Osong Public Health and Research Perspectives最新文献

{"title":"Effectiveness of non-pharmacological school-based therapies for cigarette smoking cessation among adolescents in South and Southeast Asian countries: a systematic review and meta-analysis.","authors":"Fahad Ali Mangrio, Penpaktr Uthis, Suwimon Rojnawee, Alicia K Matthews","doi":"10.24171/j.phrp.2024.0320","DOIUrl":"10.24171/j.phrp.2024.0320","url":null,"abstract":"<p><strong>Background: </strong>This review and meta-analysis examined the effectiveness of non-pharmacological therapies delivered through school-based interventions for smoking cessation among adolescents in South and Southeast Asian countries.</p><p><strong>Methods: </strong>A systematic search was conducted across PubMed, Scopus, Science Direct, BioMed Central, the Cochrane Library, and ProQuest Dissertations & Theses Global from inception to October 2024. Eligible studies comprised randomized controlled trials and quasi-experimental studies that compared non-pharmacological smoking cessation interventions delivered in schools or other educational institutions. Data on smoking abstinence outcomes were extracted from published studies, and odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model via the Mantel-Haenszel estimator.</p><p><strong>Results: </strong>Seven studies involving 1,260 participants were included. The meta-analysis demonstrated that non-pharmacological school-based therapies significantly increased smoking abstinence compared to controls (OR, 2.83; 95% CI, 1.83-4.40; p<0.001. Subgroup analyzes revealed benefits across both randomized controlled trials and quasi-experimental studies with varying abstinence rates. Studies utilizing biochemical verification showed significant positive effects despite substantial heterogeneity, and short-term (<3 months) abstinence was significantly higher in intervention groups compared to controls. Overall, no differences were found between subgroups regarding intervention effectiveness.</p><p><strong>Conclusion: </strong>This meta-analysis indicates that non-pharmacological school-based interventions positively impact smoking abstinence rates, although effectiveness may vary based on study design, follow-up duration, and use of biochemical verification. The findings underscore the need for further research with larger sample sizes, extended follow-up periods, and improved methodological rigor in these regions.</p>","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":"195-210"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between diabetes medication self-efficacy and quality of life in older adults with diabetes: a cross-sectional study in Turkey.","authors":"Nilhan Töyer Şahin, İlayda Kömürcü, Seda Aşcı","doi":"10.24171/j.phrp.2025.0218","DOIUrl":"https://doi.org/10.24171/j.phrp.2025.0218","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to investigate the relationship between diabetes medication self-efficacy and quality of life in older adults with diabetes.</p><p><strong>Methods: </strong>The study included 192 older adults who attended the diabetes clinic of a public hospital in Istanbul. Data were collected between June and October 2024. Participants were informed about the study and provided both verbal and written consent. Data collection instruments comprised a sociodemographic questionnaire, the diabetes medication self-efficacy scale, and the quality of life scale for older adults.</p><p><strong>Results: </strong>Of the participants, 98 (51.0%) were women and 105 (54.7%) were aged 65 to 74 years. The mean diabetes medication self-efficacy score was 38.95±10.31, and the mean quality of life score was 18.24±6.37. A weak but statistically significant positive correlation was observed between the autonomy and satisfaction subscale of quality of life and the necessity subscale of self-efficacy (p<0.05).</p><p><strong>Conclusion: </strong>This study, which examined the relationship between self-efficacy in diabetes management and quality of life in older adults, provides valuable guidance for clinical practice aimed at improving care for this population.</p>","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of intimate partner violence during pregnancy on maternal mental health and child development: a birth cohort study in central Vietnam.","authors":"Han Dai Tri Tran, Cuc Thi Vu, Hoang Thuy Linh Nguyen, Duc Nu Hong Vo, Bao-Yen Luong-Thanh, Thang Van Vo","doi":"10.24171/j.phrp.2025.0178","DOIUrl":"https://doi.org/10.24171/j.phrp.2025.0178","url":null,"abstract":"<p><strong>Objectives: </strong>This study measured the impact of prenatal intimate partner violence (p-IPV) on maternal mental health and suspected developmental delays (SDDs) in children at 6 months of age in central Vietnam.</p><p><strong>Methods: </strong>Data were drawn from a community-based birth cohort of 285 mother-child dyads in Hue citycity, central Vietnam. The exposure factor was p-IPV, assessed using the revised conflict tactics scale (CTS2). Maternal mental health was measured with the patient health questionnaire-9. Child development at 6 months was screened using the Vietnamese version of the Ages and Stages Questionnaire, 3rd Edition (ASQ-3). Robust Poisson regression was used to estimate associations of p-IPV with maternal mental health and SDDs.</p><p><strong>Results: </strong>Among the women, 18.9% reported experiencing p-IPV. SDDs were identified in 13% of the children, with communication delays being the most prevalent (10.9%). The association between p-IPV and SDDs remained significant after adjustment for confounders in multilevel models, with the highest relative risk (RR) observed in the fully adjusted model (RR, 2.43; 95% confidence interval [CI], 1.08-5.48). p-IPV exposure was significantly associated with postpartum depression in the crude and partially adjusted models, but this association became non-significant after full adjustment-most notably after accounting for prenatal depression, which remained a predictor of postpartum depression (RR, 1.15; 95% CI, 1.06-1.25).</p><p><strong>Conclusion: </strong>p-IPV is significantly associated with increased risk of postpartum depression and developmental delays in early infancy. Integrating IPV screening and targeted interventions into prenatal care may contribute to improved developmental outcomes in children and better maternal health.</p>","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing adherence to anti-tuberculosis treatment in Morocco: a cross-sectional study from the Béni Mellal-Khénifra region.","authors":"Mohamed Dellal, Sanae Batoui, Youness Aassem, Khalid Habbari","doi":"10.24171/j.phrp.2025.0153","DOIUrl":"https://doi.org/10.24171/j.phrp.2025.0153","url":null,"abstract":"<p><strong>Objectives: </strong>Adherence to anti-tuberculosis treatment is essential for achieving successful outcomes and preventing the emergence of drug-resistant strains. This study aimed to evaluate adherence levels and identify factors associated with non-adherence among tuberculosis patients in the Béni Mellal-Khénifra region of Morocco. We hypothesized that sociodemographic, clinical, and behavioral factors influence adherence.</p><p><strong>Methods: </strong>A facility-based cross-sectional study was conducted from January 2023 to December 2024 in 2 Tuberculosis and Respiratory Disease Diagnostic Centers in the Béni Mellal-Khénifra region. A total of 481 patients who had been on treatment for at least 2 months were recruited using convenience sampling. Data were collected through structured, pre-tested questionnaires administered in face-to-face interviews and verified against treatment cards and medical records. Adherence was defined as taking ≥90% of prescribed doses. Multivariable logistic regression was used to identify independent predictors of non-adherence.</p><p><strong>Results: </strong>Among the 481 participants, 8.1% were non-adherent. Significant predictors of non-adherence included forgetfulness (adjusted odds ratio [AOR], 38.84; 95% confidence interval [CI], 11.35-132.88), adverse effects (AOR, 14.26; 95% CI, 3.17-64.13), male sex (AOR, 6.77; 95% CI, 1.45-31.60), rural residence (AOR, 4.42; 95% CI, 1.37-14.25), self-adjusted dosing (AOR, 5.83; 95% CI, 1.20-28.34), stopping treatment after symptom improvement (AOR, 6.56; 95% CI, 1.34-32.14), and missed follow-up visits (AOR, 6.74; 95% CI, 1.56-29.19).</p><p><strong>Conclusion: </strong>Although overall adherence was high, 8.1% of patients were non-adherent. Strategies to improve adherence should focus on addressing forgetfulness, managing side effects, enhancing access in rural areas, and reinforcing patient education and follow-up systems to improve treatment outcomes in this and similar settings.</p>","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of digital literacy on older adults' self-rated health, depression, and life satisfaction: a cross-sectional study using 2023 National Survey of Older Koreans.","authors":"Myo-Gyeong Kim, Jeonghae Hwang, Nan-He Yoon","doi":"10.24171/j.phrp.2025.0255","DOIUrl":"https://doi.org/10.24171/j.phrp.2025.0255","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined the associations between digital literacy and self-rated health (SRH), depression, and life satisfaction among older adults in the Republic of Korea.</p><p><strong>Methods: </strong>Data were obtained from the 2023 National Survey of Older Koreans (n=9,951). Digital literacy was evaluated based on participants' ability to use 8 smartphone functions and their perceived difficulty adapting to a digital society. Dependent variables included SRH, depression (measured using the short form of Geriatric Depression Scale), and life satisfaction (assessed through a composite score across 7 domains). Multiple logistic regression was applied for SRH and depression, while linear regression was conducted for life satisfaction, adjusting for sociodemographic and health-related covariates.</p><p><strong>Results: </strong>Higher digital literacy was significantly associated with better SRH and greater life satisfaction. Compared to participants with no digital skills, those with moderate or high digital literacy had higher odds of reporting good SRH and significantly higher life satisfaction scores. Older adults who reported difficulty adapting to a digital society demonstrated significantly lower SRH and life satisfaction. However, after adjusting for covariates, the association between digital literacy and depression was not statistically significant.</p><p><strong>Conclusion: </strong>Higher digital literacy is linked to better SRH and greater life satisfaction. Moreover, digital literacy reduced the explanatory power of socioeconomic variables, suggesting that it serves as an important behavioral determinant. These findings underscore the importance of promoting digital literacy as a means of improving health equity and well-being in aging populations.</p>","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging innovation and policy: comparative pathways of national vaccine development in low- and middle-income countries.","authors":"Vahid Marandi","doi":"10.24171/j.phrp.2025.0208","DOIUrl":"https://doi.org/10.24171/j.phrp.2025.0208","url":null,"abstract":"<p><strong>Objectives: </strong>To examine how national innovation and policy configurations enabled vaccine development in Brazil, Cuba, India, and Iran, and to distil lessons for low- and middle-income country (LMIC) vaccine sovereignty.</p><p><strong>Methods: </strong>Narrative review of peer-reviewed and grey literature (2020-2023), guided by a structured search and screening approach; synthesis mapped to national and sectoral innovation system perspectives and technology readiness levels.</p><p><strong>Results: </strong>Cuba and Iran leveraged mission-oriented public research and development (R&D) and domestic platforms; India combined indigenous R&D with large-scale licensed manufacturing; Brazil's scientific capacity was constrained by fragmented governance and supply-chain dependence. Adaptive regulation (e.g., emergency use authorization/conditional approvals), targeted technology transfer, and South-South partnerships accelerated progress but raised longer-term questions about intellectual property (IP) control and economic sustainability.</p><p><strong>Conclusion: </strong>Institutional coherence, strategic IP management, and regional manufacturing alliances are as critical as scientific capacity for LMIC vaccine self-reliance. Policy priorities include pre-negotiated tech-transfer frameworks, regulatory preparedness, and investment in public R&D linked to distributed manufacturing.</p>","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of construal-level messaging in the COVID-19 Vaccine Injury Compensation Program in the Republic of Korea: a randomized controlled trial.","authors":"Jihyun Moon, Se-Hoon Jeong, Young June Choe, Cho Ryok Kang, Taemi Kim, Dooyoung Kim, Jong-Koo Lee","doi":"10.24171/j.phrp.2024.0354","DOIUrl":"https://doi.org/10.24171/j.phrp.2024.0354","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the impact of high-level versus low-level construal messages about the coronavirus disease 2019 (COVID-19) Vaccine Injury Compensation Program (CVICP) on public attitudes toward the program and COVID-19 vaccination.</p><p><strong>Methods: </strong>A randomized controlled experimental design was employed. Adults aged 18 to 64 residing in the Republic of Korea were randomly assigned to either an experimental group (high-level construal message) or a control group (low-level construal message). Both groups viewed a 2-minute video about the CVICP, with construal level as the sole variable. Pre- and post-intervention questionnaires evaluated attitudes toward the CVICP and COVID-19 vaccination, including satisfaction, perceived necessity, and perceived effectiveness in enhancing vaccine acceptance. Data were analyzed using the paired t-test, repeated measures 2-way analysis of variance, and multiple linear regression.</p><p><strong>Results: </strong>The experimental group showed statistically significant improvements across all 6 attitude measures following exposure to the high-level construal message. By contrast, the control group demonstrated significant improvement in only 3 attitudes: satisfaction with the CVICP, willingness to recommend vaccination, and willingness for future vaccination. A significant difference between groups was observed for perceived effectiveness of the CVICP in enhancing vaccine acceptance (p=0.01), with high-level construal messaging being more impactful.</p><p><strong>Conclusion: </strong>High-level construal messages are more effective than low-level messages in shaping public perceptions and addressing vaccine hesitancy. Policymakers and health authorities should incorporate high-level construal elements into communication strategies to build trust and support for vaccination programs.</p>","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A confirmatory analysis of the knowledge, attitudes, and perceptions questionnaire for community-based surveillance of infectious diseases: a cross-sectional study in Malaysia.","authors":"Ahmed Azeez Hasan, Anis Kausar Ghazali, Norsa'adah Bachok, Najib Majdi Yaacob, Suhaily Mohd Hairon, Nur Amira Mohd Nadir, Fatimah Shukri","doi":"10.24171/j.phrp.2025.0106","DOIUrl":"https://doi.org/10.24171/j.phrp.2025.0106","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to validate the psychometric properties of the recently developed knowledge, attitudes, and perceptions questionnaire for community-based surveillance of infectious diseases (KAP-CBS-ID questionnaire), using confirmatory factor analysis (CFA) and item response theory (IRT).</p><p><strong>Methods: </strong>A cross-sectional study using multistage sampling recruited 470 schoolteachers from Kelantan, Malaysia. The self-administered KAP-CBS-ID questionnaire consists of 3 domains: knowledge (31 items), attitudes (23 items), and perceptions (21-items). Two-parameter logistic (2-PL) IRT analysis and CFA were performed to validate the knowledge section. For attitudes and perceptions sections, CFA proceeded using a 4-factor model to evaluate both model fit and construct validity.</p><p><strong>Results: </strong>2-PL IRT analysis of the knowledge section resulted in elimination of 14 items due to inadequate discrimination or difficulty parameters. The 3-factor CFA model demonstrated good fit indices for knowledge (root mean square error of approximation [RMSEA], 0.028; comparative fit index [CFI], 0.945; Tucker-Lewis index [TLI], 0.941) without any modifications. The attitudes section required re-specification, ultimately yielding 21 items across 4 factors with acceptable fit indices (standardized root mean square residual [SRMR], 0.067; RMSEA, 0.055; CFI, 0.937; TLI, 0.927). Similarly, the perceptions section was refined to 17 items across 4 factors, showing good model fit (SRMR, 0.055; RMSEA, 0.059; CFI, 0.962; TLI, 0.954). Factor loadings ranged from 0.33 to 0.98, while Raykov's rho reliability estimates ranged from 0.713 to 0.858. Factor determinacy exceeded 80% for all factors.</p><p><strong>Conclusion: </strong>The KAP-CBS-ID is a valid and reliable instrument for assessing community representatives' knowledge, attitudes, and perceptions regarding community-based surveillance of infectious diseases.</p>","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug use intentions among young adults in the Republic of Korea: a cross-sectional study applying the extended theory of planned behavior with emphasis on impulsive behavior and sensation seeking.","authors":"Aeree Sohn","doi":"10.24171/j.phrp.2025.0104","DOIUrl":"https://doi.org/10.24171/j.phrp.2025.0104","url":null,"abstract":"<p><strong>Objectives: </strong>The increasing prevalence of drug use in the Republic of Korea has emerged as a significant social concern. This study applied the extended theory of planned behavior to investigate the factors influencing intentions to use drugs among young adults (aged 20-30 years) in the Republic of Korea. The study integrated personal traits-specifically, impulsivity, sensation seeking, and self-efficacy-into 2 core theory of planned behavior constructs: attitudes and subjective norms. The principal aim was to improve the prediction of drug use intentions by incorporating these variables.</p><p><strong>Methods: </strong>Data were obtained from the 2023 National Survey of Drug Harm Perception, which sampled 1,500 individuals aged 19 to 59 years. Hierarchical regression analysis was employed to assess the influence of psychological and social factors on intentions to use drugs.</p><p><strong>Results: </strong>In the primary model, age emerged as a significant predictor of drug use intentions (R²=0.01). The secondary model showed that positive attitudes toward drugs, subjective norms, and lower self-efficacy significantly increased drug use intentions (R²=0.23). In the final tertiary model, the addition of sensation seeking and impulsivity further amplified these intentions (R²=0.25).</p><p><strong>Conclusion: </strong>The findings underscore the pivotal roles of attitudes, subjective norms, and self-efficacy in shaping intentions to use drugs. Sensation seeking and impulsivity were found to further elevate vulnerability. Effective prevention efforts must address both psychological traits and social influences. Future research should examine the long-term behavioral outcomes associated with these factors.</p>","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoinformatics study of CD40 ligand-targeting vaccine constructs: a novel immunotherapeutic approach.","authors":"Seyed Amir Sadeghi, Mahroo Mohamadi, Hadi Bamehr, Fatemeh Heidarnejad, Azam Bolhassani","doi":"10.24171/j.phrp.2025.0077","DOIUrl":"https://doi.org/10.24171/j.phrp.2025.0077","url":null,"abstract":"<p><strong>Objectives: </strong>Incorporating CD40 ligand (CD40L) into vaccine strategies has shown considerable potential for enhancing immune responses. In this study, we designed and formulated a CD40L-based multi-epitope vaccine construct using immunoinformatics approaches, and compared it to a full-length CD40L-based vaccine construct.</p><p><strong>Methods: </strong>The study commenced with the identification and screening of potential T-cell and B-cell epitopes derived from the CD40L protein, followed by the construction of a multi-epitope vaccine from these selected epitopes. We analyzed and validated the physicochemical and structural properties of the vaccine constructs. Further, we predicted disulfide bonds, performed protein-protein docking, and conducted molecular dynamics simulations to evaluate the constructs. Comparative analyses of the ligand-binding site localization were conducted using LigPlot. Additionally, simulation trajectories were analyzed using multiple descriptors, including root mean square deviations, radius of gyration, and root mean square fluctuations.</p><p><strong>Results: </strong>Our findings indicated that the CD40L multi-epitope vaccine construct possessed favorable physicochemical properties and a validated structural profile. Immune simulation studies showed a stronger affinity of the multi-epitope construct for the CD40 receptor compared to the full-length CD40L construct.</p><p><strong>Conclusion: </strong>Overall, the CD40L multi-epitope vaccine construct demonstrated greater potency in eliciting an effective immune response than the full-length CD40L construct. These results highlight a promising approach to vaccine design for the prevention or treatment of infections and cancers.</p>","PeriodicalId":38949,"journal":{"name":"Osong Public Health and Research Perspectives","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}