{"title":"THE EFFECT OF PIPER SARMENTOSUM AQUEOUS EXTRACT ON BUCCAL ULCER HEALING","authors":"M. Nh, N. Na","doi":"10.22452/JUMMEC.VOL22NO1.3","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL22NO1.3","url":null,"abstract":"Oral ulcer is a lesion with multifactorial causes and occurs worldwide. The lesion usually resolved within 14 days, but the pain may have an impact on the quality of patient’s life. Therefore, having a natural derived remedy that can reduce healing time would be a great advantage. This study aims to investigate histological sections of buccal ulcer on rats treated with aqueous extract of Piper sarmentosum (AEPS). Glacial acetic acid was used to induce buccal ulcer on male Sprague Dawley rats. Control group received normal saline while the experimental group received AEPS for treatment. On certain days of post-ulcer induction, buccal ulcer tissue samples were harvested, sectioned and stained with Hematoxylin and Eosin (H&E). Histological slides were examined for inflammation and scored. The inflammation severity reduced from day 2 to day 12. In the experimental group there was a statistically significant differences of inflammation score, particularly on day 2 with a score of (2.8 + 0.2). Neutrophils were less in the experimental group and the tissue debris clearance was faster compared to control group. Full reepithelization was observed on both treated tissue sections on day 12 with less severe inflammation. Topical application of AEPS is proven to have anti-inflammatory effect by reducing the number of neutrophils during inflammation phase of oral ulcer healing. \u0000Keywords: Anti-inflammatory, oral ulcer, ulcer healing","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48982664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yeoh Cn, R. Nadiah, Cheah Sk, Wanderley Wr, M. Maaya, A. Raha
{"title":"AN UNUSUAL CASE OF PORTAL, SPLENIC AND MESENTERIC VENOUS THROMBOSIS PRESENTING WITH ACUTE ABDOMEN","authors":"Yeoh Cn, R. Nadiah, Cheah Sk, Wanderley Wr, M. Maaya, A. Raha","doi":"10.22452/JUMMEC.VOL22NO1.2","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL22NO1.2","url":null,"abstract":"Porto-spleno-mesenteric vein thrombosis is a rare, life-threatening condition of extrahepatic portal venous system thrombosis. We report a rare case of a 49-year-old lady with late presentation of acute portal vein thrombosis in a non-cirrhotic liver with an incidental finding of left adnexal teratoma. She presented with a one-week history of severe abdominal pain associated with vomiting and diarrhea. She gave no history of prior risk for venous thromboembolism or liver diseases. Physical examination revealed a tender mass extending from suprapubic to left iliac fossa. Abdominal computed tomography scans showed a well-defined fatcontaining left adnexal mass, likely a benign teratoma, with no involvement of surrounding structures or calcification. There was evidence of porto-splenic-mesenteric vein thrombosis with liver infarction, bowel and splenic ischemia. Management of the extensive thrombosis causing multi-organ failure includes resuscitation, supportive care and treatment of thrombosis. Treatment options include early anticoagulation and if feasible, thrombolysis. \u0000Keywords: Acute Abdomen, Mesenteric Vein Thrombosis, Non-Cirrhotic Vein Thrombosis, Portal Vein Thrombosis,Splenic Vein Thrombosis","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46231415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MODERN MEDICAL DEVICES AND HOSPITAL DECISIONMAKING: A REVIEW OF ETHICAL AND SOCIAL CONSIDERATIONS DURING THE MANUFACTURE AND THE USE OF ADVANCED MEDICAL DEVICES","authors":"Shudipta Choudhury","doi":"10.22452/JUMMEC.VOL22NO1.1","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL22NO1.1","url":null,"abstract":"Background: The adoption of technologically advanced medical devices assisted healthcare providers to examine and treat diseases. However, technological advancements could increase the threats to safety, security, and reliability of the devices from complications associated with manufacturing, functionality, and the clinical application of the devices. Aim: To examine the safety threats, cost implication, and bioethical standards of the manufacturing processes and the functionality of advanced medical devices. Subject and Methods: The study was a narrative review through a qualitative research methodology. The secondary data was gathered from online databases including ProQuest, ResearchGate, CINAHL/EBSCOhost, PubMed, and ScienceDirect, from books, journals, conference proceedings, and other web publications between 2007 and 2017. Results:There were safety hazards from human errors in the interpretation and the use of the advanced medical devices. Equipment imperfections and poor processes of maintenance and procurement affected the effective functionality of these medical devices. Healthcare expenditure was high, Social and bioethical considerations, users’ complaints and post-market surveillance were essential in ensuring the safety of the devices and the maintenance of quality life for the users. Conclusion: Safety hazards and cost implications of the use of technologically advanced medical devices were significantly high Social and bioethical standards in the manufacturing of medical devices contributed towards the production of safer devices.Keywords: Innovative medical devices, social and bioethical standards, healthcare costs, safety threats","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44557206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PULMONARY REHABILITATION USING MECHANICAL INSUFFLATION-EXSUFFLATION THERAPY FOR SPINAL CORD INJURY – TWO CASE STUDIES IN THE UNIVERSITY MALAYA MEDICAL CENTRE","authors":"A. A. Fauzi, N. Hasnan, Tanous Jh","doi":"10.22452/JUMMEC.VOL20NO2.5","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL20NO2.5","url":null,"abstract":"There is a high incidence of 36% to 83% of respiratory dysfunction in patients with acute cervical spinal cord injury. Complications arising from respiratory dysfunction remain one of the most common causes of morbidity and mortality in the spinal cord injured population. Specialized pulmonary care and therapy can help individuals with tetraplegia to maintain a stable respiratory status allowing active participation in active rehabilitation. This would allow them to achieve rehabilitation goals of independent function and community reintegration. Mechanical insufflation-exsufflation (MIE) therapy is an option for secretion management in individuals with acute spinal cord injury. In this paper, we present our experience using MIE as an adjunct to management of secretions in the spinal cord injured population at the University of Malaya Medical Centre.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"20 1","pages":"31-33"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44552422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Moniruddin, M. Faisal, C. AbmAlauddin, H. Md.Imdadul
{"title":"AN EVALUATION OF TREATMENT OUTCOME IN TUBERCULOSIS DIRECTLY OBSERVED TREATMENT SHORT COURSE FACILITIES IN JIGAWA STATE, NIGERIA (2010–2014)","authors":"C. Moniruddin, M. Faisal, C. AbmAlauddin, H. Md.Imdadul","doi":"10.22452/JUMMEC.VOL20NO2.1","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL20NO2.1","url":null,"abstract":"Tuberculosis (TB) is a major public health problem worldwide. It is estimated that 2 billion people, a third of the world population, have TB infection, but are not down with the disease. Globally, incident cases of TB showed a rising trend, with a 6.6 million reported in 1990, 8.3 million in 2000, 9.24 million in 2004, and an estimated 9.27 million incident cases in 2007. The aim of this study was to evaluate the treatment outcome of TB patients in Nigeria in the state of Jigawa. A cross sectional retrospective study was conducted to evaluate the treatment outcome in directly observed treatment with a short course for tuberculosis (TB DOTS) in facilities in the state between the years 2010 to 2014. The study population were all the patients with TB, who had access to DOTS therapy. Data were collected from the various local governmental areas for tuberculosis control (LGA TB) register. The LGA TB control registers contained basic information of the patients, and a statistical software SPSS-V22.0 was used to analyse the data. A total of 963 TB patients were studied. More than half (57.4%) of the patients were male, and nearly three- fourths (71.2%) of the patients accessed care from urban local government areas in the state. The greater majority (96.3%) of the cases had pulmonary tuberculosis (PTB). Among the patients, more than two-fifths (45%) were cured, and a little over one-fifth (20.6%) of them were HIV positive. This study revealed that the treatment success rate (TSR) in the Jigawa State of Nigeria was higher than the overall TSR of Nigeria, and the defaulter rate in this state was lower than the Nigerian average.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"20 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46641726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE EXPERIMENTAL ASSESSMENT OF BUILD UP FACTOR AND ATTENUATION COEFFICIENT OF BRASS COMPENSATOR APPLIED IN INTENSITY-MODULATED RADIATION THERAPY (IMRT) FOR 6MV PHOTON BEAM","authors":"B. Elnaz, H. Peyman, H. Abbas, G. Raheb, S. Zaker","doi":"10.22452/JUMMEC.VOL20NO2.4","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL20NO2.4","url":null,"abstract":"Introduction: Recent compensators are commonly applied in IMRT. The precise properties of applied compensators such as thickness, attenuation coefficient and build up factor are intensively important for IMRT calculations. Method: The brass compensator used for 6 MV photon beam was studied to estimate the relative effect of thickness and field size on IMRT calculations. Various field size together with several compensator thicknesses were examined. Result: The average reduction of effective attenuation coefficient (EAC), for the fields of 10×10 cm2 to 20×20 cm2, was 9.94%. By increasing the field size, EAC was decreased. The major reduction of EAC due to increasing field size was found to be 9.62%. The build up factor was increased by 2% to 21.8% respect to field size and compensator thickness. Also, the build up factor was increased by adding up the thickness. The rate of changes ranged from 24% to 48 %. Conclusion: The compensator thickness and field size are significantly important to calculate the effective attenuation coefficient and build up factor.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"20 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49585344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Yeong, A. Panicker, Abdullah Bjj, Y. Na, Wong Yh, O. Sz, A. Vijaynanthan
{"title":"EVALUATION OF DIFFUSION-WEIGHTED IMAGING AND APPARENT DIFFUSION COEFFICIENT MAPPING USING DIFFERENT B-VALUES FOR MAGNETIC RESONANCEGUIDED FOCUSED ULTRASOUND SURGERY: A PRELIMINARY STUDY FOR UTERINE FIBROID AND ADENOMYOMA","authors":"C. Yeong, A. Panicker, Abdullah Bjj, Y. Na, Wong Yh, O. Sz, A. Vijaynanthan","doi":"10.22452/JUMMEC.VOL20NO2.3","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL20NO2.3","url":null,"abstract":"The study was taken to assess the feasibility of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping using different b-values for magnetic resonance-guided focused ultrasound (MRgFUS) treatment of uterine fibroid and adenomyoma. The contrast-enhanced T1-weighted image (cT1WI) as well as DWIs and ADC maps of different b-values (i.e. 200, 600 and 800 s/mm²) were obtained from nine fibroid and five adenomyoma patients, immediately after, and 12 months after MRgFUS treatment. The image contrast score, non-perfused volume (NPV) and NPV ratio obtained were compared to determine the feasibility of DWI and ADC mapping for MRgFUS treatment outcome evaluation. Our finding showed that immediately after MRgFUS treatment, the DWI acquired using 200 s/mm² b-value gave the highest image contrast score among all other b-values. The NPV calculated from DWI of 200 s/ mm² showed the best correlation (R² = 0.938) with post-contrast NPV. At 12 months follow-up, there was no specific b-value considered as significantly superior to others in terms of image contrast. However, the NPVs and NPV ratios obtained from all DWIs and ADC maps of different b-values were in good agreement with the post-contrast NPV and NPV ratio. We observed that the DWI, particularly obtained with a low b-value (i.e. 200 s/mm²), is feasible for delineation and quantitative volumetric evaluation of the ablated region immediately after the MRgFUS treatment. At 12 months follow-up, both DWIs and ADC maps are feasible for NPV and NPV ratio calculation.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"20 1","pages":"13-25"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43634042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TUNNELLED PERIPHERALLY INSERTED CENTRAL CATHERER- HOW WE DO THEM","authors":"Abdullah Bjj, Vijaynanthan A, Nawawi O","doi":"10.22452/JUMMEC.VOL20NO2.2","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL20NO2.2","url":null,"abstract":"In the current study, we report a new technique to place a tunnelled peripherally inserted central catheter (PICC) at the upper arm of patient under real-time ultrasound-guided venipuncture using disposal equipment provided within a standard PICC set. The tunnelling of the PICC required an extra time of 5 minutes but was well tolerated by all patients involved in the study. The tunnelled PICC was applied on 50 patients and the infection rate as well its catheter dwell time were compared to another 50 patients with conventional PICC. The rate of patients who developed infection decreased from 34% for conventional PICC to 16% in tunnelled PICC patients. The central line-associated blood stream infections rate was also decreased from 4.4 per 1000 catheter-days for conventional PICC to 1.3 per 1000 catheter-days for tunnelled PICC. The mean time to infection development for tunnelled PICC (24 days) was longer than those observed with conventional PICC (19 days). Tunnelled PICC has also increased the mean catheter dwell time from 27 days (for conventional PICC) to 47 days. Tunnelling a PICC has the potential to reduce the infection rate while increase the catheter dwell time.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"20 1","pages":"8-12"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42901878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MUSCLE BULK, STRENGTH AND PROPRIOCEPTIVE DIFFERENCE BETWEEN ANTERIOR CRUCIATE LIGAMENT DEFICIENT AND NORMAL KNEE","authors":"M. Kalimuthu, A. H. Mokhtar","doi":"10.22452/jummec.vol20no1.1","DOIUrl":"https://doi.org/10.22452/jummec.vol20no1.1","url":null,"abstract":"The anterior cruciate ligament (ACL) deficient knee has been subjected to various research and many conclusionshave been drawn to the loss of function in relation to it. ACL reconstruction is also very commonly done asthis ligament damage is the most common injury in sports. Muscle strength and proprioception have beenpostulated to be affected alongside this injury. We conducted a cross sectional study in 19 patients who haveruptured their ACL. We measured their muscle strength, thigh muscle bulk and proprioception in comparisonto their contralateral normal knee. The Biodex Isokinetic machine was used to measure the muscle strengthand proprioception. The thigh circumference was measured manually using a measuring tape. There wassignificant reduction of muscle strength and thigh circumference in the ACL deficient limb as compared to thenormal side, p <0.05. The affected knee also showed reduction in proprioceptive ability at 70 degree angle (zscore -2.17, p <0.05), but there was no significant reduction at the other angles. These findings are importantas the data show that there is reduction in muscle strength and proprioceptive ability in an ACL deficient knee;hence, rehabilitation addressing these two areas should be emphasized pre-surgery.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"20 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42534946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IMPACT OF SHARED HEALTH SERVICES ON SERVICE QUALITY AT HEALTH CENTRES IN KAMPALA CAPITAL CITY AUTHORITY (KCCA)","authors":"Nabukeera Madinah, A. Boerhannoeddin, R. Ra","doi":"10.22452/JUMMEC.VOL20NO1.2","DOIUrl":"https://doi.org/10.22452/JUMMEC.VOL20NO1.2","url":null,"abstract":"The study aimed to assess whether sharing of health services improved service quality in health centers inKampala Capital City Authority (KCCA). With multi-stage sampling, data was gathered by face to face interviews,via translators from residents in the five divisions of KCCA, using a questionnaire. Schedules were made withLocal Council I chairmen, and support to fill in the questionnaire was given to the respondents. The statisticalmethods used for analysis included a Chi-square, Spearman correlations and hierarchical regression.The study found that regarding tangibility, sharing health services significantly determines the number ofmodern medical equipments (p=0.000) and the number of medical personnel that had a neat and professionalappearance (p=0.000) but did not determine the number of visually appealing health facilities (p=0.386).Recentralizing health care changed the mode of delivery. Health workers were responsive, reliable and providebetter care for patients. There was increased availability of basic medical equipment, and health workerswere neater in appearance with increased confidence and hence were better able to provide for the safetyof residents.","PeriodicalId":39135,"journal":{"name":"Journal of the University of Malaya Medical Centre","volume":"20 1","pages":"6-14"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45199632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}