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ANTİTÜBERKÜLER AJAN OLARAK N'-(2-(5-((TEOFİLİN-7-İL)METİL)-4-ETİL-1,2,4-TRİAZOL-3-İLTİO)ACETİL)İZONİKOTİNOHİDRAZİT
Hacettepe University Journal of the Faculty of Pharmacy Pub Date : 2022-08-10 DOI: 10.52794/hujpharm.1011368
Andrey Gotsulya, Volodymyr Zazharskyi̇, Volodymyr Parchenko, Pavlo Davydenko, Oleh Kuli̇shenko, Tetiana Brytanova
{"title":"ANTİTÜBERKÜLER AJAN OLARAK N'-(2-(5-((TEOFİLİN-7-İL)METİL)-4-ETİL-1,2,4-TRİAZOL-3-İLTİO)ACETİL)İZONİKOTİNOHİDRAZİT","authors":"Andrey Gotsulya, Volodymyr Zazharskyi̇, Volodymyr Parchenko, Pavlo Davydenko, Oleh Kuli̇shenko, Tetiana Brytanova","doi":"10.52794/hujpharm.1011368","DOIUrl":"https://doi.org/10.52794/hujpharm.1011368","url":null,"abstract":"Makale, izoniazid ve N'-(2-(5-((teofilin-7-il)metil)-4-etil-1,2,4-triazol-3-iltio)asetil)izonikotinohidrazit. Deri altı uygulama için hesaplanan N'-(2-(5-((teofilin-7-il)metil)-4-etil-1,2,4-triazol-3-iltiyo)asetil)izonikotinohidrazid dozu, etkili ve güvenli bir tüberkülosidal ilaç olarak veterinerlik uygulamaları için beklentiler.","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85081872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effectiveness of Edamame (Glycine max L. Merril) Membrane in Accelerating The Wound Healing Process of Deep-Partial Thickness Burn 毛豆(Glycine max L. Merril)膜促进深部分厚度烧伤创面愈合的作用
Hacettepe University Journal of the Faculty of Pharmacy Pub Date : 2022-08-03 DOI: 10.52794/hujpharm.1111499
I. Sutejo
{"title":"Effectiveness of Edamame (Glycine max L. Merril) Membrane in Accelerating The Wound Healing Process of Deep-Partial Thickness Burn","authors":"I. Sutejo","doi":"10.52794/hujpharm.1111499","DOIUrl":"https://doi.org/10.52794/hujpharm.1111499","url":null,"abstract":"The gold standard for deep-partial thickness burns is early excision and skin graft; however, many hospitals in Indonesia still use conventional treatment due to the high cost of surgery and the requirement of qualified medical professionals. This research aimed to study the effectiveness of edamame (Glycine max. L Merill) membrane as therapeutic innovation in deep-partial thickness burns. Forty-eight male Wistar rats with deep-partial thickness burns were assigned randomly to four groups, including control and treatment (silver sulfadiazine, the membrane with 40% and 60% edamame extract). Measuring wound healing parameters such as macroscopic evaluation, histopathologic, and hydroxyproline was examined on days 4, 10, and 16. Treatment groups of membrane edamame significantly improved wound healing than the control group. Macroscopically, histopathological findings and hydroxyproline assay confirmed the efficacy of the edamame membrane at 60%, which provided the best healing results. This study showed that edamame membrane is effective as deep-partial thickness burns wound dressing.","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76066704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemobrain: Mysteries and the importance of their revelation 化学大脑:奥秘及其揭示的重要性
Hacettepe University Journal of the Faculty of Pharmacy Pub Date : 2022-08-03 DOI: 10.52794/hujpharm.1100269
M. Tuncer
{"title":"Chemobrain: Mysteries and the importance of their revelation","authors":"M. Tuncer","doi":"10.52794/hujpharm.1100269","DOIUrl":"https://doi.org/10.52794/hujpharm.1100269","url":null,"abstract":"Chemotherapy can be associated with both acute and delayed toxic effects on the central nervous system. Among the most commonly reported neurotoxic adverse effects in adult and pediatric cancer patients treated with chemotherapy are mood alterations and neurocognitive symptoms, such as disruption of memory, impaired attention, concentration, processing speed, and executive function. As a consequence of cancer therapy, these cognitive deficits that occur at any point during or following chemotherapy are called chemotherapy-related cognitive dysfunction or \"chemobrain\". Notably, such symptoms can be progressive even after cessation of therapy and might significantly compromise the quality of life in affected patients who are unable to return to their prior social and academic level of performance. Trying to unpick the chemobrain’s pathophysiology has become a major challenge since patients undergoing chemotherapy have an increased risk of depression, anxiety, and other mood disorders, all of which can have a negative and interacting effect on cognitive function. The purpose of this review is to define and review what is known about this poorly understood phenomenon and unravel the mysteries of “chemobrain”, and summarize therapeutic avenues.","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89271442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
QUALITY BY DESIGN APPROACH FOR OPTIMIZATION AND DEVELOPMENT OF ORODISPERSIBLE FILMS OF LORNOXICAM INCLUSION COMPLEXES 采用质量设计方法对氯诺昔康包合物的光分散膜进行优化和研制
Hacettepe University Journal of the Faculty of Pharmacy Pub Date : 2022-08-03 DOI: 10.52794/hujpharm.1072840
Archana Nerella, Nagabhushanam Mv
{"title":"QUALITY BY DESIGN APPROACH FOR OPTIMIZATION AND DEVELOPMENT OF ORODISPERSIBLE FILMS OF LORNOXICAM INCLUSION COMPLEXES","authors":"Archana Nerella, Nagabhushanam Mv","doi":"10.52794/hujpharm.1072840","DOIUrl":"https://doi.org/10.52794/hujpharm.1072840","url":null,"abstract":"Lornoxicam is a non-steroidal anti-inflammatory drug, indicated in the treatment of osteoarthritis and rheumatoid arthritis. Lornoxicam is a poor water-soluble drug and hence possesses dissolution limited bioavailability. The aim of the current research work was to develop and characterize orodispersible films of Lornoxicam to enhance its bioavailability by employing Quality-by-Design (QbD) approach. Solvent casting method was used to formulate the Lornoxicam mouth dissolving films. Three formulation factors viz. amount of polymer, amount of PEG 400 and type of polymer were varied at different levels. The responses selected were disintegration time and percent drug dissolved after 5mins. Under the response surface methodology, historical data design was employed to perform the statistical analysis using Design Expert software. The developed films were found to have good elasticity, folding endurance and favorable tensile strength. The disintegration time was found to be 9 to 17 seconds and drug dissolved after 5 minutes was 49 to 95%. The statistical analysis of the results by ANOVA elucidated that there was a significant effect of all the formulation factors on the selected responses (p","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"139 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88399574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Cytotoxic Effect Assessment and Molecular Docking Studies of Disubstituted Thiadiazole Including Oxadiazole as Hybrid Component 以恶二唑为杂化组分的二取代噻二唑的合成、细胞毒作用评价及分子对接研究
Hacettepe University Journal of the Faculty of Pharmacy Pub Date : 2022-07-05 DOI: 10.52794/hujpharm.1069664
F. Hassanzadeh, E. Jafari, Sara Zarei̇, H. Sadeghi-aliabadi
{"title":"Synthesis, Cytotoxic Effect Assessment and Molecular Docking Studies of Disubstituted Thiadiazole Including Oxadiazole as Hybrid Component","authors":"F. Hassanzadeh, E. Jafari, Sara Zarei̇, H. Sadeghi-aliabadi","doi":"10.52794/hujpharm.1069664","DOIUrl":"https://doi.org/10.52794/hujpharm.1069664","url":null,"abstract":"Oxadiazole and thiadiazole are of interest building blocks used in drug design. Considering importance of mentioned scaffolds some of the thiadiazole-oxadiazolederivatives were synthesized by three steps in this study.Firstly, thiol functions of 2-amino-5-mercapto-1, 3, 4-thiadiazole was alkylated by benzyl chloride derivatives to give compounds (1a-c). The reaction of chloroacethylchloride with amine group of compounds (1a–c) terminates to amide derivatives(2a-c). Definitive products were produced by treatment of corresponding amide derivatives with 5-(4-chlorophenyl)-1, 3, 4-oxadiazole-2-thiol.Synthesized compounds were evaluated by MTT assay against two cell lines. The final molecules were docked in the active sites of the epidermal growth factor receptor tyrosine kinase to assay the possible interactions.Final products showed range of cytotoxic activity of moderate to good against tested cell lines. Compound (3a) demonstrated a higher cytotoxic activity against MCF-7 (IC50: 26 µM) and Lncap (IC50: 37 µM) cell lines in comparison with other compounds. The highest docking score was -10.55kcal/mol for compound3a.","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84502842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective Effect of farnesol against Rotenone Induced Parkinson’s Disease in Drosophila melanogaster 法尼醇对鱼藤酮诱导的帕金森病的神经保护作用
Hacettepe University Journal of the Faculty of Pharmacy Pub Date : 2022-06-10 DOI: 10.52794/hujpharm.1080352
Jayaram Saravanan, P. Krishnamurthy
{"title":"Neuroprotective Effect of farnesol against Rotenone Induced Parkinson’s Disease in Drosophila melanogaster","authors":"Jayaram Saravanan, P. Krishnamurthy","doi":"10.52794/hujpharm.1080352","DOIUrl":"https://doi.org/10.52794/hujpharm.1080352","url":null,"abstract":"The aim of this study is to evaluate the neuroprotective role of farnesol against rotenone induced neurotoxicity in Drosophila melanogaster by survival rate study, negative geotaxis assay and estimation of in vivo antioxidant parameters. To induce neurotoxicity in flies, 500µmol of rotenone was used. After successful induction the flies were treated with 300 µmol and 600 µmol of farnesol for the duration of experimental period. The survival rate study was carried out to estimate the effect of farnesol on longevity of flies and negative geotaxis assay was carried out to determine the effect of farnesol on locomotor function of flies. The results indicated that 300 µmol and 600 µmol of farnesol extended the longevity and locomotor functions of the flies in a dose dependent manner. The in vivo antioxidant studies revealed that farnesol increased the activity of catalase and SOD and decreased lipid peroxidation. Based on the effect of farnesol on survival rate, longevity assay and antioxidant assay, we conclude that farnesol might possess significant neuroprotective property.","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79391571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
İLAÇ TESLİMATINDA MEVCUT YENİ NANOTAŞIYICILAR: BİR İNCELEME
Hacettepe University Journal of the Faculty of Pharmacy Pub Date : 2022-06-10 DOI: 10.52794/hujpharm.1075668
Niharika Lal, Praveen Kumar Gaur, Sameer Rastogi̇, Kanak Lata
{"title":"İLAÇ TESLİMATINDA MEVCUT YENİ NANOTAŞIYICILAR: BİR İNCELEME","authors":"Niharika Lal, Praveen Kumar Gaur, Sameer Rastogi̇, Kanak Lata","doi":"10.52794/hujpharm.1075668","DOIUrl":"https://doi.org/10.52794/hujpharm.1075668","url":null,"abstract":"Nanoteknolojinin merkezlenmiş ilaç taşıma sistemlerinde (DDS) kullanımı, geleneksel ilaç taşıma araçları çeşitleriyle ilgili engeller nedeniyle büyük çaplı araştırmaların zorluğudur. Hedeflenen bir İlaç Dağıtım sistemi, ilaçların taşınmasını ve yakınlardaki farkındalığı artırabilir. Çoğu kanser terapötikleri için hedeflenen taşıma süreçleri, birkaç on yılın ötesinde dik bir yukarı doğru itme olduğunu kanıtlamıştır. Ancak, çok sayıda başarılı bilim-öncesi araştırmayla karşılaştırıldığında, en iyi pasif merkezli Nanotaşıyıcılar (NC'ler) bilimsel kullanım için akredite edilmişti ve aktif olarak merkezli NC'lerin hiçbiri bilimsel denemelerin ötesinde üstünlüğe sahip değildi. Burada, kısıtlı bilimsel çeviri ve başarısı için yetenek güdülerine karar vermek için merkezli taşıma süreçlerinin arkasındaki ilkeleri gözden geçiriyoruz. Yeni aktif merkezli NC'lerin iyileştirilmesi için dikkate alınması gereken standartları ve endişeleri savunuyoruz. Ayrıca, stratejilere odaklanan isabetli bir tümörün iyileştirilmesi için olası talimatları vurgularız.","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81544635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HR-LCMS Analysis and Antihyperlipidemic Effect of Ethanolic Leaf Extract of Momordica charantia L. 苦瓜叶乙醇提取物的HR-LCMS分析及降血脂作用。
Hacettepe University Journal of the Faculty of Pharmacy Pub Date : 2022-05-30 DOI: 10.52794/hujpharm.1063583
P. Karale, S. Dhawale, M. Karale
{"title":"HR-LCMS Analysis and Antihyperlipidemic Effect of Ethanolic Leaf Extract of Momordica charantia L.","authors":"P. Karale, S. Dhawale, M. Karale","doi":"10.52794/hujpharm.1063583","DOIUrl":"https://doi.org/10.52794/hujpharm.1063583","url":null,"abstract":"","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84409909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alzheimer Hastalığının Gelişimsel Sürecinde ve Tedavisinde Potansiyel Öneme Sahip Tıbbi Bitkiler ve Fitokimyasallar
Hacettepe University Journal of the Faculty of Pharmacy Pub Date : 2022-05-09 DOI: 10.52794/hujpharm.1014770
Sevgi Gezici, Nazım Şekeroğlu
{"title":"Alzheimer Hastalığının Gelişimsel Sürecinde ve Tedavisinde Potansiyel Öneme Sahip Tıbbi Bitkiler ve Fitokimyasallar","authors":"Sevgi Gezici, Nazım Şekeroğlu","doi":"10.52794/hujpharm.1014770","DOIUrl":"https://doi.org/10.52794/hujpharm.1014770","url":null,"abstract":"","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73888830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epilepsi Tedavisinde Valproik Asit Kullanımı ve Biyolojik Matrislerdeki Tayini
Hacettepe University Journal of the Faculty of Pharmacy Pub Date : 2022-04-20 DOI: 10.52794/hujpharm.1062609
Oğuz Özbek, Ömer Işildak
{"title":"Epilepsi Tedavisinde Valproik Asit Kullanımı ve Biyolojik Matrislerdeki Tayini","authors":"Oğuz Özbek, Ömer Işildak","doi":"10.52794/hujpharm.1062609","DOIUrl":"https://doi.org/10.52794/hujpharm.1062609","url":null,"abstract":"","PeriodicalId":39138,"journal":{"name":"Hacettepe University Journal of the Faculty of Pharmacy","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90657043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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