American Journal of Case Reports最新文献

{"title":"Management of Cardiac Tamponade During Systemic Lupus Erythematosus Flare with Significant Pericardial Effusion: A Case Report.","authors":"Adam D Walsh, Mitchell T Carroll","doi":"10.12659/AJCR.947859","DOIUrl":"https://doi.org/10.12659/AJCR.947859","url":null,"abstract":"<p><p>BACKGROUND Pericarditis is a frequently encountered complication of systemic lupus erythematosus (SLE). However, cardiac tamponade resulting from massive pericardial effusion is a rare sequela. Risk factors for cardiac tamponade in SLE include female sex, reduced serum complement, and positive anti-nucleosome antibody at diagnosis. Management options for cardiac tamponade, such as pericardiocentesis and pericardial window, are tailored to the individual, and clear guidelines for when to proceed with invasive intervention are lacking. CASE REPORT We present a case of cardiac tamponade associated with an SLE exacerbation in a 38-year-old woman, associated with fever, dyspnea, and pleuritic chest pain. A chest radiograph demonstrated a large left pleural effusion obscuring a widened mediastinum suspicious for pericardial effusion. After a trial of medical therapy, the patient developed new atrial fibrillation, hypotension, and tachycardia, and proceeded to pericardiocentesis following which 1.6 liters of pericardial fluid was drained over the following 24 hours. Disease control was achieved with high-dose pulsed corticosteroids and cyclophosphamide and there was no recurrence of the effusion. CONCLUSIONS This appears to be one of the largest volumes of pericardial drainage described in the literature in the setting of SLE. Cardiac tamponade can occur at any stage of the disease course in SLE. Large pleural effusions can mimic symptoms of pericardial effusion and make diagnosis challenging. Definitive management can be achieved using a combination of invasive and medical therapy. Risk factors for the development of cardiac tamponade should be identified early in the course of an SLE exacerbation to ensure prompt treatment and avoid further complications.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e947859"},"PeriodicalIF":0.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aorto-Duodenal Fistula After Emergency Endovascular Repair of a 14-cm Abdominal Aortic Aneurysm in a 68-Year-Old Man.","authors":"Maja Anna Romanowska, Miare Kuse, Elizabet Talia Yel, Tomasz Ostrowski, Oskar Gąsiorowski, Zbigniew Gałązka","doi":"10.12659/AJCR.948062","DOIUrl":"https://doi.org/10.12659/AJCR.948062","url":null,"abstract":"<p><p>BACKGROUND Aorto-duodenal fistula (ADF) is a communication between the aorta and the duodenum and requires urgent aortic repair. However, it often leads to life-threatening complications. Thus, an early and appropriate diagnostic method is necessary to deliver adequate treatment. This report describes the case of a 68-year-old man with anaorto-duodenal fistula following emergency endovascular repair of a 14-cm abdominal aortic aneurysm (AAA) identified using oral contrast computed tomography (CT), and discusses the consequences of delayed treatment and ADF management. CASE REPORT We present a case of a 68-year-old White man with abdominal bloating, who upon further examination was diagnosed with an AAA, which was successfully treated by endovascular aneurysm repair (EVAR). However, 1 year later, an endoleak was discovered and, despite the physicians' efforts, the overall treatment was complicated due to the patient's continuous postponement of treatment over several years. The aneurysm continued to expand until it reached 14 cm. Despite the successful endovascular repair of the endoleak, a duodeno-aortic fistula (DAF) was diagnosed using CT with oral contrast. The patient was managed conservatively with aneurysmal sac drainage and antibiotic therapy, which decreased the size of the aneurysmal sac. Despite early diagnostic efforts and interventions, the patient's condition deteriorated due to further complications, ultimately resulting in death. CONCLUSIONS This case report demonstrates a potential useful diagnostic role of CT with oral contrast in detecting DAF, in situations when other methods fail to do so, and emphasizes the importance of prompt intervention to prevent life-threatening complications. However, further investigations to explore the underlying mechanism and its replicability are required.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e948062"},"PeriodicalIF":0.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracoscopic Approach for Treating a Primary Hydatid Cyst in the Thymus in a Teenager: A Case Report.","authors":"Mohammad Al-Hurani, Yousef Al-Hadrab, Khaleel Raslan Ayoub, Amjad Al-Salhi, Hala Sadi Al-Sarsour, Gregor Jan Kocher","doi":"10.12659/AJCR.948600","DOIUrl":"https://doi.org/10.12659/AJCR.948600","url":null,"abstract":"<p><p>BACKGROUND Hydatid disease remains a major clinical concern, particularly in regions where it is endemic. This parasitic infection is caused by Echinococcus species. The liver and lungs are the most affected organs. Although the lungs are the most commonly affected intrathoracic organ, extrapulmonary intrathoracic hydatid disease is uncommon. However, primary mediastinal hydatid disease is a rare entity, and a primary hydatid cyst in the thymus is extremely rare. Although video-assisted thoracoscopic surgery (VATS) plays an important role in the field of thoracic surgery, its role in treating hydatid disease in the chest is not well established. This report describes a case of 17-year-old male presenting with primary hydatid cyst of the thymus treated thoracoscopically. CASE REPORT A 17-year-old male presented to our clinic with chest tightness and shortness of breath of 3 months duration. A well-defined opacity was identified on chest radiography. Subsequent computed tomography (CT) revealed a large, well-defined cystic lesion in the left hemithorax, measuring 6.5×7×11 cm. He was later scheduled for VATS to resect the cyst, which was found to be in continuity with the thymic gland. An en bloc thymectomy was performed to ensure complete peri-cystectomy. CONCLUSIONS This case is unique not only because it describes a rare location of hydatid disease, but also due to the technique of resection that was used. Based on our literature review, this is among the earliest reported cases of a hydatid cyst in this location resected via thoracoscopy. Furthermore, compared with thoracotomy, VATS offers faster recovery and reduced postoperative pain, and its application in similar cases should be further explored.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e948600"},"PeriodicalIF":0.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Closure Timing for Protective Jejunostomy in an Infant with Necrotizing Enterocolitis: A Case Report.","authors":"João Victor Ribeiro, Julia Daudt de Faro Salamonde, João Pedro Serrão Perin, Rafael Ricieri Betti Faci, Maithe Gravina Bertoldo Vieira, Giovanna Brandão Saliba, Ramiro Ananias Bragagnolo, Clara Souza Carvalho, Rogerio Fortunato de Barros","doi":"10.12659/AJCR.947801","DOIUrl":"https://doi.org/10.12659/AJCR.947801","url":null,"abstract":"<p><p>BACKGROUND Necrotizing enterocolitis (NEC) is a prevalent, life-threatening gastrointestinal disease in premature neonates, characterized by intestinal inflammation, ischemia, and potential perforation. Protective measures such as ostomies of various types are a strategy to help patients during recovery from postoperative complications. Protective jejunostomy (PJ) in such cases aims to minimize intraluminal pressure and protect distal anastomoses or compromised bowel segments. However, the optimal timing for closure remains a matter of debate, between balancing bowel rest and avoiding complications associated with prolonged ostomies. CASE REPORT We report an unusual case of a 6-month-old female patient, who presented with NEC and extensive intestinal compromise. Emergency laparotomy revealed multiple areas of bowel perforation and partial ischemia without perfusion. Surgical management included selective resection of non-viable bowel segments, primary closure of smaller perforations, creation of a PJ, and a distal ileostomy. The \"clip and drop\" technique was not used; instead, distal bowel patency was confirmed by a second intraoperative assessment and through intestinal saline solution injection on the tenth postoperative day due to high stoma output and persistent hydroelectrolyte imbalance. Postoperatively, the patient developed 2 new ileal perforations, requiring reoperation. Following the third surgical intervention, the patient demonstrated gradual recovery without major complications, followed by elective ileostomy closure after 6 months. CONCLUSIONS This case highlights the complexity of the surgical option and timing of PJ closure in complicated NEC in a 6-month-old female patient. Early closure can mitigate complications related to the stoma but carries the risk of compromising the fragile and recovering intestine. Decision-making must be careful and individualized, balancing the risks and benefits.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e947801"},"PeriodicalIF":0.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Driven Diagnosis of Hamate Hook Stress Fracture in Athlete: A Case Report.","authors":"Sayaka Hashimoto, Kiyohito Naito, So Kawakita, Takamaru Suzuki, Norizumi Imazu, Kenjiro Kawamura, Muneaki Ishijima","doi":"10.12659/AJCR.948317","DOIUrl":"https://doi.org/10.12659/AJCR.948317","url":null,"abstract":"<p><p>BACKGROUND Early diagnosing a stress fracture of the hook of the hamate is challenging with plain X-rays alone. However, it is necessary to determine the appropriate treatment method to allow athletes to return to sports as soon as possible. We present a case in which diagnosis of stress fracture of the hook of the hamate in a professional baseball player was confirmed on the day of injury by ultrasound imaging, and early intervention was performed. CASE REPORT The patient was a 22-year-old male professional baseball player. During hitting practice, he experienced pain in his right palm, then tenderness around the hook of the hamate was noted. Ultrasonography revealed disruption of the bony cortical continuity of the ulnar aspect of the hook of the hamate and a hematoma around this lesion. Stress fracture of the hook of the hamate was confirmed by computed tomography. Resection of the hook of the hamate was performed on the third day after injury. The patient returned to playing baseball 3 months after surgery. CONCLUSIONS In stress fracture of the hook of the hamate, the time required for diagnosis greatly affects the time to return to competition. To solve this clinical issue, ultrasonography was applied to the early diagnosis of stress fractures of the hook of the hamate. This study suggests that ultrasound can be a useful diagnostic tool for early diagnosis of stress fractures of the hook of the hamate.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e948317"},"PeriodicalIF":0.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144972975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon Ileo-Cecal Intussusception in Adults: A Case Report of Diagnosis and Management.","authors":"Yembu Ngwengi, Christian Beugheum, Christian Ottou, Benjamin Freddy Mindjeme, Jacqueline Soh, Roger Ngoulla","doi":"10.12659/AJCR.946853","DOIUrl":"https://doi.org/10.12659/AJCR.946853","url":null,"abstract":"<p><p>BACKGROUND This report describes the case of a 36-year-old man presenting with severe abdominal pain and small-bowel obstruction due to idiopathic ileo-cecal intussusception. Intussusception refers to the telescoping or folding of a segment of bowel into the section distal to it. It is one of the main differentials of small-bowel obstruction in the pediatric population, but remains exceedingly rare in adults. Intussusception in adults is generally associated with organic masses of the digestive tract, especially tumors, which act as lead points that drag the proximal bowel into a more distal segment. It is extremely uncommon to find intussusception in an adult patient with no obvious underlying bowel pathology. CASE REPORT We report a case of ileo-cecal intussusception in an adult patient that yielded no underlying bowel anomaly on surgical exploration and pathology. The patient, a 36-year-old man, presented with severe abdominal pain and was diagnosed with intussusception through computed tomography (CT) scanning. Surgical resection and anastomoses of the bowel were subsequently performed when medical therapy failed. The patient experienced diarrhea and vitamin-deficient neuropathy a month after surgery, which was diagnosed as short bowel syndrome, and which resolved with appropriate medical care. CONCLUSIONS Intussusception, while rare in adult patients, is possible even without underlying bowel disease. However, a thorough surgical exploration and proper pathology analysis are essential to confidently exclude other gut anomalies. Clinicians should be aware of possible complications like short bowel syndrome if the surgical approach is used and a significant amount of intestine is resected.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e946853"},"PeriodicalIF":0.7,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Management of Large Extraosseous Myxoid Chondrosarcoma of the Buttocks: A Case Report.","authors":"Qing Hong Lai, Chun Mei Zhong, Xue Qi Sun, Hua Ye, Yan Zhang, Jia Jing Tu, Jun Feng Sun","doi":"10.12659/AJCR.947135","DOIUrl":"10.12659/AJCR.947135","url":null,"abstract":"<p><p>BACKGROUND Extraskeletal chondrosarcoma is a rare soft tissue sarcoma with no characteristic imaging and clinical manifestations. Therefore, early preoperative diagnosis is difficult and ultimately depends on postoperative pathology and genetic diagnosis. CASE REPORT A 67-year-old man presented with a huge buttock tumor. The maximum transverse section length of the tumor was 40 cm. Due to the large size and long duration of the tumor, the tumor ruptured and invaded part of the sacrum. The preoperative diagnosis was not clear, the tumor was completely removed by surgery, and the wound was repaired. Adjuvant radiotherapy was given after surgery, and the prognosis was good. CONCLUSIONS This case report demonstrates the importance of radical surgical resection and postoperative adjuvant chemotherapy for the prognosis of extraosseous chondrosarcoma. It also suggests that sometimes the early diagnosis of this type of tumor is difficult, depending on postoperative pathology and genetic diagnosis.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e947135"},"PeriodicalIF":0.7,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Bradyarrhythmia and Reduced Cardiac Output Due to Oral Baclofen Withdrawal in a 24-Year Old Man: A Case Report.","authors":"Dinuk Sachintha Liyanage, Jitain Sivarajah, Craig Johnston, Ravindranath Tiruvoipati","doi":"10.12659/AJCR.948678","DOIUrl":"10.12659/AJCR.948678","url":null,"abstract":"<p><p>BACKGROUND Baclofen is a selective gamma-aminobutyric acid (GABA) receptor agonist and muscle relaxant prescribed to treat spasticity and muscle pain and is used off-label to treat alcohol use disorder and gastroesophageal reflux disease. Baclofen withdrawal syndrome is a rare condition that presents with abnormal cardiac rhythm and function. This report describes the case of a 24-year-old man who presented with polypharmacy overdose, including baclofen, who subsequently showed features of baclofen withdrawal, requiring baclofen reintroduction. CASE REPORT A 24-year-old man was admitted to the Intensive Care Unit after suspected polypharmacy overdose of baclofen, escitalopram, and ethanol. Thirty-six hours later, the patient developed severe bradyarrhythmia and associated reduced cardiac output/arrest, requiring inotropic and vasopressor support. Extensive cardiac workup showed no abnormalities that could explain the symptoms; however, the patient had persistent episodes of severe bradyarrhythmia and loss of cardiac output. Given the lack of improvement, potential baclofen withdrawal was hypothesized for the episodes of bradycardia and low cardiac output. Low-dose baclofen was therefore reintroduced. After 36 h of reintroducing baclofen, all episodes of severe bradyarrhythmia and low cardiac output resolved. The patient went on to make a full recovery, with ongoing low-dose baclofen therapy. This case highlights that, even in the possible setting of baclofen toxicity, baclofen withdrawal must also be considered as a potential cause of bradycardia and low cardiac output leading to hypotension. CONCLUSIONS Baclofen withdrawal can lead to life-threatening cardiac depression. Re-introduction of baclofen might be therapeutic in the management of these cases.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e948678"},"PeriodicalIF":0.7,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Pontine Myelinolysis in a Patient with Alcohol Use Disorder without Hyponatremia: A Case Report.","authors":"Anastasia Demina, Simon Amaral, Benjamin Petit, Vincent Meille, Yannick Béjot, Benoit Trojak","doi":"10.12659/AJCR.947709","DOIUrl":"10.12659/AJCR.947709","url":null,"abstract":"<p><p>BACKGROUND Central pontine myelinolysis (CPM) is an osmotic demyelination syndrome most commonly observed in patients with chronic hyponatremia who undergo rapid serum sodium correction. Risk factors for CPM include malnutrition, hypokalemia, advanced liver disease, hyperemesis gravidarum, and alcohol use disorder. In this case report, we present an unusual case of CPM in a 30-year-old man with alcohol use disorder who did not have hyponatremia during hospitalization and had no history of chronic hyponatremia. CASE REPORT A 30-year-old man was admitted to the hospital for alcohol detoxification. He presented with symptoms of alcohol withdrawal and distal lower-limb pain, accompanied by bilateral edema. After his withdrawal symptoms were controlled, persistent neurological abnormalities prompted an MRI, which revealed lesions suggestive of central pontine myelinolysis (CPM). The patient did not exhibit hyponatremia during his hospital stay. However, he had multiple previously identified risk factors for CPM, including significant alcohol consumption leading to malnutrition and refeeding syndrome-associated hypokalemia. The neurological exam performed 1 month after the onset of symptoms showed a favorable outcome without signs of dystonia or cerebellar syndrome, but with persistent left-wrist extrapyramidal rigidity. CONCLUSIONS This case report highlights the importance of a thorough neurological examination in patients with alcohol use disorder, to prevent falsely attributing neurological symptoms to alcohol intoxication. Clinicians should remain vigilant about the risk of CPM in patients with alcohol use disorder, even in the absence of hyponatremia, considering that other metabolic disturbances can contribute to its pathogenesis.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e947709"},"PeriodicalIF":0.7,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crucial Role of Early Detection in Managing Heart Failure in Kearns-Sayre Syndrome: A Case Report.","authors":"Dominik Krupka, Katarzyna Rakoczy, Adam Chełmoński, Michał Zakliczyński, Roman Przybylski, Mateusz Sokolski","doi":"10.12659/AJCR.947439","DOIUrl":"10.12659/AJCR.947439","url":null,"abstract":"<p><p>BACKGROUND Kearns-Sayre syndrome (KSS) is a rare genetic, mitochondrial disorder characterized by a triad of chronic progressive external ophthalmoplegia, pigmentary retina degeneration, and cardiac conduction disorders, with onset before the age of 20 years. The disease can also manifest as several cardiovascular (CV) disorders, such as conduction disorders or dilated cardiomyopathy, along with neuromuscular and endocrinological complications. CASE REPORT A 46-year-old man diagnosed with KSS was admitted to the Institute of Heart Diseases in the qualification process for heart transplantation (Htx). The patient's medical history began with a diagnosis of third-degree atrioventricular block, treated with pacemaker (PM) implantation at age 25. However, due to progressing left ventricle (LV) function deterioration, PM was upgraded to cardiac resynchronization therapy with defibrillator 10 years later. In the year before the admission, he had undergone 2 hospitalizations caused by acute decompensations of heart failure (ADHF). Upon admission, physical examination revealed features of congestion. Transthoracic echocardiography showed an enlarged LV with global hypokinesia, reduced ejection fraction, and right ventricle dysfunction. Due to the neurological complications and poor functional condition, the Heart Team qualified him for conservative treatment. The next hospitalization due to ADHF ended in the patient's death. CONCLUSIONS CV disorders are an important aspect of treatment of KSS patients. Our patient was referred with excessively developed complications, so he could not benefit from Htx or mechanical circulatory support. This case highlights the importance of early diagnosis and monitoring of KSS patients before the full development of complications, including HF.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e947439"},"PeriodicalIF":0.7,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}