Topics in Magnetic Resonance Imaging最新文献

{"title":"Machine Learning-Based Detection of EGFR Mutation and HER2 Overexpression in Metastatic Brain Adenocarcinoma: Systematic Review and Meta-Analysis.","authors":"Mohammad Sadra Gholami Chahkand, Mohammad Amin Karimi, Komeil Aghazadeh-Habashi, Fatemeh Esmaeilpour Moallem, Rozhin Mehrabanpour, Parisa Alsadat Dadkhah, Roja Esmailinia, Negin Esfandiari, Eftekhar Azarm, Seyyed Kiarash Sadat Rafiei, Mahsa Asadi Anar, Ali Shahriari","doi":"10.1097/RMR.0000000000000320","DOIUrl":"10.1097/RMR.0000000000000320","url":null,"abstract":"<p><strong>Background and aim: </strong>Brain metastases (BMs) are the most common intracranial malignancy, often arising from lung, breast, and melanoma cancers. Receptor tyrosine kinases, such as EGFR and HER2, drive tumor progression and resistance to therapy. Noninvasive detection of these biomarkers, especially in brain metastases, is crucial due to challenges with traditional biopsy methods. This systematic review and meta-analysis assess machine learning (ML)-based models for detecting EGFR mutations and HER2 overexpression in metastatic brain adenocarcinoma using MRI-derived radiomic features.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted following PRISMA 2020 guidelines. Studies were identified via PubMed, Scopus, and Web of Science, focusing on ML applications to MRI radiomics for detecting EGFR and HER2 in brain metastases. Data on study design, imaging modality, model type, sample size, and performance metrics were extracted. Subgroup analyses were performed by model type (deep learning vs. classical ML) and sample size (<150 vs. ≥150 participants). A random-effects model was used to pool performance metrics, and risk of bias was assessed using the RoB 2 tool. STATA version 18 and Python 3.10 were used for analyses and visualizations.</p><p><strong>Results: </strong>Of 383 identified studies, 31 (7925 participants) met the inclusion criteria. The pooled analysis showed strong diagnostic performance: AUC = 0.84, accuracy = 0.86, and sensitivity = 0.83. Subgroup analysis revealed higher AUC and accuracy in deep learning models compared with classical ML. Sensitivity analysis also indicated improved AUC in studies with larger sample sizes (≥150), though variability remained. No evidence of heterogeneity or publication bias was detected.</p><p><strong>Conclusion: </strong>ML models demonstrate strong diagnostic performance for detecting EGFR and HER2 in metastatic brain adenocarcinoma, supporting their potential as noninvasive diagnostic tools. However, these findings should be interpreted considering methodological heterogeneity and the limited use of external validation. Further prospective, multicenter studies are warranted to confirm their clinical applicability and generalizability.</p>","PeriodicalId":39381,"journal":{"name":"Topics in Magnetic Resonance Imaging","volume":"34 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen Saturation, Heart Rate, and Anxiety Levels Among Claustrophobic and Non-Claustrophobic Patients Undergoing Closed and Open MRI: A Comparative Study.","authors":"Shamsaldin Saleem Hasan, Shereen Ismail Hajee","doi":"10.1097/RMR.0000000000000319","DOIUrl":"10.1097/RMR.0000000000000319","url":null,"abstract":"<p><strong>Background and aim: </strong>Magnetic resonance imaging (MRI) is essential for diagnosis but often induces anxiety, especially in claustrophobic patients, potentially affecting image quality. This study compared oxygen saturation, heart rate, and anxiety levels between claustrophobic and non-claustrophobic patients undergoing closed and open MRI in Erbil, Iraq.</p><p><strong>Material and methods: </strong>The comparative study was conducted from October 2024 to April 2025 in the Radiology Departments of Consultant Medical City and Top Med Medical Complex Centers in Erbil using purposive sampling. The questionnaire contained 3 sections: sociodemographic variables, the Claustrophobia Questionnaire, and the State-Trait Anxiety Inventory-State Subscale. Physiological measures (oxygen saturation and heart rate) were recorded at 3 timepoints: pre-, mid-, and post-MRI. Statistical analyses included one-way ANOVA, repeated measures ANOVA, post hoc tests, and both univariate and multiple linear regression, using SPSS version 26.</p><p><strong>Results: </strong>A total of 125 participants were involved in the study. The mean anxiety score was moderate, with higher levels in claustrophobic patients. Claustrophobia scores also fell within the moderate range, indicating psychological discomfort during the MRI procedure. Physiological measurements showed that claustrophobic patients, particularly those undergoing closed MRI, experienced elevated heart rates and reduced oxygen saturation compared to non-claustrophobic individuals. Statistical analysis indicated a strong positive association between anxiety and claustrophobia, with scan entry direction, age, and sex also being significant predictors of claustrophobic responses.</p><p><strong>Conclusions: </strong>Claustrophobic patients undergoing closed MRI experience increased anxiety and physiological distress. Open MRI systems and pre-scan anxiety screening are recommended to enhance patient comfort and diagnostic outcomes.</p>","PeriodicalId":39381,"journal":{"name":"Topics in Magnetic Resonance Imaging","volume":"34 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging Findings of Placenta Accreta Spectrum Disorder: A Pictorial Review.","authors":"Eya Azouz, Omri Ahlem, Haithem Aloui, Hatem Frikha, Rami Hammami, Amal Chermiti, Saber Hassine Abouda, Badis Chaoufi, Wassim Frikha, Habiba Mizouni","doi":"10.1097/RMR.0000000000000315","DOIUrl":"https://doi.org/10.1097/RMR.0000000000000315","url":null,"abstract":"<p><strong>Abstract: </strong>Magnetic resonance imaging (MRI) is used for diagnosing placenta accreta spectrum disorders (PASDs) because of its advanced soft-tissue contrast and spatial resolution capabilities, offering better contrast, improved spatial resolution, and a wider field of view compared with ultrasound. Using a 1.5-Tesla MRI protocol with multiple sequences, MRI can detect indicative signs of PASD such as placental signal heterogeneity, interruption of the myometrium-placenta interface, and abnormal vascularization. Specific sequences such as T2 SSFSE, FIESTA, and T1-weighted and diffusion-weighted imaging are used to assess placental attachment, myometrial invasion, and intraplacental hemorrhages. Significant MRI findings include thick low-signal T2 intraplacental bands, invasions into the cervix or bladder, and abnormal periplacental vascularity. MRI complements ultrasound and is crucial for the prenatal diagnosis of PASD, aiding in treatment planning and patient management, thereby reducing the associated fetal and maternal morbidity and mortality. The objective of this pictorial review was to outline the placental MRI technique and review the main imaging findings in placental MRI for PASD. This review encompasses anonymized patient images obtained following written consent.</p>","PeriodicalId":39381,"journal":{"name":"Topics in Magnetic Resonance Imaging","volume":"33 6","pages":"e0315"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety of Patients Undergoing Magnetic Resonance Imaging (MRI): The Effectiveness of Guided Mental Imagery.","authors":"Atena Shojaie, Houshang Amiri, Tania Dehesh, Behnaz Bagherian","doi":"10.1097/RMR.0000000000000314","DOIUrl":"10.1097/RMR.0000000000000314","url":null,"abstract":"<p><strong>Background: </strong>Since magnetic resonance imaging (MRI) is an extensively used and fundamental diagnostic imaging method and anxiety is one of the most important confounding factors in its performance, using guided imagery is recommended.</p><p><strong>Objective: </strong>This study aimed to assess the effectiveness of guided imagery on the anxiety of patients undergoing MRI in 2023.</p><p><strong>Methods: </strong>88 patients were randomly assigned to intervention and control groups. The intervention group listened to the nature-based guided imagery audio file during their scan, and the control group did not receive any intervention. Data were collected using demographic information and the Spielberger Anxiety Questionnaire before and after the scan.</p><p><strong>Results: </strong>There was no significant difference between the 2 groups before the intervention regarding demographic data and anxiety. In the intervention group, the mean anxiety decreased from 104.0 ± 14.6 to 92.4 ± 9.0, showing a significant reduction in the level of anxiety in both subscales (state and trait) and the total score (P < 0.001), compared with the control group and before the intervention.</p><p><strong>Conclusion: </strong>The results showed that using guided imagery could decrease anxiety levels in patients undergoing MRI. Since patients' anxiety is one of the most important nursing diagnoses, performing cognitive methods, including guided imagery, as a simple, safe, inexpensive, and effective intervention should be considered.</p>","PeriodicalId":39381,"journal":{"name":"Topics in Magnetic Resonance Imaging","volume":"33 5","pages":"e0314"},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Learning Reconstruction of Accelerated MRI: False-Positive Cartilage Delamination Inserted in MRI Arthrography Under Traction.","authors":"Wolfram A Bosbach, Kim Carolin Merdes, Bernd Jung, Elham Montazeri, Suzanne Anderson, Milena Mitrakovic, Keivan Daneshvar","doi":"10.1097/RMR.0000000000000313","DOIUrl":"10.1097/RMR.0000000000000313","url":null,"abstract":"<p><strong>Objectives: </strong>The radiological imaging industry is developing and starting to offer a range of novel artificial intelligence software solutions for clinical radiology. Deep learning reconstruction of magnetic resonance imaging data seems to allow for the acceleration and undersampling of imaging data. Resulting reduced acquisition times would lead to greater machine utility and to greater cost-efficiency of machine operations.</p><p><strong>Materials and methods: </strong>Our case shows images from magnetic resonance arthrography under traction of the right hip joint from a 30-year-old, otherwise healthy, male patient.</p><p><strong>Results: </strong>The undersampled image data when reconstructed by a deep learning tool can contain false-positive cartilage delamination and false-positive diffuse cartilage defects.</p><p><strong>Conclusions: </strong>In the future, precision of this novel technology will have to be put to thorough testing. Bias of systems, in particular created by the choice of training data, will have to be part of those assessments.</p>","PeriodicalId":39381,"journal":{"name":"Topics in Magnetic Resonance Imaging","volume":"33 4","pages":"e0313"},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141628013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Development of the Corpus Callosum in Autism Spectrum Disorder: An MRI Study.","authors":"Suvarna Badhe, Samson Nivins, Pooja Kulkarni, Alitta Jose, Divesh Manek, Satyendra Badhe, Hemangi Sane, Nandini Gokulchandran, Prerna Badhe, Alok Sharma","doi":"10.1097/RMR.0000000000000312","DOIUrl":"https://doi.org/10.1097/RMR.0000000000000312","url":null,"abstract":"<p><strong>Background: </strong>Altered size in the corpus callosum (CC) has been reported in individuals with autism spectrum disorder (ASD), but few studies have investigated younger children. Moreover, knowledge about the age-related changes in CC size in individuals with ASD is limited.</p><p><strong>Objectives: </strong>Our objective was to investigate the age-related size of the CC and compare them with age-matched healthy controls between the ages of 2 and 18 years.</p><p><strong>Methods: </strong>Structural-weighted images were acquired in 97 male patients diagnosed with ASD; published data were used for the control group. The CC was segmented into 7 distinct subregions (rostrum, genu, rostral body, anterior midbody, posterior midbody, isthmus, and splenium) as per Witelson's technique using ITK-SNAP software. We calculated both the total length and volume of the CC as well as the length and height of its 7 subregions. The length of the CC measures was studied as both continuous and categorical forms. For the continuous form, Pearson's correlation was used, while categorical forms were based on age ranges reflecting brain expansion during early postnatal years. Differences in CC measures between adjacent age groups in individuals with ASD were assessed using a Student t-test. Mean and standard deviation scores were compared between ASD and control groups using the Welch t-test.</p><p><strong>Results: </strong>Age showed a moderate positive association with the total length of the CC (r = 0.43; Padj = 0.003) among individuals with ASD. Among the subregions, a positive association was observed only in the anterior midbody of the CC (r = 0.41; Padj = 0.01). No association was found between the age and the height of individual subregions or with the total volume of the CC. In comparison with healthy controls, individuals with ASD exhibited shorter lengths and heights of the genu and splenium of the CC across wide age ranges.</p><p><strong>Conclusion: </strong>Overall, our results highlight a distinct abnormal developmental trajectory of CC in ASD, particularly in the genu and splenium structures, potentially reflecting underlying pathophysiological mechanisms that warrant further investigation.</p>","PeriodicalId":39381,"journal":{"name":"Topics in Magnetic Resonance Imaging","volume":"33 3","pages":"e0312"},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Ring-Enhancing Brain Lesions: Fulminant Diffuse Cerebral Toxoplasmosis or Cerebral Metastases?","authors":"Sebastiaan De Keersmaecker, Sofie Van Cauter, Kim Bekelaar","doi":"10.1097/RMR.0000000000000311","DOIUrl":"10.1097/RMR.0000000000000311","url":null,"abstract":"<p><strong>Abstract: </strong>In this case report, we describe a 76-year-old woman, presenting with dizziness for the past 2 months, without other focal neurological signs. A magnetic resonance imaging of the brain was ordered by her GP. The MRI demonstrated multiple ring-enhancing lesions, both supratentorial and infratentorial. Lumbar puncture showed normal findings, in particular a normal cell count and culture. Because of the radiologic appearance, initially thought to be suggestive of cerebral abscesses, antibiotics were started. However, further workup revealed a new diagnosis of a stage IV (metastatic) small cell lung carcinoma, making diffuse brain metastases more likely. The patient was transferred to oncology/pneumology, where she was started on whole-brain radiotherapy, after which systemic therapy would start. However, because of further clinical deterioration, she was admitted at the palliative ward, where she died only 3 months after the initial presentation. In this case report, we emphasize the importance of keeping a broad differential diagnosis and briefly review the various possible pathologies causing ring-enhancing lesions.</p>","PeriodicalId":39381,"journal":{"name":"Topics in Magnetic Resonance Imaging","volume":"33 2","pages":"e0311"},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging in Preterm Infant: A Systematic Review on Clinical Procedure Safety.","authors":"Raffaele Falsaperla, Silvia Marino, Noemi Ganci, Guido Leone, Catia Romano, Angela Tropea, Placido Romeo, Janette Mailo, Martino Ruggieri","doi":"10.1097/RMR.0000000000000310","DOIUrl":"10.1097/RMR.0000000000000310","url":null,"abstract":"<p><strong>Background: </strong>Currently, there is no evidence that MRI produces harmful effects on premature newborns, as well as short-term and long-term safety issues regarding radiofrequency fields and loud acoustic environment, while the examination that is being performed has not been clearly investigated. MRI of the brain conducted on preterm infants should be part of the diagnostic workup, when necessary. This article is intended to evaluate the short-term safety of MRI performed in preterm infants, when required, by analyzing all vital parameters available before, during, and after the MRI procedures.</p><p><strong>Methods: </strong>We conducted a systematic review of the literature on electronic medical databases (PubMed and ClinicalTrials.gov) following the Preferred Reported Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We included all preterm infants who underwent MRI whose clinical, hemodynamic, and respiratory parameters were reported. The quality of the included articles was assessed using QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies) tool.</p><p><strong>Results: </strong>Six studies were included with a total of 311 preterm infants. No severe adverse event, such as death, occurred during MRI procedures. Vital signs remained stable in about two-thirds of all patients.</p><p><strong>Conclusions: </strong>Given the general clinical safety of MRI, we suggest it as a tool to be used in preterm infants in Neonatal Intensive Care Units, when necessary. We further suggest the development of standard protocols to guide the use of MRI in preterm infants to maximize the clinical safety of the procedure.</p>","PeriodicalId":39381,"journal":{"name":"Topics in Magnetic Resonance Imaging","volume":"33 1","pages":"e0310"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biparametric Quantitative MRI for Prostate Cancer Detection.","authors":"Meltem Uyanik, Hari T Vigneswaran, Graham R Hale, Peter Gann, Richard Magin, Michael R Abern","doi":"10.1097/RMR.0000000000000308","DOIUrl":"10.1097/RMR.0000000000000308","url":null,"abstract":"<p><strong>Objectives: </strong>This study sought to prospectively investigate a novel quantitative biparametric prostate magnetic resonance imaging (MRI) protocol to detect prostate cancer (PCa) in biopsy-naïve men. Secondarily, this study reports the accuracy of fractional order calculus (FROC) diffusion and quantitative T2 compared with the Prostate Imaging Reporting & Data System (PI-RADS).</p><p><strong>Methods: </strong>This prospective pilot study (NCT04175730) enrolled 50 prostate biopsy-naïve men who met eligibility criteria. All men received 3T MRI with T2 and diffusion-weighted imaging (DWI) (b-values: 50-4,000 s/mm2). Men with PI-RADS lesions ≥3 underwent targeted and systematic prostate biopsy, omitting systematic biopsy cores in peripheral zone lesions. DWI series images were fit to signal decay to calculate ADC (mm2/s) and the FROC model for coefficient DF (mm2/s). The primary end point was detection of Gleason grade group ≥2 (GG≥2) PCa. Receiver operating characteristic regression and area under the curve (AUC) were reported.</p><p><strong>Results: </strong>Forty-eight men underwent MRI and biopsy. Mean age was 61.5 years (56-68), 29% were White, 52% were African American, mean PSA was 6.0 ng/mL (4.9-8.0), and mean PSA density was 0.14 ng/mL2. In total, 61 PI-RADS ≥3 lesions were targeted for biopsy. GG≥2 PC was found in 7% (1/14) of PI-RADS 3 lesions, 28% (10/36) of PI-RADS 4 lesions, and 36% (4/11) of PI-RADS 5 lesions. The AUC for detection of GG≥2 PC was 0.63 (0.5-0.76) for PI-RADS, 0.82 (0.68-0.96) for ADC, and 0.87 (0.77-0.97) for the FROC model.</p><p><strong>Conclusion: </strong>This small prospective pilot study demonstrates the feasibility of a novel quantitative biparametic MRI protocol to detect prostate cancer in biopsy-naïve men.</p>","PeriodicalId":39381,"journal":{"name":"Topics in Magnetic Resonance Imaging","volume":"32 6","pages":"66-72"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Magnetic Resonance Imaging-Based Superficial Femoral Artery Velocity Measurements in Diabetic and Nondiabetic Patients With Peripheral Artery Disease.","authors":"Ankita Sinharoy, Neeti Reddy, John Kent Lin, Vijay Nambi, Eric Y Yang, Panagiotis Kougias, Addison A Taylor, Alan B Lumsden, Christie M Ballantyne, Gerd Brunner","doi":"10.1097/RMR.0000000000000309","DOIUrl":"10.1097/RMR.0000000000000309","url":null,"abstract":"<p><strong>Background: </strong>Longitudinal associations of noninvasive 2-dimensional phase-contrast magnetic resonance imaging (2D-PC-MRI) velocity markers of the superficial femoral artery (SFA) were analyzed along with the characteristics of peripheral artery disease (PAD). We hypothesized that the 2-year differences in MRI-based measures of SFA velocity were associated with longitudinal changes in markers of PAD.</p><p><strong>Methods: </strong>A total of 33 (11 diabetic, 22 nondiabetic) patients with PAD with baseline and 2-year follow-up MRI scans were included in this secondary analysis of the Effect of Lipid Modification on Peripheral Artery Disease after Endovascular Intervention Trial (ELIMIT). Electrocardiographically gated 2D-PC-MRI was performed at a proximal and a distal location of the distal SFA territory. SFA lumen, wall, and total vessel volumes and the normalized wall index (NWI) were analyzed.</p><p><strong>Results: </strong>Baseline characteristics did not differ between diabetic and nondiabetic PAD patients. Maximum proximal and distal SFA velocity measures did not differ between baseline and 2 years (41.98 interquartile range (IQR) (23.58-72.6) cm/s vs. 40.31 IQR (26.69-61.29) cm/s; P = 0.30). Pooled analysis (N = 33) showed that the 24-month change in the NWI was inversely associated with the 24-month change in the proximal maximal SFA velocity (beta = -168.36, R2 = 0.150, P value = 0.03). The 24-month change of the maximum velocity differences between the proximal and distal SFA locations was inversely associated with the 24-month changes in peak walking distance (beta = -0.003, R2 = 0.360, P value = 0.011).</p><p><strong>Conclusion: </strong>The 2-year change of SFA plaque burden is inversely associated with the 2-year change of proximal peak SFA blood flow velocity. 2D-PC-MRI measured SFA velocity may be of interest in assessing PAD longitudinally.</p>","PeriodicalId":39381,"journal":{"name":"Topics in Magnetic Resonance Imaging","volume":"32 6","pages":"57-65"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}