International Journal of Infertility and Fetal Medicine最新文献_第8页

First Case of Successful Implantation and Live Birth after Double Trophectoderm Biopsy before and after Vitrification on the Same Cohort of Blastocyst 同一群囊胚玻璃化前后双滋养外胚层活检成功着床及活产首例

International Journal of Infertility and Fetal Medicine Pub Date : 2017-01-01 DOI: 10.5005/JP-JOURNALS-10016-1160

Harsha Bhadarka, NayanaH Patel, Yuvraj D Jadeja, K. Patel, Niket Patel, M. Patel, K. Rao

引用次数: 0

Role of laboratory investigations to assess maternal and perinatal outcome in hypertensive mothers 实验室调查的作用，以评估产妇和围产期结局在高血压母亲

International Journal of Infertility and Fetal Medicine Pub Date : 2017-01-01 DOI: 10.5005/JP-JOURNALS-10016-1142

D. Preethi, L. Rai, M. Nambiar, Pratap Kumar, M. Pai, S. Amin

{"title":"Role of laboratory investigations to assess maternal and perinatal outcome in hypertensive mothers","authors":"D. Preethi, L. Rai, M. Nambiar, Pratap Kumar, M. Pai, S. Amin","doi":"10.5005/JP-JOURNALS-10016-1142","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1142","url":null,"abstract":"Introduction: The aim of this study was to evaluate the relevance of routinely done laboratory parameters in women with hypertensive disorders in pregnancy. Materials and methods: Hypertensive pregnant women were divided into two groups based on perinatal outcome as those with and without poor perinatal outcome. They were analyzed with various laboratory tests done at the time of diagnosis: Hematological parameters, such as hemoglobin, hematocrit, platelet count, total leukocyte count, and differential count; renal parameters, such as serum urea, creatinine, and uric acid; liver function tests; and serum lactate dehydrogenase (LDH). Coagulation parameters, such as prothrombin time, activated partial thromboplastin time, and international normalized ratio were compared between the two groups. Data were presented as mean ± standard deviation; α level of p < 0.05 was set as statistically significant. Results: Among the various hematological parameters, platelet count showed statistically significant differences between hypertensives with and without perinatal mortality or morbidity (p = 0.029, p = 0.029 respectively). All renal parameters showed statistically significant differences (p ≤ 0.005). Serum aspartate aminotransferase (p = 0.034) among the liver parameters and serum LDH (p = 0.024) showed statistically significant differences between the two groups. Coagulation parameters were abnormal among patients with thrombocytopenia. Conclusion: Blood pressure alone is not sufficient in monitoring women with hypertensive disorders in pregnancy. Laboratory parameters that are cost-effective and routinely done in most laboratories are significant in assessing the severity of maternal disease and the perinatal outcome. It can hence, be used to monitor hypertensive women in pregnancy.","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"2 1","pages":"18-23"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73279740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Critical Analysis of the Current Assisted Reproductive Technology Guidelines 当前辅助生殖技术指南的批判性分析

International Journal of Infertility and Fetal Medicine Pub Date : 2017-01-01 DOI: 10.5005/JP-JOURNALS-10016-1159

P. Sharma, M. Mittal, K. Rao

{"title":"Critical Analysis of the Current Assisted Reproductive Technology Guidelines","authors":"P. Sharma, M. Mittal, K. Rao","doi":"10.5005/JP-JOURNALS-10016-1159","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1159","url":null,"abstract":"Aim: To present an overview of the current Artificial Reproductive Techniques (ART) guidelines focussing on grey zones Introduction: Infertility is a major health and social concern in modern day India. Due to the great diversity in management protocols and absence of standard operating procedures, there is a necessity to develop country-specific guidelines for assisted reproduction. Also, there is need to curb unethical practices. Guidelines in this regard have undergone several changes over the years. It is important that adequate care is taken before the bill becomes a law so that both patients and health workers mutually benefit from ART Overview: The present article gives an insight into the development of guidelines over the years with elaboration of the salient features of the current ART Bill under specific chapter headings, ten chapters in total. Also discussed is the recent Surrogacy Bill. In each context, critical analysis is provided that underscores the grey areas that need to be addressed. At the end of the article, certain recommendations have been put forward to aid the successful implementation of current guidelines Clinical significance: It is imperative that all ART practitioners be well versed with the current ART guidelines as ignorance cannot be cited as an excuse under any circumstance. Also, practitioners can give valuable inputs before the bill finally becomes a law. The law must ensure that physicians are not unnecessarily persecuted in the name of patient rights, as this will lead to fearful practice, which in turn will hamper patient management.","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"78 1","pages":"113-119"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86791509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Study on Infertility—Etiology, Medication Therapy Management, and Outcomes at a Tertiary Care Hospital 某三级医院不孕症的病因、药物治疗管理和结局研究

International Journal of Infertility and Fetal Medicine Pub Date : 2017-01-01 DOI: 10.5005/JP-JOURNALS-10016-1158

Purvi K. Khanuja, J. Sunny, Sunita Pawar, Vandana Nimbargi, K. Rao

引用次数: 1

Comparison between Day 2 and Day 3 Embryo Transfer following in vitro Fertilization/Intracytoplasmic Sperm Injection 体外受精/胞浆内单精子注射后第2天和第3天胚胎移植的比较

International Journal of Infertility and Fetal Medicine Pub Date : 2017-01-01 DOI: 10.5005/JP-JOURNALS-10016-1151

Hemant Shintre, H. Pai, D. Talreja, K. R. Shah, K. Rao

{"title":"Comparison between Day 2 and Day 3 Embryo Transfer following in vitro Fertilization/Intracytoplasmic Sperm Injection","authors":"Hemant Shintre, H. Pai, D. Talreja, K. R. Shah, K. Rao","doi":"10.5005/JP-JOURNALS-10016-1151","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1151","url":null,"abstract":"Aim: To compare reproductive outcomes of day 2 and day 3 embryo transfer (ET). Materials and methods: In this retrospective records study, all couples who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and ET cycles at Lilavati Hospital & Research Centre over a period of 1 year were studied. Data were collected and analyzed by chi-square test and unpaired t-test by Statistical Package for the Social Sciences, version 16. Results: There was no statistically significant difference between the clinical and demographic parameters of group day 3 and day 2 ET. In our study, clinical pregnancy rate was 45% in day 3 ET and 36.5% in day 2 ET group [odds ratio (OR) 1.43, p-value 0.49]. The ongoing pregnancy rate was 39.2% in day 3 ET and 26.9% in day 2 ET group (OR 1.75, p-value 0.26). We observed that the miscarriage rate was 5.9% in day 3 ET and was 5.8% in day 2 ET group (p-value 0.69, OR 1.02). We observed one case each of multiple pregnancy, ectopic pregnancy, and fetal anomaly (anencephaly) in day 2 ET group, while in day 3 ET group, no such case was detected. Conclusion: There are chances that day 3 ET has better clinical and ongoing pregnancy rates than day 2 ET, but the difference is not statistically significant. Study showed similar miscarriage rates in both groups and very low incidence of complications like multiple pregnancy, ectopic pregnancy, and fetal anomaly. So, it is safe to schedule and transfer embryos either on day 2 or on day 3 for planning and programming cycles in coordination with patient and IVF team and for adjusting weekends (nonworking days). Clinical significance: Many steps of IVF procedure became standardized. However, the optimum timing of ET is still debatable. Several studies comparing ET on day 2 vs day 3 after oocyte retrieval have been performed, but the conclusions are conflicting. Despite development in culture media allowing blastocyst transfer, many centers still practice day 2/3 ET.","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"53 1","pages":"68-74"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80404404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study to evaluate Association of Tobacco Chewing and Smoking with Semen Parameters 咀嚼烟草、吸烟与精液参数相关性的研究

International Journal of Infertility and Fetal Medicine Pub Date : 2017-01-01 DOI: 10.5005/jp-journals-10016-1156

R. Vohra, S. Priyadarshi, Neeraj Aggarwal, N. Vyas, S. Yadav, V. Tomar, K. Rao

引用次数: 0

Efficacy of Cabergoline in the Prevention of Ovarian Hyperstimulation Syndrome: A Randomized, Double-blind and Placebo-controlled Trial 卡麦角林预防卵巢过度刺激综合征的疗效:一项随机、双盲和安慰剂对照试验

International Journal of Infertility and Fetal Medicine Pub Date : 2017-01-01 DOI: 10.5005/JP-JOURNALS-10016-1149

Sankalp Singh, Swati Singh, A. K. Raman, S. Ramakrishnan, C. Ashraf, K. Rao

{"title":"Efficacy of Cabergoline in the Prevention of Ovarian Hyperstimulation Syndrome: A Randomized, Double-blind and Placebo-controlled Trial","authors":"Sankalp Singh, Swati Singh, A. K. Raman, S. Ramakrishnan, C. Ashraf, K. Rao","doi":"10.5005/JP-JOURNALS-10016-1149","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1149","url":null,"abstract":"Introduction: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication that arises due to assisted reproductive technologies (ARTs) during infertility treatment. Recently, the use of selective dopamine receptor agonists on D2 receptors (e.g., cabergoline) has been suggested in the prevention of OHSS. The aim of this study was to evaluate the effect of cabergoline in the prevention of OHSS in high-risk patients undergoing ART. Materials and methods: This was a randomized, double-blind, parallel group (cabergoline group and placebo) study. A total of 110 women undergoing in vitro fertilization (IVF)–intracytoplasmic sperm injection procedure using a long agonist protocol with high risk for OHSS were recruited for the study on the day of final trigger. All the patients were followed up every 48 hours for 10 days from the day of the final trigger and clinically assessed with ultrasound and blood tests. The size of ovaries and fluid collection in the pouch of Douglas (POD) was measured with ultrasound. A sample size of 92 subjects was calculated for the study to be powered at 80%. Assuming a drop-out rate of 10%, 110 subjects were enrolled for the study. Results: There was no significant difference observed in the size of right and left ovary, POD fluid volume, total leukocyte count (TLC), and serum estradiol level (E2 level) between both the groups from day 0 to day 8, except packed cell volume. No significant difference was observed in the incidence rate of moderate OHSS between both groups (p = 0.728). The differences in clinical pregnancy rate, implantation rate, and live birth rate were also insignificant. Conclusion: Cabergoline does not reduce the incidence of moderate OHSS when compared with placebo. Large, welldesigned studies are needed to evaluate the effectiveness of cabergoline when used for the prevention of OHSS.","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"56 1","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72887971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Successful Live Births after Laparoscopic Management of Heterotypic Pregnancies in Assisted Reproductive Technology Cycles: A Tertiary Fertility Center Experience 辅助生殖技术周期中异型妊娠腹腔镜管理后成功活产:第三生育中心经验

International Journal of Infertility and Fetal Medicine Pub Date : 2017-01-01 DOI: 10.5005/JP-JOURNALS-10016-1161

Aradhana Kalra, A. Nadkarni, P. Nadkarni, Pooja Singh, K. Rao

{"title":"Successful Live Births after Laparoscopic Management of Heterotypic Pregnancies in Assisted Reproductive Technology Cycles: A Tertiary Fertility Center Experience","authors":"Aradhana Kalra, A. Nadkarni, P. Nadkarni, Pooja Singh, K. Rao","doi":"10.5005/JP-JOURNALS-10016-1161","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1161","url":null,"abstract":"Background: To review and analyze the incidence of heterotypic pregnancies after intracytoplasmic sperm injection (ICSI) and embryo transfer and to report pregnancy outcome after successful management of heterotypic pregnancies. Setting: Nadkarni’s 21st Century Hospitals and Test Tube Baby Center, Surat, Gujarat, India. Design: Retrospective study. Materials and methods: Retrospective data were taken from hospital records from January 2013 to December 2015. A total of 2,771 patients underwent in vitro fertilization IVF/ICSI, out of which 1,455 patients were pregnant (52.5%). Out of the pregnant patients, the incidence of ectopic (EP) and heterotypic pregnancies was calculated. The etiological factors, management of heterotypic pregnancies, and their pregnancy outcome were reported. Conclusion: Out of the 1,455 pregnant patients, there were 29 EPs (EPs: 1.99%) and 5 were heterotypic (0.34%). Laparoscopic intervention was done for all five of them and successful pregnancy outcome was reported in terms of live birth. Clinical significance: Heterotypic pregnancy is rare and poses a diagnostic dilemma in assisted reproductive technology (ART) cycles. Serial beta-human chorionic gonadotropin (hCG) measurement is not reliable and ultrasonography may not confirm due to the presence of ovarian hyperstimulation syndrome (OHSS) or multiple cysts. Early diagnosis is ideal and good perinatal outcome can be achieved by prompt and excellent laparoscopic management of the heterotypic pregnancies.","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"90 1","pages":"125-127"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84110516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia 维生素C、维生素E、锌、硒和辅酶Q10对特发性少弱精子症不育男性的影响

International Journal of Infertility and Fetal Medicine Pub Date : 2017-01-01 DOI: 10.5005/JP-JOURNALS-10016-1147

A. Alahmar, K. Rao

{"title":"Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia","authors":"A. Alahmar, K. Rao","doi":"10.5005/JP-JOURNALS-10016-1147","DOIUrl":"https://doi.org/10.5005/JP-JOURNALS-10016-1147","url":null,"abstract":"Introduction: Accumulating evidence suggests that oxidative stress plays an important role in the development of male infertil ity and recently antioxidants have been tried to treat men with idiopathic infertility. Objective: To assess the effect of treatment with vitamin C, vitamin E, zinc, selenium, and coenzyme Q10 on seminal fluid parameters in infertile men with idiopathic oligoasthenozoo spermia. Materials and methods: A prospective randomized trial was conducted on 32 infertile men with idiopathic oligoasthenozoo spmia who received a daily supplement of one caplet contain ing vitamin C (90 mg/day), vitamin E (15 mg/day), coenzyme Q10 (4 mg/day), selenium (30 μg/day), and zinc (5 mg/day) for 3 months. Semen analysis was performed at baseline and 3 months after treatment using World Health Organization (WHO) 2010 guidelines. Results: Significant improvement in sperm concentration was observed after combination therapy (9.13 ± 4.29 vs 11.3 ± 6.05 × 106/mL, p < 0.05). Sperm progressive motility (18.1 ± 8.68 vs 24.6 ± 10.2%, p < 0.01) and total motility (28.4 ± 8.71 vs 34.4 ± 11.7%, p < 0.01) also increased significantly following treatment. No change, however, was observed in semen volume or the proportion of sperms with normal morphology. Conclusion: The combination of vitamin C, vitamin E, zinc, selenium, and coenzyme Q10 can significantly improve sperm concentration and motility in infertile men with idiopathic oligo asthenozoospermia, which could be attributed to their synergistic antioxidant action.","PeriodicalId":38998,"journal":{"name":"International Journal of Infertility and Fetal Medicine","volume":"7 1","pages":"45-49"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87420803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Role of Metalloproteinases in the Pathogenesis of Unexpected Poor Ovarian Response with a Possible Genetic Predisposition 金属蛋白酶在意想不到的卵巢不良反应的发病机制中的作用与可能的遗传易感性

International Journal of Infertility and Fetal Medicine Pub Date : 2017-01-01 DOI: 10.5005/jp-journals-10016-1140

M. Tzafetas, K. Lathouras, T. Tantanasis, S. Fidani, K. Tziomalos, K. Kalinderi, A. Loufopoulos, V. Zournatzi, K. Rao

引用次数: 0