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An Ethical Argument for Ending Human Trials of Amyloid-Lowering Therapies in Alzheimer's Disease. 结束阿尔茨海默病淀粉样蛋白降低疗法人体试验的伦理论证》。
AJOB Neuroscience Pub Date : 2024-04-01 Epub Date: 2022-10-05 DOI: 10.1080/21507740.2022.2129858
Timothy Daly, Karl Herrup, Alberto J Espay
{"title":"An Ethical Argument for Ending Human Trials of Amyloid-Lowering Therapies in Alzheimer's Disease.","authors":"Timothy Daly, Karl Herrup, Alberto J Espay","doi":"10.1080/21507740.2022.2129858","DOIUrl":"10.1080/21507740.2022.2129858","url":null,"abstract":"<p><p>Given the past two decades of over 40 failed trials of amyloid-lowering therapies in Alzheimer's Disease (AD), many of which succeeded in lowering amyloid as designed, we present an ethical argument for emptying the drug pipeline of tests of amyloid-lowering agents so as to end the historical dominance of the amyloid-reducing therapeutic approach in AD.</p>","PeriodicalId":39022,"journal":{"name":"AJOB Neuroscience","volume":" ","pages":"80-81"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33504601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personality and Authenticity in Light of the Memory-Modifying Potential of Optogenetics: A Reply to Objections about Potential Therapeutic Applicability of Optogenetics. 从光遗传学改变记忆的潜力看人格和真实性：回答有关光遗传学潜在治疗适用性的反对意见。
AJOB Neuroscience Pub Date : 2024-04-01 Epub Date: 2021-06-17 DOI: 10.1080/21507740.2021.1938292
Agnieszka K Adamczyk, Przemysław Zawadzki
{"title":"Personality and Authenticity in Light of the Memory-Modifying Potential of Optogenetics: A Reply to Objections about Potential Therapeutic Applicability of Optogenetics.","authors":"Agnieszka K Adamczyk, Przemysław Zawadzki","doi":"10.1080/21507740.2021.1938292","DOIUrl":"10.1080/21507740.2021.1938292","url":null,"abstract":"","PeriodicalId":39022,"journal":{"name":"AJOB Neuroscience","volume":" ","pages":"W4-W7"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39241227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strong Bipartisan Support for Controlled Psilocybin Use as Treatment or Enhancement in a Representative Sample of US Americans: Need for Caution in Public Policy Persists. 两党强烈支持在具有代表性的美国样本中将受控迷幻药用作治疗或增强疗效：公共政策仍需谨慎
AJOB Neuroscience Pub Date : 2024-04-01 Epub Date: 2024-02-05 DOI: 10.1080/21507740.2024.2303154
Julian D Sandbrink, Kyle Johnson, Maureen Gill, David B Yaden, Julian Savulescu, Ivar R Hannikainen, Brian D Earp
{"title":"Strong Bipartisan Support for Controlled Psilocybin Use as Treatment or Enhancement in a Representative Sample of US Americans: Need for Caution in Public Policy Persists.","authors":"Julian D Sandbrink, Kyle Johnson, Maureen Gill, David B Yaden, Julian Savulescu, Ivar R Hannikainen, Brian D Earp","doi":"10.1080/21507740.2024.2303154","DOIUrl":"10.1080/21507740.2024.2303154","url":null,"abstract":"<p><p>The psychedelic psilocybin has shown promise both as treatment for psychiatric conditions and as a means of improving well-being in healthy individuals. In some jurisdictions (e.g., Oregon, USA), psilocybin use for both purposes is or will soon be allowed and yet, public attitudes toward this shift are understudied. We asked a nationally representative sample of 795 US Americans to evaluate the moral status of psilocybin use in an appropriately licensed setting for either treatment of a psychiatric condition or well-being enhancement. Showing strong bipartisan support, participants rated the individual's decision as morally positive in both contexts. These results can inform effective policy-making decisions around supervised psilocybin use, given robust public attitudes as elicited in the context of an innovative regulatory model. We did not explore attitudes to psilocybin use in unsupervised or non-licensed community or social settings.</p>","PeriodicalId":39022,"journal":{"name":"AJOB Neuroscience","volume":" ","pages":"82-89"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 更正。
AJOB Neuroscience Pub Date : 2024-04-01 Epub Date: 2024-02-08 DOI: 10.1080/21507740.2024.2311041
{"title":"Correction.","authors":"","doi":"10.1080/21507740.2024.2311041","DOIUrl":"10.1080/21507740.2024.2311041","url":null,"abstract":"","PeriodicalId":39022,"journal":{"name":"AJOB Neuroscience","volume":" ","pages":"i"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dementia Prevention Guidelines Should Explicitly Mention Deprivation. 痴呆症预防指南应明确提及剥夺。
AJOB Neuroscience Pub Date : 2024-01-01 Epub Date: 2023-06-28 DOI: 10.1080/21507740.2023.2225461
Timothy Daly
{"title":"Dementia Prevention Guidelines Should Explicitly Mention Deprivation.","authors":"Timothy Daly","doi":"10.1080/21507740.2023.2225461","DOIUrl":"10.1080/21507740.2023.2225461","url":null,"abstract":"<p><p>The brain requires sustained interaction with a rich physical and social environment to stay healthy. Individuals without access to such enabling environments and who instead live and grow in disabling environments tend to have greater risk of developing dementia. But research and policymaking as regards dementia risk reduction have so far focused almost exclusively on the role of how individuals' health behaviors change their risk profile. This exclusive focus on \"lifestyle\" is both ethically problematic and therapeutically inadequate. I highlight a growing literature on three different kinds of deprivation, an independent and overlooked risk factor for dementia that invites upstream action against inequalities. Future prevention guidelines should include explicit mention of deprivation as a risk factor and be developed around the need to make society fairer. Meanwhile, interventions and discourse based on lifestyle modification should respect the principle of \"no ought without support.\"</p>","PeriodicalId":39022,"journal":{"name":"AJOB Neuroscience","volume":" ","pages":"73-76"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10049043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Conditions for Ethical Chemical Restraints. 道德化学约束的条件。
AJOB Neuroscience Pub Date : 2024-01-01 Epub Date: 2022-10-12 DOI: 10.1080/21507740.2022.2126539
Parker Crutchfield, Michael Redinger
{"title":"The Conditions for Ethical Chemical Restraints.","authors":"Parker Crutchfield, Michael Redinger","doi":"10.1080/21507740.2022.2126539","DOIUrl":"10.1080/21507740.2022.2126539","url":null,"abstract":"<p><p>The practice of medicine frequently involves the unconsented restriction of liberty. The reasons for unilateral liberty restrictions are typically that being confined, strapped down, or sedated are necessary to prevent the person from harming themselves or others. In this paper, we target the ethics of chemical restraints, which are medications that are used to intentionally restrict the mental states associated with the unwanted behaviors, and are typically not specifically indicated for the condition for which the patient is being treated. Specifically, we aim to identify the conditions under which chemical restraints are ethically permissible. It is wrong to assume that what is morally true of physical restraints is also true of chemical restraints. Our aim is thus to identify the conditions under which chemical restraints are permissible while distinguishing these conditions from those of the application of physical restraints.</p>","PeriodicalId":39022,"journal":{"name":"AJOB Neuroscience","volume":" ","pages":"3-16"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33502589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Do Psychiatrists Think About Caring for Patients Who Have Extremely Treatment-Refractory Illness? 精神科医生如何看待护理患有极难治愈疾病的患者？
AJOB Neuroscience Pub Date : 2024-01-01 Epub Date: 2023-06-28 DOI: 10.1080/21507740.2023.2225467
Natalie J Dorfman, Jennifer Blumenthal-Barby, Peter A Ubel, Bryanna Moore, Ryan Nelson, Brent M Kious
{"title":"What Do Psychiatrists Think About Caring for Patients Who Have Extremely Treatment-Refractory Illness?","authors":"Natalie J Dorfman, Jennifer Blumenthal-Barby, Peter A Ubel, Bryanna Moore, Ryan Nelson, Brent M Kious","doi":"10.1080/21507740.2023.2225467","DOIUrl":"10.1080/21507740.2023.2225467","url":null,"abstract":"<p><p>Questions about when to limit unhelpful treatments are often raised in general medicine but are less commonly considered in psychiatry. Here we describe a survey of U.S. psychiatrists intended to characterize their attitudes about the management of suicidal ideation in patients with severely treatment-refractory illness. Respondents (<i>n</i> = 212) received one of two cases describing a patient with suicidal ideation due to either borderline personality disorder or major depressive disorder. Both patients were described as receiving all guideline-based and plausible emerging treatments. Respondents rated the expected helpfulness and likelihood of recommending each of four types of intervention: hospitalization, additional medication changes, additional neurostimulation, and additional psychotherapy. Across both cases, most respondents said they were likely to provide each intervention, except for additional neurostimulation in borderline personality disorder, while fewer thought each intervention would be helpful. Substantial minorities of respondents indicated that they would provide an intervention they did not think was likely to be helpful. Our results suggest that while most psychiatrists recognize the possibility that some patients are unlikely to be helped by available treatments, many would continue to offer such treatments.</p>","PeriodicalId":39022,"journal":{"name":"AJOB Neuroscience","volume":" ","pages":"51-58"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10049041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the Relative Intrusiveness of Physical and Chemical Restraints. 论物理和化学限制的相对侵扰性。
AJOB Neuroscience Pub Date : 2024-01-01 Epub Date: 2024-01-11 DOI: 10.1080/21507740.2023.2292499
Gabriel De Marco, Thomas Douglas, Lisa Forsberg, Julian Savulescu
{"title":"On the Relative Intrusiveness of Physical and Chemical Restraints.","authors":"Gabriel De Marco, Thomas Douglas, Lisa Forsberg, Julian Savulescu","doi":"10.1080/21507740.2023.2292499","DOIUrl":"10.1080/21507740.2023.2292499","url":null,"abstract":"","PeriodicalId":39022,"journal":{"name":"AJOB Neuroscience","volume":"15 1","pages":"26-28"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Humanizing Patients and Their Needs Might Affect Psychiatrists' Thinking about Futility. 人性化病人及其需求可能会影响精神科医生对无期徒刑的思考。
AJOB Neuroscience Pub Date : 2024-01-01 Epub Date: 2024-01-11 DOI: 10.1080/21507740.2023.2292510
Rachel B Cooper, Sarah E Levitt, Daniel Z Buchman
{"title":"Humanizing Patients and Their Needs Might Affect Psychiatrists' Thinking about Futility.","authors":"Rachel B Cooper, Sarah E Levitt, Daniel Z Buchman","doi":"10.1080/21507740.2023.2292510","DOIUrl":"10.1080/21507740.2023.2292510","url":null,"abstract":"","PeriodicalId":39022,"journal":{"name":"AJOB Neuroscience","volume":"15 1","pages":"64-67"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On Being Conscious as a Basic Liberty. 论有意识是一种基本自由。
AJOB Neuroscience Pub Date : 2024-01-01 Epub Date: 2024-01-11 DOI: 10.1080/21507740.2023.2292489
Peter Shiu-Hwa Tsu, Shunsuke Sugimoto
{"title":"On Being Conscious as a Basic Liberty.","authors":"Peter Shiu-Hwa Tsu, Shunsuke Sugimoto","doi":"10.1080/21507740.2023.2292489","DOIUrl":"10.1080/21507740.2023.2292489","url":null,"abstract":"","PeriodicalId":39022,"journal":{"name":"AJOB Neuroscience","volume":"15 1","pages":"24-26"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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