Thyroid Research最新文献

{"title":"Incidence and treatment outcomes of Graves' disease in Thailand: a single-center retrospective observational study.","authors":"Wasit Kanokwongnuwat,&nbsp;Nawarat Penpong,&nbsp;Chaninporn Sangsri","doi":"10.1186/s13044-022-00142-4","DOIUrl":"https://doi.org/10.1186/s13044-022-00142-4","url":null,"abstract":"<p><strong>Background: </strong>Treatment patterns and outcomes of Graves' disease (GD) are variable around the world. However, studies on treatment outcomes of GD from the Asian populations are limited. We aimed to evaluate treatment outcomes of GD in Thailand.</p><p><strong>Methods: </strong>Patients with new diagnoses of GD in a single center between 2014-2018 were retrospectively reviewed. The diagnosis of GD was based on clinical features, which included diffuse goiter, Graves' orbitopathy (GO), pretibial myxedema and acropachy.</p><p><strong>Results: </strong>The age-adjusted incidence of GD was 26.57 per 100,000 per year. The study included 355 patients aged 15 years or above with a follow-up period of at least 24 months. Antithyroid drug (ATD) was the most popular first-line treatment modality with 98.7% patients receiving the treatment, followed by radioactive iodine (RAI) treatment in 1.3% patients. The most effective treatment modality was surgery with a remission rate of 100%. ATD had a lowest remission rate of 23.8%. Multivariable Cox regression analysis showed GO (HR 1.76, 95% CI 1.08-2.88) and initial TSH < 0.01 uIU/ml (HR 1.61, 95% CI 1.14-2.28) were significant factors associated with an increased treatment failure rate.</p><p><strong>Conclusion: </strong>Treatment failure with ATD in patients with GD was frequent in this population. The diagnosis of GD based solely on clinical features may explain the high treatment failure rate in this study. More definitive treatment could be used to prevent relapse and complications of the disease.</p>","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":"15 1","pages":"24"},"PeriodicalIF":2.2,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10459132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: surgical management of symptomatic pretracheal thyroid gland in a patient with dual ectopic thyroid.","authors":"Masayuki Saito,&nbsp;Hirona Banno,&nbsp;Yukie Ito,&nbsp;Mirai Ido,&nbsp;Manami Goto,&nbsp;Takahito Ando,&nbsp;Junko Kousaka,&nbsp;Yukako Mouri,&nbsp;Kimihito Fujii,&nbsp;Tsuneo Imai,&nbsp;Shogo Nakano,&nbsp;Toyonori Tsuzuki","doi":"10.1186/s13044-022-00141-5","DOIUrl":"https://doi.org/10.1186/s13044-022-00141-5","url":null,"abstract":"<p><strong>Background: </strong>Dual ectopic thyroid, a very rare condition, is defined as the simultaneous presence of ectopic thyroid tissue in two abnormal locations. Here, we report the surgical management of a patient with dual ectopic thyroid.</p><p><strong>Case presentation: </strong>The patient was a 12-year-old boy with right para-midline swelling for 2 months. On physical examination of the upper anterior neck, there was a 4 cm × 3 cm mass that was soft, mobile, smooth, and painless. Blood examination showed euthyroidism. Neck ultrasonography showed a well-circumscribed multilocular cyst. We followed up by observation only because the patient had no local symptoms or malignancy. After 2 years, the mass gradually enlarged, so we performed surgery to improve cosmetic outcomes. Preoperative neck CT revealed both a high-density solid mass at the base of the tongue and a central low-density region surrounded by a high-density area at the pretracheal region below the hyoid. The infrahyoid mass was surgically removed, and the sublingual mass was left intact. Pathological findings showed the growth of multiple-size follicles, leading to a diagnosis of adenomatous goiter. Postoperative ^123-I scintigraphy showed radioactive iodine uptake in the sublingual lesion, but none in the normal thyroid bed despite the extirpation of thyroid tissue. Postoperative thyroid hormone replacement was started for subclinical hypothyroidism. One year postoperatively, the patient became euthyroid.</p><p><strong>Conclusion: </strong>Surgical excision was used to manage a symptomatic cervical infrahyoid mass related to dual ectopic thyroid. Postoperatively, thyroid hormone replacement was required both to prevent enlargement of the remaining sublingual thyroid and to maintain adequate thyroid hormone levels.</p>","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":"15 1","pages":"23"},"PeriodicalIF":2.2,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10275354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary and multiple thyroid nodules as predictors of malignancy: a systematic review and meta-analysis.","authors":"Aqeeb Ur Rehman,&nbsp;Muhammad Ehsan,&nbsp;Haseeba Javed,&nbsp;Muhammad Zain Ameer,&nbsp;Aleenah Mohsin,&nbsp;Muhammad Aemaz Ur Rehman,&nbsp;Ahmad Nawaz,&nbsp;Zunaira Amjad,&nbsp;Fatima Ameer","doi":"10.1186/s13044-022-00140-6","DOIUrl":"https://doi.org/10.1186/s13044-022-00140-6","url":null,"abstract":"<p><strong>Background: </strong>The debate on whether or not there is a difference in the incidence of thyroid cancer between the patients with Solitary thyroid Nodule (STN) and Multinodular Goiter (MNG) has been constantly present for the last few decades. With newer studies yielding mixed results, it was imperative to systematically compile all available literature on the topic.</p><p><strong>Methods: </strong>PubMed/MEDLINE, Cochrane Central, ScienceDirect, GoogleScholar, International Clinical Trials registry, and reference lists of the included articles were systematically searched for article retrieval. No filter was applied in terms of time, study design, language or country of publication. Rigorous screening as per PRISMA guidelines was undertaken by 2 independent reviewers in order to identify the articles that were most relevant to the topic.</p><p><strong>Results: </strong>Twenty-two studies spanning from 1992 to 2018 were included in this analysis and encompassed 50,321 patients, 44.2% of which belonged to the STN subgroup and 55.37% to the MNG subgroup. MNG was found to be associated with a significantly lower risk of thyroid cancer (OR = 0.76; 95% CI 0.61-0.96) when compared with STN. Papillary carcinoma was the most frequently occurring carcinoma across both groups, followed by follicular and medullary carcinomas. A subgroup analysis was performed to assess the efficacy of the two most commonly employed diagnostic tools i.e. surgery and fine needle aspiration cytology (FNAC), however it yielded nonsignificant results, indicating a comparable usefulness of the two. Another subgroup analysis run on the basis of the presumed iodine status of the participants also yielded nonsignificant results.</p><p><strong>Conclusion: </strong>There is a higher incidence of thyroid cancer among patients of STN, however, given the low quality of existing evidence on the topic, it is crucial to conduct larger studies that can establish association with a greater precision.</p>","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":"15 1","pages":"22"},"PeriodicalIF":2.2,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9427926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pregnant women with history of hashimoto's thyroiditis diagnosed with Kikuchi-Fujimoto disease: the first case report.","authors":"Bashar Bazkke,&nbsp;Joli Osman,&nbsp;Mohammad Shahrour,&nbsp;Mohammad Ziadeh,&nbsp;Aya Haji Mohamad,&nbsp;Mohamed Imad Eddin Mouhandes,&nbsp;Ammar Niazi","doi":"10.1186/s13044-022-00135-3","DOIUrl":"https://doi.org/10.1186/s13044-022-00135-3","url":null,"abstract":"<p><strong>Background: </strong>Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting disorder characterized by regional lymphadenopathy. Clinical symptoms range from mild fever and tenderness to upper respiratory syndrome. A few cases have been observed during pregnancy or Hashimoto's disease. What we describe here is the first observed case of KFD in a pregnant woman with a history of Hashimoto's thyroiditis.</p><p><strong>Case presentation: </strong>A 36-year-old woman presented to Aleppo University Hospital during the 13^th week of gestation with a painful cervical node on the right side of her neck. The patient's previous medical history confirmed Hashimoto's thyroiditis for several years. After histopathological examinations and radiological investigations, she was diagnosed with Kikuchi-Fujimoto disease and treated with corticosteroids. Although the patient did not adhere to the treatment very well due to her concerns for the fetus, the clinical picture improved after delivery. The patient now is on follow-up and continuing the current treatment with corticosteroids.</p><p><strong>Conclusions: </strong>Further investigations need to be conducted to understand the possible autoimmune etiology of KFD when it is associated with Hashimoto's thyroiditis disease. It is also necessary to understand the relationship between this disease and pregnancy.</p>","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":"15 1","pages":"16"},"PeriodicalIF":2.2,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10874398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meeting Abstracts from the 70^th Annual British Thyroid Association Meeting : London, UK. 20^th May 2022.","authors":"","doi":"10.1186/s13044-022-00129-1","DOIUrl":"https://doi.org/10.1186/s13044-022-00129-1","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":"15 Suppl 1","pages":"11"},"PeriodicalIF":2.2,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40618365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virchow node of an unusual aetiology – the experience of a clinical case","authors":"M. Borges-Canha, João Sérgio-Neves, Inês Albuquerque, J. Pacheco, M. Silva, A. Oliveira, D. Carvalho","doi":"10.1186/s13044-022-00128-2","DOIUrl":"https://doi.org/10.1186/s13044-022-00128-2","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48925648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proportion of serum thyroid hormone concentrations within the reference ranges in athyreotic patients on levothyroxine monotherapy: a retrospective study","authors":"Mitsuru Ito, Sawako Takahashi, Mikiko Okazaki-Hada, M. Minakata, Kazuyoshi Kohsaka, Tomohiko Nakamura, Toshihiko Kasahara, Takumi Kudo, E. Nishihara, S. Fukata, M. Nishikawa, Takashi Akamiuzu, A. Miyauchi","doi":"10.1186/s13044-022-00127-3","DOIUrl":"https://doi.org/10.1186/s13044-022-00127-3","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46972958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioiodine treatment outcome by dosimetric parameters and renal function in hyperthyroidism","authors":"Joachim N. Nilsson, Rebecca Elovsson, D. Thor, J. Calissendorff, O. Ardenfors","doi":"10.1186/s13044-022-00126-4","DOIUrl":"https://doi.org/10.1186/s13044-022-00126-4","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49110622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of multinodular goiter and primary hyperparathyroidism leads to a diagnosis of AL amyloidosis","authors":"Chandani Patel Chavez, Maria del Mar Morales Hernandez, J. Kresak, W. Woodmansee","doi":"10.1186/s13044-022-00125-5","DOIUrl":"https://doi.org/10.1186/s13044-022-00125-5","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47556504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum depression in maternal thyroidal changes","authors":"Paula Michele da Silva Schmidt, A. Longoni, R. Pinheiro, A. Assis","doi":"10.1186/s13044-022-00124-6","DOIUrl":"https://doi.org/10.1186/s13044-022-00124-6","url":null,"abstract":"","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43347106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}