No To Hattatsu最新文献_第10页

[The beginning of the gender equality in the Japanese Society of Child Neurology]. 【日本儿童神经学会性别平等的开端】。

No To Hattatsu Pub Date : 2015-09-01

Yoshimi Kaga

引用次数: 0

[A 9-month-old boy manifesting generalized hypotonia and tented mouth]. [一个9个月大的男孩表现出全身性张力低下和口部帐篷状]。

No To Hattatsu Pub Date : 2015-09-01

Tadashi Shiohama

引用次数: 0

[Efficacy and tolerability of topiramate, lamotrigine, and levetiracetam in children with refractory epilepsy]. [托吡酯、拉莫三嗪和左乙拉西坦治疗难治性癫痫的疗效和耐受性]。

No To Hattatsu Pub Date : 2015-09-01

Takeo Kato, Masatoshi Nakata, Minako Ide, Keiko Saito, Takeshi Yoshida, Tomonari Awaya, Toshio Heike

{"title":"[Efficacy and tolerability of topiramate, lamotrigine, and levetiracetam in children with refractory epilepsy].","authors":"Takeo Kato, Masatoshi Nakata, Minako Ide, Keiko Saito, Takeshi Yoshida, Tomonari Awaya, Toshio Heike","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Topiramate (TPM), lamotrigine (LTG), and levetiracetam (LEV) are three new-generation antiepileptic drugs (AEDs) which have recently come into use in add-on therapy for refractory childhood epilepsy in Japan. The aim of this study was to evaluate their efficacy and tolerability, and to clarify the role of these three AEDs in childhood epilepsy therapy.Methods: Three separate audits were conducted between July 2007 and July 2012. All patients studied had epilepsy refractory to other AEDs. Efficacy was confirmed if a patient became seizure-free or achieved > 50% reduction (50% responder rate: 50% RR) in seizure frequency for 12 months after starting add-on therapy.Results: A total of 55 children received TPM, 44 LTG, and 38 LEV. The 50% RR of partial epilepsy was 31.8% for LTG, 41.8% for TPM, and 52.6% for LEV. The 50% RR of generalized epilepsy was 28.6% for LTG, 26.7% for TPM, and 44.4% for LEV. The incidence of adverse events was 9.1% for LTG, 43.6% for TPM, and 15.8% for LEV.Conclusion: LEV was the most effective of the three add-on therapies in refractory childhood epilepsy with partial and generalized onset. Regarding seizure-free, TPM was more effective than the other therapies, but it had many side effects. LTG tended to be more effective for generalized epilepsy, particularly idiopathic epilepsy, than partial epilepsy. We conclude that it is necessary to develop a treatment plan for pediatric epilepsies after considering the advantages and disadvantage of these new AEDs.","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"47 5","pages":"354-9"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34186218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A clinical study of laryngotracheal separation in spinal muscular atrophy type I patients]. [喉气管分离治疗脊髓型肌萎缩症的临床研究]。

No To Hattatsu Pub Date : 2015-09-01

Tomohito Fujioka, Kousuke Nakano, Satoshi Maniwa

引用次数: 0

[Cognitive and linguistic abilities of a boy with PVL showing relatively higher VIQ compared to PIQ]. [与PIQ相比，PVL男孩的认知和语言能力表现出相对较高的VIQ]。

No To Hattatsu Pub Date : 2015-09-01

Yukako Muramatsu, Jun Natsume, Miho Nakamura

{"title":"[Cognitive and linguistic abilities of a boy with PVL showing relatively higher VIQ compared to PIQ].","authors":"Yukako Muramatsu, Jun Natsume, Miho Nakamura","doi":"","DOIUrl":"","url":null,"abstract":"In this study, we investigated the cognitive processing and language abilities of a 13-year-old boy with moderate periventricular leukomalacia (PVL), spastic diplegia and exotropia who had discrepant scores in the verbal intelligence quotient (VIQ) and performance intelligence quotient (PIQ) in the Wechsler Intelligence Scale for Children, third edition (VIQ; 82 > PIQ; under 40). In the Kaufman Assessment Battery for Children and Das-Naglieri Cognitive Assessment System, his performance was poor at simultaneous processing compared to sequential processing. He could not copy three-dimensional figures, and he could place only two out of eight blocks correctly in the second level models of Benton three-dimensional block construction test, showing visuospatial impairment typical of patients with PVL. Despite the relatively high score in VIQ, there was a gap among the scores of the subtests in the Illinois Test of Psycholinguistic Abilities. He tended to get low scores in tests that required visual abilities. In addition, there was also an impairment in reading fluency tested by the Diagnostic Criteria and Medical Guideline for Specific Developmental Disorders. He was much less fluent in reading syllables, words or sentences (6.0 SD or more compared to 12-year-old boys). The relatively higher score in VIQ superficially suggests adequate language ability. However, in the present study, precise investigation revealed some discrepancies even within the field of language. Thus, defining stronger and weaker points of a patient is important in order to determine optimal medical or educational approaches.","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"47 5","pages":"363-6"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34186220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Effectiveness and safety of long-term levetiracetam treatment in patients with refractory epilepsy]. [左乙拉西坦长期治疗难治性癫痫的有效性和安全性]。

No To Hattatsu Pub Date : 2015-07-01

Mitsuhiro Matsuo, Akiko Fuji, Tetsuo Matsuzaka, Hiroshi Baba, Keisuke Toda, Tomonori Ono, Shigeki Tanaka, Tatsuharu Sato, Hiroyuki Moriuchi

{"title":"[Effectiveness and safety of long-term levetiracetam treatment in patients with refractory epilepsy].","authors":"Mitsuhiro Matsuo, Akiko Fuji, Tetsuo Matsuzaka, Hiroshi Baba, Keisuke Toda, Tomonori Ono, Shigeki Tanaka, Tatsuharu Sato, Hiroyuki Moriuchi","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To evaluate the long-term effects and tolerability of levetiracetam (LEV) in refractory epilepsy.Methods: LEV was administered to 76 patients whose seizures were inadequately controlled by their current medications. The patients were followed for a minimum of 18 months but less than 2 years. The efficacy of LEV treatment was assessed retrospectively as the proportion of patients who experienced at least a 50% reduction in the frequency of seizures (50% RR), and adverse events were analyzed.Results: The 50% RR in all 76 patients was 42%. The 50% RRs in the 54 patients with localization-related epilepsy and in the 20 patients with generalized epilepsy were 42% and 35%, respectively. The patients who responded most remarkably to the therapy, with at least a 75% reduction in the frequency of seizures, were more often those with localization-related epilepsy. Among adverse events, irritability and hyperactivity/impulsivity were observed more frequently in this study than in previous reports. These events were observed predominantly in patients suffering from autism or attention deficit hyperactivity disorder (AD/HD) as a comorbidity. γ-GTP values were improved in 14 of 17 patients whose values prior to beginning LEV treatment were higher than the normal range. This beneficial effect presumably resulted from a dose reduction or the discontinuation of other hepatotoxic antiepileptic drugs.Conclusions: LEV was useful for the treatment of refractory epilepsy, and long-term efficacy was demonstrated. LEV also appeared to be less hepatotoxic. Behavioral changes should be monitored carefully when LEV is administered to patients with concomitant autism or AD/HD.","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"47 4","pages":"272-8"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34057246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Primary cilia and hedgehog signaling]. [初级纤毛和刺猬信号]。

No To Hattatsu Pub Date : 2015-07-01

Katsunori Fujii

引用次数: 0

[Parenting resilience for rearing a child with autism spectrum disorder: a qualitative study]. [养育自闭症谱系障碍儿童的父母韧性:一项定性研究]。

No To Hattatsu Pub Date : 2015-07-01

Kota Suzuki, Tomoka Kobayashi, Karin Moriyama, Makiko Kaga, Michio Hiratani, Kyota Watanabe, Yushiro Yamashita, Takashi Hayashi, Masumi Inagaki

{"title":"[Parenting resilience for rearing a child with autism spectrum disorder: a qualitative study].","authors":"Kota Suzuki, Tomoka Kobayashi, Karin Moriyama, Makiko Kaga, Michio Hiratani, Kyota Watanabe, Yushiro Yamashita, Takashi Hayashi, Masumi Inagaki","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Resilience is defined as the dynamic process of positive adaptation despite the experience of adversity. The aims of this study were to apply the concept of resilience to the mothers of children with autism spectrum disorder (ASD), which we call \"parenting resilience\" for rearing a child with ASD, and to explain the construct of parenting resilience.Methods: Interviews were conducted with 23 mothers of adults with ASD to collect data on rearing these children from infancy to adulthood. Data were analyzed using a modified grounded-theory approach.Results: The analytic theme was the thought process from the problems associated with raising developmentally challenged children to the implementation of the appropriate coping method. We proposed a model comprising twelve concepts and five categories, i. e., \"a sense of motherhood\", \"self-efficacy\", \"knowledge of the child's characteristics\", \"perceived social support\", and \"foresight\". The model assumes that a sense of motherhood and self-efficacy motivate these mothers to cope with the problems associated with developmentally challenged children, and they derive the way of dealing with it from knowledge of the child's characteristics, perceived social support, and foresight.Discussion: We suggest that the construct of parenting resilience for rearing a child with ASD is composed of the proposed categories and concepts.","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"47 4","pages":"283-8"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34057248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Study of lamotrigine efficacy on behavior disorders affecting patients with severe mental retardation]. [拉莫三嗪治疗重度智力低下患者行为障碍的疗效研究]。

No To Hattatsu Pub Date : 2015-07-01

Tetsuji Kubagawa, Junichi Furusho, Yusuke Isozaki

{"title":"[Study of lamotrigine efficacy on behavior disorders affecting patients with severe mental retardation].","authors":"Tetsuji Kubagawa, Junichi Furusho, Yusuke Isozaki","doi":"","DOIUrl":"","url":null,"abstract":"Objective: We studied the effect of lamotrigine (LTG) in children/adults with severe mental retardation and behavioral problems.Methods: We studied 10 cases with the following conditions: (1) severe or profound mental retardation, (2) various behavioral problems and troubles in daily life, (3) insufficient effects or side effects from antipsychotic drugs, (4) ongoing epileptic seizures or EEG indications of epilepsy, (5) no previous LTG administration, (6) the ability to provide informed consent. We began administering small doses and increased to a maximum dose of LTG in 50 mg/day. We determined the improvement of behavioral problems based on family and patient interviews or our medical examinations.Results: Treatment (still ongoing) has resulted in 7 of the 10 cases showing effects of LTG. Also, 2 of the remaining 3 cases have discontinued medication due to evident changes of mood. Eight cases have showed effects with doses of 10 mg or less per day. We encountered one adult subject who seems to have realized the neuropsychological effect on recognition impairment. We speculated that this patient came to read other people's emotional changes and expected to be either criticized or directed.Conclusions: Small doses of LTG appear to improve behavioral problems in children/adults with severe mental retardation.","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"47 4","pages":"289-92"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34057249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Historiae]. [历史]。

No To Hattatsu Pub Date : 2015-07-01

Nobuhito Morota

引用次数: 0