I. Markova, S. Bondarenko, O. Paina, B. Aubova, P. Kozhokar, A. Frolova, I. Barkhatov, E. Babenko, Alexander A Alyanskiy, K. Ekushov, T. Gindina, E. Semenova, I. Moiseev, L. Zubarovskaya, B. Afanasyev
{"title":"Features of response to blinatumomab and inotuzumab ozogamicin therapy in patients with relapse/refractory B-cells acute lymphoblastic leukemia in real clinical practice","authors":"I. Markova, S. Bondarenko, O. Paina, B. Aubova, P. Kozhokar, A. Frolova, I. Barkhatov, E. Babenko, Alexander A Alyanskiy, K. Ekushov, T. Gindina, E. Semenova, I. Moiseev, L. Zubarovskaya, B. Afanasyev","doi":"10.18620/ctt-1866-8836-2020-9-1-47-52","DOIUrl":"https://doi.org/10.18620/ctt-1866-8836-2020-9-1-47-52","url":null,"abstract":"included 182 patients with r/r B-ALL, their age was from one to 72 years old. 128 patients were treated with blinatumomab, 54 patients received inotuzumab ozogamicin. Overall response was high in both groups, 96 (75%) and 44 (82%). Th e major predictors of response were adult age (OR= 3.819; 95% CI, 1.744-8.223; p=0.001) and clinical indications, i.e., active disease or measurable residual disease (OR= 0.018; 95% CI, 0.153-0.841; p=0.01). Th e other clinical or disease parameters had no signifi cant impact on response. Features of response to blinatumomab and inotuzumab ozogamicin therapy in patients with relapse/refractory B-cells acute lymphoblastic leukemia in real clinical practice. Cell Th er Transplant 9(1):","PeriodicalId":39111,"journal":{"name":"Cellular Therapy and Transplantation","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90524167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Kozhokar, O. Paina, A. Frolova, Z. Rakhmanova, A. Borovkova, E. Semenova, A. Osipova, K. Ekushov, O. Slesarchuk, V. Ovechkina, E. Babenko, Alina A. Vitrishchak, B. Smirnov, L. Zubarovskaya, B. Afanasyev
{"title":"Efficiency of second allogeneic HSCT in the children with acute leukemias with relapses after first transplantation","authors":"P. Kozhokar, O. Paina, A. Frolova, Z. Rakhmanova, A. Borovkova, E. Semenova, A. Osipova, K. Ekushov, O. Slesarchuk, V. Ovechkina, E. Babenko, Alina A. Vitrishchak, B. Smirnov, L. Zubarovskaya, B. Afanasyev","doi":"10.18620/ctt-1866-8836-2019-8-4-33-40","DOIUrl":"https://doi.org/10.18620/ctt-1866-8836-2019-8-4-33-40","url":null,"abstract":"Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is effective treatment in high risk hematological malignancies. Nevertheless, the relapse rates after allo-HSCT range from 10% to 70%.There are no optimal strategy of the relapse therapy after allo-HSCT. Possible therapeutic options include re-induction chemotherapy, immunoadoptive therapy (DLI), target drugs, immunotherapy (CAR-T) and second allo-HSCT. The presented study is a retrospective single-institution experience of second allo-HSCT in the patients (pts) with acute leukemia relapses or graft failure in high-risk cases. The aim of our study was to analyze the outcomes after second allo-HSCT in 50 children with hematological malignancies, i.e., ALL (n=24), AML (n=15), MPDs/MDS (n=11). Forty-four patients achieved engraftment, with median neutrophil engraftment time of 21 days (12 to 41). Remission was achieved in 44 pts (88%). Median follow-up period was 3 years 7 months. Overall survival (OS), according to Kaplan-Meier method, was 48% in the whole group. Relapse-free survival (RFS) was 60%. The five-year OS in ALL group was 46.2%; in AML group, 53.3%; in MPDs/MDS, 44.4%. Causes of death were as follows: relapse/progression in 65% (n=17), transplant-related mortality (TRM), in 18% (n=9; 95%CI, 8.8%-29.8%); cumulative relapse rate was 34% (95% CI, 21.6%-48%). comparable","PeriodicalId":39111,"journal":{"name":"Cellular Therapy and Transplantation","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76763558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"XIII R. Gorbacheva Memorial Symposium Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy: an Overview","authors":"B. Afanasyev","doi":"10.18620/ctt-1866-8836-2019-8-3-14-25","DOIUrl":"https://doi.org/10.18620/ctt-1866-8836-2019-8-3-14-25","url":null,"abstract":"","PeriodicalId":39111,"journal":{"name":"Cellular Therapy and Transplantation","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91048419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Marina, G. Alisa, V Markova Inna, V. Oksana, A. Yulia, S. Anastasia, N. S. Aleksandr, Y Nikolaev Ilya, M. Svetlana, S. Tatyana, G Gevorgian Asmic, V Paina Olesya, A. Tatiana, I. Elena, V. Maria, S. Ivan, S. Ludmila, N. Nikolay, V. Boris
{"title":"Outcomes of allogeneic hematopoietic stem cell transplantation in children and adults with prior invasive fungal diseases","authors":"O. Marina, G. Alisa, V Markova Inna, V. Oksana, A. Yulia, S. Anastasia, N. S. Aleksandr, Y Nikolaev Ilya, M. Svetlana, S. Tatyana, G Gevorgian Asmic, V Paina Olesya, A. Tatiana, I. Elena, V. Maria, S. Ivan, S. Ludmila, N. Nikolay, V. Boris","doi":"10.18620/ctt-1866-8836-2019-8-2-17-25","DOIUrl":"https://doi.org/10.18620/ctt-1866-8836-2019-8-2-17-25","url":null,"abstract":"Marina O. Popova 1, Alisa G. Volkova 1, Inna V. Markova 1, Oksana V. Ayzsilnieks 1, Yulia A. Rogacheva 1, Anastasia S. Frolova 1, Aleksandr N. Shvetcov 1, Ilya Y. Nikolaev 1, Svetlana M. Ignatyeva 2, Tatyana S. Bogomolova 2, Asmic G. Gevorgian 1, Olesya V. Paina 1, Tatiana A. Bykova 1, Elena I. Darskaya 1, Maria V. Vladovskaya 1, Ivan S. Moiseev 1, Ludmila S. Zubarovskaya 1, Nikolay N. Klimko 1,2, Boris V. Afanasyev 1 1 Raisa Gorbacheva Memorial Research Institute of Pediatric Oncology, Hematology and Transplantation, Chair of Hematology, Transfusiology and Transplantology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia 2 Dept. of Clinical Mycology, I. Mechnikov North-Western State Medical University, St. Petersburg, Russia Outcomes of allogeneic hematopoietic stem cell transplantation in children and adults with prior invasive fungal diseases","PeriodicalId":39111,"journal":{"name":"Cellular Therapy and Transplantation","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84784755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PD-1 receptor on immune cells, its expression and potential role in cancer therapy","authors":"D. S. Elezov, I. Kudryavtsev","doi":"10.18620/ctt-1866-8836-2019-8-2-8-16","DOIUrl":"https://doi.org/10.18620/ctt-1866-8836-2019-8-2-8-16","url":null,"abstract":"","PeriodicalId":39111,"journal":{"name":"Cellular Therapy and Transplantation","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85101906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Fedorova, K. Lepik, M. Popova, Y. Vlasova, O. Kudyasheva, Y. Rogacheva, E. Lepik, V. Porunova, A. Osipova, Yury R. Zalyalov, E. I. Darskaya, I. Markova
{"title":"Highlights of the 24th European Hematology Association Congress, Amsterdam 2019","authors":"L. Fedorova, K. Lepik, M. Popova, Y. Vlasova, O. Kudyasheva, Y. Rogacheva, E. Lepik, V. Porunova, A. Osipova, Yury R. Zalyalov, E. I. Darskaya, I. Markova","doi":"10.18620/ctt-1866-8836-2019-8-2-82-90","DOIUrl":"https://doi.org/10.18620/ctt-1866-8836-2019-8-2-82-90","url":null,"abstract":"","PeriodicalId":39111,"journal":{"name":"Cellular Therapy and Transplantation","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76801526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. A. Kulagin, A. Volkova, I. Nikolaev, O. Goloshchapov, A. Smirnova, T. Rudakova, E. I. Darskaya, E. Morozova, N. Mikhaylova, J. D. Rabik, V. G. Timchik, T. I. Shchemelinina, R. D. Skvortsova, T. Razumovskaya, S. Bondarenko, I. Moiseev, V. N. Marchenko, V. Trofimov, B. Afanasyev
{"title":"Clinical features and prognostic value of functional disorders and pulmonary comorbidity in adult patients prior to allogeneic hematopoietic stem cell transplantation","authors":"E. A. Kulagin, A. Volkova, I. Nikolaev, O. Goloshchapov, A. Smirnova, T. Rudakova, E. I. Darskaya, E. Morozova, N. Mikhaylova, J. D. Rabik, V. G. Timchik, T. I. Shchemelinina, R. D. Skvortsova, T. Razumovskaya, S. Bondarenko, I. Moiseev, V. N. Marchenko, V. Trofimov, B. Afanasyev","doi":"10.18620/ctt-1866-8836-2019-8-2-26-37","DOIUrl":"https://doi.org/10.18620/ctt-1866-8836-2019-8-2-26-37","url":null,"abstract":"Egor A. Kulagin 1, Alisa G. Volkova 2, Ilya Yu. Nikolaev 2, Oleg V. Goloshchapov 2, Anna G. Smirnova 2, Tatiana A. Rudakova 2, Elena I. Darskaya 2, Elena V. Morozova 2, Nataliya B. Mikhaylova 2, Julia D. Rabik 3, Victoria G. Timchik 3, Tatiana I. Shchemelinina 3, Ruf D. Skvortsova 3, Tatiana S. Razumovskaya 3, Sergey N. Bondarenko 2, Ivan S. Moiseev 2, Valeriy N. Marchenko 1, Vasiliy I. Trofimov 1, Boris V. Afanasyev 2 1 M. Chernorutskiy Department of Hospital Therapy, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia 2 Raisa Gorbacheva Memorial Research Institute of Pediatric Oncology, Hematology and Transplantation, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia 3 Department of Functional Diagnostics No2, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia Clinical features and prognostic value of functional disorders and pulmonary comorbidity in adult patients prior to allogeneic hematopoietic stem cell transplantation Cellular Therapy and Transplantation (CTT). Vol. 8, No. 2, 2019 doi: 10.18620/ctt-1866-8836-2019-8-2-26-37 Submitted: 30 July 2019, accepted: 09 August 2019","PeriodicalId":39111,"journal":{"name":"Cellular Therapy and Transplantation","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73376958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Rudakova, A. Kulagin, I. Moiseev, T. Bykova, S. Bondarenko, M. Barabanshikova, A. Beinarovich, A. Osipova, V. Ovechkina, A. Alyanskiy, E. I. Darskaya, E. Morozova, B. Afanasyev
{"title":"Thrombopoietin receptor agonists for treatment of poor graft function after allogeneic hematopoietic stem cell transplantation in adults","authors":"T. Rudakova, A. Kulagin, I. Moiseev, T. Bykova, S. Bondarenko, M. Barabanshikova, A. Beinarovich, A. Osipova, V. Ovechkina, A. Alyanskiy, E. I. Darskaya, E. Morozova, B. Afanasyev","doi":"10.18620/ctt-1866-8836-2019-8-2-38-44","DOIUrl":"https://doi.org/10.18620/ctt-1866-8836-2019-8-2-38-44","url":null,"abstract":"Tatiana A. Rudakova, Alexander D. Kulagin, Ivan S. Moiseev, Tatyana A. Bykova, Sergey N. Bondarenko, Maria V. Barabanshikova, Anastasia V. Beinarovich, Anna A. Osipova, Varvara N. Ovechkina, Alexander L. Alyanskiy, Elena I. Darskaya, Elena V. Morozova, Boris V. Afanasyev Raisa Gorbacheva Memorial Research Institute of Pediatric Oncology, Hematology and Transplantation, Chair of Hematology, Transfusiology and Transplantology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia Thrombopoietin receptor agonists for treatment of poor graft function after allogeneic hematopoietic stem cell transplantation in adults Cellular Therapy and Transplantation (CTT). Vol. 8, No. 2, 2019 doi: 10.18620/ctt-1866-8836-2019-8-2-38-44 Submitted: 31 July 2019, accepted: 09 August 2019","PeriodicalId":39111,"journal":{"name":"Cellular Therapy and Transplantation","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77108170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Smirnova, S. Bondarenko, I. Moiseev, I. Markova, E. I. Darskaya, I. Golubovskaya, Bella I. Ayubova, E. Babenko, I. Barkhatov, A. Alyanskiy, T. Gindina, A. Kulagin, B. Afanasyev
{"title":"Successful treatment of extramedullary relapsed/refractory B-acute lymphoblastic leukemia with Inotuzumab ozogamicin before and after allogeneic stem cell transplantation","authors":"A. Smirnova, S. Bondarenko, I. Moiseev, I. Markova, E. I. Darskaya, I. Golubovskaya, Bella I. Ayubova, E. Babenko, I. Barkhatov, A. Alyanskiy, T. Gindina, A. Kulagin, B. Afanasyev","doi":"10.18620/ctt-1866-8836-2019-8-2-63-67","DOIUrl":"https://doi.org/10.18620/ctt-1866-8836-2019-8-2-63-67","url":null,"abstract":"63 CTT JOURNAL | VOLUME 8 | NUMBER 2 | JUNE-JULY 2019 Anna G. Smirnova, Sergey N. Bondarenko, Ivan S. Moiseev, Inna V. Markova, Elena I. Darskaya, Irina K. Golubovskaya, Bella I. Ayubova, Elena V. Babenko, Ildar M. Barkhatov, Alexander L. Alyanskiy, Tatiana L. Gindina, Alexander D. Kulagin, Boris V. Afanasyev Raisa Gorbacheva Memorial Research Institute of Pediatric Oncology, Hematology and Transplantation, Chair of Hematology, Transfusiology and Transplantology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia Successful treatment of extramedullary relapsed/refractory B-acute lymphoblastic leukemia with Inotuzumab ozogamicin before and after allogeneic stem cell transplantation Cellular Therapy and Transplantation (CTT). Vol. 8, No. 2, 2019 doi: 10.18620/ctt-1866-8836-2019-8-2-63-67 Submitted: 10 July 2019, accepted: 26 July 2019","PeriodicalId":39111,"journal":{"name":"Cellular Therapy and Transplantation","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87154212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Fedotovskikh, Galija M. Shaymardanova, M. Askarov, Maiya S. Zhumabayeva, Gulmira S. Dosataeva, Aigerim Smagulova, Sapargul Marat, Tatyana G. Ezhelenko
{"title":"Efficiency of mesenchymal stem cell therapy in ulcerative colitis as assessed by the morphology of colon mucosa","authors":"G. Fedotovskikh, Galija M. Shaymardanova, M. Askarov, Maiya S. Zhumabayeva, Gulmira S. Dosataeva, Aigerim Smagulova, Sapargul Marat, Tatyana G. Ezhelenko","doi":"10.18620/ctt-1866-8836-2019-8-2-58-62","DOIUrl":"https://doi.org/10.18620/ctt-1866-8836-2019-8-2-58-62","url":null,"abstract":"","PeriodicalId":39111,"journal":{"name":"Cellular Therapy and Transplantation","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81673519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}