Medical Journal Armed Forces India最新文献

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Intermittent phototherapy vs continuous phototherapy for treatment of neonatal hyperbilirubinemia: A randomized control trial 间歇光疗vs连续光疗治疗新生儿高胆红素血症:一项随机对照试验
Medical Journal Armed Forces India Pub Date : 2026-05-01 Epub Date: 2025-07-08 DOI: 10.1016/j.mjafi.2025.05.007
Gopalakrishnan Shridhar , Sarvesh Kohli , Bhaskar Bharadwaj , Reema Solanki , Karthik Ram Mohan , Shuvendu Roy , K.M. Adhikari
{"title":"Intermittent phototherapy vs continuous phototherapy for treatment of neonatal hyperbilirubinemia: A randomized control trial","authors":"Gopalakrishnan Shridhar ,&nbsp;Sarvesh Kohli ,&nbsp;Bhaskar Bharadwaj ,&nbsp;Reema Solanki ,&nbsp;Karthik Ram Mohan ,&nbsp;Shuvendu Roy ,&nbsp;K.M. Adhikari","doi":"10.1016/j.mjafi.2025.05.007","DOIUrl":"10.1016/j.mjafi.2025.05.007","url":null,"abstract":"<div><h3>Background</h3><div><span>Though safe, phototherapy has short and long-term side-effects. This </span>randomized control trial<span> (RCT), evaluated the efficacy and safety of intermittent versus continuous phototherapy in treatment of neonatal hyperbilirubinemia<span>. The aim of this study was to compare intermittent versus continuous phototherapy for treatment of nonhemolytic neonatal hyperbilirubinemia<span> and the primary objective was to compare rate of decline of bilirubin between neonates treated with intermittent versus continuous phototherapy.</span></span></span></div></div><div><h3>Methods</h3><div>RCT conducted over two years. All late preterm (≥ 35 weeks) and term neonates requiring phototherapy as per AAP 2004 guidelines (Low and Medium risk groups) were eligible for inclusion and were randomized to either continuous or intermittent phototherapy using serially numbered opaque sealed envelopes, after informed parental consent.</div></div><div><h3>Results</h3><div>Among 130 neonates, randomized in a 1:1 allocation ratio, mean (±SD) TSB at enrolment was 17.1 (±1.1) and 17.3 (±1.3) mg/dl; p value 0.35, and the rate of fall of bilirubin was 0.14 (0.08 to 0.20 IQR) and 0.16 (0.10 to 0.18 IQR) mg/dl/hr; p value 0.88 in the continuous and intermittent phototherapy groups respectively. The mean (95% CI) difference between the two groups was 0.010 (-0.0165 to 0.0365) mg/dl/hr, within the pre-defined limits of non-inferiority (Δ=0.05 mg/dl/h). The median duration of phototherapy was lower, (24 (12 to 24) hours in the intermittent phototherapy group as compared to 34 (26 to 44) hours in the continuous phototherapy group; p value 0.09.</div></div><div><h3>Conclusion</h3><div>Intermittent phototherapy (with 12 hours on and 12 hours off cycles), along with clinical and lab monitoring was as effective as continuous phototherapy in the treatment of non-hemolytic neonatal hyperbilirubinemia.</div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"82 3","pages":"Pages 324-330"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147854061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biochemical markers in first-episode psychosis: A case-control study 首发精神病的生化指标:一项病例对照研究
Medical Journal Armed Forces India Pub Date : 2026-05-01 Epub Date: 2026-04-13 DOI: 10.1016/j.mjafi.2026.01.007
Ritwik Mishra , Surender Sharma , S. Shashivadhanan , M.D. Niyaz , Ankit Singal , G.S. Bhalla , Neha Sharma
{"title":"Biochemical markers in first-episode psychosis: A case-control study","authors":"Ritwik Mishra ,&nbsp;Surender Sharma ,&nbsp;S. Shashivadhanan ,&nbsp;M.D. Niyaz ,&nbsp;Ankit Singal ,&nbsp;G.S. Bhalla ,&nbsp;Neha Sharma","doi":"10.1016/j.mjafi.2026.01.007","DOIUrl":"10.1016/j.mjafi.2026.01.007","url":null,"abstract":"<div><h3>Background</h3><div>It is being increasingly realized that immunological dysregulation and alteration of levels of cytokines play an important role in the etiology of psychotic symptoms, particularly of first-episode psychosis (FEP). Earlier studies have theorized that disrupted levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) and other cytokines like C-reactive protein and tumor necrosis factor-alpha (TNF-α) play a role in symptom development in FEP patients. The study was done to evaluate serum levels of IL-6, IL-10, and IL-10-to-IL-6 ratio in FEP patients versus a healthy control population.</div></div><div><h3>Methods</h3><div>A case-control study was conducted with 120 individuals (60 FEP patients and 60 healthy controls age and sex matched) at a tertiary care facility in Western Maharashtra from January 2023 to December 2023. The serum levels of IL-6 and IL-10 were analyzed using enzyme-linked immunosorbent assay. Independent t-tests were used to analyze data for continuous variables and odds ratios (ORs) with 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>FEP patients exhibited IL-10 levels significantly higher than controls (6.39 ± 1.17 pg/mL vs 4.42 ± 0.58 pg/mL; p &lt; 0.001) and lower IL-6 levels than controls (3.98 ± 0.56 pg/mL vs 4.31 ± 0.39 pg/mL; p &lt; 0.001). The average IL-10-to-IL-6 ratio was also significantly different in FEP cases at 1.65 ± 0.46 and controls at 1.03 ± 0.11, with p &lt;0.001. High IL-10 (OR = 2.85; 95% CI: 1.35–6.04) and high IL-10-to-IL-6 ratio (OR = 2.11; 95% CI: 1.02–4.39) were both significantly correlated with FEP, while high IL-6 levels were inversely correlated with FEP (OR = 0.41; 95% CI: 0.20–0.86). Mean body weight of FEP patients was also decreased significantly compared with controls (68.6 kg vs 72.7 kg; p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>FEP patients have increased levels of IL-10, reduced levels of IL-6, and an increased IL-10-to-IL-6 ratio. Change in concentration of these cytokines could be involved in pathophysiology. The reduced body weight among the FEP patients may suggest underlying constitutional or metabolic factors that predispose them to the illness.</div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"82 3","pages":"Pages 350-355"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147854725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sister Mary Joseph nodule 玛丽·约瑟夫修女结节
Medical Journal Armed Forces India Pub Date : 2026-05-01 Epub Date: 2025-07-07 DOI: 10.1016/j.mjafi.2025.05.018
Rafael Fayos-Gregori, Vicent Martínez-Cozar, Miguel Mansilla-Polo
{"title":"Sister Mary Joseph nodule","authors":"Rafael Fayos-Gregori,&nbsp;Vicent Martínez-Cozar,&nbsp;Miguel Mansilla-Polo","doi":"10.1016/j.mjafi.2025.05.018","DOIUrl":"10.1016/j.mjafi.2025.05.018","url":null,"abstract":"","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"82 3","pages":"Pages 374-376"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147854805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risperidone redefined: A three-decade odyssey of broadening indications and evolving formulations 利培酮的重新定义:扩大适应症和不断发展的配方的三十年奥德赛
Medical Journal Armed Forces India Pub Date : 2026-05-01 Epub Date: 2026-04-08 DOI: 10.1016/j.mjafi.2026.02.016
Amit Chail , Markanday Sharma , Rajiv Kumar Saini , Prateek Yadav
{"title":"Risperidone redefined: A three-decade odyssey of broadening indications and evolving formulations","authors":"Amit Chail ,&nbsp;Markanday Sharma ,&nbsp;Rajiv Kumar Saini ,&nbsp;Prateek Yadav","doi":"10.1016/j.mjafi.2026.02.016","DOIUrl":"10.1016/j.mjafi.2026.02.016","url":null,"abstract":"<div><div>Risperidone, one of the most widely prescribed second-generation antipsychotics globally, is distinguished by its broad therapeutic utility and adaptable formulation strategies. It was the second atypical antipsychotic introduced after clozapine and its pharmacological profile was characterized by potent antagonism of dopamine D2 and serotonin 5HT2A receptors. It provided more effective management of positive, negative, and mood symptoms across psychiatric disorders while minimizing extrapyramidal side effects compared to first-generation agents. Since its introduction, risperidone’s indications have expanded significantly to encompass schizophrenia, bipolar I disorder, and autism-related irritability across diverse age groups from children aged five years to older adults. This therapeutic breadth is matched by remarkable formulation versatility, beginning with oral tablets and liquid syrup, progressing to intramuscular depot injections, and most recently culminating in subcutaneous extended-release formulations approved in 2018, 2023, and 2025. These innovations address critical challenges in psychiatric care, particularly medication adherence, by offering flexible dosing intervals and eliminating the need for oral supplementation in newer formulations. This article provides a comprehensive review of risperidone’s basic pharmacology, its evolving landscape of Food and Drug Administration–approved and off-label indications, the transformative journey from oral to long-acting injectable formulations, and the complex interplay among drug attitudes, patient perceptions, and treatment acceptance.</div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"82 3","pages":"Pages 255-259"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147854709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic management of Zenker’s diverticulum Zenker憩室的内镜治疗
Medical Journal Armed Forces India Pub Date : 2026-05-01 Epub Date: 2026-04-12 DOI: 10.1016/j.mjafi.2026.03.010
Ritesh Acharya , Shubham Kumar , Jimil Shah , Surinder Singh Rana
{"title":"Endoscopic management of Zenker’s diverticulum","authors":"Ritesh Acharya ,&nbsp;Shubham Kumar ,&nbsp;Jimil Shah ,&nbsp;Surinder Singh Rana","doi":"10.1016/j.mjafi.2026.03.010","DOIUrl":"10.1016/j.mjafi.2026.03.010","url":null,"abstract":"<div><div>Zenker's diverticulum (ZD) is an acquired hypopharyngeal outpouching resulting from upper esophageal sphincter dysfunction. Patients usually present with dysphagia, regurgitation, aspiration, or chronic cough, and the condition predominantly affects elderly individuals. Traditionally, open surgical approaches were considered the standard of care but have been associated with significant morbidity. Over the past two decades, endoscopic techniques have revolutionized the management of ZD. The basic principle of all endoscopic treatment approaches is cricopharyngeal myotomy, which relieves the functional obstruction and consequent dysphagia. Flexible endoscopic septum division (FESD) has emerged as a widely adopted method due to its being minimally invasive, simple, and safe. More recently, third-space endoscopic procedures such as Zenker's per oral endoscopic myotomy (Z-POEM) have expanded the therapeutic armamentarium. In addition, hybrid techniques that combine features of FESD and Z-POEM are being developed to maximize efficacy while minimizing complications. This narrative review will provide an overview of the various endoscopic techniques currently available for the management of ZD.</div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"82 3","pages":"Pages 260-266"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147854802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic pilonidal sinus treatment (EPSiT): A modern answer to an age-old problem 内窥镜治疗(EPSiT):一个古老问题的现代答案
Medical Journal Armed Forces India Pub Date : 2026-05-01 Epub Date: 2024-11-19 DOI: 10.1016/j.mjafi.2024.10.007
Gursewak Singh , Rohit Mehra , Ashwin Galagali , Piyush Prem Mhaske
{"title":"Endoscopic pilonidal sinus treatment (EPSiT): A modern answer to an age-old problem","authors":"Gursewak Singh ,&nbsp;Rohit Mehra ,&nbsp;Ashwin Galagali ,&nbsp;Piyush Prem Mhaske","doi":"10.1016/j.mjafi.2024.10.007","DOIUrl":"10.1016/j.mjafi.2024.10.007","url":null,"abstract":"<div><h3>Background</h3><div>Pilonidal Sinus<span> Disease (PSD) is a cause of serious morbidity with varied clinical presentations. The management of the disease has seen sea-changes in the last few decades. Endoscopic pilonidal sinus treatment (EPSiT) involves the use of appropriately sized endoscope<span> to delineate the anatomy of pilonidal sinus tract including any side branching tracts and ablating them using monopolar electrode under vision. Use of EPSiT in the Armed Forces settings has limited experience and we extended the use of EPSiT to ascertain its benefits in the manpower intensive military settings.</span></span></div></div><div><h3>Methods</h3><div>This prospective study included 43 patients. The procedure was performed using the technique described by Meinero et al. including diagnostic and operative phase. Intraoperative findings were recorded and patients were followed up for the duration of the study. Data analysis was performed using statistical software Statistical Package for Social Sciences.</div></div><div><h3>Results</h3><div><span>Male to female ratio in this study was 3.3:1. 81.4% of the patients presented with primary disease whereas 18.6% had recurrent disease. The operative time ranged from 12-35 minutes. The mean length of the tract was found to be 7.6 ± 1.9 cm. A single, two and three fistulous openings were seen in 69.8%, 23.2% and 7% patients, respectively. Return to work was within a range of 2-7 days. Average visual analogue scale (VAS) score of patients on post operative day (POD) 1 was 2.72 ± 0.83. Complete </span>wound healing was achieved within 21 days in 97.7% patients.</div></div><div><h3>Conclusion</h3><div>EPSiT an ideal procedure of choice among combatants where early return to work translates to operational readiness.</div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"82 3","pages":"Pages 276-282"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147854713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of pre-operative magnetic resonance imaging (pelvis and abdomen) and combined tumour markers HE4 and CA125 in diagnosing early and advanced carcinoma endometrium 术前磁共振成像(骨盆和腹部)及联合肿瘤标志物HE4和CA125在诊断早期和晚期子宫内膜癌中的应用
Medical Journal Armed Forces India Pub Date : 2026-05-01 Epub Date: 2025-10-28 DOI: 10.1016/j.mjafi.2025.07.003
Bikram Bhardwaj , Sanjay Singh , Aruna Menon , Davinder Bhardwaj , Bidhan Roy , Rony Chakravorty , Saurabh Bobdey
{"title":"Utility of pre-operative magnetic resonance imaging (pelvis and abdomen) and combined tumour markers HE4 and CA125 in diagnosing early and advanced carcinoma endometrium","authors":"Bikram Bhardwaj ,&nbsp;Sanjay Singh ,&nbsp;Aruna Menon ,&nbsp;Davinder Bhardwaj ,&nbsp;Bidhan Roy ,&nbsp;Rony Chakravorty ,&nbsp;Saurabh Bobdey","doi":"10.1016/j.mjafi.2025.07.003","DOIUrl":"10.1016/j.mjafi.2025.07.003","url":null,"abstract":"<div><h3>Background</h3><div>Endometrial cancer is the most common gynaecological cancer and is known to be the fourth commonest cancer overall and the seventh leading cause of cancer-causing death. Measurement of serum CA125 is commonly used in evaluation and follow up process of patients with ovarian cancer. HE4- a novel tumour marker is over-expressed in patients with serous and endometroid epithelial ovarian carcinomas and uterine cancers. The aim of this study was to assess utility of pre-operative magnetic resonance imaging (MRI) (pelvis and abdomen) and combined Tumour Markers HE4 &amp; CA125 in diagnosing Early and Advanced stage disease in endometrial cancer.</div></div><div><h3>Methods</h3><div>The present cross sectional pilot study was carried out at the outpatient department of Obst &amp; Gynae in a tertiary care hospital. During the study period from March 2021 to Feb 2023, patients with diagnosis of carcinoma endometrium were included. A total 25 cases were included. CA 125 and HE 4 tumor markers were done for each patient Depth of myometrial invasion, histological grade, cervical stromal involvement and presence or absence of nodal metastasis was recorded and pre-op stage assessed.</div></div><div><h3>Results</h3><div>More than 50% of endometrial cancers are diagnosed in women older than 55. Type I (grade 1 or 2 endometrioid) endometrial cancer is commoner 80% and type II (grade 3 endometrioid, serous, clear cell, and carcinosarcoma) in remaining 20% cases. Sensitivity and specificity of CA 125 was 100% each. Sensitivity and specificity of HE 4 was 75% and 60% each.</div></div><div><h3>Conclusion</h3><div>Higher levels of HE4 and CA125 were observed in patients with deep myometrial invasion and higher grade of tumor.</div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"82 3","pages":"Pages 337-342"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147854714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Segmental Darier's disease along blaschko's line: Unique presentation 沿布拉施科线的节段性达里尔病:独特的表现
Medical Journal Armed Forces India Pub Date : 2026-05-01 Epub Date: 2025-04-30 DOI: 10.1016/j.mjafi.2025.03.006
M. Aravind Prasanna , R. Yogindher Singh , Manobalan Karuna , M Lavanya
{"title":"Segmental Darier's disease along blaschko's line: Unique presentation","authors":"M. Aravind Prasanna ,&nbsp;R. Yogindher Singh ,&nbsp;Manobalan Karuna ,&nbsp;M Lavanya","doi":"10.1016/j.mjafi.2025.03.006","DOIUrl":"10.1016/j.mjafi.2025.03.006","url":null,"abstract":"<div><div><span>Darier disease<span> (DD) is an inherited acantholytic disorder with autosomal dominant inheritance, having a mutation in ATP2A2 gene on </span></span>chromosome 12<span><span>. DD usually presents with hyperkeratotic papules and subsequently coalesce to form a plaque over seborrheic areas on the trunk, intertriginous areas, face, and scalp<span>. Histologically, acantholysis and </span></span>dyskeratosis characterize the disease. Herein, we report a case of a 59-year-old male patient with DD with the segmental presentation following blaschko lines.</span></div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"82 3","pages":"Pages 356-358"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147854726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive factors for liver and kidney injury in acetaminophen poisoning: A cross-sectional study 对乙酰氨基酚中毒肝、肾损伤的预测因素:一项横断面研究
Medical Journal Armed Forces India Pub Date : 2026-05-01 Epub Date: 2025-09-25 DOI: 10.1016/j.mjafi.2025.07.010
Rokhsareh Meamar , Razieh Yazdi , Awat Feizi , Melika Namvar , Seyed Ali Mirbod , Nastaran Eizadi-Mood
{"title":"Predictive factors for liver and kidney injury in acetaminophen poisoning: A cross-sectional study","authors":"Rokhsareh Meamar ,&nbsp;Razieh Yazdi ,&nbsp;Awat Feizi ,&nbsp;Melika Namvar ,&nbsp;Seyed Ali Mirbod ,&nbsp;Nastaran Eizadi-Mood","doi":"10.1016/j.mjafi.2025.07.010","DOIUrl":"10.1016/j.mjafi.2025.07.010","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study was to identify predictive factors for liver and kidney injury in patients with acetaminophen (APAP) poisoning.</div></div><div><h3>Method</h3><div>This cross-sectional retrospective study was conducted on patients over 18 years of age admitted from January to December 2020 with APAP poisoning without prior liver or kidney issues.</div></div><div><h3>Results</h3><div>Out of 2878 poisoned patients admitted, 146 patients with a mean age of 27.48 ± 8.92 years had APAP poisoning. Among them, 26.7% of patients experienced kidney injury, 15.1% had elevated aspartate aminotransferase (AST) and 6.11% had elevated alanine aminotransferase (ALT) both indicating hepatic injury. The amount of APAP consumed by the patient was identified as one of the best predictive factors for hepatic injury. Specifically, for every 1-g increase in APAP consumed by the patient, the odds of increased AST were 13% (odds ratio [OR] = 1.13 95% confidence interval [CI]: 1.002-1.27], P = 0.045), the odds of increased ALT were 15% (OR = 1.15 [95% CI: 0.99-1.22], P = 0.073), and the odds of an outcome with complications increased by 12% (OR = 1.12 [95% CI: 1.01-1.25], P = 0.031). The area under the curve (AUC) showed a significant relationship between the amount of APAP and the probability of hepatic injury (ALT) (AUC: 0.689; 95% CI: 0.520-0.858) (P = 0.028). The cut-off point for predicting an increase in ALT was determined to be 8.75 g of APAP, with a sensitivity of 55.6% and specificity of 71.4%.</div></div><div><h3>Conclusion</h3><div>The amount of APAP ingested is a clinical tool used to predict hepatic injury resulting from acute APAP overdose in adults. The recommended cut-off point of 8.75 g of APAP can help predict an increase in ALT levels.</div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"82 3","pages":"Pages 343-349"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147854058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of clinical performance of occlusal laminates fabricated using two CAD-CAM ceramics: A pilot study 两种CAD-CAM陶瓷制作的咬合层压板临床性能的比较评价:一项初步研究
Medical Journal Armed Forces India Pub Date : 2026-05-01 Epub Date: 2024-12-20 DOI: 10.1016/j.mjafi.2024.11.014
Amit Khattak
{"title":"Comparative evaluation of clinical performance of occlusal laminates fabricated using two CAD-CAM ceramics: A pilot study","authors":"Amit Khattak","doi":"10.1016/j.mjafi.2024.11.014","DOIUrl":"10.1016/j.mjafi.2024.11.014","url":null,"abstract":"<div><h3>Background</h3><div>Attrition and erosion are common wasting diseases of the teeth, which left untreated cause extensive loss of tooth structure, leading to sensitivity and pain. Ceramic occlusal<span> laminates are a new treatment modality for management of these conditions keeping in view the principles of “Minimally Invasive Dentistry”. This treatment modality offers durable restorations utilizing the latest materials and equipment with minimal preparation of tooth structure. Two ceramic materials have been evaluated for their clinical performance in the management of dental attrition and erosion.</span></div></div><div><h3>Methods</h3><div>Forty Computer aided design–Computer aided manufacturing laminates (CAD-CAM) were placed in twenty patients in the age group 30 to 60 with occlusal wear of teeth. Two teeth in each patient, one mandibular first molar<span><span> on the right side and one on the left side were prepared to receive a Lithium disilicate laminate and a Zirconia laminate respectively. The restorations were fabricated using Lithium disilicate ingots and Zirconia blanks respectively and luted using </span>resin cement. The restorations were evaluated clinically for fracture and dislodgement. Data collected was subjected to suitable statistical analysis.</span></div></div><div><h3>Results</h3><div>Statistical analysis revealed that incidences of fracture and dislodgement were not significant for both the materials over the entire duration of observation of the study. There were three incidences of fracture for both the materials and five of dislodgement till the end of the study.</div></div><div><h3>Conclusion</h3><div>There was no statistically significant fracture or dislodgement for both the materials. The restorations were stable at the end of the study.</div></div>","PeriodicalId":39387,"journal":{"name":"Medical Journal Armed Forces India","volume":"82 3","pages":"Pages 297-302"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147854708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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