electron Microscope) analysis. The green synthesized ZnO NPs show promising anti-microbial activity by exhibiting a 12 mm zone of inhibition against S. aureus, 11 mm in E. faecalis, 9 mm in S. mutans, and 11 mm in C. albicans. In anti-diabetic activity, the green synthesized ZnO NPs showed a maximum inhibition percentage of up to 80% at the maximum concentration of 50 µg/mL.</p><p><strong>Conclusion: </strong>Green synthesized ZnO NPs using red tea and clove showed maximum efficacy in anti-microbial properties which can lead to huge potential use as antibacterial agents. Simultaneously, anti-diabetic activity showed an excellent inhibition percentage which can be a potent therapeutic agent in the field of nanomedicine in diabetes management.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":"80 Suppl 1","pages":"10-16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiological factors and management of vertigo - a retrospective study.","authors":"S Shyam Sudhakar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Vertigo and dizziness are symptoms of various underlying conditions, ranging from benign to severe, affecting up to 40% of adults. Understanding the etiological factors and demographic characteristics associated with these symptoms is crucial for improving diagnostic accuracy and management. This study aims to identify the etiological factors contributing to vertigo and dizziness in a clinical setting and assess the effectiveness of treatment strategies.</p><p><strong>Materials and methods: </strong>Retrospective cohort study conducted at Department of ENT and Head & Neck Surgery, Saveetha Medical College Hospital, Thandalam, Chennai, Tamil Nadu, India from September 2022 to March 2024. We included patients presenting with vertigo or dizziness, excluding those with non-vestibular dizziness or incomplete medical records. We analysed demographic data, medical history, and clinical findings from patient records. Data analysis was performed. Continuous variables were compared using independent sample t-tests and categorical variables using chi-square tests.</p><p><strong>Results: </strong>The study included 268 patients, predominantly females (57.8%) and individuals aged 40-50 years (29.9%). Benign Paroxysmal Positional Vertigo (BPPV) was the most common etiological factor (41.0%), followed by orthostatic dysregulation (17.2%) and vestibular peripheral dysfunction (VPD) (16.0%). Clinical presentations and outcomes varied with the underlying etiology. Overall, 91.0% of the patients showed improvement following treatment, with 7.1% achieving full recovery.</p><p><strong>Conclusion: </strong>This study highlights the complexity of vertigo and dizziness, which are influenced by various factors and demographics. This emphasizes the importance of tailored management strategies and a patient-centered, multidisciplinary approach, emphasizing customized treatments to improve patient outcomes.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":"80 Suppl 1","pages":"59-64"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of myocardial injury in patients with COVID-19: A retrospective study.","authors":"M J Siti Nurul Azimah, A Laily Noor Zuliaty, S A Sharifah Shafinaz, S Huzairi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The coronavirus disease of 2019 (COVID-19) predominantly impacts the pulmonary system; however, it also has harmful consequences for the cardiovascular system through the occurrence of myocardial injury.</p><p><strong>Materials and methods: </strong>This retrospective study analysed 119 COVID-19 patients admitted to Al-Sultan Abdullah Hospital (HASA) from March until December 2020. Demographics, medical histories, admission laboratory results, electrocardiogram (ECG), echocardiogram (echo), were captured from the hospitals' health records. Myocardial injury is an injury to the myocardium that can be diagnosed by elevated cardiac troponin T or I level above the 99th percentile upper reference limit (URL), an abnormal ECG, and an abnormal echo. Data were analysed using Statistical Package for Social Sciences (SPSS) Version 27.</p><p><strong>Results: </strong>From this study, it was founded that the prevalence of myocardial injury is 36.1% (43 subjects out of 119). The risk factors are older age (odds ratio, 2.347; p=0.028), males (odds ratio, 2.019; p=0.125), Indians (odds ratio, 3.659; p=0.296), hypertension (odds ratio, 2.776; p=0.009), diabetes mellitus (odds ratio, 1.732; p=0.155) and category 4 and 5 COVID-19 patients (odds ratio, 2.325; p=0.038).</p><p><strong>Conclusion: </strong>Myocardial injury is prevalent among patients affected by COVID-19 and is associated with older age, hypertension and category 4 and 5 COVID-19. The researchers suggested conducting a more thorough investigation of the sizable population in multiple settings and conducting a prospective study where all infected COVID-19 patients have to undergo several tests, such as ECG, troponin T, and echocardiogram.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":"80 1","pages":"96-101"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}