{"title":"Autoimmune encephalitis with anti-NMDAR antibodies in multiple myeloma – case report and literature review","authors":"Anna Stanowska, Barbara Wach, M. Wnuk","doi":"10.5114/PPN.2019.86259","DOIUrl":"https://doi.org/10.5114/PPN.2019.86259","url":null,"abstract":"Purpose: The initial presentation of autoimmune encephalitis (AIE) may resemble other disorders and a comprehensive investigation is required. In this paper we emphasize the challenges faced by a treating team performing a differential diagnosis and the ne- cessity for insightful multidisciplinary collaboration. Case description: We report on the case of a 67-year old man who developed transient disturbances of consciousness in the course of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, which was the first manifestation of malignant myeloma. To our knowledge, this is the first case of anti-NMDAR encephalitis associated with multiple myeloma described in the literature. Comment: AIE with anti-NMDAR antibodies has become a well-characterised variant of the condition. AIE may or may not be associated with tumour; therefore it is necessary to use the screening approach for primary malignancy. A proper diagnosis is essential in management due to AIE’s potential to respond to immunotherapy and tumour removal if one is present.","PeriodicalId":39142,"journal":{"name":"Postepy Psychiatrii i Neurologii","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5114/PPN.2019.86259","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70510224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychomotor retardation in recurrent depression and the related factors","authors":"K. Romanowicz, K. Kozłowska, A. Wichniak","doi":"10.5114/ppn.2019.89129","DOIUrl":"https://doi.org/10.5114/ppn.2019.89129","url":null,"abstract":"Purpose: The article aims at presenting the current state of knowledge concerning the relationship between psychomotor retardation, balance control and modulation of bioelectric brain activity and the patient’s mental state, temperament traits and selected cognitive functions in patients suffering from recurrent depressive disorder. Views: The article contains an overview of research published between 1998 and 2018 based on PubMed, Google Scholar databases on both the main symptoms of depression with particular focus on psychomotor functions, and the relationship between motor activity and temperament traits (in particular neuroticism, trait anxiety, depressive temperament and the dominance of the BIS – Behavioral Inhibition System over the BAS – Behavioral Activation System), as well as selected cognitive functions (e.g. processing speed, attention span, operating memory and visual-spatial memory). The latter, as reported by studies both in this group of patients (recurrent depression) and in other groups (e.g. schizophrenia) may also be lowered during the remission period. The article lists simple and easily available tools that have been used for years in neurological and psychological clinical work, along with quantitative methods of data collection (QEEG, actigraphy, posturography). Conclusions: In patients with recurrent depressive disorders, a change in motor functions is observed, manifested by a motor retardation and changes in the balance and gait dynamics, as well as changes in the quantitative assessment of bioelectric brain activity. The relationship between these biological parameters and clinical symptoms of depression and their usefulness as biomarkers of depression is currently being evaluated in an experimental study conducted by the authors.","PeriodicalId":39142,"journal":{"name":"Postepy Psychiatrii i Neurologii","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5114/ppn.2019.89129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70510844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The application of neural networks in the work of forensic experts in child abuse cases","authors":"W. Oronowicz-Jaśkowiak","doi":"10.5114/ppn.2019.92489","DOIUrl":"https://doi.org/10.5114/ppn.2019.92489","url":null,"abstract":"Purpose: One of the tasks that court experts in the field of forensic sexology have to perform is the assessment of secured pornographic materials involving minors. Forensic experts use their specialist knowledge to answer questions posed by the procedural authorities, including whether the material may induce sexual stimulation and whether an offender may be identified as having a disorder of sexual preference in the form of pedophilia. The aim of the article is to present the possibility of using neural networks in forensic sexology. Views: Neural networks are mathematical structures whose basic elements are artificial neurons modelled on the work of biological neurons. They are used in a variety of commercial and scientific tasks. Models for classifying pornographic materials (both images and films) and for estimating the age of the minors presented in these images are introduced. Neural networks can be used to categorize pornographic materials in the context of the growing levels of sexualization of minors. Moreover, the training of neural networks to classify specific objects in the pornographic material shown in these images could allow for the differentiation between the various categories of pornographic materials involving minors. Conclusions: Neural networks can be widely used in forensic sexology as an element supporting the work of forensic experts. The presented research results seem to be very promising, but the area requires further research.","PeriodicalId":39142,"journal":{"name":"Postepy Psychiatrii i Neurologii","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5114/ppn.2019.92489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70511390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clozapine-induced myocarditis","authors":"Piotr Jahołkowski, P. Mierzejewski, P. Świtaj","doi":"10.5114/ppn.2018.81365","DOIUrl":"https://doi.org/10.5114/ppn.2018.81365","url":null,"abstract":"","PeriodicalId":39142,"journal":{"name":"Postepy Psychiatrii i Neurologii","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5114/ppn.2018.81365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70509813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacotherapy of challenging behaviours in children \u0000and adolescents with autism spectrum disorder","authors":"D. Puzio, A. Gmitrowicz, I. Makowska","doi":"10.5114/ppn.2019.86257","DOIUrl":"https://doi.org/10.5114/ppn.2019.86257","url":null,"abstract":"Purpose: The article attempts to answer the question whether a drug-therapy of challenging behaviours in paediatric patients with autism is warranted. If so, how should it be implemented, including mainly the choice of agent, dosage, length of therapy and drug’s expected efficacy and safety. Views: Challenging behaviours (CB) are common problems in discussed population that additionally aggravate the level of individual functioning. When a drug-therapy of CB is concerned, there is an alarming tendency of increasing antipsychotic use and polypharmacy which exceeds the body of evidence. Out of many agents studied, only risperidone and aripiprazole exhibit established evidence for effectiveness and safety during a short-term use. Research shows comparable efficacy of these drugs and several particularities in secondary outcomes profile. It is established that in pedopsychiatric patients with autism and challenging behaviours both agents equally increase body weight in a statistically significant way; however, risperidone is associated with bigger risk of metabolic changes and extrapyramidal symptoms than aripiprazole. In addition, risperidone significantly augments the risk of hyperprolactinaemia while aripiprazole exhibits no such an action. Aripiprazole, on the other hand, is linked with higher frequency of sedation. Conclusions: Drug-therapy of CB in autism should be considered only as an addition to comprehensive interventions when behavioural and psychosocial measures lack effectiveness. The safety/efficacy profile in long-term use remains undetermined and needs further studies.","PeriodicalId":39142,"journal":{"name":"Postepy Psychiatrii i Neurologii","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5114/ppn.2019.86257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70510518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}