Osong Public Health and Research Perspectives最新文献_第9页

Immunoinformatics study of CD40 ligand-targeting vaccine constructs: a novel immunotherapeutic approach. CD40配体靶向疫苗构建的免疫信息学研究：一种新的免疫治疗方法。

IF 1.6

Osong Public Health and Research Perspectives Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.24171/j.phrp.2025.0077

Seyed Amir Sadeghi, Mahroo Mohamadi, Hadi Bamehr, Fatemeh Heidarnejad, Azam Bolhassani

{"title":"Immunoinformatics study of CD40 ligand-targeting vaccine constructs: a novel immunotherapeutic approach.","authors":"Seyed Amir Sadeghi, Mahroo Mohamadi, Hadi Bamehr, Fatemeh Heidarnejad, Azam Bolhassani","doi":"10.24171/j.phrp.2025.0077","DOIUrl":"10.24171/j.phrp.2025.0077","url":null,"abstract":"Background: Incorporating CD40 ligand (CD40L) into vaccine strategies has shown considerable potential for enhancing immune responses. In this study, we designed and formulated a CD40Lbased multi-epitope vaccine construct using immunoinformatics approaches, and compared it to a full-length CD40L-based vaccine construct.Methods: The study commenced with the identification and screening of potential T-cell and B-cell epitopes derived from the CD40L protein, followed by the construction of a multi-epitope vaccine from these selected epitopes. We analyzed and validated the physicochemical and structural properties of the vaccine constructs. Further, we predicted disulfide bonds, performed protein-protein docking, and conducted molecular dynamics simulations to evaluate the constructs. Comparative analyses of the ligand-binding site localization were conducted using LigPlot. Additionally, simulation trajectories were analyzed using multiple descriptors, including root mean square deviations, radius of gyration, and root mean square fluctuations.Results: Our findings indicated that the CD40L multi-epitope vaccine construct possessed favorable physicochemical properties and a validated structural profile. Immune simulation studies showed a stronger affinity of the multi-epitope construct for the CD40 receptor compared to the full-length CD40L construct.Conclusion: Overall, the CD40L multi-epitope vaccine construct demonstrated greater potency in eliciting an effective immune response than the full-length CD40L construct. These results highlight a promising approach to vaccine design for the prevention or treatment of infections and cancers.","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":"311-332"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12666417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic diversity and spatiotemporal population structure of Anopheles sinensis in the Republic of Korea based on the mitochondrial cytochrome c oxidase subunit I (COI) marker. 基于线粒体细胞色素c氧化酶亚基I （COI）标记的韩国中华按蚊遗传多样性和时空种群结构

IF 1.6

Osong Public Health and Research Perspectives Pub Date : 2025-08-01 Epub Date: 2025-06-11 DOI: 10.24171/j.phrp.2025.0052

Haneul Jung, Bo Gyeong Han, Hyun-Il Shin, Myoung-Ro Lee, Jung-Won Ju, Hee-Il Lee

{"title":"Genetic diversity and spatiotemporal population structure of Anopheles sinensis in the Republic of Korea based on the mitochondrial cytochrome c oxidase subunit I (COI) marker.","authors":"Haneul Jung, Bo Gyeong Han, Hyun-Il Shin, Myoung-Ro Lee, Jung-Won Ju, Hee-Il Lee","doi":"10.24171/j.phrp.2025.0052","DOIUrl":"10.24171/j.phrp.2025.0052","url":null,"abstract":"Background: Anopheles sinensis is a predominant malaria vector found throughout the Republic of Korea (ROK). Population genetic analysis can provide insights into the origins and migration patterns of malaria vectors by assessing genetic variation and distribution among populations.Methods: In this study, we examined the population genetic structure of An. sinensis in the ROK using mitochondrial cytochrome c oxidase subunit I (COI) marker.Results: A total of 903 specimens of An. sinensis were collected from 9 sampling regions, including malaria-endemic and non-endemic areas. All populations displayed characteristics typical of migrant populations, with high haplotype diversity (Hd) and low nucleotide diversity (Pi). Network analysis identified 124 haplotypes grouped into 2 clusters. Both clusters included haplotypes from malaria-endemic and non-endemic areas. Cluster I shared its most recent common ancestry with Chinese reference sequences, while cluster II had related with Japanese reference sequences. Pairwise genetic distance (FST) analysis indicated generally low genetic differentiation among populations. Furthermore, FST values tended to increase proportionally with geographical distance between regions. Analysis of molecular variance confirmed that individual mosquitoes within the population had a large effect on the overall variation. Neutrality tests using 4 methods (Tajima's D, Fu's Fs, Fu and Li's D, and Fu and Li's F) yielded negative values, suggesting that An. sinensis populations are expanding in all studied regions.Conclusion: This study characterizes the genetic attributes of An. sinensis in the ROK, providing valuable insights into the biology of this important malaria vector and contributing useful data for malaria control strategies.","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":"348-356"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12666396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and determinants of medication adherence in Moroccan patients with type 2 diabetes: a multicenter cross-sectional study. 摩洛哥2型糖尿病患者药物依从性的患病率和决定因素：一项多中心横断面研究

IF 1.6

Osong Public Health and Research Perspectives Pub Date : 2025-08-01 Epub Date: 2025-07-09 DOI: 10.24171/j.phrp.2025.0014

Maryem Arraji, Nadia Al Wachami, Younes Iderdar, Fatima Zahra Bouchachi, Karima Boumendil, Mohamed Chahboune

{"title":"Prevalence and determinants of medication adherence in Moroccan patients with type 2 diabetes: a multicenter cross-sectional study.","authors":"Maryem Arraji, Nadia Al Wachami, Younes Iderdar, Fatima Zahra Bouchachi, Karima Boumendil, Mohamed Chahboune","doi":"10.24171/j.phrp.2025.0014","DOIUrl":"10.24171/j.phrp.2025.0014","url":null,"abstract":"Background: This study was performed to evaluate the prevalence of medication adherence and its determinants among Moroccan patients with type 2 diabetes mellitus.Methods: A multicenter cross-sectional survey was conducted from February to June 2024, involving 584 patients from the Casablanca-Settat and Rabat-Sale-Kenitra regions of Morocco. Medication adherence was assessed using the general medication adherence scale. Associations between independent variables and adherence were analyzed using chi-square tests and multivariate logistic regression.Results: Medication adherence was observed in 96.2% of participants. Multivariate analysis revealed significantly lower medication adherence among patients using 2 or more oral antidiabetic drugs (adjusted odds ratio [aOR], 0.026; 95% confidence interval [CI], 0.001-0.642; p=0.026) and those with a diabetes duration of 11 to 15 years (aOR, 0.037; 95% CI, 0.001-0.956; p=0.047).Conclusion: Despite a high overall adherence rate, patients on dual or polytherapy and those with longer disease duration exhibited lower adherence in multivariate analysis. Targeted interventions are needed to improve adherence in these high-risk groups.","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":"392-405"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12666394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of direct prehospital transport on mortality in patients with severe trauma based on the injury severity score: a nationwide observational study in the Republic of Korea. 基于损伤严重程度评分的严重创伤患者院前直接转运对死亡率的影响：韩国一项全国性观察性研究

IF 1.6

Osong Public Health and Research Perspectives Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.24171/j.phrp.2025.0102

Sun Ju Kim, KeunKyun Kim, Oh Hyun Kim, Chan Yong Park

{"title":"Impact of direct prehospital transport on mortality in patients with severe trauma based on the injury severity score: a nationwide observational study in the Republic of Korea.","authors":"Sun Ju Kim, KeunKyun Kim, Oh Hyun Kim, Chan Yong Park","doi":"10.24171/j.phrp.2025.0102","DOIUrl":"10.24171/j.phrp.2025.0102","url":null,"abstract":"Background: Severe trauma remains a leading cause of death in the Republic of Korea. In response, regional trauma centers were established in 2012. This study evaluated the impact of direct prehospital transport to trauma centers on in-hospital mortality among patients with severe trauma using the national trauma registry.Methods: This nationwide observational study utilized data from the Korean community-based trauma registry between 2016 and 2020. Patients with an injury severity score >15 who were directly transported from the prehospital setting were included. Variables analyzed encompassed demographics, injury mechanism, transport time, hospital level, and outcomes. The primary outcome was in-hospital mortality. Both logistic regression and decision tree models were employed.Results: A total of 24,567 patients were included. Overall mortality decreased by 5.2% during the study period. Patients transported to level 1 or 2 trauma centers had a lower mortality rate (23.6%) compared to those transported to level 3 or 4 hospitals (28.0%). The proportion of direct transports to high-level centers increased from 46.7% to 64.1% between 2016 and 2020. Despite longer transport times, patients transported to high-level institutions exhibited improved survival, particularly when transport exceeded 30 minutes, suggesting that hospital selection may be more critical than minimizing transport time.Conclusion: Direct transport to high-level trauma centers improves survival among patients with severe trauma, even when transport times are prolonged. These findings support the importance of a well-organized trauma system that emphasizes hospital capability in prehospital triage decisions.","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":"381-391"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12666393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Republic of Korea's health system at a turning point: from infectious disease threats to comprehensive reform. 大韩民国的卫生系统处于转折点：从传染病威胁到全面改革。

IF 2.1

Osong Public Health and Research Perspectives Pub Date : 2025-06-01 Epub Date: 2025-06-27 DOI: 10.24171/j.phrp.2025.0235

Jong-Koo Lee

引用次数: 0

First report of human Mycobacterium bovis infection in a veterinary laboratory worker in the Republic of Korea. 韩国首次报告一名兽医实验室工作人员感染人牛分枝杆菌。

IF 2.1

Osong Public Health and Research Perspectives Pub Date : 2025-06-01 Epub Date: 2025-04-16 DOI: 10.24171/j.phrp.2024.0343

Ji-Yeon Lee, Seong Wook Pyo, Jieun Kim, Young-Joon Park

{"title":"First report of human Mycobacterium bovis infection in a veterinary laboratory worker in the Republic of Korea.","authors":"Ji-Yeon Lee, Seong Wook Pyo, Jieun Kim, Young-Joon Park","doi":"10.24171/j.phrp.2024.0343","DOIUrl":"10.24171/j.phrp.2024.0343","url":null,"abstract":"Background: In the Republic of Korea, the previous surveillance system for zoonotic tuberculosis (TB) involved the X-ray testing of humans in contact with Mycobacterium bovis-infected livestock. In contrast, the updated surveillance system incorporates the genotyping of cultured Mycobacterium isolates for high-risk occupational groups. This study aimed to systematically document the detection, diagnosis, assessment, and response in the epidemic investigation of zoonotic TB in a laboratory worker in the Republic of Korea.Methods: M. bovis was confirmed using spoligotyping and whole genome sequencing. Clinical characteristics were reviewed through epidemiological investigation and interviews with the affected individual. Transmission routes and secondary spread were assessed via field epidemiological investigations and contact evaluations using chest X-ray and interferon gamma release assay for latent TB infection.Results: A 56-year-old laboratory worker presented with chest X-ray findings compatible with TB and subsequently tested positive for M. bovis. She had no clinical or family history of TB and remained asymptomatic. She completed a 6 month treatment regimen of isoniazid, rifampin, ethambutol, and pyrazinamide without hospitalization. Although no direct transmission pathways for zoonotic TB were identified, her work in a laboratory, processing specimens for zoonotic TB, indicated potential laboratory related exposure.Conclusion: This case underscores the importance of stringent use of personal protective equipment among high-risk occupational groups and the implementation of an enhanced surveillance system to report zoonotic TB. These findings highlight the need for a One Health approach and proactive surveillance, emphasizing the necessity of refining and strengthening surveillance systems for precise monitoring and an effective response.","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":"292-299"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of vitamin D and the VDR gene polymorphism in sepsis risk and mortality: a systematic review and meta-analysis. 维生素D和VDR基因多态性在败血症风险和死亡率中的作用：一项系统综述。

IF 2.1

Osong Public Health and Research Perspectives Pub Date : 2025-06-01 Epub Date: 2025-04-29 DOI: 10.24171/j.phrp.2025.0006

Wiwi Jaya, Sumarno Reto Prawiro, Hani Susianti, Aswoco Andyk Asmoro

{"title":"The role of vitamin D and the VDR gene polymorphism in sepsis risk and mortality: a systematic review and meta-analysis.","authors":"Wiwi Jaya, Sumarno Reto Prawiro, Hani Susianti, Aswoco Andyk Asmoro","doi":"10.24171/j.phrp.2025.0006","DOIUrl":"10.24171/j.phrp.2025.0006","url":null,"abstract":"Background: Vitamin D regulates immune function, cell proliferation, and differentiation. Its deficiency is linked to sepsis, although the causal relationship remains unclear. Studies suggest a strong correlation between FokI polymorphism and sepsis in the context of vitamin D deficiency. This study examined the association between vitamin D levels, the VDR FokI polymorphism, and sepsis risk through a systematic review and meta-analysis.Methods: Relevant articles from 2014-2024 were identified from various databases, including PubMed, Scopus, and Cochrane. A meta-analysis was conducted to assess the difference in vitamin D levels between the sepsis and control groups, as well as the relationship between VDR FokI genotypes (TT, CT, CC) and sepsis risk.Results: Vitamin D levels in sepsis patients were consistently lower than in the control group, with a mean difference of -4.17 ng/mL (95% confidence interval, -7.87 to -0.47; p=0.03). However, the relationship between VDR FokI genotype and sepsis risk was not statistically significant (p>0.05), although several individual studies showed a positive correlation. High heterogeneity was found in the analysis of vitamin D levels (I2=100%) and FokI genotypes (I2=91%), which affected the interpretation of the results.Conclusion: Vitamin D deficiency is a potential risk factor for sepsis, while the relationship between the VDR FokI polymorphism and sepsis risk requires further investigation. These findings highlight the importance of early detection of vitamin D deficiency as a preventive strategy in at-risk populations, although additional studies with more standardized designs are needed to definitively confirm this relationship.","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":"211-222"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and evaluation of a multi-epitope subunit vaccine against human norovirus using an immunoinformatics approach. 利用免疫信息学方法设计和评价人诺如病毒多表位亚单位疫苗。

IF 2.1

Osong Public Health and Research Perspectives Pub Date : 2025-06-01 Epub Date: 2025-04-25 DOI: 10.24171/j.phrp.2024.0349

Zxcy L Nonog, Edward C Banico, Ma Easter V Sajo, Pablo V Serrano, Fredmoore L Orosco

{"title":"Design and evaluation of a multi-epitope subunit vaccine against human norovirus using an immunoinformatics approach.","authors":"Zxcy L Nonog, Edward C Banico, Ma Easter V Sajo, Pablo V Serrano, Fredmoore L Orosco","doi":"10.24171/j.phrp.2024.0349","DOIUrl":"10.24171/j.phrp.2024.0349","url":null,"abstract":"Background: This study aimed to identify safe, conserved, and highly immunogenic epitopes from all proteins of human-infecting norovirus (NoV) and to design a multi-epitope subunit vaccine construct from these epitopes using an immunoinformatics approach. Additionally, the vaccine construct was evaluated using both sequence- and structure-based assessments.Methods: Conserved fragments were identified from all proteins of human-infecting NoV, and B and T lymphocyte epitopes were subsequently predicted using multiple epitope prediction tools. The selected epitopes were linked to form a multi-epitope construct, incorporating various adjuvants in the design. Vaccine constructs with different adjuvants were analyzed for their physicochemical properties and immune simulation profiles, and the optimal combination was selected as the final vaccine candidate for further study. Finally, molecular docking and dynamics simulations were performed to visualize the interaction between the construct and a host immune receptor.Results: Twenty-two safe, conserved, and highly immunogenic epitopes were identified from all human-infecting NoV proteins. The construct adjuvanted with 50S ribosomal protein L7/L12 (50SrpL7/L12) was chosen as the final vaccine candidate due to its optimal physicochemical properties and favorable immune simulation profile. Furthermore, the construct exhibited high binding affinity and a stable interaction with toll-like receptor 4).Conclusion: The multi-epitope subunit vaccine designed in this study shows promise as a potential NoV vaccine candidate for human immunization. Further in vitro and in vivo experiments are warranted to validate these findings.","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":"236-251"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standardizing the approach to clinical-based human microbiome research: from clinical information collection to microbiome profiling and human resource utilization. 规范基于临床的人类微生物组研究方法：从临床信息收集到微生物组分析和人力资源利用。

IF 2.1

Osong Public Health and Research Perspectives Pub Date : 2025-06-01 Epub Date: 2025-04-11 DOI: 10.24171/j.phrp.2024.0319

Jung Wook Kim, Eun Chae Choi, Kwang Jun Lee

{"title":"Standardizing the approach to clinical-based human microbiome research: from clinical information collection to microbiome profiling and human resource utilization.","authors":"Jung Wook Kim, Eun Chae Choi, Kwang Jun Lee","doi":"10.24171/j.phrp.2024.0319","DOIUrl":"10.24171/j.phrp.2024.0319","url":null,"abstract":"Background: This study presents the standardized protocols developed by the Clinical-Based Human Microbiome Research and Development Project (cHMP) in the Republic of Korea.Methods: It addresses clinical metadata collection, specimen handling, DNA extraction, sequencing methods, and quality control measures for microbiome research.Results: The cHMP involves collecting samples from healthy individuals and patients across various body sites, including the gastrointestinal tract, oral cavity, respiratory system, urogenital tract, and skin. These standardized procedures ensure consistent data quality through controlled specimen collection, storage, transportation, DNA extraction, and sequencing. Sequencing encompasses both amplicon and whole metagenome methods, followed by stringent quality checks. The protocols conform to international guidelines, ensuring that the data generated are both reliable and comparable across microbiome studies.Conclusion: The cHMP underscores the importance of methodological standardization in enhancing data integrity, reproducibility, and advancing microbiome-based research with potential applications for improving human health outcomes.","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":"300-307"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of cognitive behavior therapy on abstinence among healthy smokers: a systematic review and meta-analysis of randomized controlled trials. 认知行为疗法对健康吸烟者戒烟的影响：随机对照试验的系统回顾和荟萃分析。

IF 2.1

Osong Public Health and Research Perspectives Pub Date : 2025-06-01 Epub Date: 2025-06-09 DOI: 10.24171/j.phrp.2025.0019

Rajesh Kumar, Priyanka Malhotra, Vishwas As, Kalpana Beniwal, Gopal Singh Charan

{"title":"Effect of cognitive behavior therapy on abstinence among healthy smokers: a systematic review and meta-analysis of randomized controlled trials.","authors":"Rajesh Kumar, Priyanka Malhotra, Vishwas As, Kalpana Beniwal, Gopal Singh Charan","doi":"10.24171/j.phrp.2025.0019","DOIUrl":"10.24171/j.phrp.2025.0019","url":null,"abstract":"Background: The objectives of this review and meta-analysis were twofold: first, to critically evaluate the effectiveness of cognitive behavioral therapy (CBT)-based interventions relative to standard care or control conditions in promoting smoking abstinence at the end of treatment, and second, to determine abstinence rates at 3 and 6 months of follow-up.Methods: A comprehensive search of electronic databases, including PubMed, Cochrane Library, PsycINFO, Embase, and ClinicalTrials.gov, was conducted for randomized controlled trials published from 2001 to September 2024. Studies evaluating the effect of CBT on abstinence rates among healthy smokers (aged ≥12 years) were included and analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Results: Out of 1,514 study records screened, 7 studies (comprising 17 arms and 1,438 participants) met eligibility criteria for inclusion in the final analysis. The pooled analysis revealed that CBT significantly improved smoking abstinence rates, demonstrating a fourfold increase in effectiveness compared to controls (odds ratio [OR], 4.04; 95% confidence interval [CI], 2.73-5.99; I2=19%; p<0.00001). Additionally, CBT significantly impacted smoking cessation at 3-month follow-up (OR, 1.62; 95% CI, 1.11-2.38; I2=0%; p=0.01) and 6-month follow-up (OR, 2.19; 95% CI, 1.59-3.00; I2=0%; p<0.00001).Conclusion: CBT has demonstrated efficacy in facilitating smoking abstinence, particularly immediately after treatment, with sustained but diminished effects over time. However, robust conclusions on the efficacy of CBT require further studies involving larger sample sizes, diverse geographical regions, and longer follow-up periods.","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":"223-235"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0