American Journal of Case Reports最新文献

{"title":"Evidence of Vertical Dengue Transmission: A Case of Fever in a 4-Day-Old Neonate.","authors":"Bugis Mardina Lubis, Rycha Dwi Syafutri, Halisa Tiara Ariani Matondang, Dewi Sari","doi":"10.12659/AJCR.948417","DOIUrl":"https://doi.org/10.12659/AJCR.948417","url":null,"abstract":"<p><p>BACKGROUND Dengue is a virus transmitted by Aedes mosquitoes, with rare cases of vertical transmission occurring through infected mothers. Acute infection can be identified by molecular viral testing or by detecting dengue non-structural protein 1 (NS1) and elevated serum IgM. This report describes the case of a 4-day-old male neonate with fever, rash, and jaundice due to vertical transmission of maternal dengue virus infection, confirmed by NS1 detection. CASE REPORT We report a case of a 4-day-old male neonate admitted with high fever, rash, and jaundice. Initial laboratory investigations showed thrombocytopenia, elevated liver enzymes, and signs of systemic inflammation. The mother and infant both tested positive for dengue NS1 antigen, confirming vertical transmission. The neonate received supportive management in the neonatal intensive care unit (NICU), including intravenous fluids and platelet transfusions. He gradually recovered without complications and was discharged in stable condition. CONCLUSIONS This case underscores the importance of considering congenital dengue in neonates born to mothers with peripartum dengue infection. NS1 antigen testing can aid early diagnosis, even before seroconversion occurs. Prompt supportive care, especially monitoring and treating thrombocytopenia, is essential for a favorable outcome. Increased awareness and standardized management guidelines are needed to improve neonatal care in similar cases.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e948417"},"PeriodicalIF":0.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of Severe Refractory ARDS in Hemophagocytic Lymphohistiocytosis with VV-ECMO: A Case Report and Analysis.","authors":"Mengqi Guan, Yan Qian, Zihua Tang, Yingya Cao, Xiaogan Jiang, Weihua Lu, Qiancheng Xu","doi":"10.12659/AJCR.949154","DOIUrl":"https://doi.org/10.12659/AJCR.949154","url":null,"abstract":"<p><p>BACKGROUND Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening systemic inflammatory disorder characterized by cytokine storm, coagulation abnormalities, and pancytopenia, which can rapidly progress to multi-organ failure. Although acute respiratory distress syndrome (ARDS) is a less common but severe complication of HLH, veno-venous extracorporeal membrane oxygenation (VV-ECMO) can serve as a lifesaving intervention in cases unresponsive to standard treatments. Emerging case reports indicate that, when appropriately indicated, VV-ECMO can offer substantial clinical benefits. CASE REPORT A 45-year-old woman presented with 1 week of high-grade fever, fatigue, anorexia, and progressive dyspnea. Initial workup showed thrombocytopenia (platelets 30×10⁹/L), elevated C-reactive protein, and bilateral ground-glass opacities on chest computed tomography. Despite lung-protective settings, her PaO₂/FiO₂ ratio stayed below 80 mmHg. VV-ECMO was started on day 2 in the Intensive Care Unit, promptly restoring SpO₂ and reducing vasopressor needs. Further evaluation met HLH-2004 criteria: hyperferritinemia, high soluble CD25, splenomegaly, bone marrow hemophagocytosis, and elevated EBV DNA. Under ECMO support, she received high-dose methylprednisolone (1 g/day×5 days), a prednisone taper, and etoposide on day 18. She was weaned from ECMO on day 8, extubated on day 20, and discharged on day 45, with normalized laboratory values. At the 4-year follow-up, she remained in complete remission. CONCLUSIONS Early VV-ECMO can be life-saving in adult patients with HLH-associated ARDS by providing a window for targeted immunosuppression and chemotherapy. Rapid HLH recognition, multidisciplinary management, and timely ECMO initiation are essential. Further studies should refine patient selection, timing, and integrated treatment protocols.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e949154"},"PeriodicalIF":0.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Piggy-Back Technique for Orthotopic Liver Transplantation in a 67-Year-Old Woman with Situs Inversus Totalis: A Case Report.","authors":"Wen-Rui Wu, Li Pang, Fa-Peng Zhang, Ming-Bin Feng, Lei-Bo Xu, Chao Liu","doi":"10.12659/AJCR.948098","DOIUrl":"10.12659/AJCR.948098","url":null,"abstract":"<p><p>BACKGROUND Situs inversus totalis (SIT) is a rare congenital condition characterized by complete mirror-image reversal of the thoracic and abdominal organs. This anatomical anomaly poses unique challenges for major abdominal surgeries, particularly liver transplantation, due to altered vascular and visceral orientation. While successful liver transplantations in patients with SIT have been reported, technical guidance remains limited. CASE REPORT We report a case of a 67-year-old woman with end-stage liver disease due to idiopathic cirrhosis and complete SIT. She had a prior splenectomy, hepatocellular carcinoma treated with transarterial chemoembolization, and a preoperative MELD score of 40. A full-size graft from a donation after brain death donor was used. The transplantation was performed using a modified piggy-back technique, without venovenous bypass. Due to reversed anatomy, a wide triangular end-to-side cavo-caval anastomosis was applied to ensure venous outflow. The graft was positioned in the left upper quadrant, without fixation. Vascular and biliary anastomoses were completed without tension or kinking. Total operative time was 485 min, with minimal blood loss. Postoperative recovery was uneventful, and the patient was discharged on day 77. Six-month follow-up revealed no complications. CONCLUSIONS Liver transplantation in patients with SIT is feasible and safe when appropriate technical modifications are used. The modified piggy-back technique provides a reliable solution for venous reconstruction and graft stability in the context of reversed anatomy.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e948098"},"PeriodicalIF":0.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Hemo-Mediastinum Following Laparoscopic Appendectomy: A Case Report.","authors":"Abanoub Awad, Isaac Theerman, Jeremy F McBride, Jason Beckermann","doi":"10.12659/AJCR.949251","DOIUrl":"10.12659/AJCR.949251","url":null,"abstract":"<p><p>BACKGROUND Intra-thoracic bleeding in the form of hemo-mediastinum is a rare condition often resulting from trauma or malignancy, or can occur spontaneously. Spontaneous intra-thoracic bleeding, particularly following laparoscopic appendectomy, is extremely uncommon and not typically associated with such procedures. CASE REPORT A 65-year-old man with a history of interstitial lung disease due to mixed connective tissue disease, chronic cough, pleurodesis, and coronary artery disease developed massive mediastinal hematoma and hemodynamic instability following an uncomplicated laparoscopic appendectomy for gangrenous appendicitis. Symptoms included chest pain and hemoptysis with a hemoglobin drop from 16.2 g/dL preoperatively to 13.2 g/dL. Contrast-enhanced computed tomography (CT) of the chest identified a large right upper-mediastinal hematoma with active contrast extravasation. Interventional radiology (IR) embolized the bleeding vessel. Due to continuous hemoptysis and hemodynamic instability, the patient was taken back to IR for a right bronchial artery angiogram and bronchoscopy. The angiogram showed an irregular segment, likely the source of the hemoptysis; this was embolized with glue. Persistent respiratory compromise and concern for tamponade physiology prompted surgical intervention. A video-assisted thoracoscopic approach was converted to thoracotomy for complete evacuation of the hematoma and lysis of adhesions. The patient's condition stabilized postoperatively, and he was discharged home in good condition on hospital day 10. CONCLUSIONS This case highlights an unusual complication of spontaneous hemo-mediastinum after laparoscopic appendectomy, emphasizing the importance of early identification and timely intervention in managing this complication. To our knowledge, this is the first reported case of post-appendectomy hemo-mediastinum.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e949251"},"PeriodicalIF":0.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One Patient with 3 Antibody-Confirmed Neurological Autoimmune Syndromes: A Case Report and Review of the Literature.","authors":"Lauren A Nguyen, Frishan Rocel O Paulo, Jordan J Petersen, J Douglas Miles","doi":"10.12659/AJCR.948329","DOIUrl":"10.12659/AJCR.948329","url":null,"abstract":"<p><p>BACKGROUND The occurrence of multiple autoimmune neurological disorders in one patient is rare. Here, we present the case of a woman who exhibited clinical features and antibody titers consistent with myasthenia gravis (MG), neuromyelitis optica (NMO), and anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. CASE REPORT A 37-year-old woman with a 10-year history of MG presented with a sudden loss of central vision in her right eye. Magnetic resonance imaging (MRI) revealed new enhancement of the right optic nerve, and additional cervical and thoracic spine scans showed continuous demyelination of the central cord. Given these findings, a primary demyelinating condition was suspected, and an NMO antibody test confirmed the diagnosis. Two years later, the patient developed significant behavioral changes, including neglecting her usual activities and displaying diminished responsiveness. She became mute and uncooperative with commands. Based on clinical suspicion of anti-NMDAR encephalitis, a comprehensive work-up revealed the presence of NMDAR antibodies, confirming the diagnosis. The patient was treated with plasma exchange, resulting in a marked improvement in her encephalopathy. CONCLUSIONS Over 12 years, this patient developed clinical manifestations of 3 distinct neurological autoimmune disorders. This case underscores the critical need for clinicians to remain alert to overlapping neurological conditions, enabling timely diagnoses and interventions that can help improve clinical outcomes and prevent unnecessary delays in treatment.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e948329"},"PeriodicalIF":0.7,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinguishing Wernicke Encephalopathy from Artery of Percheron Infarction in a 43-Year-Old Man: A Case Report.","authors":"Syed Raza, Salma Mohamed, Nazia Naz S Khan","doi":"10.12659/AJCR.948636","DOIUrl":"10.12659/AJCR.948636","url":null,"abstract":"<p><p>BACKGROUND Wernicke's encephalopathy (WE) and Artery of Percheron (AOP) infarction share overlapping presentations, including mental status changes, ocular-motor signs, and similar thalamic MRI findings; but require distinct time-sensitive treatment, making prompt differentiation critical. WE results from thiamine deficiency, often due to alcohol use, causing oxidative damage in highly metabolically active brain regions. In contrast, an AOP infarction results from thrombotic occlusion of a rare perforating artery. The aim of this case report is to delineate the similarities and differences between WE and AOP infarction and to underscore the importance of early empiric thiamine replacement. CASE REPORT A 43-year-old man presented with altered mental status, fever, and generalized weakness. Non-contrast head computed tomography (CT) showed cerebellar hypoattenuation, prompting activation of a code stroke. The lesion was later deemed artifactual, and he was admitted for further evaluation. The following morning, the patient's condition acutely changed, with new oculomotor abnormalities and worsening right lower extremity weakness. An urgent brain MRI demonstrated symmetric hyperintensities in the medial thalami. Uncertain whether the lesions represented an AOP infarction or WE, the team ordered a serum thiamine analysis, which returned low. Intravenous thiamine was initiated, resulting in rapid clinical improvement, and confirming WE as the final diagnosis. CONCLUSIONS WE can closely mimic AOP infarction both on clinical presentation and on radiologic appearance. High-dose thiamine is a low-risk, potentially lifesaving intervention, particularly when initial CT imaging is nondiagnostic and further imaging is pending. Empiric thiamine administration is especially warranted if MRI shows bilateral thalamic lesions of uncertain etiology.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e948636"},"PeriodicalIF":0.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic Adrenocortical Adenoma Causing Malignant Hypertension and Hypokalemia.","authors":"Xiaoyong Hu, Djandan Tadum Arthur Vithran, Zhaoying Yang, Hongjian Li","doi":"10.12659/AJCR.948022","DOIUrl":"10.12659/AJCR.948022","url":null,"abstract":"<p><p>BACKGROUND Ectopic adrenocortical adenomas are rare and can produce aldosterone autonomously, causing resistant hypertension and hypokalemia. Atypical locations pose diagnostic challenges. This report describes a 45-year-old man with malignant hypertension and hypokalemia due to an aldosterone-producing ectopic adrenal adenoma located between the pancreas and left adrenal gland. CASE REPORT A 45-year-old man with a 9-year history of poorly controlled hypertension presented with dizziness, vomiting, and fatigue. On admission, blood pressure was 192/110 mmHg and serum potassium was 2.07 mmol/L. Physical examination revealed left ventricular hypertrophy and hypertensive end-organ damage. Laboratory test results showed elevated plasma aldosterone (47.61 ng/dL) and suppressed renin (0.04 ng/mL/h), yielding an aldosterone-to-renin ratio of 1190. Abdominal CT and MRI identified a 3-cm solid cystic mass between the pancreatic tail and lateral branch of the left adrenal gland. Cortisol circadian rhythm, dehydroepiandrosterone sulfate, and plasma metanephrines were within normal limits, excluding other functional adrenal tumors. The patient underwent complete surgical resection of the ectopic adrenal adenoma. Histopathology confirmed adrenal cortical adenoma with focal adrenal medullary hyperplasia. At 1-year follow-up, he had normal blood pressure and serum potassium levels on an antihypertensive regimen. CONCLUSIONS This case highlights a rare ectopic aldosterone-producing adrenal adenoma near the pancreas. A thorough biochemical and imaging workup was essential for diagnosis, and surgical resection achieved clinical resolution. Ectopic adrenal tumors should be considered in the differential diagnosis of resistant hypertension with hypokalemia when standard adrenal imaging is inconclusive.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e948022"},"PeriodicalIF":0.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Closure of an Ischemic Ventricular Septal Rupture in a 73-Year-Old Man: A Case Report.","authors":"Carlos Andres Mejia-Gomez, Paula Andrea Cardenas Marin, Maria Juliana Reyes-Cardona, Miller Giraldo-Sandoval, Camilo Andres Calderon-Miranda, Jorge Alexander Zambrano-Franco, Pastor Olaya, Jairo Sanchez-Blanco, Carlos Enrique Vesga-Reyes","doi":"10.12659/AJCR.947065","DOIUrl":"10.12659/AJCR.947065","url":null,"abstract":"<p><p>BACKGROUND Acquired ventricular septal defect is an uncommon complication of myocardial infarction that can require surgical repair. Percutaneous closure techniques avoid the risks associated with major cardiac surgery, particularly in elderly patients. This report presents the case of a 73-year-old man with a post-infarction ventricular septal defect successfully treated by percutaneous closure. CASE REPORT A 73-year-old man was admitted with ST-elevation myocardial infarction. Coronary angiography revealed 2-vessel disease, and successful stenting of the left anterior descending artery was performed. Transthoracic echocardiography demonstrated an apical ventricular septal defect. Given the patient's hemodynamic stability, the heart team recommended delayed percutaneous closure. However, the patient requested voluntary discharge. He was readmitted 2 weeks later with dyspnea and chest pain. The defect was closed percutaneously due to technical feasibility, elevated surgical risk, and patient preference. Post-procedural recovery was uneventful, and he was in NYHA functional class I at outpatient follow-up. CONCLUSIONS Ischemic ventricular septal rupture is a rare but potentially fatal complication of transmural myocardial infarction, requiring prompt recognition and management by a heart team. Presentation ranges from chest pain or a new murmur to cardiogenic shock. Diagnosis relies on imaging modalities, including transthoracic or transesophageal echocardiography and cardiac magnetic resonance imaging. Management options include surgical and percutaneous closure, with ventricular septal rupture repair mortality exceeding 40%. Treatment selection depends on the patient's clinical status and the size, location, and complexity of the defect. This report highlights the role of percutaneous closure in post-infarction ventricular septal rupture and illustrates a successful outcome in an elderly patient.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e947065"},"PeriodicalIF":0.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukemoid Reactions in Pancreatic Cancer: A Case Series.","authors":"Teng Huang, Tangchun Liu, Siqi Liu, Zhengfei Yang","doi":"10.12659/AJCR.948491","DOIUrl":"10.12659/AJCR.948491","url":null,"abstract":"<p><p>BACKGROUND This article presents a rare case of pancreatic cancer complicated by a leukemoid reaction, alongside 4 similar cases treated at our hospital between 2016 and 2024. Leukemoid reactions are uncommon paraneoplastic manifestations, and their optimal management remains undefined. Herein, we systematically analyze the clinical characteristics and potential molecular mechanisms involved in the development and progression of tumor-associated leukemoid reactions, and summarize our diagnostic and therapeutic approaches. CASE REPORT We reviewed the records of 5 patients at our hospital who had malignancies complicated by leukemoid reactions. Medical histories, laboratory tests, imaging findings, bone marrow biopsy results, and treatment details were collected and analyzed. We explored the pathogenesis, diagnostic strategies, and treatment modalities for leukemoid reactions. A 52-year-old man with advanced pancreatic adenocarcinoma and a KRAS p.G12D mutation, developed extreme leukocytosis (96.22×10⁹ white blood cells/L) in the context of hepatic metastases. Despite broad-spectrum antimicrobial coverage, cytoreductive therapies, and supportive measures (bilirubin adsorption and plasma exchange, continuous veno-venous hemofiltration), his condition rapidly deteriorated, culminating in multi-organ failure. The 4 additional patients - 1 each with metastatic breast cancer, colon cancer, cholangiocarcinoma, and recurrent pancreatic cancer - exhibited similarly aggressive courses, with only transient stabilization observed in the breast cancer case. CONCLUSIONS Patients with malignancies complicated by leukemoid reaction generally have a poor prognosis. Clinicians should be alert to markedly elevated white blood cell counts, promptly investigate underlying causes, and initiate individualized treatments. Future research should focus on the molecular mechanisms driving the development and progression of leukemoid reactions and therapeutic interventions to enhance patient survival and clinical outcomes.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e948491"},"PeriodicalIF":0.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing Disseminated Peritoneal Leiomyomatosis: Malignancy-Like Presentation in a 59-Year-Old Woman.","authors":"Changchao Xiao, Haixing Ju, Jun Cao","doi":"10.12659/AJCR.947246","DOIUrl":"10.12659/AJCR.947246","url":null,"abstract":"<p><p>BACKGROUND Disseminated peritoneal leiomyomatosis (DPL), or leiomyomatosis peritoneal disseminata, is a benign condition that presents with multiple lower abdominal peritoneal nodules consisting of smooth muscle cells, which can slowly increase in size. The risk of malignant transformation is 2% to 5%. The mechanisms underlying the pathogenesis and malignancy of DPL are unclear and can be associated with a variety of factors. This report describes a 59-year-old woman presenting with multiple abdominal masses and a diagnosis of DPL. CASE REPORT This report describes a 59-year-old female patient who experienced abdominal pain and difficulty defecating. Proctoscopy showed intestinal stenosis and inflammatory changes. She may have had renal dysfunction. The medical history showed that the patient had uterine fibroids in the past and had undergone hysterectomy surgery. We cannot confirm whether the patient received hormone therapy before admission. Based on the results of histopathology and immunohistochemistry, it was considered to be a DPL. The patient died 6 months after surgery. CONCLUSIONS DPL is a rare disease that is difficult to diagnose and traditionally considered a benign condition. This report emphasizes the importance of understanding the presentation and distribution of DPL, as it can mimic the deposition of malignant tumors. This case also emphasizes the importance of diagnosing benign tumors through histopathology. The mechanism of malignant transformation of DPL is currently unclear, and it is of great significance to combine multiple detection methods in clinical practice to determine its malignancy.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e947246"},"PeriodicalIF":0.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12291607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}