Medical Journal Armed Forces India最新文献_第4页

Computer simulation in pharmaceutical research and drug development for pharmacokinetic and therapeutic optimization 药物研究和药物开发中用于药代动力学和治疗优化的计算机模拟

Medical Journal Armed Forces India Pub Date : 2024-12-01 DOI: 10.1016/j.mjafi.2022.10.007

Vikas Jogpal, Aashish Sharma, Rahul Pratap Singh, Vikas Jhawat

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Aplasia cutis congenita 先天性皮肤增生症

Medical Journal Armed Forces India Pub Date : 2024-12-01 DOI: 10.1016/j.mjafi.2023.12.002

Divyanshi, Subhash Chandra Shaw

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Neonatal caudal regression syndrome: Devil lies in details 新生儿尾端退化综合征:细节决定成败

Medical Journal Armed Forces India Pub Date : 2024-12-01 DOI: 10.1016/j.mjafi.2022.12.004

Praneetha Mude, Usha Devi, Pankaj K. Mohanty, Tapas K. Som, Tanushree Sahoo

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Fibrous bodies in pituitary adenoma 垂体腺瘤中的纤维体

Medical Journal Armed Forces India Pub Date : 2024-12-01 DOI: 10.1016/j.mjafi.2024.02.005

Abhilasha Nijalingappa Shigihalli, Anil Kumar, Mandeep Sharma, Arun Prasad Balasubramanian, Manoj Gopal Madakshira

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Prevalence and impact of obstructive sleep apnea in type 2 diabetes mellitus: A descriptive cross-sectional study 2型糖尿病患者阻塞性睡眠呼吸暂停的患病率和影响：一项描述性横断面研究

Medical Journal Armed Forces India Pub Date : 2024-12-01 DOI: 10.1016/j.mjafi.2022.07.008

Puneet Saxena , Dharmendra Singh , Yashpal Singh

{"title":"Prevalence and impact of obstructive sleep apnea in type 2 diabetes mellitus: A descriptive cross-sectional study","authors":"Puneet Saxena , Dharmendra Singh , Yashpal Singh","doi":"10.1016/j.mjafi.2022.07.008","DOIUrl":"10.1016/j.mjafi.2022.07.008","url":null,"abstract":"<div><h3>Background</h3><div>Obstructive sleep apnea<span> (OSA) has been reported to have a high prevalence in patients with type 2 diabetes mellitus. There is scarcity of literature on relationship between OSA and diabetes in Indian population.</span></div></div><div><h3>Methods</h3><div><span>A cross-sectional observational study was conducted at a tertiary care hospital and 80 consecutive and consenting patients with diabetes were enrolled over 24 months from 01 Sep 2014 to 31 Aug 2016. After a detailed history and clinical examination, all patients were subjected to a level I polysomnography (PSG), and their blood sample was drawn for the assessment of diabetes control, insulin resistance, and </span>microvascular complications.</div></div><div><h3>Results</h3><div>Out of 80 patients with diabetes, 30 (37.5%) patients had a high-risk score on Berlin questionnaire and 59 (73.8%) patients had evidence of OSA by PSG. The prevalence of OSA in diabetics with normal body mass index<span><span>, waist circumference, and neck circumference was 65.5%, 64.2%, and 67.2%, respectively. Patients with OSA had a significantly higher mean glycosylated hemoglobin (correlation coefficient 0.53) and higher insulin resistance (correlation coefficient 0.78). Patients with microvascular complications had a higher prevalence of OSA than those without. This included </span>neuropathy<span> (100% versus 62.5%), retinopathy<span> (100% versus 69.6%) and diabetic kidney disease (DKD) (90.9% versus 52.8%). Patients with any microvascular complication were significantly more likely to have OSA (odds ratio 13.66, 95% confidence interval 3.94–47.37, p < 0.001).</span></span></span></div></div><div><h3>Conclusion</h3><div><span>Indian patients with diabetes have a high prevalence of OSA, regardless of obesity. Patients with diabetes and OSA have poorer diabetes control, more insulin resistance, and higher prevalence of microvascular complications like nephropathy, </span>neuropathy<span>, and retinopathy.</span></div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"80 ","pages":"Pages S50-S56"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42015694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protected or not? Hepatitis B vaccination status among healthcare workers and the level of protection post-vaccination 是否受保护？医护人员乙肝疫苗接种情况及接种后防护水平

Medical Journal Armed Forces India Pub Date : 2024-12-01 DOI: 10.1016/j.mjafi.2023.01.013

Manish Manrai , P. Harikrishnan , Rajesh Sahu , S.P.S. Shergill

{"title":"Protected or not? Hepatitis B vaccination status among healthcare workers and the level of protection post-vaccination","authors":"Manish Manrai , P. Harikrishnan , Rajesh Sahu , S.P.S. Shergill","doi":"10.1016/j.mjafi.2023.01.013","DOIUrl":"10.1016/j.mjafi.2023.01.013","url":null,"abstract":"<div><h3>Background</h3><div>Hepatitis B virus infection is one of the major concerns in global health care<span><span>. With a far-reaching health, social, economic impact, preventive strategies form the cornerstone of its management. Knowledge about vaccination status and protection rendered thereof would aid in more wholesome management among highrisk population groups like healthcare workers. The aim of this study was to evaluate the </span>Hepatitis B vaccination status among Healthcare workers (HCW) and the level of protection post-vaccination.</span></div></div><div><h3>Methods</h3><div><span>During the study period a total of 420 HCWs were included in the study. The details of vaccination status was ascertained by an online questionnaire. Serum samples were evaluated for </span>HBsAg<span> status and Anti HBs<span> titres to assess the level of protection against HBV infection. Those who were HBsAg negative, anti-HBc total was assessed.</span></span></div></div><div><h3>Results</h3><div>Our study revealed a high vaccination status among HCWs, n-384 (93.2%). However, the percentage of HCWs who were completely vaccinated was low (56.3%). Most of the study population, n-395 (95.6%) had protective titres of anti-HBs which showed a declining trend with increasing duration since the last dose of the vaccine.</div></div><div><h3>Conclusion</h3><div>Hepatitis B infection continues to be an important health hazard with significant morbidity and mortality. Healthcare workers are at higher risk of contracting the infection. Merely considering the vaccination status without knowing the protective anti-HBs titres is to be discouraged as it has been observed that the protective antibody titres show a declining trend with time as even completely vaccinated individuals had non-protective levels of antibody titres.</div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"80 ","pages":"Pages S153-S159"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42048620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experience in developing and implementing the self-directed learning assessment tools among undergraduate medical students 在医科本科生中开发和实施自主学习评估工具的经验

Medical Journal Armed Forces India Pub Date : 2024-12-01 DOI: 10.1016/j.mjafi.2023.04.002

Puja Dulloo , Suman Singh , Minal Patel , Praveen Singh , Amol Dongre , Neeraj Vedi

{"title":"Experience in developing and implementing the self-directed learning assessment tools among undergraduate medical students","authors":"Puja Dulloo , Suman Singh , Minal Patel , Praveen Singh , Amol Dongre , Neeraj Vedi","doi":"10.1016/j.mjafi.2023.04.002","DOIUrl":"10.1016/j.mjafi.2023.04.002","url":null,"abstract":"<div><h3>Background</h3><div>The upcoming changes in digital technology have motivated health professionals to be lifelong learners and be updated with the recent trends. Self-directed learning (SDL) is one of the approaches for making undergraduate students health/ profession students lifelong learners. Moreover, the SDL approach allows learners to work in a team and gain social skills. The aim of the study was to develop and validate the facilitator and peer score sheet as an assessment tool for self-directed learning in the department of physiology, in the Indian context.</div></div><div><h3>Method</h3><div>The facilitator and peer score sheet was developed and validated by the Delphi technique. The score sheet was implemented as a pilot test for one of the SDL modules in the department of physiology for undergraduate students.</div></div><div><h3>Result</h3><div>Two Delphi rounds were conducted till the content validity index (CVI) for the Facilitator Score Sheet (FSS), for 10 items attained was 0.977 and a CVI of 0.90 for seven items was for the Peer Score Sheet (PSS). The Coefficient of Variance (CV) in FSS for items 6, 10, and 11 and in PSS for item 6 was more than 30, which is not acceptable, so the item needed to be modified or removed from the list.</div></div><div><h3>Conclusion</h3><div>Varied assessment strategies are required for the SDL module to attain academic gain as per cognitive and affective attributional gains. Although novel, the present scale needs to be modified after incorporating all the recommendations from different stakeholders before reusing it for the students’ SDL module.</div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"80 ","pages":"Pages S204-S209"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42384983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disseminated talaromycosis: Truly uncommon or uncommonly recognized? 弥散性芳香菌病:真的不常见还是不常见?

Medical Journal Armed Forces India Pub Date : 2024-12-01 DOI: 10.1016/j.mjafi.2022.12.008

Padamata Harika , Bhushan Asthana , Rohit Vashisht , Naveen Yadav , Nandita Hazra , Manish Manrai , Anil S. Menon

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Topical imiquimod: A miraculous option in extramammary Paget’s disease? 局部咪喹莫特：治疗乳腺外Paget病（EMPD）的神奇选择？

Medical Journal Armed Forces India Pub Date : 2024-12-01 DOI: 10.1016/j.mjafi.2022.05.003

Richa Kumar, Manas Chatterjee

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Autoerotism and foreign body bladder 自体性行为和异物膀胱

Medical Journal Armed Forces India Pub Date : 2024-12-01 DOI: 10.1016/j.mjafi.2022.07.004

Rahul Sandhu , Deepak Dwivedi

引用次数: 0