抗真菌药物的不良反应

Q4 Medicine

Adverse Drug Reaction Bulletin Pub Date : 2008-08-01 DOI:10.1097/FAD.0b013e32831844cb

N. Gogtay, U. Kulkarni, T. Panchabhai

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引用次数: 3

摘要

免疫功能低下的宿主数量的增加导致真菌感染的发生率增加，主要是念珠菌和曲霉引起的真菌感染。较老的药物两性霉素B和氟胞嘧啶继续使用，但分别与肾毒性、肝毒性和骨髓抑制等主要不良反应有关。旧的咪唑局部用于浅表真菌病可产生局部反应。三唑类药物可引起肝毒性，由于其CYP450酶代谢，易受药物相互作用的影响。视力障碍和光敏性与使用伏立康唑有关。棘白菌素可引起输液相关反应。

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Adverse reactions to antifungal agents

An increase in the number of immunocompromised hosts has led to an increase in the incidence of fungal infections, predominantly those caused by Candida and Aspergillus spp. The older drugs amphotericin B and flucytosine continue to be used but are associated with major adverse effects such as nephrotoxicity, hepatotoxicity and bone marrow depression, respectively. The older imidazoles used topically for superficial mycoses can produce local reactions. Triazoles as a class can cause hepatotoxicity and are susceptible to drug interactions due to their metabolism by CYP450 enzymes. Visual disturbances and photosensitivity are associated with the use of voriconazole. Echinocandins can provoke infusion-related reactions.

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来源期刊

Adverse Drug Reaction Bulletin Medicine-Pharmacology (medical)

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： For over 40 years, Adverse Drug Reaction Bulletin has provided comprehensive coverage in the field of adverse drug reactions. Each issue contains an invited article on a topic of current interest, dealing with specific conditions from drug-induced lung disorders to drug-induced sexual dysfunction, or types of drugs from lipid-lowering agents to poisons antidotes. This bimonthly journal"s articles are timely, succinct and fully referenced