Pediatric Endocrinology, Diabetes and Metabolism最新文献_第2页

The effect of insulin on the central nervous system: insights into neurological complications and management of type 1 diabetes in the pediatric population. 胰岛素对中枢神经系统的影响：对儿科1型糖尿病的神经系统并发症和管理的见解

Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2025-01-01 DOI: 10.5114/pedm.2025.152597

Łukasz Świątek, Jan Jeske, Miłosz Miedziaszczyk, Ilona Idasiak-Piechocka, Paulina Wais

{"title":"The effect of insulin on the central nervous system: insights into neurological complications and management of type 1 diabetes in the pediatric population.","authors":"Łukasz Świątek, Jan Jeske, Miłosz Miedziaszczyk, Ilona Idasiak-Piechocka, Paulina Wais","doi":"10.5114/pedm.2025.152597","DOIUrl":"10.5114/pedm.2025.152597","url":null,"abstract":"Introduction: Insulin is primarily known for its role in glucose homeostasis regulation. Since the discovery that insulin crosses the blood-brain barrier (BBB) in the year 1954, the influence of insulin on the central nervous system (CNS) has been under continuous research.Aim of the study: The aim of this paper is to review the current knowledge about the effects of insulin on CNS function in the pediatric population with special attention to diabetes type 1.Material and methods: The PubMed and Cochrane search engines were used in the data searching process.Conclusions: Recent studies have shown that insulin has substantial glycemic and non-glycemic effects on the human brain. In pediatric populations, insulin's non-glycemic effects on CNS function are of particular interest due to the critical role of insulin in brain development, cognitive maturation, and learning. Therefore, children and adolescents with diabetes type 1 (T1DM), resulting in insulin deficiency and dysregulated glucose metabolism, require special attention.Conclusions: While insulin therapy is essential for glycemic control in pediatric patients with T1DM, researchers suggest that insulin also has a crucial effect on the central nervous system (CNS), which may have implications for neurodevelopment and cognitive function in this group of patients.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"31 2","pages":"68-74"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of antioxidant and antidiabetic properties of meliponine honey from different stingless bee species and origins: a scoping review. 不同种类和来源的无刺蜜蜂蜂蜜抗氧化和抗糖尿病特性的比较：范围综述。

Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2025-01-01 DOI: 10.5114/pedm.2025.152596

Junaidin Junaidin, Abdurachman Abdurachman, I Ketut Sudiana

{"title":"Comparison of antioxidant and antidiabetic properties of meliponine honey from different stingless bee species and origins: a scoping review.","authors":"Junaidin Junaidin, Abdurachman Abdurachman, I Ketut Sudiana","doi":"10.5114/pedm.2025.152596","DOIUrl":"10.5114/pedm.2025.152596","url":null,"abstract":"Introduction: Meliponine honey, derived from stingless bees, has significant therapeutic potential due to its bioactive compounds, such as polyphenols and flavonoids, which contribute to its antioxidant and antidiabetic properties. However, the variations in honey quality based on bee species and geographical origin still require further exploration to maximize its benefits. This study aimed to evaluate the variations in antioxidant and antidiabetic properties of meliponine honey based on stingless bee species and their geographical origins.Material and methods: This scoping review follows the Joanna Briggs Institute methodology, including a comprehensive literature search in major scientific databases such as PubMed, Scopus, DOAJ, Wiley Online, and Google Scholar. Data from relevant studies were extracted and analyzed using a thematic synthesis approach to identify patterns in the bioactivity of Trigona honey.Results: A total of 23 articles met the inclusion criteria. The analysis revealed that the antioxidant properties of meliponine honey are influenced by phenolic and flavonoid content, which vary according to geographical origin, local flora, and bee species. The antidiabetic activity of the honey is associated with its ability to inhibit a-amylase and a-glucosidase enzymes and enhance insulin release. Honey from regions such as Kalimantan and Sarawak exhibited higher bioactive content compared to other areas.Conclusions: Meliponine honey is a promising natural therapeutic agent for diabetes management, with its bioactive quality influenced by bee species, geographical origin, and botanical sources. This study supports further development to optimize the benefits of meliponine honey through holistic approaches and broader clinical trials.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"31 2","pages":"59-67"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic consequences of coeliac disease in children with type 1 diabetes - is it worth following a gluten-free diet? 1型糖尿病儿童乳糜泻的全身性后果——是否值得遵循无麸质饮食？

Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2024-01-01 DOI: 10.5114/pedm.2024.146861

Karolina Ruszkiewicz, Joanna Nazim

{"title":"Systemic consequences of coeliac disease in children with type 1 diabetes - is it worth following a gluten-free diet?","authors":"Karolina Ruszkiewicz, Joanna Nazim","doi":"10.5114/pedm.2024.146861","DOIUrl":"10.5114/pedm.2024.146861","url":null,"abstract":"Introduction: Coeliac disease (CD) often coexists with type 1 diabetes mellitus (T1D). Children with double diagnosis are frequently asymptomatic, which raises the question of whether to introduce a strict gluten-free diet (GFD) or not.Aim of the study: To summarise data on systemic consequences of coeliac disease in children with type 1 diabetes mellitus.Material and methods: The PubMed database was searched for papers to identify meta-analyses, reviews and clinical trials focusing on children.Results: Coeliac disease, like type 1 diabetes may adversely influence glycaemic control, growth, weight gain, lipid profile and bone health as well as increase the risk of vascular complications. A strict gluten-free diet, at least partly, prevents the development of systemic complications of both disorders.Conclusions: Dietary restrictions do not have a negative impact on the quality of life of young diabetic patients hence a gluten-free diet with its multifaceted beneficial effects should be recommended to all children with diabetes and coeliac disease.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"30 4","pages":"221-226"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hereditary vitamin D resistant rickets (HVDRR) case series: phenotype, genotype, conventional treatment, and adjunctive cinacalcet therapy. 遗传性维生素 D 抗性佝偻病（HVDRR）病例系列：表型、基因型、常规治疗和西那卡塞辅助治疗。

Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2024-01-01 DOI: 10.5114/pedm.2024.139367

Noman Ahmad, Sundus A Ansari, Nabil A Aleysae, Emily L G Heaphy, Mrouge M Sobaihi, Balgees A Alghamdi, Ali S Alzahrani

{"title":"Hereditary vitamin D resistant rickets (HVDRR) case series: phenotype, genotype, conventional treatment, and adjunctive cinacalcet therapy.","authors":"Noman Ahmad, Sundus A Ansari, Nabil A Aleysae, Emily L G Heaphy, Mrouge M Sobaihi, Balgees A Alghamdi, Ali S Alzahrani","doi":"10.5114/pedm.2024.139367","DOIUrl":"10.5114/pedm.2024.139367","url":null,"abstract":"Introduction: Hereditary vitamin D resistant rickets (HVDRR) is a rare autosomal recessive disorder marked by end-organ resistance of 1,25-dihydroxyvitamin D secondary to various mutations in the vitamin D receptor gene. The currently accepted treatment modality involves bypassing the affected receptors in the gut with high-dose intravenous calcium. In a few limited case reports, cinacalcet, a calcimimetic, has been used as an adjunctive therapy.Material and methods: Retrospective chart reviews were conducted to collect the clinical and biochemical data of 8 patients with HVDRR from 5 Saudi families. Four patients received only high-dose calcium, while the remaining 4 received adjuvant cinacalcet. Serum chemistry and PTH levels were measured before and during cinacalcet treatment. Gene sequencing was performed to identify the disease-causing mutation.Results: All 8 patients exhibited alopecia and secondary hyperparathyroidism. Other clinical and biochemical features of rickets were present to varying degrees. Genetic analysis revealed 3 distinct mutations: a ligand-binding domain mutation in 3 unrelated patients, a ligand-binding domain mutation in 2 sisters, and a missense DNA-binding domain mutation in 3 brothers. While the overall response to therapy was variable, none of the 4 patients who received adjunctive cinacalcet developed hypocalcaemia, and there was some initial promise in improving serum PTH levels.Conclusions: This series provides new insight into the clinical and biochemical characteristics as well as treatment responses in Saudi children with HVDRR. The findings suggest that cinacalcet is a safe and potentially valuable adjuvant in this understudied population; however, further research is required to verify these results.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"30 2","pages":"74-80"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary response in GHD children treatment as a predictor for long-term therapy effectiveness therapy effectiveness. GHD儿童治疗的初级反应是长期治疗效果的预测因素。

Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2024-01-01 DOI: 10.5114/pedm.2024.139270

Jan M Kapała, Tomasz Maroszczuk, Aleksandra Sitarz, Anna Kącka, Dorota Charemska

{"title":"Primary response in GHD children treatment as a predictor for long-term therapy effectiveness therapy effectiveness.","authors":"Jan M Kapała, Tomasz Maroszczuk, Aleksandra Sitarz, Anna Kącka, Dorota Charemska","doi":"10.5114/pedm.2024.139270","DOIUrl":"10.5114/pedm.2024.139270","url":null,"abstract":"Introduction: Short stature in growth hormone deficiency (GHD) can be treated with recombinant human growth hormone (rhGH), which is proven to be both safe and effective. However, a considerable number of patients does not achieve satisfying therapy outcomes.Aim of the study: To evaluate the predictive effect of height increase in the first year of rhGH treatment on long-term therapy outcomes.Material and methods: 165 short-stature children (mean age 10.72 ±3.33 years; 63% males), diagnosed with GHD, treated with rhGH for at least one year (mean follow-up 4.32 ±1.80 years), divided into 2 groups according to the change in height standard deviation score (SDS) after the first year of rhGH treatment: good responders (GR) and poor responders (PR). Then, in one-year intervals, patient's chronological age, bone age, height, weight, insulin-like growth factor level, and rhGH dose were all assessed.Results: In the GR group, mean height velocity SDS up to five years of observation was 1.19 ±0.41/year and in the PR group 0.59 ±0.38/year. The differences were statistically significant (p < 0.05).Conclusions: The primary response to the rhGH treatment in GHD children seems to be a good predictor for long-term therapy outcomes.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"30 2","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and molecular characterisation of children with monogenic obesity: a case series. 单基因肥胖症儿童的临床和分子特征：病例系列。

Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2024-01-01 DOI: 10.5114/pedm.2024.140934

Arun George, Santhosh Navi, Pamali Nanda, Roshan Daniel, Kiran Anand, Sayan Banerjee, Inusha Panigrahi, Devi Dayal

{"title":"Clinical and molecular characterisation of children with monogenic obesity: a case series.","authors":"Arun George, Santhosh Navi, Pamali Nanda, Roshan Daniel, Kiran Anand, Sayan Banerjee, Inusha Panigrahi, Devi Dayal","doi":"10.5114/pedm.2024.140934","DOIUrl":"10.5114/pedm.2024.140934","url":null,"abstract":"Introduction: To study the clinical profile and molecular diagnosis of children with severe early-onset non-syndromic monogenic obesity.Methods: The clinical and molecular data (performed using whole exome sequencing) of 7 children with early-onset (< 5 years) non-syndromic monogenic obesity were extracted from the Obesity Clinic files and analysed retrospectively.Results: The median (IQR) age at presentation was 18 (10.5-27) months. Of the 7 patients, 5 were boys, 3 had a history of parental consanguinity, and 4 had a family history of severe early-onset obesity. All patients exhibited hyperphagia and showed signs of insulin resistance. Dyslipidaemia and fatty liver were observed in 4. The variants identified in 6 patients included 2 in leptin receptor, and one each in melanocortin 4 receptor, pro-opiomelanocortin, leptin, and neurotrophic tyrosine kinase receptor type 2 genes. Notably, 4 of these variants were novel.Conclusions: This case series provides valuable insights into the spectrum of genetic mutations associated with non-syndromic monogenic obesity in North Indian children. The findings underscore the significance of next-generation sequencing in identifying the aetiology of severe early-onset obesity.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"30 2","pages":"104-109"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guidelines of the Polish Society of Pediatric Endocrinology and Diabetology and Pediatric Section of Diabetes Poland on insulin therapy using hybrid closed-loop systems in children and adolescents with diabetes in Poland. 波兰儿科内分泌与糖尿病学会和波兰糖尿病学会儿科分会关于在波兰儿童和青少年糖尿病患者中使用混合闭环系统进行胰岛素治疗的指南。

Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2024-01-01 DOI: 10.5114/pedm.2024.144041

Agnieszka Szadkowska, Agata Chobot, Barbara Głowińska-Olszewska, Przemysława Jarosz-Chobot, Beata Mianowska, Małgorzata Myśliwiec, Agnieszka Szypowska, Agnieszka Zubkiewicz-Kucharska, Mieczysław Walczak

{"title":"Guidelines of the Polish Society of Pediatric Endocrinology and Diabetology and Pediatric Section of Diabetes Poland on insulin therapy using hybrid closed-loop systems in children and adolescents with diabetes in Poland.","authors":"Agnieszka Szadkowska, Agata Chobot, Barbara Głowińska-Olszewska, Przemysława Jarosz-Chobot, Beata Mianowska, Małgorzata Myśliwiec, Agnieszka Szypowska, Agnieszka Zubkiewicz-Kucharska, Mieczysław Walczak","doi":"10.5114/pedm.2024.144041","DOIUrl":"10.5114/pedm.2024.144041","url":null,"abstract":"Currently, hybrid closed loop (HCL) systems represent the most advantageous therapeutic option for people with diabetes requiring intensive insulin therapy. They make it possible to achieve optimal metabolic control of the disease in any age group while improving the quality of life of children and adolescents with diabetes and their families. Therefore, we present recommendations for the use of HCL systems in children and adolescents focusing on systems currently available in Poland. These systems should be the first choice in terms of method of insulin therapy in the paediatric population. They can be implemented at any stage of diabetes management. These recommendations are based on scientific evidence and experts' experience. They include principles for the initiation, optimisation, and ongoing management of HCL therapy, as well as the required HCL-related education.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"30 3","pages":"132-147"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of parents' awareness of the anti-inflammatory diet and its impact on their child's health: survey study. 评估家长对抗炎饮食的认识及其对孩子健康的影响：调查研究。

Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2024-01-01 DOI: 10.5114/pedm.2024.142589

Monika Soczewka, Justyna Waśniowska, Katarzyna Krawczyk, Andrzej Kędzia, Bogda Skowrońska, Elżbieta Niechciał

{"title":"Assessment of parents' awareness of the anti-inflammatory diet and its impact on their child's health: survey study.","authors":"Monika Soczewka, Justyna Waśniowska, Katarzyna Krawczyk, Andrzej Kędzia, Bogda Skowrońska, Elżbieta Niechciał","doi":"10.5114/pedm.2024.142589","DOIUrl":"10.5114/pedm.2024.142589","url":null,"abstract":"Introduction: The latest evidence highlights that an unhealthy diet and poor nutrition status are some of the modifiable behavioural risk factors responsible for the development of non-communicable diseases (NCDs). Anti-inflammatory diets are important in both the treatment and prevention of disease (e.g. hypertension, obesity, Hashimoto's thyroiditis). The concept of these diets has common core foundations and recommendations. The family environment from early childhood plays a particularly important role in shaping healthy eating patterns of children and youths. Thus, parents' nutritional knowledge, attitudes, and dietary practices are essential in preventing NCD development and improving their children's health as their primary guardians. This study aims to assess parents' awareness of an anti-inflammatory diet.Material and methods: A total of 325 parents participated in the study. Data for the study were collected anonymously using the CAWI method. The research tool was an original questionnaire about parents' awareness of anti-inflammatory diets.Results: Of the 325 parents participating in the study, 204 (62.8%) admitted that they did not know which products to use in an anti-inflammatory diet. About half of them (165; 50.8%) had unsatisfactory knowledge of the anti-inflammatory diet, 66 (30.3%) had a good level of knowledge, and only 16 (5.5%) respondents had an excellent level of knowledge.Conclusions: Parental awareness of the use of the anti-inflammatory diet was insufficient in the study group. It seems important to implement appropriate educational activities on the anti-inflammatory diet to expand parents' knowledge of the impact of nutrition on children's development.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"30 3","pages":"125-131"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142509816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenal cortical carcinoma: Paediatric aspects - literature review. 肾上腺皮质癌：儿科方面--文献综述。

Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2024-01-01 DOI: 10.5114/pedm.2024.139271

Patrycja Dasiewicz, Elżbieta Moszczyńska, Wiesława Grajkowska

{"title":"Adrenal cortical carcinoma: Paediatric aspects - literature review.","authors":"Patrycja Dasiewicz, Elżbieta Moszczyńska, Wiesława Grajkowska","doi":"10.5114/pedm.2024.139271","DOIUrl":"10.5114/pedm.2024.139271","url":null,"abstract":"Introduction: Adrenocortical carcinoma (ACC) is a rare malignancy in children. Because of this, each patient with suspected ACC requires individualised management, which should be determined at a meeting of a team of multidisciplinary experts in the field.Aim of the study: To summarise data on symptoms, genetic predisposition, and diagnostic procedures for ACC in children.Material and methods: Papers were searched in the PubMed database to identify published randomised clinical trials, reviews, systematic reviews, meta-analyses, and case reports.Results: Most cases of ACC in children occur under the age of 5 years. The most common presenting symptom in 60-80% of paediatric patients is rapidly progressive virilisation. Diagnostics are based on laboratory and imaging evaluation. The mainstay of treatment is surgery, with laparotomy being the preferred method of surgery. Diagnosis is based on histological examination of surgically removed tissue. The Wieneke index is most commonly used in paediatric practice. However, some cases are still classified as \"indeterminate histology\". Predisposing genetic factors are found in most children with ACC, most commonly a mutation of the TP53 gene.Conclusions: Patients should be diagnosed in large clinical centres with experience in this field. The treatment strategy should be individualised. Genetic testing for TP53 gene mutations is indicated in patients with ACC.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"30 2","pages":"81-90"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Less common forms of diabetes in young population. 年轻人中较少见的糖尿病。

Pediatric Endocrinology, Diabetes and Metabolism Pub Date : 2024-01-01 DOI: 10.5114/pedm.2024.136279

Anna Tekielak, Ewa Otto-Buczkowska, Ewa Rusak

{"title":"Less common forms of diabetes in young population.","authors":"Anna Tekielak, Ewa Otto-Buczkowska, Ewa Rusak","doi":"10.5114/pedm.2024.136279","DOIUrl":"10.5114/pedm.2024.136279","url":null,"abstract":"Types diabetes other than type 1 are generally considered rare in children and adolescents. The incidence of type 2 diabetes has increased dramatically over the past decade in some ethnic groups. The increased incidence of this type of diabetes mellitus has corresponded tem-porally to unprecedented increases in body weight and obesity prevalence in adolescents in various ethnic populations. Early treatment of insulin resistance is important to prevent the development of diabetes. In therapy, lifestyle modification is essential for weight loss, and if this is not enough, pharmacotherapy is required. Maturity-onset diabetes of the young (MODY), another type of insulin-dependent diabetes, is characterised by early onset and autosomal dominant inheritance. MODY is mainly caused by β-cell defects, resulting in insufficient insulin secretion for a given blood glucose level. Unlike non-insulin-dependent diabetes in youth (NIDDM-Y), there is no significant increase in insulin resistance. The purpose of this article is to characterise and present types of diabetes other than type 1 found in the young population.","PeriodicalId":39165,"journal":{"name":"Pediatric Endocrinology, Diabetes and Metabolism","volume":"30 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11037089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0