Medical Journal of Malaysia最新文献

筛选
英文 中文
Factors that influence motor control in individuals with nonspecific low back pain: A scoping review. 影响非特异性腰背痛患者运动控制能力的因素:范围综述。
Medical Journal of Malaysia Pub Date : 2024-03-01
E Yojana, Z Zahari, S A Bukry
{"title":"Factors that influence motor control in individuals with nonspecific low back pain: A scoping review.","authors":"E Yojana, Z Zahari, S A Bukry","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>One of the most common musculoskeletal pain that causes disability in healthcare settings is low back pain that presents without a specific cause and is known as nonspecific low back pain (NSLBP). NSLBP can cause impairment in motor control, which is the ability of the body to execute a precise and stabilized movement in space. Many factors affect motor control dysfunction and lead to different physical impairments, consequently requiring different approaches in clinical settings. However, the study regarding the alteration of motor control and the factors coming with NSLBP are still limited. Thus, this study is aimed to determine the factors affecting motor control in NSLBP conditions.</p><p><strong>Materials and methods: </strong>This is a scoping review of articles published from January 2012 to November 2022. This review follows the PRISMA guideline. The articles were searched through Scopus and Web of Sciences using the keywords \"motor control\" and \"nonspecific low back pain\". After finding the articles, the information was extracted, including authors, year of publication, country, objective, type of study, and motor control analysis summary.</p><p><strong>Results: </strong>The search retrieved 1318 articles; however, after a thorough selection process, only eight articles were included for further review. The factors that affect motor control were related to trunk neuromuscular adaption, the precision of trunk control, motor control changes, motor abundance, and motor control impairment in the LBP population with or without comparison to healthy subjects.</p><p><strong>Conclusion: </strong>Motor control in NSLBP is affected by various factors. The pain can lead to changes in motor behavior, alignment, postural control, proprioception, and stability strategy. If the changes happen for a long time, it will cause further structural and core control changes as an adaptation.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring measurement tools to optimise hospital physician distribution. 探索优化医院医生分配的测量工具。
Medical Journal of Malaysia Pub Date : 2024-03-01
N A M Suan, S A Soelar, R A Rani, N A Anuar, K A A Aziz, H K Chan, W K Cheah, S S M Sani, R M Said, M R A Hassan
{"title":"Exploring measurement tools to optimise hospital physician distribution.","authors":"N A M Suan, S A Soelar, R A Rani, N A Anuar, K A A Aziz, H K Chan, W K Cheah, S S M Sani, R M Said, M R A Hassan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Equitable healthcare delivery is essential and requires resources to be distributed, which include assets and healthcare workers. To date, there is no gold standard for measuring the correct number of physicians to meet healthcare needs. This rapid review aims to explore measurement tools employed to optimise the distribution of hospital physicians, with a focus on ensuring fair resource allocation for equitable healthcare delivery.</p><p><strong>Materials and methods: </strong>A literature search was performed across PubMed, EMBASE, Emerald Insight and grey literature sources. The key terms used in the search include 'distribution', 'method', and 'physician', focusing on research articles published in English from 2002 to 2022 that described methods or tools to measure hospital-based physicians' distribution. Relevant articles were selected through a two-level screening process and critically appraised. The primary outcome is the measurement tools used to assess the distribution of hospital-based physicians. Study characteristics, tool advantages and limitations were also extracted. The extracted data were synthesised narratively.</p><p><strong>Results: </strong>Out of 7,199 identified articles, 13 met the inclusion criteria. Among the selected articles, 12 were from Asia and one from Africa. The review identified eight measurement tools: Gini coefficients and Lorenz curve, Robin Hood index, Theil index, concentration index, Workload Indicator of Staffing Need method, spatial autocorrelation analysis, mixed integer linear programming model and cohortcomponent model. These tools rely on fundamental data concerning population and physician numbers to generate outputs. Additionally, five studies employed a combination of these tools to gain a comprehensive understanding of physician distribution dynamics.</p><p><strong>Conclusion: </strong>Measurement tools can be used to assess physician distribution according to population needs. Nevertheless, each tool has its own merits and limitations, underscoring the importance of employing a combination of tools. The choice of measuring tool should be tailored to the specific context and research objectives.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case study on the source apportionment of indoor air quality at a kindergarten in eastern Peninsular Malaysia using cluster analysis. 利用聚类分析法对马来西亚半岛东部一所幼儿园的室内空气质量源头分配进行案例研究。
Medical Journal of Malaysia Pub Date : 2024-03-01
S S Sidek, S R M Yatim, S Abdullah, F A Shafie, A R Ishak, N C Dom, M Porusia
{"title":"A case study on the source apportionment of indoor air quality at a kindergarten in eastern Peninsular Malaysia using cluster analysis.","authors":"S S Sidek, S R M Yatim, S Abdullah, F A Shafie, A R Ishak, N C Dom, M Porusia","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Indoor air quality is an important concern for kindergartener because young children are more vulnerable to the effects of poor air quality. Poor indoor air quality can cause respiratory problems and other health issues, which can negatively affect a child's ability to learn and grow. Aim of this study is to determine the trend and status of indoor air pollutants in study areas by using descriptive statistics and cluster analysis.</p><p><strong>Materials and methods: </strong>Air temperature (T), relative humidity (RH), air movement (AM), carbon dioxide (CO2), formaldehyde (HCHO), and particulate matter (PM) are the monitored parameters. Monitoring was carried out in the kindergarten for three consecutive days starting from 8.00am to 12.00pm.</p><p><strong>Results: </strong>Indoor carbon dioxide readings were higher at 0800 when parents drove to kindergarten to drop off their children without turning off the engine. In addition to this, the PM10 reading at 1000 was high but still within the standard range according to ICOP-IAQ 2010.</p><p><strong>Conclusion: </strong>The findings highlight the importance of indoor air quality improvement measures for kindergarten buildings which can be used to improve indoor air quality in kindergarten environments.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A descriptive study on the knowledge and attitude of nurses toward the prevention of pressure ulcers in the intensive care unit. 关于重症监护病房护士对预防压疮的知识和态度的描述性研究。
Medical Journal of Malaysia Pub Date : 2024-03-01
N Bakar, S S Abdullah, N A Sohor
{"title":"A descriptive study on the knowledge and attitude of nurses toward the prevention of pressure ulcers in the intensive care unit.","authors":"N Bakar, S S Abdullah, N A Sohor","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The study's objectives are to investigate the level of knowledge, attitude, and performance (KAP) of nurses on the prevention of pressure ulcers (PUs) prevention in the intensive care (ICU) and also to identify the relationship between nurses' KAP toward the implementation of preventive measures for PUs.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted among 60 registered nurses in the ICU at Taiping Hospital. to assess the nurses' knowledge and attitude level using the Knowledge and Attitude on prevention of PUs questionnaire. A descriptive analysis and Pearson Correlation were used to analyze the data.</p><p><strong>Result: </strong>From a total of 60 nurses 36 (60%) of nurses demonstrated a moderate level of KAP, and 17 (28%) demonstrated a high level of knowledge. They also exhibited neutral attitudes towards PUs prevention 49 (82%). The findings revealed a positive relationship between nurses' KAP toward implementing preventive measures on PUs (p=0.04; r=0.3). The findings show that nurses regularly performed the assessment of the risk factors of PUs for all hospitalized patients when performing PUs care. However, the plan for preventive nursing care was not properly reviewed.</p><p><strong>Conclusion: </strong>This study suggested that appropriate guidelines, education programs, and an environment that makes it possible to provide continuing education should be created for nurses to prevent PUs in the ICU.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimising care: Impact of regular nephrologist appointments on clinical outcome for chronic kidney disease patients in primary care. 优化护理:定期预约肾科医生对基层医疗机构慢性肾病患者临床疗效的影响。
Medical Journal of Malaysia Pub Date : 2024-03-01
V Paranthaman, M Y How, K Charanjit, S L Koh
{"title":"Optimising care: Impact of regular nephrologist appointments on clinical outcome for chronic kidney disease patients in primary care.","authors":"V Paranthaman, M Y How, K Charanjit, S L Koh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The rise in the cases of chronic kidney disease (CKD) with the increasing prevalence of non-communicable diseases such as type 2 diabetes mellitus and hypertension is a major public health concern in Malaysia. This results in the many cases of chronic kidney disease being managed in primary healthcare clinics. This study examines the pre- and post-clinical outcomes of scheduled nephrologist visits on CKD patients in a primary health care clinic in Ipoh, Perak.</p><p><strong>Materials and methods: </strong>This is a retrospective crosssectional study reviewing the medical records of patients seen by visiting nephrologists from January 2019 to December 2021 in Greentown Health Clinic. The study population are patients with CKD stage 3b, 4 and 5 who are followed up in Greentown Health Clinic. Universal sampling was done, a total of 87 patients reviewed at least once by the visiting nephrologist and with retrievable medical records were included in the study. Those whose medical records were irretrievable were excluded. Blood pressure, urine protein, fasting blood sugar (FBS), glycated haemoglobin (HbA1c), serum creatinine, eGFR and fasting lipid profile (FLP) pre- and post-visits were collected by reviewing patient medical records and laboratory results. The results were then analysed and compared using SPSS version 26.</p><p><strong>Results: </strong>The median age of patients in this study was 66 years of age, the majority were male patients (54%) and Malay ethnicity (62.1%). Absence of urine microalbuminuria pre and post referral remain the same (n = 11). During prenephrologist visits, a higher percentage of patients exhibited moderate (30-300 mg/g) and severe (>300 mg/g) increase in urine albuminuria (15.7% and 7.2%, respectively) compared to the post-referral period. In patients with significant urine protein pre-referral, patient group with urine protein 3+ showed the highest increment of 30.1% (n = 22), in comparison to 19.3% (n = 16) observed during prereferral. Statistically significant clinical outcomes between pre- and post-referral to the nephrologist include reduction of systolic blood pressure [141±15 mmHg versus 135 ±12 mmHg, p = 0.001] and diastolic blood pressure [median = 80 mmHg (IQR: 10) versus median=71 mmHg (IQR: 17), p < 0.001]. Similarly, total cholesterol [median = 4.4 mmol/L (IQR: 1.4) versus median = 4.0 mmol/L (IQR: 1.5, p = 0.001] and LDL [median = 2.5 mmol/L (IQR: 1.2) versus median = 2.2 mmol/L (IQR: 1.2), p < 0.001)] exhibited statistically significant differences between pre- and post-referral. However, HDL remained unchanged and other outcome variables showed no significant differences.</p><p><strong>Conclusion: </strong>Incorporating nephrologist visits in primary care seems to have positive impact towards patient clinical outcomes. Results shown in this study can aid other primary care clinics in the decision to initiate nephrologist services in the primary care setting as a multi","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salvage neck surgery in recurrent nodal NPC: Do all patients require a comprehensive neck dissection in the modern MRI era? 复发性结节性鼻咽癌的颈部挽救手术:在现代磁共振成像时代,是否所有患者都需要进行全面的颈部切除术?
Medical Journal of Malaysia Pub Date : 2024-03-01
D X C Yin, S M Chiow, A Karandikar, J P N Goh, B M Manish, J W J Gan, E W Z Fu, H Li, M Y Lim
{"title":"Salvage neck surgery in recurrent nodal NPC: Do all patients require a comprehensive neck dissection in the modern MRI era?","authors":"D X C Yin, S M Chiow, A Karandikar, J P N Goh, B M Manish, J W J Gan, E W Z Fu, H Li, M Y Lim","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The standard treatment for regional failure in nasopharyngeal carcinoma (NPC) is the radical neck dissection (RND). Our study sought to determine if magnetic resonance imaging (MRI) may accurately predict nodal involvement to allow selected levels of neck dissection to be preserved.</p><p><strong>Study design and setting: </strong>We analysed retrospectively all NPC patients in our centre undergoing neck dissections as salvage therapy for nodal recurrence. Nodal involvement based on the preoperative MRI was assessed and compared with postoperative histopathology.</p><p><strong>Methods: </strong>This is a retrospective study conducted on patients in our centre with recurrent NPC from February 2002 to February 2017. Patients were identified from the database of the otolaryngology oncology division at our institution. Of these, 28 patients met all our inclusion and exclusion criteria. We calculated sensitivity and specificity as well as average number of nodes per patient.</p><p><strong>Results: </strong>In our study, we calculated the false negative and false positive rates of preoperative MRI neck by levels. Overall sensitivity of MRI picking up disease by level was 76% and specificity was 86%.</p><p><strong>Conclusion: </strong>Based on our study, we will be missing a total of 10 (7.1%) diseased neck levels in eight (28.5%) patients. MRI alone, therefore, does not provide enough information to allow safe selective preservation of neck levels in surgical salvage of neck recurrences in NPC.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge and practices of radiation protection among Malaysian radiographers working in nuclear medicine: A preliminary study. 马来西亚核医学放射技师的辐射防护知识和实践:初步研究。
Medical Journal of Malaysia Pub Date : 2024-03-01
N K Kasmat, N S Mohamad, M A Tajuddin, M H Mahmud
{"title":"Knowledge and practices of radiation protection among Malaysian radiographers working in nuclear medicine: A preliminary study.","authors":"N K Kasmat, N S Mohamad, M A Tajuddin, M H Mahmud","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study is aimed to determine knowledge and practices on radiation protection among radiographers in nuclear medicine department. A cross-sectional survey was conducted among radiographers in nuclear medicine departments in four health institutions in Malaysia. A set of questionnaires was distributed to 17 respondents using convenience sampling. Approximately more than 75% and 44% - 56% of the radiographers have good knowledge of radiation protection and frequent adherence to radiation protection practices, respectively. Levels of education and length of service were statistically correlated with radiation protection knowledge and practices attributes (p < 0.05), respectively. More training is necessary for knowledge and practice improvement.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The level of knowledge and acceptance towards the COVID-19 vaccine among the community in Johor Bahru, Johor. 柔佛州新山社区对 COVID-19 疫苗的了解和接受程度。
Medical Journal of Malaysia Pub Date : 2024-03-01
A H Mohd Anuar, N N Mohamad Anuar, S N I Isa, M Bahari
{"title":"The level of knowledge and acceptance towards the COVID-19 vaccine among the community in Johor Bahru, Johor.","authors":"A H Mohd Anuar, N N Mohamad Anuar, S N I Isa, M Bahari","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Several necessary initiatives have been made to create a readily available vaccine against the Coronavirus Disease 2019 (COVID-19) worldwide pandemic. However, the vaccination program's success is dependent on the population's willingness as well as their knowledge of vaccination. Hence, the present study aimed to assess the level of knowledge and acceptance towards the COVID-19 vaccine among the community in Johor Bahru, Johor.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted using an online survey between February and May 2022, with 423 respondents. The questionnaire consisted of socio-demographic, assessment of knowledge level and acceptance level towards COVID-19 vaccine. The descriptive analysis and non-parametric tests were employed to investigate the study outline objectives.</p><p><strong>Results: </strong>Of all 423 participants, 293 (69.3%) of the participants had a high level of knowledge about the COVID- 19 vaccine (median knowledge score 6; IQR = 3), and 239 (56.5%) were reported to have a low level of vaccine acceptance (median acceptance scores 4; IQR=2). The knowledge level towards the COVID-19 vaccine was significantly associated with the vaccine acceptance level (p<0.001).</p><p><strong>Conclusion: </strong>The community's level of knowledge towards COVID-19 vaccine was high; however, the vaccine acceptance was low.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of quality of life among individuals with paraplegic spinal cord injury after discharge from hospital to community in Pakistan. 巴基斯坦脊髓截瘫患者出院后生活质量的预测因素。
Medical Journal of Malaysia Pub Date : 2024-03-01
F J Khanzada, M G Masuri, M D Abdul Rahim, A Z Che Daud
{"title":"Predictors of quality of life among individuals with paraplegic spinal cord injury after discharge from hospital to community in Pakistan.","authors":"F J Khanzada, M G Masuri, M D Abdul Rahim, A Z Che Daud","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to determine the predictors of quality of life (QOL) among persons with paraplegic spinal cord injury (SCI) after discharge from the hospital to the community in Pakistan, based on the International Classification of Functioning (ICF) components, including participation, impairments of body function/structures, personal factors, and environmental factors.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted with, one hundred and forty individuals with paraplegic SCI, who met the inclusion and exclusion criteria and attended an outpatient rehabilitation clinic. The impairment of body function/structures of participants was assessed using the American Spinal Injury Association (ASIA) Scale, which classified them as A, B, C, D, or E. A set of questionnaire survey forms was used to collect sociodemographic information, occupational participation, environmental factors, and QOL by using a demographic questionnaire, World Health Organization Disability Assessment Schedule 2.0 (WHODAS-II), Craig Hospital Inventory of Environmental Factors (CHIEF) scale and World Health Organization Quality of Life (WHOQOL) BREF form respectively.</p><p><strong>Results: </strong>The results showed that occupational participation was the strongest predictor of QOL among persons with paraplegic SCI (β=-0.586, p<0.001). In the second step, variables representing body function/structure factors (ASIA-A, B, C, D, E) were added, and the overall model explained 40.7% of the variance in QOL. In the third step, personal factors (age groups, gender, marital status, level of education, and rehabilitation duration) were added, and the overall model explained 51.4% of the variance in QOL. In the final step, environmental factors (CHIEF 12 Items scale) were added, but they did not significantly explain the model.</p><p><strong>Conclusion: </strong>The findings suggest that occupational participation was found to be the most significant predictor of QOL among individuals with paraplegic SCI. Body function/structure factors, personal factors, and environmental factors were also significant predictors, but to a lesser extent. The findings of this study can inform healthcare professionals and policymakers in developing interventions and, policies targeting occupational participation, and personal factors that may be effective to improve the QOL of individuals with paraplegic SCI in Pakistan.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The current state of understanding of oncology expanded access programs in Malaysia. 马来西亚对肿瘤扩大治疗计划的认识现状。
Medical Journal of Malaysia Pub Date : 2024-03-01
F L Yong, W C Tan
{"title":"The current state of understanding of oncology expanded access programs in Malaysia.","authors":"F L Yong, W C Tan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>An expanded access program (EAP) is a regulatory mechanism that provides access to an investigational drug, which is not approved for use, in treating life-threatening conditions when all the standard-ofcare treatments are exhausted.</p><p><strong>Materials and methods: </strong>An online, anonymous, voluntary survey was conducted to assess the level of knowledge and understanding about EAPs among Malaysian oncologists using SurveyMonkey® between April 2020 and June 2020. Oncologists who had enquired about EAP in the past, were invited at random to participate in the survey. Participants who did not provide consent or failed to complete the survey were excluded.</p><p><strong>Results: </strong>A total of 15 oncologists participated in the survey, from both public (46.6%) and private (46.6%) practices. Most respondents (80%) had filed between 1 to 10 EAP applications in the past 12 months. For 73.3% respondents, resources or training were not provided for EAPs from institutions. Around 53% of the respondents reported that their knowledge of EAPs and application processes including country regulations is 'good'. The majority of respondents (73.3%) reported that the educational modules on an overview of EAPs, country regulations and the EAP application process will be beneficial. Most participants received information about the existing EAPs either by reaching out to a pharmaceutical sponsor or through another health care provider and some received information about the existing EAPs through their institutions or patients/caregivers. Most of the respondents recommended that pharmaceutical companies should have readily available information related to the availability and application of EAPs for all pipeline products on their websites.</p><p><strong>Discussion: </strong>EAPs are crucial treatment access pathways to provide investigational drugs to patients who have exhausted their treatment options and are not eligible for participation in clinical trials. Malaysian oncologists have a fair understanding about the EAPs and the application processes.</p><p><strong>Conclusion: </strong>Additional training and awareness are needed for Malaysian oncologists to upscale the utilisation of EAPs.</p>","PeriodicalId":39388,"journal":{"name":"Medical Journal of Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信