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Adverse Drug Reaction Bulletin最新文献

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Statin-induced myopathy in the elderly: Part 1 老年人他汀类药物引起的肌病:第1部分
Adverse Drug Reaction Bulletin Pub Date : 2009-04-01 DOI: 10.1097/FAD.0b013e32832c0ce1
S. Chew
{"title":"Statin-induced myopathy in the elderly: Part 1","authors":"S. Chew","doi":"10.1097/FAD.0b013e32832c0ce1","DOIUrl":"https://doi.org/10.1097/FAD.0b013e32832c0ce1","url":null,"abstract":"The incidence of cardiovascular disease is higher in the elderly, who therefore derive greater absolute benefit from appropriate prophylaxis with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins). However, there is also a high prevalence of polypharmacy in the elderly that predisposes them to statin-induced myopathy and adverse drug interactions. Here I seek to identify the predisposing factors and clinical presentation of statin-induced myopathy in the elderly. Part 2 will cover the diagnosis and management of statin-induced myopathy so that statins can be prescribed appropriately and safely in the elderly.","PeriodicalId":39261,"journal":{"name":"Adverse Drug Reaction Bulletin","volume":"&NA; 1","pages":"979–982"},"PeriodicalIF":0.0,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/FAD.0b013e32832c0ce1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Routes of drug administration: uses and adverse effects: Part 2: sublingual, buccal, rectal, and some other routes 给药途径:使用和不良反应:第2部分:舌下、口腔、直肠和一些其他途径
Adverse Drug Reaction Bulletin Pub Date : 2009-02-01 DOI: 10.1097/FAD.0b013e32832a0b18
J. Aronson
{"title":"Routes of drug administration: uses and adverse effects: Part 2: sublingual, buccal, rectal, and some other routes","authors":"J. Aronson","doi":"10.1097/FAD.0b013e32832a0b18","DOIUrl":"https://doi.org/10.1097/FAD.0b013e32832a0b18","url":null,"abstract":"Drugs are effective only if they reach their site of action. This can be achieved by direct application or in many indirect ways, usually via the bloodstream. Here I describe the uses and characteristic adverse effects of commonly used routes of administration. In part 1 I dealt with intramuscular injection and subcutaneous injection. Here I consider several other routes.","PeriodicalId":39261,"journal":{"name":"Adverse Drug Reaction Bulletin","volume":"&NA; 1","pages":"975–978"},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/FAD.0b013e32832a0b18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Routes of drug administration: uses and adverse effects: Part 1: Intramuscular and subcutaneous injection 给药途径:用途和不良反应:第1部分:肌肉注射和皮下注射
Adverse Drug Reaction Bulletin Pub Date : 2008-12-01 DOI: 10.1097/FAD.0b013e328329bb21
J. Aronson
{"title":"Routes of drug administration: uses and adverse effects: Part 1: Intramuscular and subcutaneous injection","authors":"J. Aronson","doi":"10.1097/FAD.0b013e328329bb21","DOIUrl":"https://doi.org/10.1097/FAD.0b013e328329bb21","url":null,"abstract":"Drugs are effective only if they reach their site of action. This is usually achieved by oral administration, but other routes are possible. Here I describe the uses and characteristic adverse effects of commonly used routes of administration. In this part I deal with intramuscular and subcutaneous injection and in part 2 other routes.","PeriodicalId":39261,"journal":{"name":"Adverse Drug Reaction Bulletin","volume":"&NA; 1","pages":"971–974"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/FAD.0b013e328329bb21","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Adverse reactions to antifungal agents 抗真菌药物的不良反应
Adverse Drug Reaction Bulletin Pub Date : 2008-08-01 DOI: 10.1097/FAD.0b013e32831844cb
N. Gogtay, U. Kulkarni, T. Panchabhai
{"title":"Adverse reactions to antifungal agents","authors":"N. Gogtay, U. Kulkarni, T. Panchabhai","doi":"10.1097/FAD.0b013e32831844cb","DOIUrl":"https://doi.org/10.1097/FAD.0b013e32831844cb","url":null,"abstract":"An increase in the number of immunocompromised hosts has led to an increase in the incidence of fungal infections, predominantly those caused by Candida and Aspergillus spp. The older drugs amphotericin B and flucytosine continue to be used but are associated with major adverse effects such as nephrotoxicity, hepatotoxicity and bone marrow depression, respectively. The older imidazoles used topically for superficial mycoses can produce local reactions. Triazoles as a class can cause hepatotoxicity and are susceptible to drug interactions due to their metabolism by CYP450 enzymes. Visual disturbances and photosensitivity are associated with the use of voriconazole. Echinocandins can provoke infusion-related reactions.","PeriodicalId":39261,"journal":{"name":"Adverse Drug Reaction Bulletin","volume":"&NA; 1","pages":"963–966"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/FAD.0b013e32831844cb","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Interpretation of postmortem toxicology: more complicated than it might seem – Part 2 死后毒理学解释:比看起来更复杂-第二部分
Adverse Drug Reaction Bulletin Pub Date : 2008-06-01 DOI: 10.1097/FAD.0b013e32830ceb2e
R. Flanagan
{"title":"Interpretation of postmortem toxicology: more complicated than it might seem – Part 2","authors":"R. Flanagan","doi":"10.1097/FAD.0b013e32830ceb2e","DOIUrl":"https://doi.org/10.1097/FAD.0b013e32830ceb2e","url":null,"abstract":"All the available evidence must be taken into account when investigating a death if poisoning is suspected. An overall knowledge of the circumstances, time course, clinical/postmortem observations, poisons thought to be involved and their toxicology and metabolism, is important, as well as knowledge of the samples available for analysis and the analytical methods used. Part 1 of this review discussed operational considerations in postmortem toxicology, including the importance of proper sample collection. Some further problems and pitfalls in the interpretation of quantitative data, especially as regards the possibility of postmortem increases in blood concentrations (postmortem redistribution), are outlined in this second part. Despite the problems listed above, toxicological analysis of specimens obtained postmortem can often provide evidence of exposure and sometimes also an estimate of the magnitude of exposure, provided always that interpretation of the analytical results is undertaken with due caution.","PeriodicalId":39261,"journal":{"name":"Adverse Drug Reaction Bulletin","volume":"95 1","pages":"959–962"},"PeriodicalIF":0.0,"publicationDate":"2008-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/FAD.0b013e32830ceb2e","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Interpretation of postmortem toxicology: more complicated than it might seem – Part 1 死后毒理学解释:比看起来更复杂-第一部分
Adverse Drug Reaction Bulletin Pub Date : 2008-04-01 DOI: 10.1097/FAD.0b013e32830ceaea
R. Flanagan
{"title":"Interpretation of postmortem toxicology: more complicated than it might seem – Part 1","authors":"R. Flanagan","doi":"10.1097/FAD.0b013e32830ceaea","DOIUrl":"https://doi.org/10.1097/FAD.0b013e32830ceaea","url":null,"abstract":"The aim of postmortem toxicology is to help establish the role that drugs or other poisons played in a death, or in events immediately before death. It was thought that concentrations of poisons measured in blood obtained at autopsy reflected the situation perimortem. However, we now know that interpretation of postmortem toxicology must take into consideration what is known of the clinical pharmacology, including pharmacokinetics, and toxicology of the agent(s) in question, the circumstances under which death occurred, including the possible mechanism(s) of exposure and other factors such as the age of the deceased. Further important considerations include that changes may occur in the composition of body fluids, especially blood, after death.Part 1 of this review discusses operational considerations in postmortem toxicology, including sample collection. Some further problems and pitfalls in the interpretation of quantitative data, especially as regards the possibility of postmortem increases in blood concentrations (postmortem redistribution), are outlined in Part 2.","PeriodicalId":39261,"journal":{"name":"Adverse Drug Reaction Bulletin","volume":"&NA; 1","pages":"955–958"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/FAD.0b013e32830ceaea","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Adverse drug interactions 药物不良相互作用
Adverse Drug Reaction Bulletin Pub Date : 2008-02-01 DOI: 10.1097/FAD.0b013e328302c585
K. Baxter, J. Sharp
{"title":"Adverse drug interactions","authors":"K. Baxter, J. Sharp","doi":"10.1097/FAD.0b013e328302c585","DOIUrl":"https://doi.org/10.1097/FAD.0b013e328302c585","url":null,"abstract":"Drug interactions are numerous and varied, but not always clinically significant. Here we consider those factors that determine whether or not a drug interaction becomes clinically important, and the drugs commonly implicated in interactions.","PeriodicalId":39261,"journal":{"name":"Adverse Drug Reaction Bulletin","volume":"&NA; 1","pages":"951–954"},"PeriodicalIF":0.0,"publicationDate":"2008-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/FAD.0b013e328302c585","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse reactions to drugs used to treat alcoholism 治疗酒精中毒药物的不良反应
Adverse Drug Reaction Bulletin Pub Date : 2007-12-01 DOI: 10.1097/FAD.0b013e328300788f
B. Theron, S. Singhal
{"title":"Adverse reactions to drugs used to treat alcoholism","authors":"B. Theron, S. Singhal","doi":"10.1097/FAD.0b013e328300788f","DOIUrl":"https://doi.org/10.1097/FAD.0b013e328300788f","url":null,"abstract":"The armamentarium of drugs used in the treatment of alcohol abuse has grown with newer and novel therapies introduced to improve compliance and adverse effect profiles. There is now a range of treatments particularly aimed at reducing craving and improving abstinence rates, including opioid antagonists (both long-acting and short-acting) and γ-aminobutyric-acid receptor analogues, which have a good evidence base and are reasonably well tolerated.","PeriodicalId":39261,"journal":{"name":"Adverse Drug Reaction Bulletin","volume":"&NA; 1","pages":"947–250"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/FAD.0b013e328300788f","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
SUBJECT AND DRUG INDEXES TO ADVERSE DRUG REACTION BULLETIN: Nos 242–247 February 2007 – December 2007 药物不良反应通报:第242-247期2007年2月- 2007年12月
Adverse Drug Reaction Bulletin Pub Date : 2007-12-01 DOI: 10.1097/fad.0b013e32830078a3
{"title":"SUBJECT AND DRUG INDEXES TO ADVERSE DRUG REACTION BULLETIN: Nos 242–247 February 2007 – December 2007","authors":"","doi":"10.1097/fad.0b013e32830078a3","DOIUrl":"https://doi.org/10.1097/fad.0b013e32830078a3","url":null,"abstract":"abatacept, 927 infliximab, 927, 928, 929 acamprosate, 948 aciclovir, 941 adalimumab, 928, 929 ipecacuanha, 937 iproniazid, 932 irbesartan, 945 adenofovir, 940 lamivudine, 940 amphotericin, 939, 940 anakinra, 927, 928 benazepril, 944 buprenorphine, 932 bupropion, 932, 933 buspirone, 932, 933 captopril, 944 celecoxib, 940 chlordiazepoxide, 947 chlorphenamine, 932, 933 ciclosporin, 939, 941 cidofovir, 940 ciprofloxacin, 941 citalopram, 932 clomipramine, 931 clopidogrel, 941 cocaine, 941 codeine, 932 colestyramine, 928 co-trimoxazole, 941 dextromethorphan, 932, 933 diamorphine, 941 diazepam, 933, 947 didanosine, 940 dihydrocodeine, 932 dihydroergotamine, 932, 933 disulfiram, 948, 949 droperidol, 947 duloxetine, 933 ecstasy, See methylenedioxymethamphetamine efavirenz, 941 enalapril, 944 etanercept, 927, 928, 929 ethanol, 941, 947–950 fentanyl, 932, 933 flumazenil, 947 fluoxetine, 932 fluvoxamine, 932 foscarnet, 940 haloperidol, 947 Hypericum perforatum. See St John’s wort imipramine, 931 immunoglobulin, 927, 929, 941 indinavir, 941","PeriodicalId":39261,"journal":{"name":"Adverse Drug Reaction Bulletin","volume":"&NA; 1","pages":"&NA;"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/fad.0b013e32830078a3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse effects of angiotensin-converting enzyme inhibitors and Angiotensin-II receptor blockers in pregnancy 血管紧张素转换酶抑制剂和血管紧张素ii受体阻滞剂对妊娠的不良影响
Adverse Drug Reaction Bulletin Pub Date : 2007-10-01 DOI: 10.1097/FAD.0b013e3282fe180f
R. L. Branch, U. Martin
{"title":"Adverse effects of angiotensin-converting enzyme inhibitors and Angiotensin-II receptor blockers in pregnancy","authors":"R. L. Branch, U. Martin","doi":"10.1097/FAD.0b013e3282fe180f","DOIUrl":"https://doi.org/10.1097/FAD.0b013e3282fe180f","url":null,"abstract":"Hypertension is a common adverse effect of pregnancy. Angiotensin-converting enzyme inhibitors and angitoensin-II blocking drugs are commonly used, and some mothers may have been taking them when they became pregnant. Both classes of drugs have severe adverse effects on the developing fetus, and this risk occurs throughout pregnancy.","PeriodicalId":39261,"journal":{"name":"Adverse Drug Reaction Bulletin","volume":"&NA; 1","pages":"943–946"},"PeriodicalIF":0.0,"publicationDate":"2007-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/FAD.0b013e3282fe180f","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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