No To Hattatsu最新文献_第9页

[Evaluation of quality of life in attention-deficit hyperactivity disorder children without comorbidity]. [无合并症的注意缺陷多动障碍儿童的生活质量评价]。

No To Hattatsu Pub Date : 2015-09-01

Fumikazu Sano, Hideaki Kanemura, Kakuro Aoyagi, Tomoko Tando, Kanji Sugita, Masao Aihara

{"title":"[Evaluation of quality of life in attention-deficit hyperactivity disorder children without comorbidity].","authors":"Fumikazu Sano, Hideaki Kanemura, Kakuro Aoyagi, Tomoko Tando, Kanji Sugita, Masao Aihara","doi":"","DOIUrl":"","url":null,"abstract":"Object: Improving quality of life (QOL) is one of the most important therapeutic goals for children with attention-deficit hyperactiv- ity disorder (AD/HD). The aim of this study was to measure QOL in AD/HD children without comorbidity and to examine associations between QOL and clinical symptoms of AD/HD for targeting early intervention.Methods: Twenty-two enrolled patients and their parents completed the Questionnaire for Measuring Health-Related Quality of Life in Children (KINDL-R). Patients and teachers completed AD/HD rating scale-IV. Associations between QOL and clinical symptoms were assessed using t tests and correlations.Results: Mean total score of the self-reported KINDL-R was 70.8. No difference in total QOL score was seen between AD/HD children and controls; however, the self-esteem subscale rated by AD/HD children was significantly higher than that of controls (p < 0.001). Total KINDL-R score correlated negatively with AD/HD rating scale-IV rated by teachers (p < 0.05). A difference was observed between AD/HD children in a lower QOL group and their parents in a subscale regarding QOL at school.Conclusions: These findings suggest that evaluation of QOL in AD/HD children without comorbidity is useful for identifying AD/HD children who might benefit from early intervention.","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"47 5","pages":"349-53"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34186217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Scintigraphic imaging in the diagnosis of failed intrathecal baclofen therapy: a case report of a 7-year-old boy with ventriculoperitoneal shunt]. [鞘内巴氯芬治疗失败的显像诊断:1例7岁男孩脑室-腹膜分流术]。

No To Hattatsu Pub Date : 2015-09-01

Akiko Shibata, Mariko Yamamoto, Yu Watanabe, Hiroshi Terashima, Hirofumi Kashii, Masaya Kubota, Nobuhito Morota

{"title":"[Scintigraphic imaging in the diagnosis of failed intrathecal baclofen therapy: a case report of a 7-year-old boy with ventriculoperitoneal shunt].","authors":"Akiko Shibata, Mariko Yamamoto, Yu Watanabe, Hiroshi Terashima, Hirofumi Kashii, Masaya Kubota, Nobuhito Morota","doi":"","DOIUrl":"","url":null,"abstract":"Intrathecal baclofen (ITB) therapy is popular for the management of intractable spasticity. In 2007, the indications of ITB therapy expanded to include spasticity of children in Japan. In this report, we assessed the utility of radioisotopic scintigraphy in the diagnosis of failed ITB therapy. A 7-year-old boy with schizencephaly, hydrocephalus, and spastic quadriplegia had an ITB pump implanted. In his infancy, he had undergone ventriculoperitoneal shunt implantation. One month after the ITB operation, the ITB therapeutic effect diminished. Several examinations confirmed that the pump function was normal and catheter failure had not occurred. However, radioisotopic scintigraphy revealed that the baclofen had been washed out to blood circulation more rapidly than is typically observed. We considered two possible causes for this; obstruction of the cerebrospinal space due to kyphosis and excessive washout of celebrospinal fluid through the ventriculoperitoneal shunt. The catheter was moved to a more caudal site surgically, and his spasticity improved. The use of radioisotopic scintigraphy to identify the distribution of baclofen is an effective technique for investigation of baclofen pump system malfunction.","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"47 5","pages":"367-71"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34186221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Relation between psychological development and respiratory management in patients with congenital central hypoventilation syndrome in Japan]. [日本先天性中枢性低通气综合征患者心理发育与呼吸管理的关系]。

No To Hattatsu Pub Date : 2015-09-01

Kaori Irahara, Tomomi Ogata, Hiroshi Ozawa, Ushio Otaki, Keiichi Yamamoto, Takehiro Ishizuka, Kiyoshi Arimoto, Satoshi Kimiya, Koichi Arakawa, Kazuhiro Muramatsu

{"title":"[Relation between psychological development and respiratory management in patients with congenital central hypoventilation syndrome in Japan].","authors":"Kaori Irahara, Tomomi Ogata, Hiroshi Ozawa, Ushio Otaki, Keiichi Yamamoto, Takehiro Ishizuka, Kiyoshi Arimoto, Satoshi Kimiya, Koichi Arakawa, Kazuhiro Muramatsu","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To evaluate the psychological development of patients with congenital central hypoventilation syndrome (CCHS).Methods: We performed a questionnaire-based survey of 17 patients with CCHS aged over 7 years and assessed their clinical course, respiratory management, and psychological development.Results: CCHS was present at birth in 15 patients, of which eight presented with respiratory failure with a low Apgar score. Twelve patients required mechanical ventilation with intubation, and five received mask ventilation. All patients with intubation underwent tracheostomy between 1 and 12 months of age (median 5.5 months), and most of them had associated conditions such as Hirschsprung disease. Four of 12 patients with intubation were eventually switched to mask ventilation and one to diaphragm pacing and mask ventilation. The patients undergoing mask ventilation had relatively milder disease severity and had fewer complications than did the patients with intubation. The psychological development of patients who received tracheostomy ranged from normal to severe retardation. Retardation was more likely to be severe in patients who received tracheostomy in late infancy. All patients who received mask ventilation experienced borderline to moderate psychological retardation. This effect could be attributed to poor compliance with mask fitting.Conclusion: Our findings suggest that the psychological development of CCHS patients was influenced by hypoxia; tracheostomy and strict respiratory management since the neonatal period were needed for neurological protection.","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"47 5","pages":"343-7"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34186216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The beginning of the gender equality in the Japanese Society of Child Neurology]. 【日本儿童神经学会性别平等的开端】。

No To Hattatsu Pub Date : 2015-09-01

Yoshimi Kaga

引用次数: 0

[A 9-month-old boy manifesting generalized hypotonia and tented mouth]. [一个9个月大的男孩表现出全身性张力低下和口部帐篷状]。

No To Hattatsu Pub Date : 2015-09-01

Tadashi Shiohama

引用次数: 0

[Efficacy and tolerability of topiramate, lamotrigine, and levetiracetam in children with refractory epilepsy]. [托吡酯、拉莫三嗪和左乙拉西坦治疗难治性癫痫的疗效和耐受性]。

No To Hattatsu Pub Date : 2015-09-01

Takeo Kato, Masatoshi Nakata, Minako Ide, Keiko Saito, Takeshi Yoshida, Tomonari Awaya, Toshio Heike

{"title":"[Efficacy and tolerability of topiramate, lamotrigine, and levetiracetam in children with refractory epilepsy].","authors":"Takeo Kato, Masatoshi Nakata, Minako Ide, Keiko Saito, Takeshi Yoshida, Tomonari Awaya, Toshio Heike","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Topiramate (TPM), lamotrigine (LTG), and levetiracetam (LEV) are three new-generation antiepileptic drugs (AEDs) which have recently come into use in add-on therapy for refractory childhood epilepsy in Japan. The aim of this study was to evaluate their efficacy and tolerability, and to clarify the role of these three AEDs in childhood epilepsy therapy.Methods: Three separate audits were conducted between July 2007 and July 2012. All patients studied had epilepsy refractory to other AEDs. Efficacy was confirmed if a patient became seizure-free or achieved > 50% reduction (50% responder rate: 50% RR) in seizure frequency for 12 months after starting add-on therapy.Results: A total of 55 children received TPM, 44 LTG, and 38 LEV. The 50% RR of partial epilepsy was 31.8% for LTG, 41.8% for TPM, and 52.6% for LEV. The 50% RR of generalized epilepsy was 28.6% for LTG, 26.7% for TPM, and 44.4% for LEV. The incidence of adverse events was 9.1% for LTG, 43.6% for TPM, and 15.8% for LEV.Conclusion: LEV was the most effective of the three add-on therapies in refractory childhood epilepsy with partial and generalized onset. Regarding seizure-free, TPM was more effective than the other therapies, but it had many side effects. LTG tended to be more effective for generalized epilepsy, particularly idiopathic epilepsy, than partial epilepsy. We conclude that it is necessary to develop a treatment plan for pediatric epilepsies after considering the advantages and disadvantage of these new AEDs.","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"47 5","pages":"354-9"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34186218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A clinical study of laryngotracheal separation in spinal muscular atrophy type I patients]. [喉气管分离治疗脊髓型肌萎缩症的临床研究]。

No To Hattatsu Pub Date : 2015-09-01

Tomohito Fujioka, Kousuke Nakano, Satoshi Maniwa

引用次数: 0

[Cognitive and linguistic abilities of a boy with PVL showing relatively higher VIQ compared to PIQ]. [与PIQ相比，PVL男孩的认知和语言能力表现出相对较高的VIQ]。

No To Hattatsu Pub Date : 2015-09-01

Yukako Muramatsu, Jun Natsume, Miho Nakamura

{"title":"[Cognitive and linguistic abilities of a boy with PVL showing relatively higher VIQ compared to PIQ].","authors":"Yukako Muramatsu, Jun Natsume, Miho Nakamura","doi":"","DOIUrl":"","url":null,"abstract":"In this study, we investigated the cognitive processing and language abilities of a 13-year-old boy with moderate periventricular leukomalacia (PVL), spastic diplegia and exotropia who had discrepant scores in the verbal intelligence quotient (VIQ) and performance intelligence quotient (PIQ) in the Wechsler Intelligence Scale for Children, third edition (VIQ; 82 > PIQ; under 40). In the Kaufman Assessment Battery for Children and Das-Naglieri Cognitive Assessment System, his performance was poor at simultaneous processing compared to sequential processing. He could not copy three-dimensional figures, and he could place only two out of eight blocks correctly in the second level models of Benton three-dimensional block construction test, showing visuospatial impairment typical of patients with PVL. Despite the relatively high score in VIQ, there was a gap among the scores of the subtests in the Illinois Test of Psycholinguistic Abilities. He tended to get low scores in tests that required visual abilities. In addition, there was also an impairment in reading fluency tested by the Diagnostic Criteria and Medical Guideline for Specific Developmental Disorders. He was much less fluent in reading syllables, words or sentences (6.0 SD or more compared to 12-year-old boys). The relatively higher score in VIQ superficially suggests adequate language ability. However, in the present study, precise investigation revealed some discrepancies even within the field of language. Thus, defining stronger and weaker points of a patient is important in order to determine optimal medical or educational approaches.","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"47 5","pages":"363-6"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34186220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Effectiveness and safety of long-term levetiracetam treatment in patients with refractory epilepsy]. [左乙拉西坦长期治疗难治性癫痫的有效性和安全性]。

No To Hattatsu Pub Date : 2015-07-01

Mitsuhiro Matsuo, Akiko Fuji, Tetsuo Matsuzaka, Hiroshi Baba, Keisuke Toda, Tomonori Ono, Shigeki Tanaka, Tatsuharu Sato, Hiroyuki Moriuchi

{"title":"[Effectiveness and safety of long-term levetiracetam treatment in patients with refractory epilepsy].","authors":"Mitsuhiro Matsuo, Akiko Fuji, Tetsuo Matsuzaka, Hiroshi Baba, Keisuke Toda, Tomonori Ono, Shigeki Tanaka, Tatsuharu Sato, Hiroyuki Moriuchi","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To evaluate the long-term effects and tolerability of levetiracetam (LEV) in refractory epilepsy.Methods: LEV was administered to 76 patients whose seizures were inadequately controlled by their current medications. The patients were followed for a minimum of 18 months but less than 2 years. The efficacy of LEV treatment was assessed retrospectively as the proportion of patients who experienced at least a 50% reduction in the frequency of seizures (50% RR), and adverse events were analyzed.Results: The 50% RR in all 76 patients was 42%. The 50% RRs in the 54 patients with localization-related epilepsy and in the 20 patients with generalized epilepsy were 42% and 35%, respectively. The patients who responded most remarkably to the therapy, with at least a 75% reduction in the frequency of seizures, were more often those with localization-related epilepsy. Among adverse events, irritability and hyperactivity/impulsivity were observed more frequently in this study than in previous reports. These events were observed predominantly in patients suffering from autism or attention deficit hyperactivity disorder (AD/HD) as a comorbidity. γ-GTP values were improved in 14 of 17 patients whose values prior to beginning LEV treatment were higher than the normal range. This beneficial effect presumably resulted from a dose reduction or the discontinuation of other hepatotoxic antiepileptic drugs.Conclusions: LEV was useful for the treatment of refractory epilepsy, and long-term efficacy was demonstrated. LEV also appeared to be less hepatotoxic. Behavioral changes should be monitored carefully when LEV is administered to patients with concomitant autism or AD/HD.","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"47 4","pages":"272-8"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34057246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Primary cilia and hedgehog signaling]. [初级纤毛和刺猬信号]。

No To Hattatsu Pub Date : 2015-07-01

Katsunori Fujii

引用次数: 0