Effectiveness of Edamame (Glycine max L. Merril) Membrane in Accelerating The Wound Healing Process of Deep-Partial Thickness Burn

Abstract

The gold standard for deep-partial thickness burns is early excision and skin graft; however, many hospitals in Indonesia still use conventional treatment due to the high cost of surgery and the requirement of qualified medical professionals. This research aimed to study the effectiveness of edamame (Glycine max. L Merill) membrane as therapeutic innovation in deep-partial thickness burns. Forty-eight male Wistar rats with deep-partial thickness burns were assigned randomly to four groups, including control and treatment (silver sulfadiazine, the membrane with 40% and 60% edamame extract). Measuring wound healing parameters such as macroscopic evaluation, histopathologic, and hydroxyproline was examined on days 4, 10, and 16. Treatment groups of membrane edamame significantly improved wound healing than the control group. Macroscopically, histopathological findings and hydroxyproline assay confirmed the efficacy of the edamame membrane at 60%, which provided the best healing results. This study showed that edamame membrane is effective as deep-partial thickness burns wound dressing.